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大跨度高支架螺栓球钢结构网架施工技术

建筑机械化 2024年第5期45卷 78-81页

作者：汪兴文张宗凯周鲁泽中国建筑第二工程局有限公司华东分公司上海200135

以溧阳曹山未来城项目D-01地块项目会展中心网架结构工程为例,研究大跨度高支架螺栓球钢结构网架施工技术。结合该工程中螺栓球钢网架结构连接结构,确定螺栓球材料,采用液压同步提升技术完成该结构施工,并严格按照相关施工标准,进行网... 详细信息

以溧阳曹山未来城项目D-01地块项目会展中心网架结构工程为例,研究大跨度高支架螺栓球钢结构网架施工技术。结合该工程中螺栓球钢网架结构连接结构,确定螺栓球材料,采用液压同步提升技术完成该结构施工,并严格按照相关施工标准,进行网架结构提升后,采用气体保护焊完成螺栓球焊接处理,保证网架整体稳定性。

关键词：大跨度高支架螺栓球钢结构网架施工技术

永川北区页岩气超高强度加砂压裂工艺技术探索

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石油化工应用 2024年第4期43卷 32-37页

作者：王兴文刘琦王峻峰穆轲帆中国石化西南油气分公司石油工程技术研究院四川德阳618000

永川北区页岩气田位于重庆市,开发层系为志留系五峰组-龙马溪组,埋深4100 m左右,目前处于开发评价阶段。储层具有高应力、高破裂压力、高闭合压力、天然裂缝发育程度低等特征,面临难以形成复杂人工裂缝网络、加砂难度大、高导流能力难... 详细信息

永川北区页岩气田位于重庆市,开发层系为志留系五峰组-龙马溪组,埋深4100 m左右,目前处于开发评价阶段。储层具有高应力、高破裂压力、高闭合压力、天然裂缝发育程度低等特征,面临难以形成复杂人工裂缝网络、加砂难度大、高导流能力难保持等问题。本文通过支撑剂输送机理研究,明确了支撑剂粒径、液体黏度和施工排量是影响加砂难度的重要因素,提出了相应的强加砂工艺措施。应用于水平井YY2-2井,单段加砂强度最高7.70 t/m,平均5.82 t/m,综合砂比提升至10.2%。压后评估表明,超高强度加砂压裂工艺技术大幅提高了改造体积和人工裂缝复杂程度,初期试采效果远超前期实施井。为永川北区产能建设提供了支撑,同时为类似深层页岩气的有效开发提供了技术借鉴。

关键词：页岩气加砂强度加砂难度超高强度水平井

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整车进气温度对动力性影响

传动技术 2024年第1期38卷 13-17页

作者：王兴文树向君肖旻王召婧周舟上汽集团创新研究开发总院上海201805

随着经济发展,家庭收入增多,私家车数量逐步增加,上下班高峰期城市拥堵情况加剧,汽车无法畅通行驶,怠速工况、低速工况等越来越多,而此时加大油门,往往出现动力响应不足,启动慢等现象,原因之一是进气温度高,进气温度高导致进气密度降低... 详细信息

随着经济发展,家庭收入增多,私家车数量逐步增加,上下班高峰期城市拥堵情况加剧,汽车无法畅通行驶,怠速工况、低速工况等越来越多,而此时加大油门,往往出现动力响应不足,启动慢等现象,原因之一是进气温度高,进气温度高导致进气密度降低及爆震倾向增大,点火提前角推迟,燃烧效率变差,最终导致燃烧效率低,性能下降。如何使进气温度降低越发受到各主机厂重视。通过理论分析和热负荷实验等手段,规划整车进气系统结构,从进气口布置、材料选择等多个方面有效地降低了进气温度。

关键词：进气温度动力性热负荷进气系统

螺旋CT能谱成像对结直肠癌病理分化程度的诊断价值

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华北理工大学学报（医学版） 2024年第2期26卷 94-100页

作者：李泽茂冯莉王星稳周伟陈伟彬华北理工大学附属医院CT室河北唐山063000 华北理工大学基础医学院河北唐山063000

目的探讨术前应用CT能谱成像技术预测结直肠癌患者病理分化程度的准确性。方法收集2019年9月~2022年12月于华北理工大学附属医院经术前结肠镜或手术病理确诊为结直肠癌的患者82例。依据结直肠癌病理分化程度分为中高分化组(62例)和低... 详细信息

目的探讨术前应用CT能谱成像技术预测结直肠癌患者病理分化程度的准确性。方法收集2019年9月~2022年12月于华北理工大学附属医院经术前结肠镜或手术病理确诊为结直肠癌的患者82例。依据结直肠癌病理分化程度分为中高分化组(62例)和低分化组(20例)。采用GE Revolution CT扫描仪对患者进行能谱成像扫描,测量并记录动、静脉期病灶40~140kev单能量CT值、碘基值(IC)、水基值(WC)以及有效原子序数(Eff-Z),并计算标准化碘基值(NIC)和能谱曲线斜率(λ)。结果动脉期:低分化组40~140kev单能量CT值均高于中高分化组(P<0.05);低分化组结直肠癌IC、NIC、λ均高于中高分化组(P<0.05)。静脉期:低分化组40~130kev单能量CT值均高于中高分化组(P<0.05),低分化组结直肠癌IC、NIC、λ、Eff-Z均高于中高分化组(P<0.05)。相比于动脉期,静脉期40~90kev单能量CT值及能谱参数IC+NIC+λ+Eff-Z联合预测结直肠癌不同分化程度的效能较好,其AUC为0.943。结论能谱CT成像可以在术前较好的预测结直肠癌分化程度,为临床医师提供影像学依据。

关键词：结直肠癌分化程度能谱成像单能量CT值

Promoter variations in DBR2-like affect artemisinin production in different chemotypes of Artemisia annua

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Horticulture Research 2023年第9期10卷 220-232页

作者： xingwen wang Lan Wu Li Xiang Ranran Gao Qinggang Yin Mengyue wang Zhaoyu Liu Liang Leng Yanyan Su Huihua Wan Tingyu Ma Shilin Chen Yuhua Shi Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine Artemisinin Research CenterInstitute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Institute of Herbgenomics Chengdu University of Traditional Chinese MedicineChengdu 611137China Amway(China)Botanical R&D Center Wuxi 214115China Key Lab of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of the People’s Republic of ChinaInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China

Artemisia annua is the only known plant source of the potent antimalarial artemisinin,which occurs as the low-and high-artemisinin producing(LAP and HAP)***,the different mechanisms of artemisinin producing between these two chemotypes were still not fully ***,we performed a comprehensive analysis of genome resequencing,metabolome,and transcriptome data to systematically compare the difference in the LAP chemotype JL and HAP chemotype *** analysis revealed that 72.18%of sesquiterpenes was highly accumulated in HAN compared to *** omics analysis found a DBR2-Like(DBR2L)gene may be involved in artemisinin ***2L was highly homologous with DBR2,belonged to ORR3 family,and had the DBR2 activity of catalyzing artemisinic aldehyde to dihydroartemisinic *** resequencing and promoter cloning revealed that complicated variations existed in DBR2L promoters among different varieties of *** and were clustered into three variation *** promoter activity of diverse variant types showed obvious ***,the core region(-625 to 0)of the DBR2L promoter was identified and candidate transcription factors involved in DBR2L regulation were ***,the result indicates that DBR2L is another key enzyme involved in artemisinin *** promoter variation in DBR2L affects its expression level,and thereby may result in the different yield of artemisinin in varieties of *** provides a novel insight into the mechanism of artemisinin-producing difference in LAP and HAP chemotypes of ***,and will assist in a high yield of artemisinin in ***.

关键词： thereby insight homologous

lncRNA HITT Inhibits Lactate Production by Repressing PKM2 Oligomerization to Reduce Tumor Growth and Macrophage Polarization

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Research 2022年第3期2022卷 205-223页

作者： Kunming Zhao xingwen wang Dong Zhao Qingyu Lin Yi Zhang Ying Hu School of Life Science and Technology Harbin Institute of TechnologyHarbinHeilongjiang ProvinceChina 150001 School of Public Health Qingdao UniversityQingdaoChina 266071

Lactic acid acidifies the tumor microenvironment and promotes multiple critical oncogenic processes,including immune *** kinase M2(PKM2)is a dominant form of pyruvate kinase(PK)expressed in cancers that plays essential roles in metabolic reprograming and lactate production,rendering it as an attractive therapeutic target of ***,the mechanism underlying PKM2 regulation remains ***,we show that long noncoding RNA(lncRNA)HIF-1αinhibitor at transcription level(HITT)inhibits lactate production in a PKM2-dependent ***,it physically interacts with PKM2 mapped to a region that has been involved in both dimer(less-active)and tetramer(more-active)formation,inhibiting PKM2 oligomerization and leading to dramatic reduction of PK *** glucose starvation,HITT was reduced as a result of miR-106 induction,which subsequently facilitates PKM2 oligomerization and increases vulnerability to apoptosis under glucose starvation *** addition,the interaction also reduces lactate secretion from cancer cells,which subsequently polarizes macrophages toward an M2-like anti-inflammatory phenotype and thus possibly contributes to immune escape in *** study highlights an important role of an lncRNA in regulating PKM2 activity and also reveals a metabolic regulatory effect of PKM2 on macrophage polarization.

关键词： PKM2 Polarization rendering

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单分子荧光成像研究单颗粒纳米催化机制

化学学报 2023年第8期81卷 1002-1014页

作者：王晓王星文肖乐辉南开大学化学学院天津300071 中南大学化学化工学院长沙410083

纳米颗粒通常具有优异的催化性能,但由于其内在的异质性,宏观水平的表征难以确定单个纳米颗粒可靠的构效关系和潜在的催化反应机制.单分子荧光成像技术具有单分子灵敏度、高时空分辨率的优点,可以在单颗粒水平实现反应产物的超灵敏检测... 详细信息

纳米颗粒通常具有优异的催化性能,但由于其内在的异质性,宏观水平的表征难以确定单个纳米颗粒可靠的构效关系和潜在的催化反应机制.单分子荧光成像技术具有单分子灵敏度、高时空分辨率的优点,可以在单颗粒水平实现反应产物的超灵敏检测,因而在纳米催化领域得到了广泛应用.本文综述了单分子荧光成像的发展以及该技术在揭示单颗粒纳米催化反应机制中的应用,主要包括尺寸效应、晶面效应、表面缺陷、等离激元效应、双金属效应、活化能、纳米限域效应以及单颗粒催化通讯等方面.最后总结和展望了单分子荧光成像技术在纳米催化研究中的挑战与发展方向.

关键词：单分子荧光单颗粒时空分辨率纳米催化机制构效关系

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Single stage complete resection of giant dumbbell lumbar ganglioneuroma: a case report and review of the literature

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Chinese Neurosurgical Journal 2016年第4期2卷 239-244页

作者： Zuowei wang xingwen wang Fengzeng Jian Li Chen Department of Neurosurgery Department of Neurosurgery Xuanwu Hospital Capital Medical UniversityDivision of Spine China International Neurological Institute Beijing People's Republic of China Department of Pathology Xuanwu Hospital Capital Medical UniversityBeijing People's Republic of China

Ganglioneuroma is a rare benign tumor, which is usually located in the posterior mediastinum and retroperitoneum. Occasionally, it involves the paraspinal region with intraspinal extension and becomes dumbbell shaped. Dumbbell ganglioneuromas rarely affect the lumbar spine, and only nine cases of dumbbell lumbar ganglioneuromas have been reported previously. We are reporting an extremely rare case of a giant dumbbell tumor in the lumbar spine. We performed a one stage total resection of the tumor with posterior approach and long-segment fixation and fusion. This approach is different from previous methods. Histopathological examination of the surgical specimen confirmed the diagnosis of ganglioneuroma. Thirty months follow up showed a satisfactory outcome. Single-stage posterior tumor resection with fixation and fusion is effective and an appropriate choice for the treatments of lumbar dumbbell ganglioneuromas.

关键词： Ganglioneuroma Dumbbell Lumbar spine Surgery

Pseudo-beam method for compressive buckling characteristics analysis of space inflatable load-carrying structures

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Acta Mechanica Sinica 2009年第5期25卷 659-668页

作者： Changguo wang Huifeng Tan xingwen Du Center for Composite Materials,Harbin Institute of Technology, 150001 Harbin, China Center for Composite Materials Harbin Institute of Technology Harbin China

This paper extends Le van＇s work to the case of nonlinear problem and the complicated configuration. The wrinkling stress distribution and the pressure effects are also included in our analysis. Pseudo-beam method is presented based on the inflatable beam theory to model the inflatable structures as a set of inflatable beam elements with a prestressed state. In this method, the discretized nonlinear equations are given based upon the virtual work principle with a 3-node Timoshenko＇s beam model. Finite element simulation is performed by using a 3-node BEAM189 element incorporating ANSYS nonlinear program. The pressure effect is equivalent included in our method by modifying beam element cross-section parameters related to pressure. A benchmark example, the bending case of an inflatable cantilever beam, is performed to verify the accuracy of our proposed method. The comparisons reveal that the numerical results obtained with our method are close to open published analytical and membrane finite element results. The method is then used to evaluate the whole buckling and the loadcarrying characteristics of an inflatable support frame subjected to a compression force. The wrinkling stress and region characteristics are also shown in the end. This method gives better convergence characteristics, and requires much less computation time. It is very effective to deal with the whole load-carrying ability analytical problems for large scale inflatable structures with complex configuration.

关键词： Inflatable structure - Pseudo-beam method Inflatable beam theory Nonlinear buckling finite element