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Nanoadjuvant-triggered STING activation evokes systemic immunotherapy for repetitive implant-related infections

Bioactive Materials 2024年第5期35卷 82-98页

作者： Dongdong Xu Jun Hu Jiawei Mei Jun Zhou Zhengxi Wang Xudong Zhang Quan Liu Zheng Su wanbo zhu Hongjian Liu Chen zhu Department of Orthopedics The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450000PR China Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of Chin1Hefei230001PR China Department of Orthopedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai200233PR China Department of Laboratory Medicine Long Hua HospitalShanghai University of Traditional Chinese MedicineShanghai200032PR China

Repetitive implant-related infections(IRIs)are devastating complications in orthopedic surgery,threatening implant survival and even the life of the *** conceal bacterial-associated antigens(BAAs)and result in a"cold tumor"-like immune silent microenvironment,allowing the persistence of *** address this challenge,an iron-based covalent organic framed nanoadjuvant doped with curcumin and platinum(CFCP)was designed in the present study to achieve efficient treatment of IRIs by inducing a systemic immune ***,enhanced sonodynamic therapy(SDT)from CFCP combined with iron ion metabolic interference increased the release of bacterial-associated double-stranded DNA(dsDNA).Immunogenic dsDNA promoted dendritic cell(DC)maturation through activation of the stimulator of interferon gene(STING)and amplified the immune stimulation of neutrophils via interferon-β(IFN-β).At the same time,enhanced BAA presentation aroused humoral immunity in B and T cells,creating long-term resistance to repetitive ***,CFCP served as neoadjuvant immunotherapy for sustained antibacterial protection on implants and was expected to guide clinical IRI treatment and relapse prevention.

关键词： Implant-related infections Systemic immunotherapy cGAS-STING pathway Interferon Neutrophil activation

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Fetuin-A is an immunomodulator and a potential therapeutic option in BMP4-dependent heterotopic ossification and associated bone mass loss

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Bone Research 2022年第4期10卷 867-881页

作者： Chen Kan Jiazhao Yang Haitao Fan Yuanjuan Dai Xingxing Wang Rui Chen Jia Liu Xiangyue Meng Wei Wang Guiling Li Jiao Zhou Ya Zhang wanbo zhu Shiyuan Fang Haiming Wei Hong Zheng Siying Wang Fang Ni Department of Pathophysiology School of Basic Medical SciencesAnhui Medical UniversityHefeiChina Department of Hematology The First Affiliated Hospital of USTCThe CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Institute of Immunology University of Science and Technology of ChinaHefeiChina Department of Orthopaedics The First Affiliated Hospital of USTCHefeiChina Department of Orthopaedics Fuyang Hospital of Anhui Medical UniversityFuyangChina

Heterotopic ossification(HO)is the abnormal formation of bone in extraskeletal ***,the mechanisms linking HO pathogenesis with bone mass dysfunction remain ***,we showed that mice harboring injury-induced and BMP4-dependent HO exhibit bone mass loss similar to that presented by patients with ***,we found that injury-induced hyperinflammatory responses at the injury site triggered HO initiation but did not result in bone mass loss at 1 day post-injury(dpi).In contrast,a suppressive immune response promoted HO propagation and bone mass loss by 7 *** immune dysregulation by PD1/PDL1 blockade dramatically alleviated HO propagation and bone mass *** further demonstrated that fetuin-A(FetA),which has been frequently detected in HO lesions but rarely observed in HO-adjacent normal bone,acts as an immunomodulator to promote PD1 expression and M2 macrophage polarization,leading to *** with recombinant FetA inhibited hyperinflammation and prevented HO and associated bone mass ***,our findings provide new insights into the osteoimmunological interactions that occur during HO formation and suggest that FetA is an immunosuppressor and a potential therapeutic option for the treatment of HO.

关键词： PD1 therapeutic inhibited

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New insight into the origin and evolution of the flora and fauna of Hainan Island, China

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Science China Earth Sciences 2025年第1期68卷 52-61页

作者： Hua zhu Center for Integrative Conservation Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences Yunnan International Joint Laboratory of Southeast Asia Biodiversity Conservation Yunnan Key Laboratory for the Conservation of Tropical Rainforests and Asian Elephants

The origin of the biota of Hainan Island, China, remains a fundamental scientific problem. Comparative studies on the biota, geological tectonics, and paleomagnetism proposed that during the Eocene, Hainan Island connected Vietnam and Guangxi, and then moved to the southeast to reach its present location. This review mainly discusses its biota origin from molecular phylogeny and palaeobotanical research. The formation and evolution of the biological groups of Hainan Island were identified via research on their genomes, phylogeny, and molecular biogeography. This research showed that the genera and species that appeared and diverged early in their evolution(i.e., before the Miocene) can be explained by the land connection between Hainan Island, Vietnam, and Guangxi during the Eocene-Oligocene. According to Southeast Asian tectonic theory, in the Middle Miocene(at about 15 million years ago), Hainan Island had moved to its present position. The population and genetic divergence of species with late divergence times(after 15 Ma) can be reasonably explained by the close proximity(or land connection) between Hainan Island and the Leizhou Peninsula, enabling genetic communication between Hainan Island and the Chinese mainland, but have exceptional cases. Conclusions have been obtained through palaeobotanical studies, showing that in the Eocene-Oligocene period, southwest China and Hainan Island had subtropical vegetation and flora. However, the fossil group in southeast China(in Maoming, near present-day Hainan Island) in the Late Eocene indicated a tropical rainforest vegetation and flora. This suggests that in the Paleogene, Hainan Island may have been located near or on the southwest border of Guangxi and northern Vietnam, rather than in its present location. The floristic division of the flora of Hainan Island basically presents a northeast-southwest inclined distribution pattern. This pattern can be explained by the counterclockwise rotation of Hainan Island during i

关键词： Molecular phylogeny Biogeography Paleobotany Origin of flora and fauna Hainan Island of China

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干细胞源性外泌体促骨折愈合的机制及临床应用进展

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中国组织工程研究 2019年第5期23卷 815-820页

作者：朱万博卢锦森杨家赵方诗元安徽医科大学附属安徽省立医院安徽省合肥市230001

背景:根据干细胞源性外泌体的生物学特点,不断有研究发现其在促成骨分化、血管生成和骨质矿化中具有特异性作用,是潜在的促骨折愈合材料。目的:综述干细胞源性外泌体促骨折愈合的机制及其临床应用最新研究进展,以期为临床应用提供思路... 详细信息

背景:根据干细胞源性外泌体的生物学特点,不断有研究发现其在促成骨分化、血管生成和骨质矿化中具有特异性作用,是潜在的促骨折愈合材料。目的:综述干细胞源性外泌体促骨折愈合的机制及其临床应用最新研究进展,以期为临床应用提供思路。方法:检索PubMed数据库及CNKI中国期刊全文数据库收录的干细胞源性外泌体促进骨折愈合的相关文章。英文检索词为"stem cell derived exosome,fracture healing,bone regeneration,osteogenic differentiation",中文检索词为"干细胞,外泌体,骨折愈合,骨再生,成骨分化"。按照纳入与排除标准最终纳入49篇文献进行归纳总结。结果与结论:(1)干细胞源性外泌体能通过选择性携带遗传因子、蛋白质、转录因子等生物活性物质在骨折愈合微环境中发挥促进作用;(2)干细胞源性外泌体主要通过改善骨折微环境、促进血管形成、成骨分化、骨矿化等方式促进骨折愈合;(3)受制于高效经济的分离提取方式和适合的使用载体,干细胞源性外泌体促骨折愈合的临床应用尚需要进一步研究。

关键词：干细胞外泌体骨折愈合骨折愈合微环境干细胞外泌体成骨分化组织工程

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舰尾流下自动着舰进场动力补偿的仿真与分析

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航空兵器 2023年第1期30卷 69-73页

作者：黄旭东朱万博闻子侠刘玮航空工业西安飞行自动控制研究所西安710065

着舰过程中舰尾流影响舰载机高度和速度,造成着舰偏差,甚至会导致复飞。针对舰尾流造成舰载机自动着舰落点精度差的问题,本文首先介绍传统速度恒定动力补偿、迎角恒定动力补偿2种方案,并对迎角恒定动力补偿控制方案进行改进,减小纵向高... 详细信息

着舰过程中舰尾流影响舰载机高度和速度,造成着舰偏差,甚至会导致复飞。针对舰尾流造成舰载机自动着舰落点精度差的问题,本文首先介绍传统速度恒定动力补偿、迎角恒定动力补偿2种方案,并对迎角恒定动力补偿控制方案进行改进,减小纵向高度通道与速度通道的耦合程度,降低舰尾流对下滑道控制精度的影响。通过数学仿真对比了3种方案抑制舰尾流稳态分量的效果。仿真结果表明,改进的迎角恒定动力补偿方案能够有效抑制舰尾流垂直分量的影响,并能够改善舰尾流水平分量的影响。

关键词：自动着舰舰尾流进场动力补偿速度恒定迎角恒定舰载机

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异构多智能体的数据驱动输出一致性跟踪控制

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宇航学报 2024年第10期45卷 1666-1675页

作者：马梓元朱万博梁文鑫龚华军王新华南京航空航天大学自动化学院南京210016 航空工业西安飞行自动控制研究所西安710076

针对一类异构多智能体编队一致性跟踪控制问题,考虑到实际系统中控制输入和输出均基于离散采样数据,且部分状态信息无法通过传感器获取,提出一种数据驱动的异构多智能体一致性输出跟踪控制方案。该方案利用数字采样控制方法和离散时间输... 详细信息

针对一类异构多智能体编队一致性跟踪控制问题,考虑到实际系统中控制输入和输出均基于离散采样数据,且部分状态信息无法通过传感器获取,提出一种数据驱动的异构多智能体一致性输出跟踪控制方案。该方案利用数字采样控制方法和离散时间输入-输出采样数据,设计了包含无人机和无人车的异构多智能体一致性跟踪控制策略。通过状态观测器,利用降维输出信息实现了对全维状态信息的一致性跟踪控制。采用基于收缩映射原理的稳定性分析,验证了所提出的一致性跟踪控制方案对于每个闭环信号的有界性。同时,通过数值仿真验证了理论分析结果以及无人机和无人车的一致性跟踪控制性能。

关键词：无人机多智能体编队控制一致性跟踪控制数据驱动

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退火温度对冷拔钢丝织构与性能的影响

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金属热处理 2019年第1期44卷 22-25页

作者：张正贵朱万波姚旭升陈昊男肖铁沈阳大学机械工程学院辽宁沈阳110044 抚顺电瓷制造有限公司辽宁抚顺113008

采用精确的线材织构测定方法分析了冷拔钢丝在450、550和650℃退火过程中织构变化,并采用光学显微镜和显微硬度计研究了此过程中钢丝的显微组织和显微硬度。结果表明:冷拔钢丝在不同温度下退火过程中,随着退火温度的升高,显微组织由纤... 详细信息

采用精确的线材织构测定方法分析了冷拔钢丝在450、550和650℃退火过程中织构变化,并采用光学显微镜和显微硬度计研究了此过程中钢丝的显微组织和显微硬度。结果表明:冷拔钢丝在不同温度下退火过程中,随着退火温度的升高,显微组织由纤维状转变为等轴晶,硬度显著下降;不同温度退火后的织构与拉拔态的织构类型相同,以丝织构为主,且沿着线材径向呈现一定梯度分布。但是随着退火温度的升高,丝织构强度下降。另外,退火过程中,冷拔钢丝的硬度与丝织构强度具有相似的变化趋势。

关键词：钢丝冷拔退火织构

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Modification of Maxwell model for conductivity prediction of carbon nanotubes-filled polymer composites with tunneling effect

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 25-36页

作者： Jue zhu Longyuan LI Ningtao zhu Zhejiang Provincial Engineering Research Center for the Safety of Pressure Vessel and Pipeline Key Laboratory of Impact and Safety Engineering (Ningbo University) Ministry of Education School of Engineering Computing and Mathematics University of Plymouth Xi'an Zhanshi Testing & Engineering Co.Ltd.

Carbon nanotubes(CNTs) have garnered great attention in recent years due to their outstanding electrical, thermal, and mechanical properties. The incorporation of small amounts of CNTs in polymers can substantially improve the sensitivity of the polymer's electrical conductivity. This paper presents a modified Maxwell model to evaluate the electrical conductivity of CNTs-filled polymer composites by introducing a transition zone to account for the tunneling effect. In this modified Maxwell model, the CNTs-filled polymer composite is modeled as a three-phase composite, consisting of a matrix(polymer), inclusions(CNTs), and a transition zone(tunneling zone). The effective electrical conductivity(EEC) of the composite is calculated based on the volume fractions and electrical conductivities of the matrix, inclusions, and transition zone. The model's validity is confirmed through the use of available test data, which demonstrates its capability to accurately capture the nonlinear conductivity behavior observed in CNTs-polymer composites. This study offers valuable insights into the design of high-performance conductive polymer nanocomposites, and enhances the understanding of electrical conduction mechanisms in CNT-dispersed polymer composites.

关键词： Nanoclay

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体积分数为65%SiCp/A356复合材料的微观结构和界面反应研究

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有色金属工程 2021年第2期11卷 31-37页

作者：朱万波张正贵王全兆肖伯律沈阳大学机械工程学院材料科学系沈阳110044 中国科学院金属研究所沈阳110016

采用粉末冶金法制备出不同保温时间(6、12 h)的65%(体积分数,下同)SiCp/A356复合材料。利用光学金相显微镜(OM)、X射线衍射仪(XRD)、扫描电子显微镜(SEM)、透射电子显微镜(TEM)等对65%SiCp/A356复合材料的微观结构与界面反应进行研究。... 详细信息

采用粉末冶金法制备出不同保温时间(6、12 h)的65%(体积分数,下同)SiCp/A356复合材料。利用光学金相显微镜(OM)、X射线衍射仪(XRD)、扫描电子显微镜(SEM)、透射电子显微镜(TEM)等对65%SiCp/A356复合材料的微观结构与界面反应进行研究。结果表明:在630℃热压温度下,保温12 h的材料致密度优于保温6 h的材料,孔洞少,有明显Si相析出;发生轻微的界面反应,反应产物以MgAl2O4为主,未发现有害相Al4C3。保温12 h材料弹性模量、热导率和热膨胀系数分别为210 GPa、216 W/(m·K)和7.3×10-6/℃(50~300℃)。

关键词：粉末冶金铝基复合材料微观结构界面反应 SiC

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Late Paleozoic to early Mesozoic volcanic-sedimentary history of the southeastern margin of the Central Asian Orogenic Belt: Timing of uplift of the Inner Mongolia paleo-uplift

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Science China Earth Sciences 2025年第1期68卷 297-309页

作者： Wenxing HAO Jin-Hui YANG Guang zhu State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences School of Resource and Environmental Engineering Hefei University of Technology

The Kulun region is located in the eastern Bainaimiao arc belt on the southeastern margin of the Central Asian Orogenic Belt(CAOB), adjacent to the North China Craton(NCC) to the south. This region records the closure of the PaleoAsian Ocean during the Paleozoic to early Mesozoic and is key to study the tectonic evolution of the northern margin of the *** conducted zircon U-Pb geochronology and Hf isotope analysis of volcanic-sedimentary and intrusive rocks in the Kulun region. The volcanic-sedimentary rocks were previously assigned an early Carboniferous age, but include volcanic rocks with ages of 267–266 Ma and sedimentary rocks with youngest detrital zircon age peaks of 265–244 Ma, which were intruded by a granite with an age of 242 Ma. This indicates that these rocks are actually middle Permian to Middle Triassic in age(267–242Ma) and correspond to the Qingfengshan and Liujiagou formations. Moreover, two volcanic rock samples have high εHf(t) values(+1.6 to +16.1) and relatively young two-stage Hf model ages(1095–327 Ma), indicating their sources associated with the CAOB. The age spectra and Hf isotopic characteristics of detrital zircons from the sedimentary rocks suggest that, during the middle Permian to Middle Triassic, the sedimentary provenance in the Kulun region was mainly the CAOB. However, by the Early Jurassic, the provenance changed to the NCC(i.e., the Inner Mongolia Paleo-uplift, IMPU). This result, combined with the development of a series of conglomerates on the northern margin of the NCC in the Late Triassic(i.e., Xingshikou, Xiaoyingzi,and Xiaohekou formations), indicates the Kulun region experienced an abrupt change in paleogeography during the Late Triassic, with the IMPU undergoing significant uplift and thus becoming the main sediment source in the Kulun region. Based on the Late Triassic alkaline igneous belt(235–215 Ma) in the IMPU, we speculate that this uplift was caused by detachment of the southward-subducting Paleo-Asian oceanic

关键词： Central Asian Orogenic Belt the North China Craton Zircon geochronology Hf isotopes Inner Mongolia Paleo-uplift

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