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Zinc lactate alleviates oxidative stress by modulating crosstalk between constitutive androstane receptor signaling pathway and gut microbiota profile in weaned piglets

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Animal Nutrition 2024年第1期16卷 23-33页

作者： Wenjie Tang Xuan Xiang Houfu wang Wentao Zhou Liuqin He Yulong Yin tiejun Li College of Animal Science and Technology Hunan Agricultural UniversityChangsha 410128China Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process CAS Key Laboratory of Agro-Ecological Processes in Subtropical RegionNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation Laboratory of Animal Nutrition and Human HealthCollege of Life SciencesHunan Normal UniversityChangsha 410081China College of Advanced Agricultural Science University of Chinese Academy of SciencesBeijing 100049China Sichuan Academy of Animal Sciences Animal Breeding and Genetics Key Laboratory of Sichuan ProvinceChengdu 610066China Livestock and Poultry Biological Products Key Laboratory of Sichuan Province Sichuan Animtech Feed Co.LtdChengdu 610000China

This study aimed to determine the regulatory mechanism of dietary zinc lactate(ZL)supplementation on intestinal oxidative stress damage in a paraquat(PQ)-induced piglet ***-eight piglets(mean body weight 9.51±0.23 kg)weaned at 28 d of age were randomly divided into control,ZL,PQ,and ZL+PQ groups(n=7 in each group).The ZL-supplemented diet had little effect on growth performance under normal physiological ***,under PQ challenge,ZL supplementation significantly improved average daily gain(P<0.05)and reduced the frequency of *** improved intestinal morphology and ultrastructure by significantly increasing the expression level of the jejunal tight junction protein,zonula occludens-1(ZO-1)(P<0.05),and intestinal zinc transport and absorption in PQ-induced piglets,which reduced intestinal *** supplementation also enhanced the expression of antioxidant and antiinflammatory factor-related genes and decreased inflammatory cytokine expression and secretion in PQinduced ***,ZL treatment significantly inhibited the activation of constitutive androstane receptor(CAR)signaling(P<0.01)in PQ-induced piglets and altered the structure of the gut microbiota,especially by significantly increasing the abundance of beneficial gut microbes,including UCG_002,Ruminococcus,Rikenellaceae_RC9_gut_group,Christensenellaceae_R_7_group,Treponema,unclassified_Christensenellaceae,and unclassified_Erysipelotrichaceae(P<0.05).These data reveal that pre-administration of ZL to piglets can suppress intestinal oxidative stress by improving antioxidant and anti-inflammatory capacity and regulating the crosstalk between CAR signaling and gut microbiota.

关键词： Zinc lactate Intestinal barrier Oxidative stress Inflammation Constitutive androstane receptor Gut microbiota

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油气井密封结构的变形与失效行为研究进展

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力学学报 2019年第3期51卷 635-655页

作者：王正锦王铁军西安交通大学航天航空学院/机械结构强度与振动国家重点实验室

在今后相当长一个时期,石油和天然气依然是人类的主要能源.油气井密封是油气开采中最重要的作业之一,在水平钻井、水力压裂等最新的油气开采技术中发挥着重要的作用,促进了页岩气等非常规油气开采的发展.密封质量会直接影响油气井的安... 详细信息

在今后相当长一个时期,石油和天然气依然是人类的主要能源.油气井密封是油气开采中最重要的作业之一,在水平钻井、水力压裂等最新的油气开采技术中发挥着重要的作用,促进了页岩气等非常规油气开采的发展.密封质量会直接影响油气井的安全和生产效率,密封元件的失效可造成严重的环境污染和生命财产损失.因此,深入理解密封元件的失效行为,对于油气井安全评估具有重要意义.水泥和可溶胀高弹体密封是两种最主要的密封方式.水泥密封已有百余年历史,溶胀式高弹体密封则是一种相对较新的密封技术.本文介绍这两种油气井密封结构变形与失效行为的国内外最新研究进展.首先,介绍固井水泥环固化过程中的应力演化、生产作业导致的应力、水泥环的失效模式和失效判据方面的研究进展;然后,介绍溶胀式高弹体封隔器的基本原理、力学理论、测试方法、失效模式及失稳等方面的研究进展.

关键词：油气开采密封水泥高弹体应力失效

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双气路内并联进气系统模态转换试验研究

气动研究与试验

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气动研究与试验 2024年第3期2卷 69-80页

作者：母忠强杨顺华王铁军任虎游进谢松柏张弯洲罗佳茂北京流体动力科学研究中心北京100029 中国空气动力研究与发展中心、高超声速冲压发动机国防科技重点实验室四川绵阳621000

为了探究内并联进气系统模态转换过程中的分流板调节策略,利用地面试验研究方法,研究了Ma 3.5条件下双气路进气系统在典型分流板位置的流场干涉机制,获得了高低速气路总体性能和流场变化规律。研究结果表明,分流板高度变化影响高低速气... 详细信息

为了探究内并联进气系统模态转换过程中的分流板调节策略,利用地面试验研究方法,研究了Ma 3.5条件下双气路进气系统在典型分流板位置的流场干涉机制,获得了高低速气路总体性能和流场变化规律。研究结果表明,分流板高度变化影响高低速气路总体性能和抗反压能力,同时由于流量重新分配,下游动力系统的工作状态需要匹配调节;分流板调节对高速气路性能影响更显著,随着高速气路逐渐关闭,受激波强度变化影响,高速气路总压恢复系数会经历迅速下降再缓慢上升的过程;当出口反压比超过临界值,激波系会在分流板前缘和唇口之间以低频大振幅和高频小振幅相结合的方式往复运动,该非定常效应导致流场和总体性能不稳定,模态转换过程中应避免该情况发生。

关键词：组合发动机双气路进气系统模态转换分流板地面试验系统

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预热自蔓延合成SiC粉末机理的研究

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硅酸盐学报 1998年第2期26卷 237-242页

作者：王铁军王声宏冶金部钢铁研究总院

对预热ＳＨＳ法合成ＳｉＣ粉末所需的最低预热温度及产物粒度与反应物原始粒度的关系等进行了研究．发现合成的ＳｉＣ粉末的粒度与Ｓｉ粉粒度无关，在此基础上对ＳｉＣ的形成机制进行了探讨．在通氮气情况下，预热ＳＨＳ－ＳｉＣ反应中... 详细信息

对预热ＳＨＳ法合成ＳｉＣ粉末所需的最低预热温度及产物粒度与反应物原始粒度的关系等进行了研究．发现合成的ＳｉＣ粉末的粒度与Ｓｉ粉粒度无关，在此基础上对ＳｉＣ的形成机制进行了探讨．在通氮气情况下，预热ＳＨＳ－ＳｉＣ反应中有一个β－Ｓｉ３Ｎ４的生成过程。

关键词：预热自蔓延高温合成碳化硅粉末

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生物质合成气的化学当量比调整

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太阳能学报 2005年第4期26卷 533-537页

作者：王铁军常杰中国科学院广州能源研究所

针对生物质气化气中硫化物少、V(H2/CO)低和V(CO2)高的特点,采用气化炉内铁系高温变换催化剂和气化炉外钛促进的钴钼耐硫催化剂进行水煤气变换调整H2/CO比,添加部分沼气重整过量CO2,对生物质合成气化学当量比调整进行了实验研究。结... 详细信息

针对生物质气化气中硫化物少、V(H2/CO)低和V(CO2)高的特点,采用气化炉内铁系高温变换催化剂和气化炉外钛促进的钴钼耐硫催化剂进行水煤气变换调整H2/CO比,添加部分沼气重整过量CO2,对生物质合成气化学当量比调整进行了实验研究。结果表明:气化炉内铁系催化剂调整效果不明显;在高温低硫的生物质气化气中,钛促进的钴钼耐硫催化剂具有较高的变换活性,CO转化率达到80％以上,合成气H2/CO比在1-8范围内可调;在V(CH4/CO2)=1、常压、750℃和镍基催化剂作用下沼气重整过量CO2,制备出宽V(H2/CO)、V(CO2)和 V(CH4)均低于5％(摩尔百分比)的合成气;通过水煤气变换过程结合沼气重整过程,可依据目的产物合成的要求,制备合适化学当量比、高碳转化率的生物质合成气。

关键词：生物质合成气化学当量比

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Effects of fermented sweet potato residue on nutrient digestibility, meat quality, and intestinal microbes in broilers

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Animal Nutrition 2024年第2期17卷 75-86页

作者： Ting Yao Chenyu wang Lifen Liang Xuan Xiang Hui Zhou Wentao Zhou Ruoxin Hou Tianli wang Liuqin He Shiyu Bin Yulong Yin tiejun Li Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process CAS Key Laboratory of Agro-Ecological Processes in Subtropical RegionNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of Sciences University of Chinese Academy of Sciences Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation Laboratory of Animal Nutrition and Human HealthCollege of Life SciencesHunan Normal University Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection Ministry of EducationCollege of Life ScienceGuangxi Normal University

This study aimed to investigate the effects of different proportions of dietary fermented sweet potato residue(FSPR) supplementation as a substitute for corn on the nutrient digestibility, meat quality, and intestinal microbes of yellow-feathered broilers. Experiment 1(force-feeding) evaluated the nutrient composition and digestibility of mixtures with different proportions of sweet potato residue(70%, 80%,90%, and 100%) before and after fermentation. In Experiment 2(metabolic growth), a total of 420 oneday-old yellow-feathered broilers were randomly allocated to 4 groups and fed corn-soybean mealbased diets with 0, 5%, 8%, and 10% FSPR as a substitute for corn. The force-feeding and metabolic growth experiments were performed for 9 and 70 d, respectively. The treatment of 70% sweet potato residue(after fermentation) had the highest levels of crude protein, ether extract, and crude fiber and improved the digestibility of crude protein and amino acids(P < 0.05). Although dietary FSPR supplementation at different levels had no significant effect on growth performance and intestinal morphology, it improved slaughter rate, half-chamber rate, full clearance rate, and meat color, as well as reduced cooking loss in the breast and thigh muscles(P < 0.05). Dietary supplementation with 8% and 10% FSPR increased the serum immunoglobulin M and immunoglobulin G levels in broilers(P < 0.05). Furthermore, 10% FSPR increased the Shannon index and Ruminococcaceae＿UCG-014, Ruminococcaceae＿UCG-010 and Romboutsia abundances and decreased Sutterella and Megamonas abundances(P < 0.05). Spearman's correlation analysis showed that meat color was positively correlated with Ruminococcaceae＿UCG-014(P < 0.05) and negatively correlated with Megamonas(P < 0.05). Collectively, 70% sweet potato residue(after fermentation) had the best nutritional value and nutrient digestibility. Dietary supplementation with 8% to 10%FSPR as a substitute for corn can improve the slaughter performance, meat quality

关键词： Fermented sweet potato residue Meat quality Intestinal microbiota Broiler

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Multi-scale analyses of phase transformation mechanisms and hardness in linear friction welded Ti17(a+β)/Ti17(β)dissimilar titanium alloy joint

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Chinese Journal of Aeronautics 2024年第1期37卷 312-324页

作者： Zhenguo GUO tiejun MA Xiawei YANG Ju LI Wenya LI Achilles VAIRIS State Key Laboratory of Solidification Processing Shaanxi Key Laboratory of Friction Welding TechnologiesNorthwestern Polytechnical UniversityXi’an 710072China Aeronautical Key Laboratory for Welding and Joining Technologies AVIC Manufacturing Technology InstituteBeijing 100024China Mechanical Engineering Department University of West AtticaAthens 12241Greece

The Ti17(a+β)-Ti17(β)dual alloy-dual property blisk produced using Linear Friction Welding(LFW)is considered as high-performance component in advanced ***,up to now,microstructure evolution and relationship between microstructure and micro mechanical properties of LFWed Ti17(a+β)/Ti17(β)dissimilar joint have not been thoroughly *** this work,complex analyses of the phase transformation mechanisms of the joint are conducted,and phase transformations in individual zones are correlated to their microhardness and *** reveal that a dissolution occurs under high temperatures encountered during LFW,which reduces microhardness of the joint to that of Ti17(a+β)and Ti17(β).In ThermoMechanically Affected Zone of Ti17(a+β)(TMAZ-(a+β))side joint,a large number of nanocrystalline a phases form with different *** microstructure strengthens significantly by fine grains which balances partial softening effect of a dissolution,and increases nanohardness of a phase and microhardness of TMAZ-(a+β).Superlattice metastableβphase precipitates from metastableβin Weld Zone(WZ)during quick cooling following welding,because of short-range diffusion migration of solute atoms,especiallyβstabilizing elements Mo and *** precipitation of the superlattice metastableβphase results in precipitation strengthening,which in turn increases nanohardness of metastableβand microhardness in WZ.

关键词： Linear friction welding Ti17 titanium alloy Phase transformation Microhardness Nanohardness

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Brain-inspired artificial intelligence research: A review

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Science China(Technological Sciences) 2024年第8期67卷 2282-2296页

作者： wang GuoYin BAO HuaNan LIU Qun ZHOU TianGang WU Si HUANG tiejun YU ZhaoFei LU CeWu GONG YiHong ZHANG ZhaoXiang HE Sheng Chongqing Key Laboratory of Computational Intelligence Chongqing University of Posts and TelecommunicationsChongqing 400065China Key Laboratory of Cyberspace Big Data Intelligent Security Chongqing University of Posts and TelecommunicationsChongqing 400065China College of Computer and Information Science Chongqing Normal UniversityChongqing 401331China State Key Laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of SciencesBeijing 100101China School of Psychological and Cognitive Sciences Peking UniversityBeijing 100871China State Key Laboratory of Multimedia Information Processing School of Computer SciencePeking UniversityBeijing 100871China Department of Computer Science School of ElectronicsInformation and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Faculty of Electronic and Information Engineering Xi’an Jiaotong UniversityXi’an 710049China The Center for Research on Intelligent Perception and Computing Institute of AutomationChinese Academy of SciencesBeijing 100190China Institute of Biophysics Chinese Academy of SciencesBeijing 100101China

Artificial intelligence(AI) systems surpass certain human intelligence abilities in a statistical sense as a whole, but are not yet the true realization of these human intelligence abilities and behaviors. There are differences, and even contradictions, between the cognition and behavior of AI systems and humans. With the goal of achieving general AI, this study contains a review of the role of cognitive science in inspiring the development of the three mainstream academic branches of AI based on the three-layer framework proposed by David Marr, and the limitations of the current development of AI are explored and analyzed. The differences and inconsistencies between the cognition mechanisms of the human brain and the computation mechanisms of AI systems are analyzed. They are found to be the cause of the differences and contradictions between the cognition and behavior of AI systems and humans. Additionally, eight important research directions and their scientific issues that need to focus on braininspired AI research are proposed: highly imitated bionic information processing, a large-scale deep learning model that balances structure and function, multi-granularity joint problem solving bidirectionally driven by data and knowledge, AI models that simulate specific brain structures, a collaborative processing mechanism with the physical separation of perceptual processing and interpretive analysis, embodied intelligence that integrates the brain cognitive mechanism and AI computation mechanisms,intelligence simulation from individual intelligence to group intelligence(social intelligence), and AI-assisted brain cognitive intelligence.

关键词： artificial intelligence cognitive science brain science intelligence science large language model

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美元的结构权力与全球经济调整

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财经科学 2014年第12期 22-29页

作者：王铁军华东师范大学国际关系与地区发展研究院

本文认为美国在全球货币体系中的结构性权力使其可以在大规模的资本流入、资产通胀和消费增长的情况下,诱使东亚新兴市场国家建立出口导向型经济,以此巩固其金融主导的经济增长制度。全球信贷危机明确暴露了美国货币霸权的界限,迫使全... 详细信息

本文认为美国在全球货币体系中的结构性权力使其可以在大规模的资本流入、资产通胀和消费增长的情况下,诱使东亚新兴市场国家建立出口导向型经济,以此巩固其金融主导的经济增长制度。全球信贷危机明确暴露了美国货币霸权的界限,迫使全球政治经济进行深刻的调整。本文通过分析全球经济调整的政治经济内涵,认为美国货币霸权的危机在国内体现为金融主导型增长制度的危机,在全球范围内则体现为需求不足。通过分析危机对美国资本主义模式、欧元区和中国的影响,认为全球需求不足将会在短期至中期内持续存在。

关键词：货币权力金融主导的经济增长出口带动的增长

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“满洲问题协议会”:满铁、关东军在东北的权力关系构筑

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社会科学战线 2019年第8期 143-155页

作者：王铁军辽宁大学日本研究所

'满洲问题协议会'是为协调和解决日本陆军省、大藏省和铁路部门围绕在东北的铁路问题和驻军之间所产生的不同意见而设立的机构。其中,尤其以1905年5月22日日本内阁所举行的协议会最为重要。该次会议不仅基本上中止了日本陆军省和其他省... 详细信息

'满洲问题协议会'是为协调和解决日本陆军省、大藏省和铁路部门围绕在东北的铁路问题和驻军之间所产生的不同意见而设立的机构。其中,尤其以1905年5月22日日本内阁所举行的协议会最为重要。该次会议不仅基本上中止了日本陆军省和其他省厅之间的对立意见,而且还确立了其后日本在中国东北地区所形成的'满铁'和关东都督府等殖民统治框架。由此,'满洲问题协议会'也成为日俄战争后满铁与关东军之间所构筑的相互权力关系中具有指标性意义的会议。有鉴于此,文章将'满洲问题协议会'作为研究的线索,通过对日俄战争后日本朝野在'满洲经营'问题上所产生的政策争论以及'满洲问题协议会'的会议经过等史实的系统分析,来探讨日俄战争后满铁与关东都督府之间所构造的权力关系。

关键词： “满洲问题协议会” 满铁关东军权力关系

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