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Pulmonary arterial hypertension related to human immunodeficiency virus infection:A case series

World Journal of Cardiology 2014年第6期6卷 495-501页

作者： Inês Araújo Cristina Enjuanes-Grau Carmen Jimenez Lopez-Guarch dariusz Narankiewicz Maria J Ruiz-Cano Teresa Velazquez-Martin Juan Delgado Pilar Escribano 3~(rd) Medicine Department S?o Francisco Xavier HospitalCHLO1449-005 LisboaPortugal Cardiology Department University Hospital of Canarias38320 La LagunaTenerifeSpain Teresa Velazquez-Martin Juan DelgadoPilar EscribanoPulmonary Hypertension UnitUniversity Hospital of 12 de Octubre28041 MadridSpain Internal Medicine Department Carlos Haya Hospital29010 MálagaSpain Pulmonary Hypertension Unit University Hospital of 12 de Octubre28041 MadridSpain

AIM: To present 18 new cases of human immunodeficiency virus(HIV)-related pulmonary arterial hypertension(PAH) with presenting features,treatment options and follow-up ***: This is a single-centre,retrospective,observational study that used prospectively collected data,conducted during a 14-year period on HIV-related PAH patients who were referred to a pulmonary hy-pertension unit. All patients infected with HIV were consecutively admitted for an initial evaluation of PAH during the study period and included in our study. Right heart catheterisation was used for the diagnosis of PAH. Specific PAH treatment was started according to the physician's judgment and the recommendations for idiopathic PAH. The data collected included demographic characteristics,parameters related to both HIV infection and PAH and disease ***: Eighteen patients were included. Intravenous drug use was the major risk factor for HIV infection. Risk factors for PAH,other than HIV infection,were present in 55.5% patients. The elapsed time between HIV infection and PAH diagnoses was 12.2 ± 6.9 years. At PAH diagnosis,94.1% patients had a CD4 cell count > 200 cells/μL. Highly active antiretroviral therapy(present in 47.1% patients) was associated with an accelerated onset of PAH. Survival rates were 93.8%,92.9% and 85.7% at one,two and three years,respectively. Concerning specific therapy,33.3% of the patients were started on a prostacyclin analogue,and the rest were on oral drugs,mainly phosphodiesterase-5 inhibitors. During the follow-up period,specific therapy was de-escalated to oral drugs in all of the living ***: The survival rates of HIV-related PAH patients were higher,most likely due to new aggressive specific therapy. The majority of patients were on oral specific therapy and clinically stable. Moreover,sildenafil appears to be a safe therapy for less severe HIVrelated PAH.

关键词： Human immunodeficiency virus infection Pulmonary arterial hypertension Treatment

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The Transcriptional Activity of LAMP3 Gene Involved in Autophagocytosis in Colorectal Cancer LAMP3 Expression in Colorectal Cancer

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Journal of Biosciences and Medicines 2017年第12期5卷 24-36页

作者： Martyna Bednarczyk Malgorzata Muc-Wierzgon Nikola Zmarzly Celina Kruszniewska-Rajs Beniamin Grabarek Agata Kazmierczak Bartlomiej Skowronek Klaudia Simka dariusz Waniczek Katarzyna Walkiewicz Urszula Mazurek Department of Internal Medicine School of Public Health in BytomMedical University of SilesiaKatowicePoland Department of Molecular Biology School of Pharmacy with the Division of Laboratory Medicine in SosnowiecMedical University of SilesiaKatowicePoland Chair of General Colorectal and Polytrauma SurgeryDepartment of Propaedeutics SurgeryMedical University of SilesiaKatowicePoland

Background: Autophagocytosis is a biological process involving the controlled distribution of cell fragments and organelles in order to obtain an additional source of energy. LAMP3 (lysosome-associated membrane protein 3) is a heavily glycosylated integral membrane protein located mainly in the lysosomal membrane. Recent studies have shown that it participates in tumor metastasis and drug resistance. Its main role is contribution to tumor cells proliferation, migration and invasion. The aim of this study was to determine changes in transcriptional activity of LAMP3 at various stages of colorectal cancer. In addition, an attempt was made to select miRNAs potentially regulating LAMP3 expression using bioinformatic databases. Methods: The study was conducted on healthy colon samples and colon cancer samples in four stages. Molecular analysis included the extraction of total RNA, purification of the obtained extracts, expression profile analysis using oligonucleotide microarray technique and in silico determination of miRNAs potentially regulating the LAMP3 expression. Results: The level of LAMP3 expression is higher in colorectal adenocarcinoma cells than in non-cancerous cells and depends on the stage of the disease. Conclusions: LAMP3 may promote cancer progression, metastasis and cause the resistance to treatment.

关键词： Autophagy Colorectal Cancer LAMP3 Microarrays miRNA

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在猪饲料中添加硒对屠宰价值、猪肉理化性状和感官特性的影响

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江西饲料 2014年第6期 7-11,15页

作者：贺强 dariusz Lisiakl Piotr Janiszewski Tadeusz Blicharski Karol Borzuta 江西省赣州市畜牧研究所赣州341401

本研究的目的是为了评价有机硒和无机硒在猪饲料中作为添加剂的可同化性。试验检测了这两种不同形式的硒对屠宰价值、理化性状和肉质感官的影响(试验I),并尝试性地测定硒在试验性育肥猪体内的含量(试验II)。试验I的试验对象为20头杂交猪... 详细信息

本研究的目的是为了评价有机硒和无机硒在猪饲料中作为添加剂的可同化性。试验检测了这两种不同形式的硒对屠宰价值、理化性状和肉质感官的影响(试验I),并尝试性地测定硒在试验性育肥猪体内的含量(试验II)。试验I的试验对象为20头杂交猪,基因型为(波兰大白猪×波兰长白猪)×杜洛克(Polish Large White×Polish Landrace)×Duroc;PLW×PL×Duroc);试验II则是以45头杂交育肥猪的最长肌和半膜肌作为检测样品,基因型与试验I相同。试验结果表明,在猪日常饮食中添加硒不影响屠宰性能、肉的品质和感官特性以及大部分的理化性状,并且发现硒对猪肉颜色的改变没有显著效果。经检测,有机硒实验组的育肥猪的猪肉保水能力(water holding capacity,WHC)降低,而在无机硒实验组的育肥猪的半膜肌内硒的含量最高。

关键词：猪硒可同化性猪肉品质

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The association of adenosine deaminase with coronary artery disease: Effect of gender and diabetes

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Health 2013年第2期5卷 166-169页

作者： Fulvia Gloria-Bottini Krzysztof Safranow Maria Banci Agnieszka Binczak-Kuleta Patrizia Saccucci Andrzej Ciechanowicz Andrea Magrini Zdzislawa Kornacewicz-Jach Egidio Bottini dariusz Chlubek Department of Biochemistry and Medical Chemistry Pomeranian Medical University Szczecin Poland Department of Biomedicine and Prevention School of Medicine University of Rome Tor Vergata Rome Italy Department of Cardiology Pomeranian Medical University Szczecin Poland Department of Cardiology Valmontone Hospital Valmontone Italy Department of Laboratory Diagnostics and Molecular Medicine Pomeranian Medical University Szczecin Poland

An association between ADA1 and Coronary Artery Disease (CAD) has been observed in Polish and in Italian populations but in Italian population the association was present in males only. In order to enlighten these differences we have carried out a collaborative study in the two populations. In Italy 215 subjects admitted to the Hospital for CAD, 275 subjects with Type 2 Diabetes (T2D) without CAD and 398 healthy new-borns were studied. In Poland 173 subjects with CAD and 200 healthy newborns were studied. Written informed consent was obtained from all subjects or from their mothers to participate to the study that was approved by the I.R.B. ADA1 polymorphism was determined by DNA analysis. Three way contingency table analysis was performed by a log linear model. The association between CAD and ADA1 is present in non diabetic male subjects only: OR = 0.195, p = 0.007 in the Italian population and OR = 0.163, p = 0.004 in the Polish population. The data suggest a significant role of immunological mechanisms in the pathogenesis of CAD without diabetes. Gender differences in immune diseases could explain the lack of association in females.

关键词： ADA CAD Gender Diabetes

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永恒之阴影

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作者： (波)大流士·莱比奥达(dariusz Lebioda)

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多期裂谷作用及伸展断层相关褶皱

多期裂谷作用及伸展断层相关褶皱

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2023年中国地球科学联合学术年会

作者：邓洪旦 Ken McClay 陈汉林 Emma Finch dariusz Jablonski Sukonmeth Jitmahantakul 浙江大学 Royal Holloway University of London University of Manchester Chulalongkorn University

早期的裂谷作用深刻影响后续伸展过程中岩石圈的变形行为,控制叠合盆地的发育过程。澳大利亚西北被动大陆边缘经历了晚古生代超伸展(hyperextension)裂谷作用和中生代窄裂谷作用(narrow rifting),为典型的复合型被动大陆边缘。高精度2D... 详细信息

早期的裂谷作用深刻影响后续伸展过程中岩石圈的变形行为,控制叠合盆地的发育过程。澳大利亚西北被动大陆边缘经历了晚古生代超伸展(hyperextension)裂谷作用和中生代窄裂谷作用(narrow rifting),为典型的复合型被动大陆边缘。高精度2D/3D深地震反射数据为深入研究澳大利亚西北陆缘晚古生代-中生代的多期、多种变形模式裂谷作用叠合过程提供了重要条件。

关键词：断层相关褶皱多期裂谷作用

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Non Catalytic Growth of Gallium Nitride Nanowires by Sublimation Sandwich Method on （001） Al2O3

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材料科学与工程（中英文版） 2010年第11期4卷 53-56页

作者： Pawel Dominik Joanna Gola dariusz Smolen Slawomir Podsiadlo Faculty of Chemistry Warsaw University of Technology Warsaw 00-664 Poland

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帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析

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中国肺癌杂志 2022年第1期25卷 I0007-I0018页

作者：周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino 广东省人民医院肺三科广东省医学科学院广东省肺癌研究所广州510080 Sanford Health Sioux FallsSouth Dakota Complejo Hospitalario Universitario Insular-Materno Infantil Universidad de Las Palmas de Gran CanariaGran CanariaSpainospital Universitario Insular de Gran CanariaLas Palmas de Gran CanariaLas Palmas de Gran CanariaSpain Abramson Cancer Center University of PennsylvanialadelphiaPennsylvania Wollongong Private Hospital University of WollongongWollongongAustralia Hospital Universitario 12 de Octubre CNIOUniversidad Complutense and CiberoncMadridSpain Robert Bosch Centrum für Tumorerkrankungen Robert Bosch Cancer CenterKlinik SchillerhoheGerlingenGermany Oncology Center Médica Sur Hospital-Instituto Nacional de Enfermedades RespiratoriasMexico CityMexico Maria Sklodowska-Curie National Research Institute of Oncology WarsawPoland Jilin Cancer Hospital ChangchunJilinPeople's Republic of China Department of Thoracic Oncology Kansai Medical University HospitalHirakataOsakaJapan Massachusetts General Hospital Cancer Center and Harvard Medical School BostonMassachusetts Merck Sharp&Dohme Corp. a subsidiary of Merck&Co.Inc.KenilworthNew Jersey Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori MilanItaly

背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患... 详细信息

背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。

关键词：帕博利珠单抗脑转移化疗非小细胞肺癌 PD-L1

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毒素介导眼内炎的免模型中玻璃体内注射人类免疫球蛋白减低金黄色葡萄球菌培养上清液的效应

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美国医学会眼科杂志（中文版） 2005年第3期17卷 185-185页

作者： Stephen L. Perkins Dennis P. Han Janice M. Burke Patrick M. Schlievert William J. Wirostko dariusz G. Tarasewicz Christine M. B. Skumatz 李扬（译）

目的：研究在眼内炎的兔模型中，人免疫球蛋白能否减低金黄色葡萄球菌（金葡菌）培养上清液的毒性作用。方法：免疫球蛋白与金葡菌株RN4220的产物结合，应用已知毒素（β-溶血素和毒素休克综合征毒素-1）以及浓缩的含有金葡菌外毒素（... 详细信息

目的：研究在眼内炎的兔模型中，人免疫球蛋白能否减低金黄色葡萄球菌（金葡菌）培养上清液的毒性作用。方法：免疫球蛋白与金葡菌株RN4220的产物结合，应用已知毒素（β-溶血素和毒素休克综合征毒素-1）以及浓缩的含有金葡菌外毒素（集合毒素）的培养上清液对其进行Western标记分析。为诱发眼内炎，需要将集合毒素注入兔玻璃体内。为观察免疫球蛋白的治疗效果，将免疫球蛋白与集合毒素混和后同时注入玻璃体或是在注入集合毒素后6h注入免疫球蛋白。眼内炎的严重程度通过9天内的临床检查（裂隙灯或间接眼底镜）进行分级，通过组织学切片进行评估。

关键词：人免疫球蛋白金黄色葡萄球菌玻璃体内注射培养上清液外毒素眼内炎兔模型 Western 毒素休克综合征

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