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Construction and evaluation of a liver cancer risk prediction model based on machine learning

World Journal of Gastrointestinal Oncology 2024年第9期16卷 3839-3850页

作者： Ying-Ying wang wan-xia yang Qia-Jun Du Zhen-Hua Liu Ming-Hua Lu Chong-Ge You Laboratory Medicine Center The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina

BACKGROUND Liver cancer is one of the most prevalent malignant tumors worldwide,and its early detection and treatment are crucial for enhancing patient survival rates and quality of ***,the early symptoms of liver cancer are often not obvious,resulting in a late-stage diagnosis in many patients,which significantly reduces the effectiveness of *** a highly targeted,widely applicable,and practical risk prediction model for liver cancer is crucial for enhancing the early diagnosis and long-term survival rates among affected *** To develop a liver cancer risk prediction model by employing machine learning techniques,and subsequently assess its *** In this study,a total of 550 patients were enrolled,with 190 hepatocellular carcinoma(HCC)and 195 cirrhosis patients serving as the training cohort,and 83 HCC and 82 cirrhosis patients forming the validation *** regression(LR),support vector machine(SVM),random forest(RF),and least absolute shrinkage and selection operator(LASSO)regression models were developed in the training *** performance was assessed in the validation ***,this study conducted a comparative evaluation of the diagnostic efficacy between the ASAP model and the model developed in this study using receiver operating characteristic curve,calibration curve,and decision curve analysis(DCA)to determine the optimal predictive model for assessing liver cancer *** Six variables including age,white blood cell,red blood cell,platelet counts,alpha-fetoprotein and protein induced by vitamin K absence or antagonist II levels were used to develop LR,SVM,RF,and LASSO regression *** RF model exhibited superior discrimination,and the area under curve of the training and validation sets was 0.969 and 0.858,*** values significantly surpassed those of the LR(0.850 and 0.827),SVM(0.860 and 0.803),LASSO regression(0.845 and 0.831),and ASAP(0.866 and 0.813)model

关键词： Hepatocellular carcinoma Cirrhosis Prediction model Machine learning Random forest

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Short text classification based on strong feature thesaurus

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第9期13卷 649-659页

作者： Bing-kun wanG Yong-feng HUANG wan-xia yang Xing LI Information Cognitive and Intelligent System Research Institute Department of Electronic and EngineeringTsinghua UniversityBeijing 100084China Information Technology National Laboratory Tsinghua UniversityBeijing 100084China

Data sparseness, the evident characteristic of short text, has always been regarded as the main cause of the low ac- curacy in the classification of short texts using statistical methods. Intensive research has been conducted in this area during the past decade. However, most researchers failed to notice that ignoring the semantic importance of certain feature terms might also contribute to low classification accuracy. In this paper we present a new method to tackle the problem by building a strong feature thesaurus （SFT） based on latent Dirichlet allocation （LDA） and information gain （IG） models. By giving larger weights to feature terms in SFT, the classification accuracy can be improved. Specifically, our method appeared to be more effective with more detailed classification. Experiments in two short text datasets demonstrate that our approach achieved improvement compared with the state-of-the-art methods including support vector machine （SVM） and Naive Bayes Multinomial.

关键词： Short text Classification Data sparseness Semantic Strong feature thesaurus (SFT) Latent Dirichlet allocation(LDA)

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Numerical simulation of the 3D flow field in a ring die pellet mill considering viscous heating

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International Journal of Modeling, Simulation, and Scientific Computing 2020年第3期11卷 135-153页

作者： Yong-Mei wang xiao-Peng Huang Jin-Feng Wu wan-xia yang College of Mechanical and Electrical Engineering Gansu Agricultural University Lanzhou 730070P.R.China

Viscous heating has a substantial influence on the extrusion forming process and product quality of powder *** study selected the MUZL420 ring die pellet mill as the research object,from which a 3D flow physical model was *** numerical simulation of 3D nonisothermal flow in the extrusion pelletizing process of granulated alfalfa was performed with *** distribution laws of pressure,velocity,shear rate,viscosity,viscous heating and temperature in the flow field were revealed to thoroughly investigate the pelletizing process and provide a reference for structural optimization and process *** results showed that two extrusion zones in the pelleting chamber were symmetrical with respect to the center,and the significant pressure gradient along the rotating direction of the ring die and the roller caused the material to flow back in the opposite *** were larger velocity gradients,shear rates and viscous heating levels in the deformation and compaction zone,the negative pressure zone behind the extrusion zone and the die *** distribution of viscosity was opposite to that of the shear *** temperature increase area caused by viscous heating gradually expanded from the material inlet to the bottom of the extrusion chamber along the Z-axis direction,and the temperature increased *** extrusion force and the forming temperature in the extrusion forming zone were captured in the numerical *** extrusion forming density was calculated with the regression prediction model established through the simulation experiment of pelletizing with a ring *** a comparison with the results of mean alfalfa pellet density from the ring die pellet mill experiment,the relative error was less than 5%,which indicated that the numerical simulation method was reliable.

关键词： Ring die pellet mill viscous heating 3D flow field numerical simulation

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Hyphae-mediated bioassembly of carbon fibers derivatives for advanced battery energy storage

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Carbon Energy 2024年第6期6卷 140-150页

作者： Lei Huang Zhong Qiu Ping Liu Xinhui xia Feng Cao Xinping He Chen wang wangjun wan Yongqi Zhang yang xia Wenkui Zhang Minghua Chen Jiancang Zhou Department of Critical Care Medicine Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouChina State Key Laboratory of Silicon Materials Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang ProvinceSchool of Materials Science&EngineeringZhejiang UniversityHangzhouChina College of Materials Science&Engineering Zhejiang University of TechnologyHangzhouChina State Key Laboratory of Photocatalysis on Energy and Environment Fuzhou UniversityFuzhouChina Department of Engineering Technology Huzhou CollegeHuzhouChina Zhejiang Academy of Science and Technology for Inspection&Quarantine HangzhouZhejiangChina Institute of Fundamental and Frontier Science University of Electronic Science and Technology of ChinaChengduChina Key Laboratory of Engineering Dielectric and Applications(Ministry of Education) School of Electrical and Electronic EngineeringHarbin University of Science and TechnologyHarbinChina

Ingenious design and fabrication of advanced carbon-based sulfur cathodes are extremely important to the development of high-energy lithium-sulfur batteries,which hold promise as the next-generation power ***,for the first time,we report a novel versatile hyphae-mediated biological assembly technology to achieve scale production of hyphae carbon fibers(HCFs)derivatives,in which different components including carbon,metal compounds,and semiconductors can be homogeneously assembled with HCFs to form composite *** mechanism of biological adsorption assembly is also *** a representative,reduced graphene oxides(rGOs)decorated with hollow carbon spheres(HCSs)successfully co-assemble with HCFs to form HCSs@rGOs/HCFs hosts for sulfur *** this unique architecture,not only large accommodation space for sulfur but also restrained volume expansion and fast charge transport paths are ***,multiscale physical barriers plus chemisorption sites are simultaneously established to anchor soluble lithium ***,the designed HCSs@rGOs/HCFs-S cathodes deliver a high capacity(1189 mA h g^(-1)at 0.1 C)and good high-rate capability(686 mA h g^(-1)at 5 C).Our work provides a new approach for the preparation of high-performance carbon-based electrodes for energy storage devices.

关键词： bioassembly carbon fibers energy storage graphene lithium-sulfur batteries

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Near-infrared organic lasers with ultra-broad emission bands by simultaneously harnessing four-level and six-level systems

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Chinese Chemical Letters 2024年第8期35卷 288-293页

作者： Lei wang Jun-Jie Wu Chang-Cun Yan wan-Ying yang Zong-Lu Che Xin-Yu xia Xue-Dong wang Liang-Sheng Liao Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices Institute of Functional Nano&Soft Materials(FUNSOM)Soochow UniversitySuzhou 215123China Jiangsu Engineering Laboratory of Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Macao Institute of Materials Science and Engineering Macao University of Science and TechnologyMacao SAR 999078China

Organic lasers with broad emission bands in near-infrared(NIR)region are crucial for their applications in laser communication,night-vision as well as bioimaging owing to the abundance of selectable lasing ***,for most organic gain materials,gain regions are limited in a small wavelength range because of the fixed energy level ***,we design a strategy to realize NIR organic lasers with broad emission bands based on tunable energy level systems induced by cascaded excited-state intramolecular proton transfer(ESIPT).A novel gain material named DHNN was developed,which can undergo a cascaded double-ESIPT process supporting four-level and six-level systems *** doping DHNN into polystyrene microspheres,NIR lasers with tunable emission bands can be achieved based on the careful modulation of ***,organic lasers with an ultra-broad emission band ranging from 700 nm to 900 nm was successfully achieved by harnessing four-level and six-level systems simultaneously.

关键词： Excited-state intramolecular proton transfer Organic solid-state laser Wide gain interval Near-infrared emission Molecular design

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Copper Metabolism and Cuproptosis:Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases

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Current Medical Science 2024年第1期44卷 28-50页

作者： xiao-xia BAN Hao wan Xin-xing wan Ya-ting TAN Xi-min HU Hong-xia BAN Xin-yu CHEN Kun HUANG Qi ZHANG Kun XIONG Department of Human Anatomy and Neurobiology School of Basic Medical ScienceCentral South UniversityChangsha 430013China Department of Endocrinology Third Xiangya HospitalCentral South UniversityChangsha 430013China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 430013China Affiliated Hospital Inner Mongolia Medical UniversityHohhot 010050China Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikou 571199China Hunan Key Laboratory of Ophthalmology Changsha 430013China

Copper is an essential trace element,and plays a vital role in numerous physiological processes within the human *** normal metabolism,the human body maintains copper *** deficiency or excess can adversely affect cellular ***,copper homeostasis is stringently *** studies suggest that copper can trigger a specific form of cell death,namely,cuproptosis,which is triggered by excessive levels of intracellular *** induces the aggregation of mitochondrial lipoylated proteins,and the loss of iron-sulfur cluster *** neurodegenerative diseases,the pathogenesis and progression of neurological disorders are linked to copper *** review summarizes the advances in copper homeostasis and cuproptosis in the nervous system and neurodegenerative *** offers research perspectives that provide new insights into the targeted treatment of neurodegenerative diseases based on cuproptosis.

关键词： cuproptosis copper metabolism copper homeostasis neurodegeneration neurodegenerativedisease

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Micelle-directed self-assembly of single-crystal-like mesoporous stoichiometric oxides for high-performance lithium storage

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National Science Review 2024年第4期11卷 195-205页

作者： Yanhua wan Changyao wang Xingmiao Zhang yang Yin Mengmeng Liu Bing Ma Linlin Duan Yuzhu Ma Wei Zhang Changlin Zheng Dongliang Chao Fei wang Yongyao xia Wei Li Department of Chemistry Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials State Key Laboratory of Molecular Engineering of Polymers College of Chemistry and Materials ScienceFudan University State Key Laboratory of Surface Physics and Department of Physics Fudan University

Due to their uncontrollable assembly and crystallization process,the synthesis of mesoporous metal oxide single crystals remains a formidable ***,we report the synthesis of single-crystal-like mesoporous Li2TiSiO5by using soft micelles as *** key lies in the atomic-scale self-assembly and step-crystallization processes,which ensure the formation of single-crystal-like mesoporous Li2TiSiO5microparticles via an oriented attachment growth mechanism under the confinement of an in-situ formed carbon *** mesoporous Li2TiSiO5anode achieves a superior rate capability(148 mAh g-1at5.0 A g-1) and outstanding long-term cycling stability(138 mAh g-1after 3000 cycles at 2.0 A g-1) for lithium storage as a result of the ultrafast Li+diffusion caused by penetrating mesochannels and nanosized crystal frameworks（5-10 nm）.In comparison,bulk Li2TiSiO5exhibits poor rate capability and cycle performance due to micron-scale diffusion *** method is very simple and reproducible,heralding a new way of designing and synthesizing mesoporous single crystals with controllable frameworks and chemical functionalities.

关键词： mesoporous materials micelles single-crystal-like Li2TiSiO5 lithium-ion batteries

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Enhanced charge collection of AgNWs-based top electrode to realize high-performance,all-solution processed organic solar cells

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Science China Chemistry 2024年第10期67卷 3347-3356页

作者： Juanyong wan yang Chen Weijie Chen Jinfeng xia Guang Zeng Jianlei Cao Chuang Jin Yunxiu Shen xiaoxiao Wu Haiyang Chen Junyuan Ding Xue-mei Ou Yaowen Li Yongfang Li Laboratory of Advanced Optoelectronic Materials Suzhou Key Laboratory of Novel Semiconductor-Optoelectronics Materials and DevicesCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow UniversitySuzhou 215123China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China Jiangsu Sidike New Materials Science and Technology Co. Ltd.Suqian 215400China

All-solution processed organic solar cells are the ultimate aim of printable photovoltaics,but their electrical losses arising from poor contact of top electrodes greatly limit efficiency *** solve the problem,a solution-processed hybrid top electrode was constructed using silver nanowires(AgNWs)as the skeleton and ZnO nanoparticles(ZnO-NPs)as the *** constructing the skeleton,a spin-rinsing treatment was first used to reduce the amount of the residual insulating polyvinylpyrrolidone wrapped around the AgNWs to promote intimate contact among the AgNWs in the ***,the ZnO-NPs matrix was deposited onto the AgNWs skeleton,bridging the AgNWs skeleton with the underlayer ZnO-NPs electron transporting layer(ETL).The underlayer ZnO-NPs ETL can also induce the growth of the ZnO-NPs matrix to minimize lattice mismatch,which creates additional transport channels from the ETL to the AgNWs skeleton for charge *** a result,the obtained electrode significantly enhances the electrical contact in the device,thus delivering record power conversion efficiencies of 16.04%and 14.54%for rigid and flexible all-solution processed OSCs,respectively.

关键词： solution-processed top electrode organic solar cells AgNWs electrical contact

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Heat exposure and hospitalizations for chronic kidney disease in China: a nationwide time series study in 261 major Chinese cities

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Military Medical Research 2024年第4期11卷 469-478页

作者： Fu-Lin wang wan-Zhou wang Fei-Fei Zhang Su-Yuan Peng Huai-Yu wang Rui Chen Jin-Wei wang Peng-Fei Li yang wang Ming-Hui Zhao Chao yang Lu-xia Zhang Institute of Medical Technology Peking University Health Science CenterBeijing 100191China National Institute of Health Data Science at Peking University Beijing 100191China Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100191China Renal Division Department of MedicinePeking University First HospitalPeking University Institute of NephrologyBeijing 100034China Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases Chinese Academy of Medical SciencesBeijing 100034China Advanced Institute of Information Technology Peking UniversityHangzhou 311215China National Climate Center China Meteorological AdministrationBeijing 100081China Peking-Tsinghua Center for Life Sciences Beijing 100034China

Background:Climate change profoundly shapes the population health at the global ***,there was still insufficient and inconsistent evidence for the association between heat exposure and chronic kidney disease(CKD).Methods:In the present study,we studied the association of heat exposure with hospitalizations for cause-specific CKD using a national inpatient database in China during the study period of hot season from 2015 to *** time-series regression models and random-effects Meta-analysis were developed to estimate the city-specific and national averaged associations at a 7 lag-day span,***:A total of 768,129 hospitalizations for CKD was recorded during the study *** results showed that higher temperature was associated with elevated risk of hospitalizations for CKD,especially in sub-tropical *** a 1℃ increase in daily mean temperature,the cumulative relative risks(RR)over lag 0-7 d were 1.008[95% confidence interval(CI)1.003-1.012]for *** attributable fraction of CKD hospitalizations due to high temperatures was 5.50%.Stronger associations were observed among younger patients and those with obstructive *** study also found that exposure to heatwaves was associated with added risk of hospitalizations for CKD compared to non-heatwave days(RR=1.116,95%CI 1.069-1.166)above the effect of daily mean ***:Short-term heat exposure may increase the risk of hospitalization for *** findings provide insights into the health effects of climate change and suggest the necessity of guided protection strategies against the adverse effects of high temperatures.

关键词： Chronic kidney disease Hospitalization Climate change Temperature Time-series study

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Idiopathic mesenteric phlebosclerosis missed by a radiologist at initial diagnosis: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1810-1816页

作者： Min wang Yu-xia wan Jin-Wen Liao Fei Xiong Department of Gastroenterology Changning County People’s HospitalYibin 644300Sichuan ProvinceChina Department of Gastroenterology Qianwei People’s HospitalLeshan 614400Sichuan ProvinceChina Department of Gastroenterology The People’s Hospital of Jianyang CityChengdu 641400Sichuan ProvinceChina Department of Gastroenterology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610000Sichuan ProvinceChina

BACKGROUND Idiopathic mesenteric phlebosclerosis(IMP)is a rare type of ischemic colitis characterized by thickening of the wall of the right hemicolon and calcification,sclerosis,and fibrosis of mesenteric *** diagnosis of IMP is based on typical clinical features and imaging *** report a case of IMP that was initially missed by the *** SUMMARY A 77-year-old woman was admitted to the hospital due to chronic diarrhea for over 2 *** had been consuming Chinese patent medicines(CPM)containing fructus gardeniae for more than 15 *** revealed an edematous mucosa,bluish-purple discoloration,erosions,and ulcerations throughout the colorectal *** computed tomography(CT)showed diffuse mural thickening of the entire colorectum,with tortuous thread-like calcifications in the right hemicolon,left hemicolon,and *** of the calcifications were located in the mesenteric *** diagnosis of IMP was established based on medical history,colonoscopy,CT findings,and histopathological *** patient was treated conservatively with papaverine and rifaximin,and CPM was *** diarrhea symptoms improved,indicating the effectiveness of the *** the next several years,she took opium alkaloids for an extended period and did not require hospitalization for the aforementioned gastrointestinal *** IMP is a rare gastrointestinal disease affecting Asian populations,possibly related to long-term herbal medicine *** imaging analysis is crucial for diagnosis,but insufficient understanding of the disease can lead to misdiagnosis or missed *** strategies should be personalized.

关键词： Idiopathic mesenteric phlebosclerosis Computed tomography Colonoscopy Chinese patent medicines Fructus gardeniae Case report

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