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World Journal of Diabetes 2024年第2期15卷 170-185页

作者： Han Chen guo-Xin Zhang Xiao-ying Zhou Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210003Jiangsu ProvinceChina Department of Gastroenterology Jiangsu Province HospitalNanjing 210029Jiangsu ProvinceChina

BACKGROUND Helicobacter pylori(***)infection is related to various extragastric diseases including type 2 diabetes mellitus(T2DM).However,the possible mechanisms connecting *** infection and T2DM remain *** To explore potential molecular connections between *** infection and *** We extracted gene expression arrays from three online datasets(GSE60427,GSE27411 and GSE115601).Differentially expressed genes(DEGs)commonly present in patients with *** infection and T2DM were *** genes were validated using human gastric biopsy *** between hub genes and immune cell infiltration,miRNAs,and transcription factors(TFs)were further *** A total of 67 DEGs were commonly presented in patients with *** infection and *** significantly upregulated hub genes,including TLR4,ITGAM,C5AR1,FCER1G,and FCGR2A,were finally identified,all of which are closely related to immune cell *** gene-miRNA analysis detected 13 miRNAs with at least two gene ***-gene interaction networks showed that TLR4 was coregulated by 26 TFs,the largest number of TFs among the 5 hub *** We identified five hub genes that may have molecular connections between *** infection and *** study provides new insights into the pathogenesis of ***-induced onset of T2DM.

关键词： Helicobacter pylori Type 2 diabetes mellitus Bioinformatics analysis Differentially expressed genes Hub genes

A vicinal oxygen chelate protein facilitates viral infection by triggering the unfolded protein response in Nicotiana benthamiana

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Journal of Integrative Plant Biology 2024年第7期66卷 1481-1499页

作者： Zhihong guo Ning Jiang Menglin Li Hongfang guo Qi Liu Xinyu Qin Zongying Zhang Chenggui Han ying wang Ministry of Agriculture and Rural Affairs Key Laboratory of Pest Monitoring and Green Management College of Plant ProtectionChina Agricultural UniversityBeijing 100193China

Vicinal oxygen chelate(VOC)proteins are members of an enzyme superfamily with dioxygenase or non-dioxygenase ***,the biological functions of VOC proteins in plants are poorly ***,we show that a VOC in Nicotiana benthamiana(NbVOC1)facilitates viral ***1 was significantly induced by infection by beet necrotic yellow vein virus(BNYVV).Transient overexpression of NbVOC1 or its homolog from Beta vulgaris(BvVOC1)enhanced BNYVV infection in ***,which required the nuclear localization of *** with this result,overexpressing NbVOC1 facilitated BNYVV infection,whereas,knockdown and knockout of NbVOC1 inhibited BNYVV infection in transgenic *** ***1 interacts with the basic leucine zipper transcription factors bZIP17/28,which enhances their self-interaction and DNA binding to the promoters of unfolded protein response(UPR)-related *** propose that bZIP17/28 directly binds to the NbVOC1 promoter and induces its transcription,forming a positive feedback loop to induce the UPR and facilitating BNYVV ***,our results demonstrate that NbVOC1 positively regulates the UPR that enhances viral infection in plants.

关键词： beet necrotic yellow vein virus bZIP17/28 Nicotiana benthamiana unfolded protein response VOC1

A Dielectric Ink Combining Acrylate and Cyanate Moieties for Inkjet 3D Printing with Good Thermal Stability

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Chinese Journal of Polymer Science 2024年第6期42卷 766-774页

作者： Yi-Xuan Li Liang-ying Wu Yan Yang Yao-Zhong Lu Zhong-ying Ji Yu-Xiong guo Xiao-Long wang Qiao-Sheng Pu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou730000China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsLanzhou730000China Lanzhou Traditional Chinese Medicine Hospital of Orthopedics and Traumatology Lanzhou730000China Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai Zhongke Research Institute of Advanced Materials and Green Chemical EngineeringYantai264006China

Inkjet 3D printing has potential in the additive manufacturing of electronic circuits and ***,inks that can be used for printing layers with T5%>300℃ or hardness>200 MPa have been rarely *** ester(CE)polymers have excellent thermal stability,high strength,and low shrinkage compared to other common dielectric inks for inkjet 3D printing,but cannot be quickly shaped by ultraviolet(UV)irradiation or thermal *** CEs with UV-curable monomers may be a possible way to accelerate crosslinking,but there are challenges from the adverse effects of the dilution of both *** this study,dielectric inks with acrylate and cyanate moieties were *** low viscosity and surface tension of the CE precursor(Bisphenol E cyanate ester)were combined with photocurable acrylate diluent monomers and cross-linker to realize an ink suitable for inkjet 3D *** internal dual three-dimensional cross-linked network structure resin was prepared by a combination of photocuring and thermal curing with T5%up to 326.69℃,hardness up to 431.84 MPa,dielectric constant of 2.70 at 8 GHz,and shrinkage of 1.64%.The developed dielectric inks can be applied to the 3D printing of printed circuit boards and other electronic devices that require dielectric properties.

关键词： Inkjet printing Cyanate ester resin 3D doubly cross-linked network Good thermal stability

Electrochemical chemoselective thiocarbamylation of late-stage Tyr-containing drugs and peptides

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Science China Chemistry 2024年第10期67卷 3382-3388页

作者： wan-Jie Wei Xin-Yu wang Hai-Tao Tang Fei-Hu Cui Yun-Qi Wu ying-Ming Pan State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China)Collaborative Innovation Center for Guangxi Ethnic MedicineSchool of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China

The synthesis and modification of peptides occupy a unique position in the field of drug development,and the functionalization of amino acids is a valuable strategy as an alternative to peptide ***,the development of tyrosine(Tyr)as a target amino acid is a major challenge in the field of ***,we report an electrochemical radical coupling reaction of labeling tyrosine-containing active drugs and peptides with thiocarbamate derivatives for the first *** tri-component,onepot reaction can be performed smoothly under simple,gentle,and clean electrochemical conditions and is suitable for the functionalization of various Tyr-containing drug molecular derivatives and peptides.

关键词： tyrosine electrochemical radical coupling chemical modification peptides

Targeting stroma and tumor,silencing galectin 1 treats orthotopic mouse hepatocellular carcinoma

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Acta Pharmaceutica Sinica B 2024年第1期14卷 292-303页

作者： Tahereh Setayesh ying Hu Farzam Vaziri Xin Chen Jinping Lai Dongguang Wei Yu-Jui Yvonne wan Department of Medical Pathology and Laboratory Medicine University of CaliforniaDavisSacramentoCA 95817USA Cancer Biology Program the University of Hawaii Cancer CenterHonoluluHI 96813USA Department of Pathology and Laboratory Medicine Kaiser Permanente Sacramento Medical CenterSacramentoCA 95825USA

This study examines inhibiting galectin 1(Gal1)as a treatment option for hepatocellular carcinoma(HCC).Gal1 has immunosuppressive and cancer-promoting *** data showed that Gal1 was highly expressed in human and mouse *** levels of Gal1 positively correlated with the stages of human HCC and negatively with *** roles of Gal1 in HCC were studied using overexpression(OE)or silencing using Igals1 siRNA delivered by *** to HCC initiation induced by RAS and AKT mutations,lgals1-OE and silencing had opposite impacts on tumor *** treatment effect of lgals1 siRNAwas further demonstrated by intersecting HCC at different time points when the tumor load had already reached 9%or even 42%of the body *** spatial transcriptomic profiles of Gal1 silenced and OE HCC,inhibiting matrix formation and recognition of foreign antigen in CD45t cell-enriched areas located at tumor-margin likely contributed to the anti-HCC effects of Gal1 *** the tumors,silencing Gal1 inhibited translational initiation,elongation,and ***,Gal1 silencing increased immune cells as well as expanded cytotoxic T cells within the tumor,and the anti-HCC effect of lgals1 siRNAwas ***,Gal1 silencing has a promising potential for HCC treatment.

关键词： Liver Hepatocellular carcinoma Carbohydrate-binding lectin Galectin 1 Extracellular matrix Translation Spatial transcriptomics Tumor-margin

Impaired pericyte-Müller glia interaction via PDGFRβsuppression aggravates photoreceptor loss in a rodent model of light-induced retinal injury

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1800-1808页

作者： Wei Xu Li-Jin Cui Xiao-ying Yang Xiao-Yuan Cui Jian guo guo-Xing Xu Department of Ophthalmology the First Affiliated Hospital of Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Ophthalmology National Regional Medical CenterBinhai Campus of the First Affiliated Hospital of Fujian Medical UniversityFuzhou 350212Fujian ProvinceChina Fujian Institute of Ophthalmology Fuzhou 350001Fujian ProvinceChina

AIM:To investigate the involvement of pericyte-Müller glia interaction in retinal damage repair and assess the influence of suppressing the platelet-derived growth factor receptorβ(PDGFRβ)signaling pathway in retinal pericytes on photoreceptor loss and Müller glial ***:Sprague-Dawley rats were exposed to intense light to induce retinal *** antibody against PDGFRβwere deployed to block the signaling pathway in retinal pericytes through intravitreal *** histology and Müller glial reaction were assessed following light *** vitro,normal and PDGFRβ-blocked retinal pericytes were cocultured with Müller cell line(rMC-1)to examine morphological and protein expression changes upon supplementation with light-injured supernatants of homogenized retinas(SHRs).RESULTS:PDGFRβblockage 24h prior to intense light exposure resulted in a significant exacerbation of photoreceptor *** upregulation of GFAP and p-STAT3,observed after intense light exposure,was significantly inhibited in the PDGFRβblockage *** ther upregulation of cytokines monocyte chemoattractant protein 1(MCP-1)and interleukin-1β(IL-1β)was also observed following PDGFRβ*** the in vitro coculture system,the addition of light-injured SHRs induced pericyte deformation and upregulation of proliferating cell nuclear antigen(PCNA)expression,while Müller cells exhibited neuron-like morphology and expressed ***,PDGFRβblockage in retinal pericytes abolished these cellular responses to light-induced damage,consistent with the in vivo PDGFRβblockage ***:Pericyte-Müller glia interaction plays a potential role in the endogenous repair process of retinal *** of this interaction exacerbates photoreceptor degeneration in light-induced retinal injury.

关键词： pericyte Müller glia light-induced retinal injury platelet-derived growth factor receptorβ signal pathway

Effect of Shrinkage Reducing Agent and Steel Fiber on the Fluidity and Cracking Performance of Ultra-High Performance Concrete

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Fluid Dynamics & Materials Processing 2024年第9期20卷 1941-1956页

作者： Yong wan Li Li Jiaxin Zou Hucheng Xiao Mengdi Zhu ying Su Jin Yang Wuhan Metro Bridge and Tunnel Management Co. Ltd.Wuhan430068China School of Civil Engineering Architecture and EnvironmentHubei University of TechnologyWuhan430068China

Due to the low water-cement ratio of ultra-high-performance concrete(UHPC),fluidity and shrinkage cracking are key aspects determining the performance and durability of this type of *** this study,the effects of different types of cementitious materials,chemical shrinkage-reducing agents(SRA)and steel fiber(SF)were *** with M2-UHPC and M3-UHPC,M1-UHPC was found to have better fluidity and shrinkage cracking ***,different SRA incorporation methods,dosage and different SF types and aspect ratios were *** incorporation of SRA and SF led to a decrease in the fluidity of *** internal content of 1%(NSRA-1%),SRA external content of 1%(WSRA-1%),STS-0.22 and STE-0.7 decreased the fluidity of UHPC by 3.3%,8.3%,9.2%and 25%,***,SRA and SF improved the UHPC shrinkage cracking ***-1%and STE-0.7 reduced the shrinkage value of UHPC by 40%and 60%,respectively,and increased the crack resistance by 338%and 175%,*** addition,the addition of SF was observed to make the microstructure of UHPC more compact,and the compressive strength and flexural strength of 28 d were increased by 26.9%and 19.9%,respectively.

关键词： Ultra-high performance concrete chemical shrinkage reducing agent steel fiber shrinkage cracking repair and reinforcement

Investigation of Power Density Amplification in Stacked Triboelectric Nanogenerators

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Energy & Environmental Materials 2024年第5期7卷 372-379页

作者： Fan Shen Qin Zhang Hengyu guo Chen Cao ying Gong Junlei wang Yan Peng Zhongjie Li School of Mechatronic Engineering and Automation Shanghai University Department of Applied Physics Chongqing University Institute of Artificial Intelligence School of Future Technology Shanghai University School of Mechanical and Power Engineering Zhengzhou University Shanghai Artificial Intelligence Laboratory

In engineering practice, the output performance of contact separation TENGs(CS-TENGs) increases with the increase of tribo-pair area, which includes increasing the size of single layer CS-TENGs (SCS-TENGs) or the number of units (zigzag TENGs). However, such two strategies show significant differences in output power and power density. In this study, to seek a universal CS-TENG design solution, the output performance of a SCS-TENG and a zigzag TENG (Z-TENG) is systematically compared, including voltage,current, transferred charge, instantaneous power density, and charging power density. The relationship between contact area and output voltages is explored, and the output voltage equation is fitted. The experimental results reveal that SCS-TENGs yield better performance than Z-TENGs in terms of voltage, power, and power density under the same total contact area.

关键词： contact separation power density triboelectric nanogenerators zigzag

In situ modification of heavy oil catalyzed by nanosized metal-organic framework at mild temperature and its mechanism

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Chinese Journal of Chemical Engineering 2024年第3期67卷 166-173页

作者： Li wang Ji-Xiang guo Rui-ying Xiong Chen-Hao Gao Xiao-Jun Zhang Dan Luo The Unconventional Oil and Gas Institute China University of Petroleum-BeijingBeijing 102200China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China

Two catalysts, nano-sized cobalt-metal-organic framework(Co-MOF) and nickel(Ni)-MOF, were successfully prepared by the modification method. Tetralin(C10H12) was used as the hydrogen donor for the catalytic cracking and hydrogenation modification study of the dehydrated crude oil from the Shengli Oilfield. The optimal reaction conditions were determined through orthogonal experiments, and the components of the crude oil and modified oil samples were analyzed. The results revealed that the nanoMOF catalysts were successfully prepared and exhibited high catalytic activity. They could catalyze the cracking of large molecules in heavy oil at mild temperatures(<300°C), leading to the decomposition of the hydrogen donor. When the mass fraction of the catalyst was 0.2%, the mass fraction of the hydrogen donor was 1%, and the reaction temperature was 280°C, the Ni-MOF showed the best catalytic viscosity reduction effect. It could reduce the viscosity of heavy oil at 50°C from 15761.9 m Pa.s to 1266.2 m Pa.s,with a viscosity reduction rate of 91.97%. The modification effect of Co-MOF was the next best, which could reduce the viscosity of heavy oil to 2500.1 m Pa.s with a viscosity reduction rate of 84.14%. Molecular dynamics simulations revealed a strong interaction force between the MOF surface and asphaltene molecules. In the process of heavy-oil catalytic hydrogenation, the nano-MOF catalyst exhibited high catalytic activity. On the one hand, the empty d orbitals outside the metal atoms in the catalyst could polarize the carbon atoms in the organic matter, accelerating the breaking of long chains. On the other hand, the metal atoms in the catalyst could bond with the carbon σ bonds, breaking the carbon-carbon bonds. This disrupted the structure of the recombined components in the crude oil, irreversibly reducing the viscosity of the heavy oil and improving its fluidity.

关键词： Nano-sized MOF Petroleum Viscosity reduction Catalyst Nanomaterials

Context-Aware Augmented Reality Using Human-Computer Interaction Models

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Journal of Control and Decision 2024年第1期11卷 1-14页

作者： ying Sun Qiongqiong guo Shumei Zhao Karthik Chandran G.Fathima Henan intelligent education and intelligent technology application engineering technology research center Zhengzhou Railway Vocational and technical collegeZhengzhouHenanPeople’s Republic of China Henan Provincial Research Center of Wisdom Education and Intelligent Technology Application Engineering Technology Zhengzhou Railway Vocational and technical collegeZhengzhouHenanPeople’s Republic of China Department of Mechatronics Engineering Jyothi Engineering CollegeKeralaIndia CSE Adhiyamaan College of Engineering HosurTamilnaduIndia

Augmented Reality is a technique that allows users to overlap digital information with their physical *** Augmented Reality(AR)displays have an exceptional characteristic from the Human–Computer Interaction(HCI)*** to its increasing popularity and application in diverse domains,increasing user-friendliness and AR usage are ***-aware is one approach since an AR application can adapt to the user,environment,needs and enhance ergonomic principles and *** paper proposes the Intelligent Contextaware Augmented Reality Model(ICAARM)for Human–Computer Interaction *** study explores and reduces interaction uncertainty by semantically modeling user-specific interaction with context,allowing personalised *** information is captured from an AR device to understand user interactions and *** depictions carry semantics to Augmented Reality applications about the user’s intention to interact with a specific device ***,this study describes personalised gesture interaction in VR/AR applications for immersive/intelligent environments.

关键词： Augmented Reality Context-aware Human–Computer Interaction