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Trapping, Transporting, and Splitting Cold Molecules Employing a Spatial Liquid Crystal Modulator

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Chinese Physics Letters 2013年第1期30卷 63-66页

作者： GONG Tian-Lin huang Yun-xia MU Ren-Wang JI xian-ming YANG xiao-Hua School of Science Nantong UniversityNantong 226019 State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200062

Optically transporting and splitting cold molecules are proposed by spatially pure phase modulating a Gaussian laser beam with a spatial liquid crystal modulator(SLM).Taking the experimentally available cold KRb molecules(350 nK)as an example,the computations show that the trapping depth is about 460μK and the trap can be split and transported up to 1 cm when a commercially available SLM is employed.

关键词： modulator Crystal Optically

Inhibition of smoothened decreases proliferation of Synoviocytes in rheumatoid arthritis

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Cellular & Molecular Immunology 2017年第2期14卷 214-222页

作者： Shang-ling Zhu Jian-lin huang Wei-xiang Peng Dan-chun Wu Min-qi Luo Qiu-xia Li Zhao-xia Li xiao-xue Feng Fang Liu ming-xia Wang Wei-qian Chen Nancy Olsen Song Guo Zheng Division of Rheumatology Department of Internal Medicine the Third Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong Province People's Republic of China Center for Clinic Immunology the Third Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong Province People's Republic of China Division of Rheumatology Penn State University Hershey College of Medicine Hershey PA USA Both Shang-ling Zhu and Jian-lin huang equally contributed to this work

Fibroblast-like synoviocytes （FLSs） contribute to synovial hyperplasia in rheumatoid arthritis （RA）. Smoothened （Smo） is a key component of sonic hedgehog （Shh） signaling and contributes to tumor cell proliferation. The objective of this study was to investigate the role of Smo in RA synoviocyte proliferation. FLSs were isolated from RA synovium. Shh signaling was studied using a Smo antagonist （GDC-0449） and small interfering RNA （siRNA） targeting the Smo gene in FLSs. Cell proliferation was quantified by using kit-8 assay and cell cycle distribution and apoptosis were evaluated by flow cytometry. Cell cycle-related genes and proteins were detected by real-time PCR and western blot. FLSs treated with GDC-0449 or Smo-siRNA showed significantly decreased proliferation compared to controls （P〈0.05）. Incubation with GDC-0449 or transfection with Smo-siRNA resulted in a significant increase of G1 phase cells compared to controls （P 〈 0.05）. Cell cycle arrest was validated by the significant increase in cyclin D1 and E1 mRNA expression, decrease in cyclin-dependent kinase p21 mRNA expression in Smo-siRNA transfected cells （P 〈 0.05）. Protein expression of cyclin D1 was also downregulated after Smo gene knockdown （P 〈0.05）.The results suggest that Shh signaling plays an important role in RA-FLSs proliferation in a Smo-dependent manner and may contribute to synovial hyperplasia. Targeting Shh signaling may help control joint damage in patients with RA.

关键词： cell proliferation rheumatoid arthritis smoothened protein sonic hedgehog signaling synoviocyte

Characteristics and outcome of impacted button batteries among young children less than 7 years of age in China:a retrospective analysis of 116 cases

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World Journal of Pediatrics 2018年第6期14卷 570-575页

作者： Tao huang Wen-Qing Li Zhong-Fang xia Jun Li Kai-Cheng Rao En-ming Xu Department of ENT Wuhan Children’s Hospital(Wuhan Maternal and Child Health Care Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Respiratory Medicine Wuhan Children’s Hospital(Wuhan Maternal and Child Health Care Hospital)Tongji Medical CollegeHuazhong University of Science and T echnologyNo.100 Jiangan DistrictWuhan 430016China

Background Ingestion of button batteries occurs in about ten persons per one million persons each year, with most of them children, and one in every 1000 battery ingestions leads to serious injuries. This study aimed to describe the clinical features and outcome of ingestion or inhalation of button batteries in children spanning a decade from January, 2006 to December, 2016 at a tertiary care hospital. Methods We reviewed the clinical records of children who sought treatment for inhaled or ingested button batteries at our hospital during the study period. Data on gender, age, time from ingestion to treatment, site of impaction, imaging findings, and outcomes were retrieved and analyzed. Results We identified 116 pediatric cases of ingestion or inhalation of button batteries. Their mean age was 26 months. The time from ingestion or inhalation of button batteries to treatment was 0.5 hours to 2 weeks. Ninety-seven (83.6%) button batteries were located in the nasal cavity, 13 (11.2%) in the gastrointestinal (GI) tract including 6 in the esophagus, and 7 in the stomach and lower GI tract, and 6 (5.2%) in the auditory tract. Twenty-one (21.6%) children with nasal button batteries had preoperative septal perforations and one (1.0%) had postoperative septal perforation. One child with esophageal button battery developed esophageal stricture and one died of sudden cardiac arrest perioperatively. One child had auditory dam-ages in the right tympanic membrane and ossicles. Conclusions Inhalation or ingestion may occur in the nasal cavities, the esophagus and GI tract and the auditory tract. Prompt diagnosis and treatment are required for a satisfactory outcome and ingested or inhaled button batteries require different treatment protocols.

关键词： Button battery Ingestion Inhalation Foreign body Children Nasal cavities Esophagus Auditory tract Removal

Low power and high uniformity of HfOx-based RRAM via tip-enhanced electric fields

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Science China(Information Sciences) 2019年第10期62卷 164-170页

作者： xiaokang LI Baotong ZHANG Bowen WANG xiaoyan XU Yuancheng YANG Shuang SUN Qifeng CAI Shijie HU xia AN ming LI Ru huang Key Laboratory of Microelectronic Devices and Circuits (MOE) Institute of MicroelectronicsPeking University

In this paper, the HfOx-based resistive random access memory（RRAM） devices with sub-100 nm pyramid-type electrodes were fabricated. With the help of tip-enhanced electric field around the pyramid-type electrodes, it was experimentally demonstrated that the novel devices have better cycle-to-cycle variation control, lower forming/set voltage（1.97/0.7V） and faster switching speed（≤30 ns under 0.9V pulse） as well as better endurance reliability than conventional flat electrode resistive memory devices. In addition,the novel RRAM is experimentally demonstrated with independence of electrode number for the first time to present great potential in scaling down. This novel structure metal-oxide based RRAM will be suitable for the future low-power non-volatile memory application.

关键词： RRAM pyramid-type electrode variation reliability switching speed conducting filament

In Situ HRTEM Observation of Electron-Irradiation-Induced Amorphization and Dissolution of the E(Al_(18)Cr_2Mg_3) Phase in 7475 Al Alloy

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Acta Metallurgica Sinica(English Letters) 2015年第2期28卷 147-151页

作者： Mao-Hua Li Yan-Qing Yang Bin huang xian Luo Wei Zhang Yan-xia Chen ming Han Ji-Gang Ru State Key Laboratory of Solidification Processing Northwestern Polytechnical University Beijing Institute of Aeronautical Materials

Electron irradiation effects on phase stability of the E （Al18Cr2Mg3） phase have been investigated by high- angle annular dark-field scanning transmission electron microscopy and high-resolution transmission electron microscopy （HRTEM）. The in situ HRTEM observations show that the Ala8Cr2Mg3 particles with different thickness undergo amorphization and dissolution under 300 keV electron irradiation at 25 ℃. The results indicate that the intermetallic compound Al18Cr2Mg3 is unstable under electron irradiation, and structural changes mainly depend on the thickness of particles. Amorphization in the thick particles is caused by a combination of chemical disordering and an increase in point defect concentration. Dissolution after amorphization in the thin particles is attributed to the diffusion of point defect towards the Al matrix.

关键词： Intermetallic compound Al18Cr2Mg3 Irradiation effects Amorphization Dissolution

Protective roles of trehalose in Pleurotus pulmonarius during heat stress response

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Journal of Integrative Agriculture 2019年第2期18卷 428-437页

作者： LIU Xiu-ming WU xiang-li GAO Wei QU Ji-bin CHEN Qiang huang Chen-yang ZHANG Jin-xia Key Laboratory of Microbial Resources Ministry of Agriculture and Rural Affaris/Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081P.R.China

High temperature is one of the major abiotic stresses that limit edible mushroom growth and development. The understanding of physiological alterations in response to heat stress and the corresponding mechanisms involved is vital for the breeding of heat-resistant edible mushroom strains. Although trehalose functions as a protectant against abiotic stresses in fungi, the putative role of trehalose in thermotolerance remains to be elucidated. In this study, we found heat stress inhibited the growth of two Pleurotus pulmonarius strains, heat-sensitive and less-sensitive, and the inhibition was more significant for the sensitive strain. Heat stress leads to the increase of lipid peroxidation and intracellular trehalose accumulation, with a higher level in the heat-sensitive strain, and this effect is independent of exogenous trehalose application. In addition, a lower concentration of exogenous trehalose application in sensitive strain than in less-sensitive strain was found to alleviate the inhibition of mycelium growth and further increase the intracellular trehalose concentration by heat stress. Thus, the protective effects of trehalose were more remarkable in the sensitive strain. The activities of intracellular trehalose metabolic enzymes, i.e., trehalose-6-phosphate synthase, trehalose phosphorylase and neutral trehalase, were determined, and our data indicated that the changes of these enzymes activities in the sensitive strain were more beneficial to accumulate trehalose than that in the less-sensitive strain.

关键词： edible mushroom heat stress Pleurotus pulmonarius thermotolerance trehalose

CD5阳性弥漫大B细胞淋巴瘤患者的临床特征及预后分析

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中国实验血液学杂志 2024年第3期32卷 750-755页

作者：黄秀娟杨健魏小芳伏媛赵阳阳程明霞李青芬闫海龙冯友繁陕西省人民医院血液内科陕西西安710068 甘肃省人民医院肿瘤外科甘肃兰州730000 甘肃省人民医院血液科甘肃兰州730000 陕西省人民医院急诊外科陕西西安710068

目的:分析CD5阳性弥漫大B细胞淋巴瘤(DLBCL)患者的临床特征及预后影响因素。方法:回顾性分析自2013年1月至2020年1月甘肃省人民医院就诊的161例初治DLBCL患者的临床资料,根据CD5表达情况,将患者分为CD5+组和CD5-组,并对两组患者的临床... 详细信息

目的:分析CD5阳性弥漫大B细胞淋巴瘤(DLBCL)患者的临床特征及预后影响因素。方法:回顾性分析自2013年1月至2020年1月甘肃省人民医院就诊的161例初治DLBCL患者的临床资料,根据CD5表达情况,将患者分为CD5+组和CD5-组,并对两组患者的临床特征、预后生存进行统计学分析。结果:临床特征分析结果显示,CD5+组患者的中位年龄为62岁,高于CD5-组的56岁(P=0.048);CD5+组患者女性占比为62.96%,明显高于CD5-组的41.79%(P=0.043);CD5+组IPI评分>2分患者的比例为62.96%,高于CD5-组患者的40.30%(P=0.031)。生存分析结果显示,CD5+组的中位总生存期和无进展生存期分别为27(3-77)个月、31(3-76)个月,均短于CD5-组的30(5-84)个月、32.5(4-83)个月,比较差异有统计学意义(P=0.047,P=0.026)。单因素分析结果显示,高龄、CD5表达为阳性、初诊时存在三打击或双打击、较高的IPI评分及化疗过程中未使用利妥昔单抗是影响DLBCL患者预后的危险因素,进一步行Cox多因素回归分析结果显示,除高龄外以上均是独立危险因素。结论:CD5+DLBCL患者预后相对CD5-患者更差,此类患者多见于女性,高龄、IPI评分高,是一类特殊的DLBCL亚型。

关键词：弥漫大B细胞淋巴瘤 CD5 临床特征预后

Intergenic spacer 1(IGS1) polymorphism map: A marker for the initial classification of cultivated Lentinula edodes strains in China

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Journal of Integrative Agriculture 2018年第11期17卷 2458-2466页

作者： SONG xiao-xia ZHAO Yan SONG Chun-yan LI Chuan-hua CHEN ming-jie huang Jian-chun TAN Qi Institute of Edible Fungi Shanghai Academy of Agricultural Sciences

China is currently the world＇s leading producer of Lentinula edodes and owns many cultivated strains of this species. This study was performed in order to investigate intergenic spacer I （IGS1） polymorphism and classification among 49 popular cultivated strains. The great majority of the 49 strains possessed two different IGS1 sequences, with distinct lengths and homologies. Based on the length and homology of the IGS1 sequences of the 49 strains, the strains were classified into two groups： A and B. Group A was subdivided into six subgroups. Forty-seven strains were homozygous or heterozygous among these six subgroups in group A, Cr01 was heterozygous between A and B, and Guangxiang 9 was homozygous in group B. An IGS1 polymorphism map of each cultivated L. edodes strain is reported for the first time and could be used as a marker for the initial classification and management of cultivated L. edodes strains in China.

关键词： Lentinula edodes strain intergenic spacer polymorphism genotype

Simulation of distribution of radiation energy density in water balls

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Nuclear Science and Techniques 2005年第6期16卷 347-351页

作者： TANG Shi-Biao MA Qing-Li YINZe-Jie TANG Yu huang Huan RAO Nan-xia ZHU Da-ming Department of Modern Physics University of Science and Technology of China Hefei 230026 China Department of Physics University of Missouri-Kansas City Kansas City Missouri 64110 USA

The distribution of energy deposition density in radiate region and its surrounding areas from γ-rays wassimulated and analyzed for a water-ball model with Geant4 package(Geant4.7.0,2005) developed by CERN (theCenter of European Research of Nucleus). The results show that the distribution depends strongly on the collimatingcondition of radiation beam. A well-collimated beam would reduce radiation effects on surrounding areas.

关键词：放射性能量数值模拟 γ射线计算机模拟波导光学