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Efficacy of ginseng-based Renshenguben oral solution for cancer-related fatigue among patients with advanced-stage hepatocellular carcinoma:A prospective multicenter cohort study

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 249-256页

作者： Ming-Da wang Chen Yuan Ke-Chun wang nan-ya wang Ying-Jian Liang Hong Zhu Xiang-Min Tong Tian yang Department of Hepatobiliary and Pancreatic Surgery General Surgery CenterFirst Hospital of Jilin UniversityChangchun 130021China Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical University(Naval Medical University)Shanghai 200438China Department of Clinical Laboratory Laboratory Medicine CenterZhejiang Provincial People’s HospitalHangzhou Medical CollegeHangzhou 310000China Department of Hepatobiliary Surgery First Affiliated Hospital of Harbin Medical UniversityHarbin 150007China Department of Medical Oncology First Affiliated Hospital of Soochow UniversitySuzhou 215006China fDepartment of Central Laboratory Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhou 310006China

Background:Cancer-related fatigue(CRF)is a common and debilitating symptom experienced by patients with advanced-stage cancer,especially those undergoing antitumor *** study aimed to evaluate the efficacy and safety of Renshenguben(RSGB)oral solution,a ginseng-based traditional Chinese medicine,in alleviating CRF in patients with advanced hepatocellular carcinoma(HCC)receiving antitumor ***:In this prospective,open-label,controlled,multicenter study,patients with advanced HCC at BCLC stage C and a brief fatigue inventory(BFI)score of≥4 were *** were assigned to the RSGB group(RSGB,10 mL twice daily)or the control group(with supportive care).Primary and secondary endpoints were the change in multidimensional fatigue inventory(MFI)score,and BFI and functional assessment of cancer therapy-hepatobiliary(FACT-Hep)scores at weeks 4 and 8 after *** events(AEs)and toxicities were ***:A total of 409 participants were enrolled,with 206 assigned to the RSGB *** week 4,there was a trend towards improvement,but the differences were not statistically *** week 8,the RSGB group exhibited a significantly lower MFI score(P<0.05)compared to the control group,indicating improved fatigue ***,the RSGB group showed significantly greater decrease in BFI and FACT-Hep scores at week 8(P<0.05).Subgroup analyses among patients receiving various antitumor treatments showed similar *** linear regression analyses revealed that the RSGB group experienced a significantly substantial decrease in MFI,BFI,and FACT-Hep scores at week *** serious drug-related AEs or toxicities were ***:RSGB oral solution effectively reduced CRF in patients with advanced HCC undergoing antitumor therapy over an eight-week period,with no discernible *** findings support the potential of RSGB oral solution as an adjunctive treatment for managing CRF in this patient population.

关键词： Cancer-related fatigue Hepatocellular carcinoma Renshenguben oral solution Efficacy Safety Ginseng

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Elephantiasic Pretibial Myxedema with Involvement of the Buttocks and Face

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Chinese Medical Journal 2017年第15期130卷 1887-1888页

作者： ya-nan wang Tag wang Dong-Lai Ma Li Li Department of Dermatology Peking Union Medical College Hospital Chinese Academy Medical Sciences Beijing 100730 China

To the Editor：Pretibial myxedema （PTM）,a localized thyroid-associated dermopathy,is characterized by local thickening and remodeling of the skin-it is often associated with a group of autoimmune thyroid diseases （ATDs）.[1] PTM is most frequently located across the lower legs,especially the pretibial areas or the dorsum of the ***,the fingers and hands,elbows,arms,or face are ***,we report an unusual case of PTM and vitiligo,involving buttocks and face.

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浅谈中国黄酒与日本清酒

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中国食品药品监管 2024年第4期 134-139页

作者：李颖郑博文李新月程蒙刘根喜王雅南王红阳杨光中国中医科学院中药资源中心河北中医药大学

中国黄酒是世界三大古酒之一,日本清酒的起源有赖于我国水稻种植、黄酒酿造技术的传入。黄酒和清酒都经历了漫长的发展时期,体现了所在国经济和文化的发展变迁。目前关于黄酒、清酒的相关研究较为分散,缺乏系统整理。本文对中国黄酒和... 详细信息

中国黄酒是世界三大古酒之一,日本清酒的起源有赖于我国水稻种植、黄酒酿造技术的传入。黄酒和清酒都经历了漫长的发展时期,体现了所在国经济和文化的发展变迁。目前关于黄酒、清酒的相关研究较为分散,缺乏系统整理。本文对中国黄酒和日本清酒的历史沿革、分类方法进行了梳理,概述了二者在原料、工艺、成分、功效方面的研究情况,并提出对黄酒酿造和产业发展的建议,探讨中国黄酒发展可借鉴的方法与路径。

关键词：中国黄酒日本清酒历史沿革分类方法比较研究

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物理型硬件木马失效机理及检测方法

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物理学报 2016年第11期65卷 49-57页

作者：骆扬王亚楠中国信息安全测评中心安全检测处北京100876

对两种物理型硬件木马造成芯片退化或失效的机理进行了详细分析.通过使用ATLAS二维器件仿真系统并结合Smart Spice电路逻辑仿真器,模拟了两种物理型硬件木马对反相器逻辑电路输出特性的影响.使用ATHENA工艺仿真系统模拟了掺杂离子注入... 详细信息

对两种物理型硬件木马造成芯片退化或失效的机理进行了详细分析.通过使用ATLAS二维器件仿真系统并结合Smart Spice电路逻辑仿真器,模拟了两种物理型硬件木马对反相器逻辑电路输出特性的影响.使用ATHENA工艺仿真系统模拟了掺杂离子注入工艺过程,实现了掺杂型硬件木马的金属-氧化物-半导体场效应管(MOSFET)器件;使用热载流子注入退化模型对ATLAS仿真器件进行热载流子压力测试,以模拟热载流子注入型硬件木马注入MOSFET器件并造成器件退化失效的过程,分别将上述掺杂型硬件木马和热载流子注入型硬件木马的MOSFET器件与另一个正常MOSFET器件组成同样的反相器逻辑电路.反相器使用Spice逻辑电路仿真输出DC直流、AC瞬态传输特性以研究物理型硬件木马对电路输出特性的影响.为了研究MOSFET器件的物理特性本身对硬件木马的影响,在不同温度不同宽长比(W/L)下同样对反相器进行Spice电路逻辑输出仿真.本文分析了离子掺杂工艺、热载流子注入压力测试形成的物理型硬件木马随压力强度、温度的变化对逻辑电路输出特性的影响.通过结果对比分析得出了含有物理型硬件木马的逻辑电路在DC直流输出特性上的扰动比AC瞬态传输特性更明显的结论.因此,本文提出了一种针对物理型硬件木马的检测流程.同时,该检测流程是一种具有可操作性的检测物理型硬件木马的方法.

关键词：硬件木马热载流子注入器件退化失效分析

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Pilomatrixoma misdiagnosed as dermatofibrosarcoma protuberans

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Chinese Medical Journal 2021年第16期134卷 2011-2012页

作者： ya-nan wang Xiao-Feng Zheng Hong-Zhong Jin Department of Dermatology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China.

To the Editor:Pilomatrixoma is a benign tumor that arises from hair follicle matrix cells and has a low recurrence rate.[1]Dermatofibrosarcoma protuberans(DFSP)is a lowgrade,slowly growing fibroblastic sarcoma with a high local recurrence rate and a low propensity for metastasis.[2]We report a case that was clinically suspected to be DFSP,but the surgical biopsy confirmed a diagnosis of pilomatrixoma.A 29-year-old woman presented with a 1-year history of a localized asymptomatic mass on the posterior aspect of her neck[Figure 1A].The lesion had begun as a slowly growing,asymptomatic,bean-sized,reddish *** external friction 6 months previously,the lesion had become a rapidly growing,painful,firm,reddish masswith ulceration and *** topical application of mupirocin ointment,the pain was relieved and the mass was slightly reduced in size.

关键词： sarcoma diagnosis matrix

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不同材质冷铁对铸铁件硬度的影响

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铸造设备与工艺 2024年第2期 64-66页

作者：彭志宁常振陈思明韩军魏守田王亚南共享装备股份有限公司宁夏银川750021

为了解不同材质冷铁对铸铁件硬度的影响规律,分别使用铸铁、石墨、钢三种冷铁,在传热条件相同时,对灰铸铁与球墨铸铁铸件同一部位进行激冷,并对其硬度进行检测。测试结果表明,不同材质的冷铁对相同材质铸件硬度的影响不一致。

关键词：铸铁件硬度冷铁

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膜表达IL-21的饲养层细胞对NK细胞体外扩增的影响

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中国实验血液学杂志 2024年第5期32卷 1578-1584页

作者：徐振钊张学华赵玲萍李高桦崔甜甜王晓玲李璇臧茹歌岳文王亚楠李国新习佳飞南方医科大学第一临床医学院南方医院胃肠肿瘤精准医学重点实验室普外科广东省重点实验室广东广州510515 军事科学院军事医学研究院辐射医学研究所北京100850

目的:探究膜表达IL-21的饲养层细胞对NK细胞体外扩增的影响。方法:通过电转法构建膜表达IL-21的K562稳转细胞系,细胞灭活后与NK细胞共培养,观察NK细胞增殖情况。通过乳酸脱氢酶(LDH)和干扰素-γ(IFN-γ)释放实验检测扩增获得的NK细胞体... 详细信息

目的:探究膜表达IL-21的饲养层细胞对NK细胞体外扩增的影响。方法:通过电转法构建膜表达IL-21的K562稳转细胞系,细胞灭活后与NK细胞共培养,观察NK细胞增殖情况。通过乳酸脱氢酶(LDH)和干扰素-γ(IFN-γ)释放实验检测扩增获得的NK细胞体外杀伤功能。构建NOD/SCID小鼠异种移植肠癌肿瘤模型,设置空白对照组、NK细胞组和扩增NK细胞组,检测扩增NK细胞体内肿瘤杀伤功能。结果:通过电转法成功构建了膜表达IL-21的K562细胞。与膜表达IL-21的K562细胞共培养17 d后,NK细胞的扩增倍数可达700倍,与对照组相比扩增能力明显增强(P<0.001)。体外肿瘤细胞杀伤实验检测结果显示,NK细胞和扩增后的NK细胞对肿瘤细胞的杀伤作用无明显差异,对小鼠体内肿瘤的杀伤效果也无明显差异。结论:膜表达IL-21的K562细胞可显著增强NK细胞的体外扩增能力,但不影响NK细胞的体内外杀伤功能,可用于后续NK细胞的体外规模化扩增。

关键词： NK细胞 K562细胞体外扩增白介素-21

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Effects of probiotics and prebiotics on intestinal microbiota in mice with acute colitis based on 16S rRNA gene sequencing

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Chinese Medical Journal 2019年第15期132卷 1833-1842页

作者： ya-nan wang Xiang-Chen Meng Yi-Fan Dong Xin-Hua Zhao Jia-Ming Qian Hong-Ying wang Jing-nan Li Department of Gastroenterology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China National Cancer Center/Cancer Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100021 China

Background:Imbalance of intestinal microbiota was closely related to *** these circumstances,regulation of enteric flora may be beneficial to the repair of *** aimed to investigate the effects of probiotics (Bifidobacterium and Lactobacillus),prebiotics and their combination on inflammation,and microflora in mice of acute ***:C57BL/6J mice were divided into six groups randomly (blank control group,model control group,probiotics group,synbiotics group,lactitol group and probiotics + lactitol group).Each group was given 2.5% dextran sulfate sodium drinking water for 5 days other than the blank control *** for the model control group,the other four groups were intervened with probiotics,synbiotics (probiotics and inulin),lactitol,and probiotics + *** were sacrificed after 1 week of gavage,and pathologic scores were *** feces of different periods and intestinal mucosa samples were collected to analyze the differences of intestinal microbiota by 16S rRNA *** of two groups or multiple groups were statistically examined through unpaired Student t test and analysis of variance (ANOVA),***,Tukey,Anosim,and metastats analysis were used to compare differences of microbiota among different ***:After gavage for 1 week,the pathologic scores of groups with the intervention were significantly lower than those in the model control group,and the difference was statistically significant (P < 0.05).The model control group was higher in the genus of Bacteroides (relative abundance:0.3679 vs.0.0099,P =0.0016) and lower in Lactobacillus (relative abundance:0.0020 vs.0.0122,P =0.0188),Roseburia (relative abundance:0.0004 vs.0.0109,P =0.0157),compared with the blank control ***,the same phenomenon was not found in groups gavaged with probiotics and *** with model control group,mice with intervention were increased with Bifidobacterium (relative abundance:0.017

关键词： Probiotics Lactitol Intestinal microbiota Akkermansia

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A Case of Pagetoid Bowen＇s Disease

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Chinese Medical Journal 2017年第24期130卷 3023-3024页

作者： Tian Zhu Tao wang Dong-Lai Ma ya-nan wang Li Li Department of Dermatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China

To the Editor：A 65-year-old woman presented with a cutaneous red-brown plaque on the left posterior thigh for the past 7 ***,the lesion was a slightly elevated,well-demarcated plaque with a smooth surface and was about 1 cm in diameter,without any *** the years,it slowly extended into an elevated plaque with rough surface,frequently bleeding after slight friction.

关键词： CARCINOMA IN-SITU

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Association of IL-7 with disease progression in Chinese HIV-1 seropositive individuals

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Chinese Medical Journal 2006年第4期119卷 288-293页

作者： wang Qi SHANG Hong wang ya-nan JIANG Yong-jun LIU Jing ZHANG Zi-ning AIDS Research Center First Affiliated Hospital China Medical University Shenyang 110001 China

Background Elevated levels of interleukin-7 （IL-7） have been correlated with CD4^＋ T cell depletion and the emergence of syncytium-inducing （SI） variants in human immunodeficiency virus type-1 （HIV-1） infection, and suggested as an indicator of acquired immunodeficiency syndrome （AIDS） disease progression. Therefore, we investigated the effects of IL-7 on disease progression and virus phenotype in Chinese HIV/AIDS patients. Methods In a cross-sectional study of 71 untreated HIV-1 seropositive individuals and 12 healthy donors, plasma IL-7 levels were determined by an ultra sensitive enzyme-linked immunosorbent assay （ELISA）, and its relations to CD4^＋ T cells, CD8^＋ T cells, plasma viral loads and HIV phenotypes were analyzed. Results Significant higher IL-7 levels were found in Chinese HIV/AIDS patients [（3.33±3.60） pg/ml] than those of health controls [（1.2±0.81） pg/ml] （P〈0.05）, and IL-7 levels were inversely associated with CD4^＋ T cell counts （r=-0.497, P〈0.01）. Furthermore, IL-7 levels were significant higher in patients with SI variants [（9.12±4.55） pg/ml] than those with non-syncytium-inducing variants [（1.50±2.69） pg/ml] （P〈0.01）. Conclusions Increased IL-7 levels were found in Chinese HIV/AIDS patients and significantly associated with disease progression, thus increased IL-7 plasma levels may indicate disease progression.

关键词： human immunodeficiency virus 1 acquired immunodeficiency syndrome interleukin-7 cytokines Chinese

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