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张家口市高血压视网膜病变患者情况调查及危险因素分析

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基础医学与临床 2024年第6期44卷 853-857页

作者：张佳王艳丽宋晓丛王淑珍张家口市第一医院眼科河北张家口075000

目的探讨张家口市高血压视网膜病变患者情况调查及危险因素。方法2021年5月至2022年12月对张家口市19个县区的居民进行高血压病和高血压视网膜病变筛查,所有受检人员均测量血压、眼科检查以及血糖检测,采用问卷调查形式收集患者年龄、... 详细信息

目的探讨张家口市高血压视网膜病变患者情况调查及危险因素。方法2021年5月至2022年12月对张家口市19个县区的居民进行高血压病和高血压视网膜病变筛查,所有受检人员均测量血压、眼科检查以及血糖检测,采用问卷调查形式收集患者年龄、性别、病程、体质量指数(BMI)、并发症等,统计张家口市居民高血压视网膜病变的患病率,分析影响患者的危险因素。结果实际接受检查居民8056例,共检出高血压患者1320例,高血压患病率为16.39%(1320/8056);调查出的1320例高血压患者中检查出视网膜病变患者212例,在高血压患者中患病率为13.06%(212/1320),在所有受检居民中患病率为2.63%;年龄≥60岁占比高于<60岁占比,无高血压治疗史患者占比高于有治疗史患者(P<0.05);病患组病程、收缩压、舒张压、糖尿病占比及吸烟史占比均高于对照组(P<0.05);高血压病程长、高收缩压、高舒张压、有糖尿病史是发生高血压视网膜病变发生的危险因素(P<0.05)。结论张家口市19个县区的居民高血压视网膜病变发生率较低,且在年龄≥60岁中发病率较高,病程长、高收缩压、高舒张压及糖尿病史是其危险因素。

关键词：高血压视网膜病变危险因素患病率

血清基质金属蛋白酶-9、可溶性尿激酶型纤溶酶原激活物受体及纤溶酶原激活物抑制因子-1联合检测预测老年慢性心力衰竭患者预后的价值

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实用临床医药杂志 2024年第3期28卷 34-38页

作者：杨博王艳丽崔晓敬河北省廊坊市中医医院心血管病科河北廊坊065000 河北省廊坊市人民医院急诊重症医学科河北廊坊065000

目的探讨血清基质金属蛋白酶-9(MMP-9)、可溶性尿激酶型纤溶酶原激活物受体(suPAR)及纤溶酶原激活物抑制因子-1(PAI-1)表达与老年慢性心力衰竭(CHF)患者心功能分级及预后的关系。方法选取廊坊市中医医院收治的108例CHF患者及同期50例... 详细信息

目的探讨血清基质金属蛋白酶-9(MMP-9)、可溶性尿激酶型纤溶酶原激活物受体(suPAR)及纤溶酶原激活物抑制因子-1(PAI-1)表达与老年慢性心力衰竭(CHF)患者心功能分级及预后的关系。方法选取廊坊市中医医院收治的108例CHF患者及同期50例健康体检者分别作为研究组和对照组。采集受试者血液标本,测定血清MMP-9、suPAR及PAI-1水平。比较不同纽约心脏病协会(NYHA)心功能分级患者及不同预后患者的血清指标差异,并分析各血清指标对不良预后的预测价值。结果与对照组相比,研究组血清MMP-9、suPAR、PAI-1水平更高,差异有统计学意义(P<0.05)。NYHA分级Ⅱ级、Ⅲ级、Ⅳ级CHF患者的血清MMP-9、suPAR、PAI-1水平呈逐渐升高趋势,差异均有统计学意义(P<0.05)。随访1年的结果显示,预后良好65例,预后不良43例,预后不良率为39.81%(43/108)。与预后良好患者相比,预后不良患者的年龄更大,合并高血压率更高,左室射血分数(LVEF)更低,左室舒张末期内径(LVEDD)、MMP-9、suPAR及PAI-1水平更高,差异有统计学意义(P<0.05)。Logistic回归分析显示,年龄、MMP-9、suPAR、PAI-1均是老年CHF患者预后不良的危险因素,LVEF是老年CHF患者预后不良的保护因素(P<0.05)。血清MMP-9、suPAR、PAI-1单独检测及3项联合检测的曲线下面积(AUC)分别为0.711、0.829、0.768和0.840,3项联合检测的敏感度为88.21%,特异度为79.46%。结论老年慢性CHF患者的血清MMP-9、suPAR、PAI-1表达水平与心功能分级及预后不良密切相关。

关键词：慢性心力衰竭基质金属蛋白酶-9 可溶性尿激酶型纤溶酶原激活物受体纤溶酶原激活物抑制因子-1 预后

Numerical Validation for High Order Hyperbolic Moment System of Wigner Equation

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Communications in Computational Physics 2014年第3期15卷 569-595页

作者： Ruo Li Tiao Lu yanli wang Wenqi Yao School of Mathematical Sciences Peking UniversityBeijing 100871P.R.China HEDPS and LMAM Peking UniversityBeijing 100871P.R.China BICMR Peking UniversityBeijing 100871P.R.China CAPT Peking UniversityBeijing 100871P.R.China

A globally hyperbolic moment system upto arbitrary order for the Wigner equation was derived in[6].For numerically solving the high order hyperbolic moment system therein,we in this paper develop a preliminary numerical method for this system following the NRxx method recently proposed in[8],to validate the moment system of the Wigner *** method developed can keep both mass and momentum conserved,and the variation of the total energy under control though it is not strictly *** systematically study the numerical convergence of the solution to the moment system both in the size of spatial mesh and in the order of the moment expansion,and the convergence of the numerical solution of the moment system to the numerical solution of the Wigner equation using the discrete velocity *** numerical results indicate that the high order moment system in[6]is a valid model for the Wigner equation,and the proposed numerical method for the moment system is quite promising to carry out the simulation of the Wigner equation.

关键词： Wigner equation NRxx method moment method

Gravimetric analysis for PM_(2.5) mass concentration based on year-round monitoring at an urban site in Beijing

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Journal of Environmental Sciences 2016年第2期28卷 154-160页

作者： yanli wang Wen Yang Bin Han Wenjie Zhang Mindong Chen Zhipeng Bai State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Nanjing University of Information Science & Technology

Daily PM_（2.5）（particulate matter with an aerodynamic diameter of below 2.5 μm） mass concentrations were measured by gravimetric analysis in Chinese Research Academy of Environmental Sciences（CRAES）, in the northern part of the Beijing urban area, from December 2013 to April 2015. Two pairs of Teflon（T1/T2） and Quartz（Q1/Q2） samples were obtained, for a total number of 1352 valid filters. Results showed elevated pollution in Beijing,with an annual mean PM_（2.5）mass concentration of 102 μg/m^3. According to the calculated PM_（2.5）mass concentration, 50% of our sampling days were acceptable（PM_（2.5）〈 75 μg/m^3）, 30% had slight/medium pollution（75–150 μg/m^3）, and 7% had severe pollution（〉 250 μg/m^3）. Sampling interruption occurred frequently for the Teflon filter group（75%） in severe pollution periods,resulting in important data being missing. Further analysis showed that high PM_（2.5）combined with high relative humidity（RH） gave rise to the interruptions. The seasonal variation of PM_（2.5）was presented, with higher monthly average mass concentrations in winter（peak value in February, 422 μg/m^3）, and lower in summer（7 μg/m^3 in June）. From May to August, the typical summer period, least severe pollution events were observed, with high precipitation levels accelerating the process of wet deposition to remove PM_（2.5）. The case of February presented the most serious pollution, with monthly averaged PM_（2.5）of 181 μg/m^3 and 32% of days with severe pollution. The abundance of PM_（2.5）in winter could be related to increased coal consumption for heating needs.

关键词： PM_(2.5) Gravimetric analysis Sampling interruption Pollution level Relative humidity(RH) Seasonal variation

基于风险因子理论的辅仁药业财务舞弊及防范分析

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财务管理研究 2024年第6期 78-83页

作者：王艳丽刘杨杨郑美琪新疆财经大学乌鲁木齐830012

当前,随着证券市场的快速发展,拥有一个健全的证券市场环境是所有企业和投资者的共同心愿。然而,近年来因为披露的财务报告信息不规范而被调查的上市公司越来越多。这种混乱的局面使投资者对自身的投资行为失去了准确判断,同时也影响了... 详细信息

当前,随着证券市场的快速发展,拥有一个健全的证券市场环境是所有企业和投资者的共同心愿。然而,近年来因为披露的财务报告信息不规范而被调查的上市公司越来越多。这种混乱的局面使投资者对自身的投资行为失去了准确判断,同时也影响了市场经济的正常运转。准确识别上市公司的各种财务造假手段并针对性地采取应对措施至关重要。以辅仁药业为例,基于舞弊风险因子理论,通过对辅仁药业财务舞弊手段的分析,得出如下结论:风险因子理论在分析企业财务舞弊时具有明显的优势。要预防和控制公司产生财务舞弊,则要从内部和外部两个方面入手采取有效对策,建立起一套科学完善的制度。

关键词：财务舞弊风险因子理论辅仁药业

Web search and data mining of natural products and their bioactivities in PubChem

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Science China Chemistry 2013年第10期56卷 1424-1435页

作者： HAO Ming CHENG Tiejun wang yanli BRYANT H. Stephen National Center for Biotechnology Information National Library of Medicine National Institutes of HealthBethesda MD 20894 USA

Natural products,as major resources for drug discovery historically,are gaining more attentions recently due to the advancement in genomic sequencing and other technologies,which makes them attractive and amenable to drug candidate *** and mining the bioactivity information of natural products are extremely important for accelerating drug development process by reducing ***,a number of publicly accessible databases have been established to facilitate the access to the chemical biology data for small molecules including natural ***,it is imperative for scientists in related fields to exploit these resources in order to expedite their researches on natural products as drug leads/candidates for disease ***,as a public database,contains large amounts of natural products associated with bioactivity *** this review,we introduce the information system provided at PubChem,and systematically describe the applications for a set of PubChem web services for rapid data retrieval,analysis,and downloading of natural *** hope this work can serve as a starting point for the researchers to perform data mining on natural products using PubChem.

关键词： natural products drug discovery PubChem public database data mining

A Review of the Design and Architecture of Starch-Based Dietary Foods

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Engineering 2021年第5期7卷 663-673页

作者： Yuxiang Bai Xiaoxiao Li Hangyan Ji Yu wang Danni Zheng yanli wang Zhengyu Jin State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province Jiangnan UniversityWuxi 214122China

Carbohydrates,which are mostly present in sugar,starch,and fiber,are one of the main ingredients of food and the primary source of energy in the human *** these three main sources,starch stands out as one of the most abundant reserves of *** starch would not only enhance our understanding of the functionality of starch in the human body but also aid in the design of novel starch-based dietary *** present review first provides a state-of-the-art understanding of the various classifications of dietary starches,including rapidly digesting starch(RDS),slowly digesting starch(SDS),and resistant starch(RS).Moreover,both the in vivo and in vitro determination methods of the digestibility of starch-based dietary foods are *** on the current understanding,present research strategies to design novel starch-based dietary foods through either the direct addition of modified starch or the alteration of processing conditions are ***,certain perspectives related to the future research directions of starch-based foods are also included.

关键词： Sugar Starch Fiber Dietary foods

Direct Imaging of Titania Nanotubes Located in Mouse Neural Stem Cell Nuclei

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Nano Research 2009年第7期2卷 543-552页

作者： yanli wang Jia wang Xiaoyong Deng Jiao wang Haifang wang Minghong Wu Zheng Jiao Yuanfang Liu Institute of Nanochemistry and Nanobiology Shanghai UniversityShanghai 200444China Institute of Systems Biology Shanghai UniversityShanghai 200444China Beijing National Laboratory for Molecular Sciences Department of Chemical BiologyCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

Titania nanotubes(TiO2-NTs)are a potential drug vehicle for use in *** this end,a preliminary study of the interaction of a model cell with TiO2-NTs has been carried ***2-NTs were first conjugated with a fl uorescent label,fl uorescein isothiocyanate(FITC).FITC-conjugated titania nanotubes(FITC-TiO2-NTs)internalized in mouse neural stem cells(NSCs,line C17.2)can be directly imaged by confocal *** confocal imaging showed that FITC-TiO2-NTs readily entered into the *** co-incubation with cells for 24 h,FITC-TiO2-NTs localized around the cell nucleus without crossing the *** interestingly,the nanotubes passed through the karyotheca entering the cell nucleus after co-incubation for 48 *** force microscopy(AFM)and transmission electron microscopy(TEM)were also employed in tracking the nanotubes in the *** results will be of benefit in future studies of TiO2-NTs for use as a drug vehicle,particularly for DNA-targeting drugs.

关键词： Titania nanotubes mouse neural stem cells nucleus confocal imaging atomic force microscopy

The study of electroless Ni-W-P alloy plating on glass fibers

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Rare Metals 2007年第4期26卷 365-371页

作者： HUANG Ying HUANG Fei ZHAO Wentao SHI Ke ZHAO Li wang yanli DeparUnent of Applied Chemistry School of Science Northwestern Polytechnical University Xi＇an 710072 China

Ni-W-P coatings were deposited on the surface of glass fibers by the electroless plating process. The bath was very stable through the palladium salt test. There was no phenomenon of peeling and blistering on the surface of the Ni-W-P alloy glass fibers in the thermal shock test. It showed that the deposit had high impact strength and good adhesion. The morphology of the coatings was observed by scanning electron microscope （SEM）. The elements and their contents were tested and analyzed by energy dispersion spectrometer （EDS）. The tungsten content reached up to 12.1 wt.%. The effects of the concentrations of NiSO4, Na2WO4, and NaH2PO2.H20 on the conductivity of the coatings were studied. The resistivity of the Ni-W-P alloy glass fibers reached 7.39 × 10^-3 Ωcm. The alloy coatings on glass fibers were analyzed by XRD. The results indicated that the deposit had an amorphous structure and good heat stability. The suitable work temperature range was lower than 190℃. Finally, the electromagnetic parameters of the Ni-W-P alloy glass fibers were tested and analyzed primarily. The magnetic loss reached 0.04023 and the dielectric loss reached -5.80239. The plated alloy is a kind of soft magnetic material.

关键词： Ni-W-P alloy electroless plating resistivity electromagnetic parameters glass fiber