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Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

Nano-Micro Letters 2025年第3期17卷 389-439页

作者： xiao wang Jia Zeng Donglin Gan Kun Ling Mingfang He Jianshu Li Yongping Lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

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Rise of β-furanosyl ribonucleosides as the extant RNA component facilitated by simple divalent transition-metal minerals

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Science China Chemistry 2025年

作者： Qianqian Chen Haoxing Xu Bingyue Zhao Yeersen Patehebieke Zerun Zhao xiao wang School of Chemistry and Chemical Engineering Nanjing University Frontiers Science Center for Critical Earth Material Cycling Nanjing University

The selective nucleoside synthesis through direct condensation between nucleobase and unactivated sugar in aqueous media has long been a formidable obstacle for the early chemical transformations hypothesized to construct the RNAWorld, due to product complexity and the low selectivity of the desired isomer. The preference of β-furanoside, the extant RNA component, has never been documented. Here we report an aqueous ribosylation mediated by divalent transition-metal ions, which unprecedentedly enhances the selectivity of furanosyl ribonucleosides as opposed to the traditionally predominating pyranosyl ones, with the furanoside/pyranoside ratio reaching up to 9/1. Furthermore, β-furanoside stands out for the first time as the most prevalent isomer in the presence of zinc and ammonium salts. The mechanism of this selectivity is elucidated with density functional theory calculations. The selectivity for β-furanoside can be further elevated via the adsorption on a zinc mineral. These findings exhibit as the first example that the selection of nucleosides with the desired, canonical configuration might be completed in the early stage of the RNA-forming process as opposed to later evolution, promoted by simple and widespread transition-metal minerals. The study may also find its value in synthetic chemistry as a guideline for developing a sustainable and selective glycosylation process.

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The heat transfer optimization of conical fin by shape modification

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Chinese Journal of Chemical Engineering 2016年第8期24卷 972-978页

作者： Jiansheng wang xiao wang Key Laboratory of Efficient Utilization of Low and Medium Grade Energy MOE School of Mechanical Engineering Tianjin University

In present work, a stepping optimization algorithm is proposed for the geometric optimization of conical fin, and the heat transfer rate of the fin is treated as the objective function in the optimization algorithm. The conical fin is divided into finite elements which have different generatrix slopes, and the geometry of the conical fin is finally determined by ensuring that every divided element can maintain the maximum heat transfer rate. Based on the actual condition of every element of the fin, the heat conduction equation is solved step by step. The present result shows that the optimized conical fin has more heat transfer quantity and higher fin efficiency compared with those of some typical fins. Furthermore, the theoretical feasibility and the error analysis of present optimization algorithm have been performed as well.

关键词： Fin Optimization Heat transfer Stepping optimization algorithm

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喹啉羧酸共价有机框架微球在线固相萃取4种黄曲霉毒素

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分析测试学报 2025年第1期44卷 163-171页

作者：王荣雨刘杰周静李涛王晓纪文华齐鲁工业大学(山东省科学院)山东省分析测试中心天然产物分离提取共性技术创新与应用山东省工程研究中心山东济南250014 山东明仁福瑞达制药股份有限公司山东济南250014 山东蓝城分析测试有限公司山东济南250100

以1,3,5-三(4-氨基苯基)苯、联苯二甲醛、丙酮酸为合成反应单体,氨基磺酸为催化剂,利用Doebner串联反应成功制备了具有喹啉羧酸骨架的共价有机框架(QCA-COF)微球。通过优化反应条件发现,采用1,4-二氧六环-乙腈溶液(1∶4,体积比)作为反... 详细信息

以1,3,5-三(4-氨基苯基)苯、联苯二甲醛、丙酮酸为合成反应单体,氨基磺酸为催化剂,利用Doebner串联反应成功制备了具有喹啉羧酸骨架的共价有机框架(QCA-COF)微球。通过优化反应条件发现,采用1,4-二氧六环-乙腈溶液(1∶4,体积比)作为反应溶剂时,可获得具有微米级粒径的微球。采用扫描电子显微镜、红外光谱、X射线粉末衍射、N_(2)吸脱附实验对QCA-COF微球的结构进行表征。由于QCA-COF微球具有芳环、喹啉基团、羧基等官能团,可通过氢键、π-π等多重相互作用与黄曲霉毒素进行吸附,其吸附能力优于C_(18)、PSA以及GCB等商用材料。将QCA-COF材料作为在线固相萃取柱的填料,详细优化了在线固相萃取条件。将在线固相萃取柱与高效液相色谱联用,建立了4种黄曲霉毒素的检测方法,检出限为0.024~0.030 ng·g^(-1)。经方法学验证,该方法具有较好的回收率(82.5%~105%)和精密度(4.3%~10%,n=6),适用于花生、小麦、陈皮、杏仁、决明子等食品与中药材中4种黄曲霉毒素的测定。

关键词：黄曲霉毒素在线固相萃取共价有机框架高效液相色谱

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Carbon-supported CeNCl as an efficient catalyst for CO_(2)cycloaddition

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Nano Research 2025年第1期18卷 157-163页

作者： Li Liu Lingling Zhang Xiang Chu Baokang Geng Huilin wang Zongxiang Li xiao wang Shuyan Song Hongjie Zhang School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Sinocare Incorporation Changsha 410221China Department of Chemistry Tsinghua UniversityBeijing 100084China

The cycloaddition reaction of CO_(2)with epoxide not only effectively reduces the concentration of CO_(2)in the atmosphere,but also has excellent industrial application value and up to 100%atom utilization,but there are difficulties in separation and recovery of traditional homogeneous catalysts,harsh reaction conditions of traditional heterogeneous catalysts,and activation of CO_(2)*** this paper,an easily synthesized heterogeneous catalyst CeNCl/C was used to catalyze the cycloaddition reaction of CO_(2)with styrene oxide,with a high yield of 92.7%,a high selectivity of 96.7%,a turnover numbers(TON)value of 349,and a good stability demonstrated in six cycle tests(equivalent to 216 h of testing).Through comprehensive studies,it was shown that CeNCl/C contains Lewis acid-base centers as active centers,which can effectively reduce the energy barrier required for ring opening of the reaction substrate,enhance the adsorption and activation of CO_(2),and promote the formation of intermediates,which led to the acquisition of excellent catalytic activity.

关键词： CO_(2)cycloaddition heterogeneous catalysis CeNCl Lewis acid/base

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Topology-assisted deterministic packet marking for IP traceback

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The Journal of China Universities of Posts and Telecommunications 2010年第2期17卷 116-121页

作者： wang xiao-jing wang xiao-yin Laboratory of Computer Network Defense Technology Beijing Institute of Technology Beijing 100081 China Xi'an Politics Institute Xi'an 710068 China

A novel deterministic packet marking （DPM） for IP traceback against denial of service （DOS） and distributed denial of service （DDoS） attacks is presented, which features good scalability and high accuracy. In this scheme, an ingress router pre-calculates a Hash of its IP address and splits the Hash into several fragments. When marking a packet, the router randomly selects a fragment to mark into the packet. In the traceback stage the victim identifies the marked router with the help of the map of its upstream routers. Based on the map, the victim can identify a candidate ingress router after receiving only several marked packets. The scheme overcomes defects in previous deterministic packet marking schemes, where too much packets are required to recover a router and high false positive rate occurs in case of large-scale DDoS. Theoretical analysis, the pseudo code and experimental results are provided. The scheme is proved to be accurate and efficient and can handle large-scale DDoS attacks.

关键词： network security DDoS 1P traceback deterministic packet marking (DPM)

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A Trust Region Affine Scaling Method for Bound Constrained Optimization

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Acta Mathematica Sinica,English Series 2013年第1期29卷 159-182页

作者： xiao wang School of Mathematical Sciences University of Chinese Academy of Sciences

We study a new trust region affine scaling method for general bound constrained optimiza- tion problems. At each iteration, we compute two trial steps. We compute one along some direction obtained by solving an appropriate quadratic model in an ellipsoidal region. This region is defined by an affine scaling technique. It depends on both the distances of current iterate to boundaries and the trust region radius. For convergence and avoiding iterations trapped around nonstationary points, an auxiliary step is defined along some newly defined approximate projected gradient. By choosing the one which achieves more reduction of the quadratic model from the two above steps as the trial step to generate next iterate, we prove that the iterates generated by the new algorithm are not bounded away from stationary points. And also assuming that the second-order sufficient condition holds at some nondegenerate stationary point, we prove the Q-linear convergence of the objective function values. Preliminary numerical experience for problems with bound constraints from the CUTEr collection is also reported.

关键词： Bound constrained optimization affine scaling trust region approximate projected gradient

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L^p Solutions of Backward Stochastic Volterra Integral Equations

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Acta Mathematica Sinica,English Series 2012年第9期28卷 1875-1882页

作者： Tian xiao wang School of Mathematics Shandong University

This paper is devoted to the unique solvability of backward stochastic Volterra integral equations （BSVIEs, for short）, in terms of both M-solution and the adapted solutions. We prove the existence and uniqueness of M-solutions of BSVIEs in Lp （1 〈 p 〈 2）, which extends the existing results on M-solutions. The unique solvability of adapted solutions of BSVIEs in Lp （p 〉 1） is also considered, which also generalizes the results in the existing literature.

关键词： Backward stochastic Volterra integral equations M-solutions Lp solutions adapted solutions

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An improved multiple model GM-PHD filter for maneuvering target tracking

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Chinese Journal of Aeronautics 2013年第1期26卷 179-185页

作者： wang xiao Han Chongzhao The Flight Automatic Control Research Institute of AVIC School of Electronic and Information Engineering Xi'an Jiaotong University

In this paper, an improved implementation of multiple model Gaussian mixture probability hypothesis density （MM-GM-PHD） filter is proposed. For maneuvering target tracking, based on joint distribution, the existing MM-GM-PHD filter is relatively complex. To simplify the filter, model conditioned distribution and model probability are used in the improved MM-GM-PHD filter. In the algorithm, every Gaussian components describing existing, birth and spawned targets are estimated by multiple model method. The final results of the Gaussian components are the fusion of multiple model estimations. The algorithm does not need to compute the joint PHD distribution and has a simpler computation procedure. Compared with single model GM-PHD, the algorithm gives more accurate estimation on the number and state of the targets. Compared with the existing MM-GM-PHD algorithm, it saves computation time by more than 30%. Moreover, it also outperforms the interacting multiple model joint probabilistic data association （IMMJPDA） filter in a relatively dense clutter environment.

关键词： Estimation Gaussian mixture Maneuvering target racking Multiple model Probability hypothesis density

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Ultrafiltration with in-line coagulation for the removal of natural humic acid and membrane fouling mechanism

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Journal of Environmental Sciences 2006年第5期18卷 880-884页

作者： wang Jin wang xiao-chang Department of Municipal and Environmental Engineering Beijing Jiaotong University Beijing 100044 China School of Environmental and Municipal Engineering Xi＇an University of Architecture and Technology Xi＇an 710055 China

Experimental and theoretical analysis were made on the natural humic acid removal and the membrane fouling of ultrafiltration （UF） with in-line coagulation. The results showed dissolved organic carbon （DOC） and UV254 removals by the UF with in-line coagulation at pH 7 were increased from 28% to 53% and 40% to 78% in comparison with direct UF treatment respectively. At the same time, the analysis of high performance liquid chromatography showed that UF with coagulation had significant improvement of removal of humic acid with molecular weights less than 6000 Da in particular. Compared to direct UF, the in-line coagulation UF also kept more constant permeate flux and very slight increase oftransmembrane pressure during a filtration circle. Two typical membrane fouling models were used by inducing two coefficients Kc and Kp corresponding to cake filtration model and pore narrowing model respectively. It was found that membrane fouling by pore-narrowing effect was effectively alleviated and that by cake-filtration was much decreased by in-line coagulation. Under the condition of coagulation prior to ultrafiltration at pH 7, the cake layer formed on the membrane surface became thicker, but the membrane filtration resistance was lower than that at pH 5 with the extension of operation time.

关键词： natural humic acid ultrafiltration (UF) in-line coagulation high performance liquid chromatography (HPLC) membrane fouling

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