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Surveying brain tumor heterogeneity by single-cell RNA-sequencing of multi-sector biopsies

National Science Review 2020年第8期7卷 1306-1318页

作者： Kai Yu Yuqiong hu Fan Wu Qiufang Guo Zenghui Qian waner hu Jing Chen Kuanyu Wang Xiaoying Fan Xinglong Wu John EJ Rasko Xiaolong Fan Antonio Iavarone Tao Jiang Fuchou Tang Xiao-Dong Su Biomedical Pioneering Innovation Center (BIOPIC) School of Life Sciences Peking University Beijing Advanced Innovation Center for Genomics School of Life Sciences Peking University Biomedical Institute for Pioneering Investigation via Convergence and Center for Reproductive Medicine Ministry of Education Key Laboratory of Cell Proliferation and Differentiation Department of Molecular Neuropathology Beijing Neurosurgical Institute Capital Medical University Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Chinese Glioma Genome Atlas Network (CGGA) and Asian Glioma Genome Atlas Network (AGGA) Peking-Tsinghua Center for Life Sciences Peking University Gene and Stem Cell Therapy Program Centenary Institute University of Sydney Department of Cell and Molecular Therapies Royal Prince Alfred Hospital Beijing Key Laboratory of Gene Resource and Molecular Development Laboratory of Neuroscience and Brain Development Beijing Normal University Institute for Cancer Genetics Herbert Irving Comprehensive Cancer Center Columbia University Medical Center Department of Pathology & Cell Biology Columbia University Medical Center Department of Neurology Columbia University Medical Center Center of Brain Tumor Beijing Institute for Brain Disorders

Brain tumors are among the most challenging human tumors for which the mechanisms driving progression and heterogeneity remain poorly understood. We combined single-cell RNA-seq with multi-sector biopsies to sample and analyze single-cell expression profiles of gliomas from 13 Chinese patients. After classifying individual cells, we generated a spatial and temporal landscape of glioma that revealed the patterns of invasion between the different sub-regions of gliomas. We also used single-cell inferred copy number variations and pseudotime trajectories to inform on the crucial branches that dominate tumor *** dynamic cell components of the multi-region biopsy analysis allowed us to spatially deconvolute with unprecedented accuracy the transcriptomic features of the core and those of the periphery of glioma at single-cell level. Through this rich and geographically detailed dataset, we were also able to characterize and construct the chemokine and chemokine receptor interactions that exist among different tumor and non-tumor cells. This study provides the first spatial-level analysis of the cellular states that characterize human gliomas. It also presents an initial molecular map of the cross-talks between glioma cells and the surrounding microenvironment with single-cell resolution.

关键词： glioma heterogeneity multi-sector biopsy single-cell RNA-seq

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烟台市葡萄酒产业链与创新链协同现状与数字化转型分析——以烟台张裕为例

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中国酿造 2023年第8期42卷 272-276页

作者：胡婉儿彭博李雨琪刘伟平中国农业大学烟台研究院山东烟台264670

当前我国葡萄酒市场发展势头迅猛,虽然受到疫情以及其他宏观因素的制约,但葡萄酒产业仍然存在较大的发展潜力。该文以产业链和创新链视角分析了烟台张裕葡萄酒产业链上中下游创新协同发展现状以及该企业数字化转型策略,最后提出促进葡... 详细信息

当前我国葡萄酒市场发展势头迅猛,虽然受到疫情以及其他宏观因素的制约,但葡萄酒产业仍然存在较大的发展潜力。该文以产业链和创新链视角分析了烟台张裕葡萄酒产业链上中下游创新协同发展现状以及该企业数字化转型策略,最后提出促进葡萄酒产业数字化转型的建议:通过增强数字化转型扶持力度、建立统一的产学研数字化研究体系、培养用户的数字化消费模式来完善数字化产业体系;通过合理布局产业集群、增值产业链关键环节实现产业链增值来助推产业数字化转型。

关键词：葡萄酒产业链创新链数字化转型张裕

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Significant changes in the physicochemical properties of BC-containing particles during the cold season in Beijing

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Journal of Environmental Sciences 2025年第5期151卷 667-676页

作者： Shuya hu Linghan Zeng Gang Zhao Shiyi Chen Chunsheng Zhao Weilun Zhao Min hu State Key Joint Laboratory of Environmental Simulation and Pollution Control International Joint Research Center for Atmospheric Research(IJRC)College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Nanjing University of Information Science and TechnologyNanjing 210044China

The ambient air quality has improved significantly under strict emission controls in Beijing,China over the last *** carbon(BC),as a short-lived climate forcer in ambient aerosols,profoundly impacts the air quality and *** studies have demonstrated a decline in the mass concentration of *** this study,we characterized the chemical compositions and size distributions of BC-containing particles during the cold season of 2022 in Beijing using state-of-the-art instruments capable of exclusively measuring BCcontaining *** optical properties of BC-containing particles were further calculated based on the Mie ***,we compared the properties of BC-containing particles in 2022 with the results of previous *** results showed that the diameters of BC cores became larger while the coating thickness of BC-containing particles became thinner in *** the coating materials,the mass fraction of nitrate increased obviously,and even replaced organic matter as the dominant component during the peak of the pollution *** in chemical compositions and size distributions resulted in lower mass absorption cross-sections(MAC)of BC-containing particles from 10.5±1.1 m^(2)/g in 2016 to 7.3±0.8 m^(2)/g in 2022,reduced by 30.5%.Our results demonstrate the synergistic benefits of air pollution control in improving air quality and mitigating climate ***,the MAC of BC adopted in climate models should vary with the changing air pollution *** study emphasizes that it is imperative to conduct long-term observations of BC-containing particles to better estimate BC’s climate effects.

关键词： Black carbon Chemical composition Size distribution Light absorption ability

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Study on the current situation and latent profile analysis of nurses’ perceived organizational support

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Chinese Journal of Nursing 2025年第3期60卷 340-347页

作者： Pu, Jiangfeng Wang, waner Li, Gege Xie, Zhanghao Xu, Yixuan Zhan, Ningjing huang, huigen 广东药科大学护理学院广州市510315 暨南大学护理学院汕头大学医学院南方医科大学附属广东省人民医院/广东省医学科学院医院办公室

Objective To analyze the current situation and latent profiles of nurses’ perceived organizational support，and explore the influencing factors of different types. Methods Through convenience sampling，a total of 1，860 nurses from the Pearl River Delta，Northern Guangdong，Eastern Guangdong and Western Guangdong regions of Guangdong Province were selected for the survey between October and December 2023. The demographic questionnaire，the Perceived Organizational Support Scale，and the Psychological Resilience Scale were used for investigation. The latent profiles of the nurses’ perceived organizational support，the influencing factors of latent profiles were identified by single-factor analysis and multivariate Logistic regression. Results The score of the items of the perceived organizational support in 1，819 nurses is（3.47±0.88） scores. Nurses perceived organizational support is divided into 3 latent classes，namely “poor group”（10.1%），“balanced group”（44.4%），and “rich group”（45.5%）. The influencing factors include recruitment type，hospital level，and psychological resilience（all P<0.05）. Conclusion The perceived organizational support among nurses is moderately high and heterogeneous，which could be divided into 3 latent profiles. Nursing managers should focus on nurses from the poor group and balanced group and intervene with nurses according to the influencing factors of the different latent profiles to improve the level of nurses perceived organizational support. © 2025 Chinese Nursing Journals Publishing House Co.,Ltd. All rights reserved.

关键词： Latent Profile Analysis Nurse Nursing Administration Research Perceived Organizational Support

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Degradation of carbamazepine by the UVA-LED_(365)/ClO_(2)/NaClO process:Kinetics,mechanisms and DBPs yield

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Journal of Environmental Sciences 2025年第2期148卷 399-408页

作者： Chenyan hu Yihui Wu Zhengyu Dong Ziyi Dong Shengjie Ji Lili hu Xinyu Yang Hao Liu College of Environmental and Chemical Engineering Shanghai Engineering Research Center of EnergySaving in Heat Exchange SystemsShanghai University of Electric PowerShanghai 200090China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

A mixed oxidant of chlorine dioxide(ClO_(2))and NaClO was often used in water treatment.A novel UVA-LED(_(365) nm)-activated mixed ClO_(2)/NaClO process was proposed for the degradation of micropollutants in this ***(CBZ)was selected as the target *** with the UVA_(365)/ClO_(2) process,the UVA_(365)/ClO_(2)/NaClO process can improve the degradation of CBZ,with the rate constant increasing from 2.11×10^(−4) sec^(−1) to 2.74×10^(−4) sec^(−1).In addition,the consumption of oxidants in the UVA_(365)/ClO_(2)/NaClO process(73.67%)can also be lower than that of UVA_(365)/NaClO(86.42%).When the NaClO ratio increased,both the degradation efficiency of CBZ and the consumption of oxidants can increase in the UVA_(365)/ClO_(2)/NaClO *** solution pH can affect the contribution of NaClO in the total oxidant *** the pH range of 6.0-8.0,the combination process can generate more active species to promote the degradation of *** change of active species with oxidant molar ratio was investigated in the UVA_(365)/ClO_(2)/NaClO *** ClO_(2) acted as the main oxidant,HO·and Cl·were the main active species,while when NaClO was the main oxidant,ClO·played a role in the *** chloride ion(Cl^(-)),bicarbonate ion(HCO_(3)^(-)),and nitrate ion(NO_(3)^(-))can promote the reaction *** the concentration of NaClO in the reaction solution increased,the generation of chlorates will *** UVA_(365)/ClO_(2)/NaClO process can effectively control the formation of volatile disinfection by-products(DBPs),and with the increase of ClO_(2) dosage,the formation of DBPs can also decrease.

关键词： UVA Chlorine dioxide(ClO_(2)) NaClO Carbamazepine(CBZ) Disinfection by-products

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Nitrogen-cycling processes under long-term compound heavy metal(loids)pressure around a gold mine:Stimulation of nitrite reduction

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Journal of Environmental Sciences 2025年第1期147卷 571-581页

作者： Xuesong hu Xiaoxia Liu Shuo Zhang Caihong Yu School of Chemical&Environmental Engineering China University of Mining and Technology(Beijing)Beijing 100083China Beijing Cultivated Land Construction and Protection Center Beijing 100020China

Mining and tailings deposition can cause serious heavy metal(loids)pollution to the surrounding soil *** microorganisms adapt their metabolism to such conditions,driving alterations in soil *** study aims to elucidate the response patterns of nitrogen-cycling microorganisms under long-term heavy metal(loids)*** results showed that the diversity and abundance of nitrogen-cyclingmicroorganisms showed negative feedback to heavy metal(loids)*** microorganisms were shown to be the dominant microorganisms with over 60%of relative abundance and a complex community structure including 27 ***,the key bacterial species in the denitrification process were calculated using a random forest model,where the top three key species(Pseudomonas stutzei,Sphingobium japonicum and Leifsonia rubra)were found to play a prominent role in nitrite *** gene analysis and qPCR revealed that nirK,which is involved in nitrite reduction,significantly accumulated in the most metal-rich soil with the increase of absolute abundance of 63.86%.The experimental results confirmed that the activity of nitrite reductase(Nir)encoded by nirK in the soil was increased at high concentrations of heavy metal(loids).Partial least squares-path model identified three potential modes of nitrite reduction processes being stimulated by heavy metal(loids),the most prominent of which contributed to enhanced nirK abundance and soil Nir activity through positive stimulation of key *** results provide new insights and preliminary evidence on the stimulation of nitrite reduction processes by heavy metal(loids).

关键词： N cycle Nitrite reduction Nitrite reductase Metagenome Key species

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Effect of Nb-V microalloying on the hot deformation behavior of medium Mn steels

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 360-368页

作者： Yumeng Wang Qinyi Guo Bin hu Haiwen Luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

The influence of Nb-V microalloying on the hot deformation behavior and microstructures of medium Mn steel(MMS)was investigated by uniaxial hot compression *** establishing the constitutive equations for simulating the measured flow curves,we successfully constructed deformation activation energy(Q)maps and processing maps for identifying the region of flow *** concluded the following consequences of Nb-V alloying for MMS.(i)The critical strain increases and the increment diminishes with the increasing deformation temperature,suggesting that NbC precipitates more efficiently retard dynamic recrystallization(DRX)in MMS compared with solute Nb.(ii)The deformation activation energy of MMS is significantly increased and even higher than that of some reported high Mn steels,suggesting that its ability to retard DRX is greater than that of the high Mn content.(iii)The hot workability of MMS is improved by narrowing the hot processing window for the unstable flow stress,in which fine recrystallized and coarse unrecrystallized grains are present.

关键词： medium manganese steel niobium-vanadium microalloying flow behavior dynamic recrystallization hot workability

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Development of a net ozone production rate detection system based on dual-channel cavity ring-down spectroscopy

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Journal of Environmental Sciences 2025年第3期149卷 419-430页

作者： Jinzhao Tong Renzhi hu Changjin hu Xiaoyan Liu Haotian Cai Chuan Lin Liujun Zhong JiaweiWang Pinhua Xie School of Environmental Science and Optoelectronic Technology University of Science and Technology of ChinaHefei 230026China Anhui Institute of Optics and Fine Mechanics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China School of Pharmacy Anhui Medical UniversityHefei 230032China

A novel system for measuring net photochemical ozone production rates in the atmosphere based on cavity ring-down spectroscopy(OPR-CRDS)was *** system consists of two chambers(a reaction chamber and a reference chamber)and a dual-channel O_(x)-CRDS *** minimize the wall loss of O_(x)in the chambers,the inner surfaces of both chambers are coated with Teflon *** performance of the OPR-CRDS system was *** was found that even though the photolysis frequency(J value)decreased by 10%,the decrease in the P(O_(3))caused by the ultraviolet-blocking film coating was less than 3%.The two chambers had a good consistency in the mean residence time and the measurement of NO_(2)and O_(x)under the condition of no *** detection limit of the OPR-CRDS was determined to be 0.20 ppbv/*** further verify the accuracy of the system,the direct measurement values of the OPR-CRDS systemwere comparedwith the calculation results based on radical(OH,HO_(2),and RO_(2))reactions,and a good correlation was obtained between the measured and calculated ***,the developed instrument was applied to obtain the comprehensive field observations at an urban site in the Yangtze River Delta(China)for 40 days,the time series and change characteristics of the P(O_(3))were obtained directly,and the good environmental adaptability and stability of the OPR-CRDS system were *** is expected that the new instrument will be beneficial to investigations of the relationship between P(O_(3))and its precursors.

关键词： Ozone Net photochemical production rate CRDS Atmospheric chemistry

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Accelerated warming of High Mountain Asia predicted at multiple years ahead

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Science Bulletin 2025年第3期70卷 419-428页

作者： Shuai hu Tianjun Zhou Bo Wu Key Laboratory of Earth System Numerical Modeling and Application Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of the Chinese Academy of Sciences Beijing 100049China

High-Mountain Asia(HMA)is an important source of freshwater since it holds the largest reservoir of frozen water outside the polar *** feeds ten great rivers,ultimately supporting more than 2 billion ***,the threat of accelerated glacier melt,which is a consequence of unprecedented global warming since the early 1950s,threatens water resources in the surrounding *** predictions of the near-term temperature change and synergistic mass loss of glaciers are essential but challenging to implement because of the impacts of internal climate ***,based on large ensembles of state-of-the-art decadal climate prediction experiments,we provide evidence that the internally generated surface air temperature variations in HMA can be predicted multiple years in advance,and the model initialization has robust added value to the decadal prediction ***-time decadal forecasts suggest that the HMA will experience accelerated warming in 2025-2032,where the surface warming will increase by 0.98°C(0.67 to 1.33°C;5%to 95%range)relative to the reference period 1991-2020,which is equivalent to 1.75 times the observed warming during *** decadal predictability originates from extratropical Pacific decadal variability modes,which modulate the convective heating in the tropical Pacific and influence HMA via the eastward-propagating atmospheric Kelvin *** warming in the coming decade will likely increase the shrinkage of the glacier volume over the HMA by 1.4%.This change poses unprecedented challenges,including potential water scarcity,ecosystem disruption,and increased risk of natural disasters,to HMA and surrounding regions.

关键词： Decadal prediction High Mountain Asia Surface air temperature Pacific decadal variabilities Glacier

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基于产业链视角的海洋牧场品牌建设模式——以好当家集团为例

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农业工程 2023年第10期13卷 146-149页

作者：胡婉儿李梅芳中国农业大学烟台研究院山东烟台264670

以好当家集团为例,分析了好当家集团产业链及海洋牧场品牌建设与其产业链的关联性,阐述了好当家集团品牌培育路径,即集团的营销网络和在营销环节采取的手段。基于产业链视角,构建了海洋牧场品牌建设模型,即海洋牧场品牌建设需要精准进... 详细信息

以好当家集团为例,分析了好当家集团产业链及海洋牧场品牌建设与其产业链的关联性,阐述了好当家集团品牌培育路径,即集团的营销网络和在营销环节采取的手段。基于产业链视角,构建了海洋牧场品牌建设模型,即海洋牧场品牌建设需要精准进行品牌定位、确保全产业链安全绿色、寻找产品独特创新点及深度拓展品牌营销渠道,以期为我国海洋牧场可持续发展提供有益借鉴。

关键词：海洋牧场产业链品牌建设好当家集团

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