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Morbidity and Mortality of Nosocomial Infection after Cardiovascular Surgery： A Report of 1606 Cases

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Current Medical Science 2018年第2期38卷 329-335页

作者： wan-li jiang Xiao-ping HU Zhi-peng HU Zheng TANG Hong-bing WU liang-hao CHEN Zhi-wei wanG Ying-an jiang Department of Cardiovascular Surgery Renmin Hospital of Wuhan UniversityWuhan 430060 China Department of Infectious Diseases Renmin Hospital of Wuhan UniversityWuhan 430060 China

Nosocomial infection （NI） is one of the most significant complications arising after open heart surgery, and leads to increased mortality, hospitalization time and health resource allocation. This study investigated the morbidity, mortality, and independent risk factors associated with NI following open heart surgery. We retrospectively surveyed the records of 1606 consecutive cardiovascular surgical patients to identify those that developed NI. The NI selection criteria were based on the Centers for Disease Control and Prevention （CDC） guidelines. The term NI encompasses surgical site infection （SSI）, central venous catheter-related infection （CVCRI）, urinary tract infection （UTI）, respiratory tract infection and pneumonia （RTIP）, as well as other types of infections. Of 1606 cardiovascular surgery patients, 125 developed NI （7.8%, 125/1606）. The rates of NI following surgery for congenital malformation, valve replacement, and coronary artery bypass graft were 2.6% （15/587）, 5.5% （26/473） and 13.6% （32/236）, respectively. The NI rate following surgical repair of aortic aneurysm or dissection was 16.8% （52/310）. Increased risk of NI was detected for patients with a prior preoperative stay 〉3 days （OR=2.11, 95% CI=1.39-3.20）, diabetes （OR=2.00, 95%=CI 1.26-3.20）, length of surgery 〉6 h （OR=2.26, 95% CI=1.47-3.47）, or postoperative cerebrovascular accident （OR=4.08, 95% CI=1.79-9.29）. Greater attention should be paid toward compliance with ventilator and catheter regulations in order to decrease NI morbidity and mortality following cardiovascular procedures.

关键词： nosocomial infection cardiovascular surgery morbidity mortality

Colon Interposition for Corrosive Esophageal Stricture: Single Institution Experience with 119 Cases

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Current Medical Science 2019年第3期39卷 415-418页

作者： Wen-hui ZENG wan-li jiang Gan-jun KANG Xing-hua ZHANG Guo-hua FAN Qing GENG Song-ping XIE Jie HUANG Department of Thoracic Surgery Renmin Hospital of Wuhan University Wuhan 430060 China

The colon is an alternative graft organ for esophageal *** present study reviewed our experience with the colon interposition for esophageal replacement following corrosive ingestion,to evaluate the outcomes of colon interposition based on our surgical experience. The clinical data of 119 patients who underwent colon interposition for esophageal replacement from January 2005 to March 2017 were retrospectively analyzed. The routes of the colon interposition were retrosternal in 119 (100%). The median operative time was 390 min (range: 290-610 min) and the median blood loss was 615 mL (range:270-2500 mL). Of these 119 patients, the cervical anastomosis was performed at the hypopharynx (n=20,16.8%), the larynx (n=3,2.5%), and the cervical esophagus (n=96, 80.7%). Five patients experienced cervical anastomotic leakage (4 cases for esophagus-colon, and one for hypopharynx-colon).One patient experienced wound infection of the abdominal wall. Three patients had injury of recurrent laryngeal nerve and hoarseness. Three patients had stress ulcer with bleeding and treated with octreotide. Two patients suffered from incomplete intestinal obstruction. The postoperative follow-up was made for 12 months in all patients and all of them were alive. In conclusion, The colon is well-suited for esophageal reconstruction. The selection of the colon graft should be flexible and be based on the inspection of blood supply and the length needed. We must therefore make every effort to reduce the number of postoperative complications, and improve the quality of life for patients.

关键词： corrosive esophageal stricture colon interposition outcomes

Antisense EGFR sequence enhances apoptosis in a human hepatoma cell line BEL-7404

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Cell Research 1996年第2期6卷 145-153页

作者： FU TAO HE liU FAN liU JUN GU wan li jiang YONG HUA XU (Laboratory of Cellular and Molecular Oncology, Shanghai Institute of Cell Biology, Chinese Academy of Sciences,Shanghai 200031)(Shanghai Bureau of Hygiene)(Laboratory of Molecular Biology, Nav Laboratory of Molecular Biology Naval Medical Research Institute Shanghai 200433 China

Effects of antisense epidermal growth factor receptor (EGFR) sequence on apoptotic cell death were examined in a human hepatoma cell line BEL-7404 cells. In the cells of JX-1, a sub clone of BEL-7404 stably transfected with antisense EGFR vector (Cell Research, 3:75, 1993), an enhanced rate (9.5%) of spontaneous apoptosis was detected by flow cytometry, whereas the rates of spontaneous apoptosis in JX-0 cells, a sub-clone of BEL-7404 transfected by control vector, and the parellt BEL-7404 cells were almost equal and about 1.7%. Serum-starvation for 72 h increased the rate of apoptosis of JX-1cells up to 33.7%, while JX-0 and BEL-7404 cells, under the same condition, produced less than 5% of apoptotic cells. Observation with electron microscope demonstrated that condensation and fragmentation of chromatin and formation of apoptotic bodies of ten occurred in JX-1 cells, especially during serumstarvation. These results, combined with the data of DNA fragmentation Elisa test, suggested that antisense EGFR sequence enhances apoptosis in the human hepatoma *** of intracellular Ca2+ level and the responsiveness of JX-1 cells to the induced action of EGF and tharpsigargin (TG) treatment with that of control JX-0cells indicated that antisense EGFR might interrupt the EGF/EGFR signaling pathway resulting in the decreass of intracellular Ca2+ pool content as well as the responsiveness of these cells to the extracellular signals. These findings suggest that antisense EGFR either directly or indirectly reglllates Ca2+ storage in endoplasmic reticulum,thereby enhances apoptosis in the hnman hepatoma cells.

关键词： Antisense EGFR hepatoma cells apoptosis

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He li li Sai wang Shao-jiang wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

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高分辨率遥感影像的自优化迭代分类方法

国防科技大学学报 2017年第4期39卷 77-86页

作者：史蕾万幼川李刚姜莹武汉大学遥感信息工程学院湖北武汉430079

针对高分辨率遥感影像提出了一种面向像斑的自优化迭代分类算法,基于半监督聚类算法获取训练样本,以支持向量机为核心设计了自优化迭代分类器。使用分型网络演化算法获取像斑,并从中选取少量标记样本;结合标记样本,利用半监督模糊C均值... 详细信息

针对高分辨率遥感影像提出了一种面向像斑的自优化迭代分类算法,基于半监督聚类算法获取训练样本,以支持向量机为核心设计了自优化迭代分类器。使用分型网络演化算法获取像斑,并从中选取少量标记样本;结合标记样本,利用半监督模糊C均值算法对像斑进行聚类,并基于密集度筛选得到训练样本;设计了自优化迭代支持向量机分类算法,对所有像斑进行迭代分类直到满足分类要求,并在分类过程中对近邻分类结果进行统计得到高可信度样本以自主优化训练样本集。基于以上方法分别对武汉市Quick Bird和World View影像进行分类实验,分类总精度分别达到94.67%与92%,与基于人工选取训练样本情况下进行分类的分类总精度(82%与82.67%)、常规支持向量机分类总精度(87.33%与88%)、最小二乘支持向量机分类总精度(88%与89.33%)相比,精度有明显提升,分类效果较好。

关键词：高分辨率遥感影像像斑自优化半监督模糊C均值支持向量机

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稻农化肥减量施用行为的影响因素

华南农业大学学报（社会科学版） 2017年第3期16卷 58-66页

作者：杨万江李琪浙江大学中国农村发展研究院杭州310058

基于长江流域6省678户稻农化肥施用数据,利用双对数模型和多元线性回归模型分析发现:生产方式的转变是实现农户化肥施用减量的有效路径,其中机械整田、机械插秧和田间管理服务能够显著降低化肥过量施用量,但是统一育秧服务的减量作用不... 详细信息

基于长江流域6省678户稻农化肥施用数据,利用双对数模型和多元线性回归模型分析发现:生产方式的转变是实现农户化肥施用减量的有效路径,其中机械整田、机械插秧和田间管理服务能够显著降低化肥过量施用量,但是统一育秧服务的减量作用不显著;农户参与技术培训、接受农技员技术指导和与亲朋邻居进行技术交流等技术推广方式也能够减少农户化肥过量施用行为,但是通过媒体学习技术可能会增加化肥过量施用程度。

关键词：化肥过量施用机械化生产服务技术推广

虚拟合作的伙伴选择智能决策支持系统框架研究

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系统工程理论与实践 2001年第12期21卷 60-65页

作者：万映红李江李怀祖西安交通大学管理学院陕西西安710049

在分析虚拟合作伙伴选择决策特点基础上 ,提出基于“规则 +框架”知识的评价模型重构机制与网上多智能体协同评价系统拓扑结构 ,以实现伙伴选择过程。

关键词：虚拟合作伙伴选择智能决策支持系统协同评价

秦岭小陇山保护区维管植物丰富度和种域海拔梯度格局及其对Rapoport法则验证

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应用生态学报 2014年第9期25卷 2477-2485页

作者：郑智龚大洁孙呈祥李晓军李万江西北师范大学生命科学院兰州730070

物种丰富度和种域的海拔梯度格局及其形成机制一直是生物地理学和生物多样性研究的重点.海拔Rapoport法则认为,物种丰富度随海拔升高而逐渐降低,种域逐渐变宽.本文分析了秦岭小陇山国家级自然保护区维管植物物种丰富度及其种域宽度的海... 详细信息

物种丰富度和种域的海拔梯度格局及其形成机制一直是生物地理学和生物多样性研究的重点.海拔Rapoport法则认为,物种丰富度随海拔升高而逐渐降低,种域逐渐变宽.本文分析了秦岭小陇山国家级自然保护区维管植物物种丰富度及其种域宽度的海拔梯度格局;采用4种常用方法,验证不同类群、不同生长型和不同阶元的物种丰富度与其分布中点间的关系,并检验其是否支持海拔Rapoport法则.结果表明:除窄域种外,秦岭小陇山维管植物物种丰富度随海拔升高呈先升后降的单峰分布格局;狭域种主要分布在低海拔和高海拔段,低海拔段的丰富度高于高海拔段;物种海拔分布宽度与海拔关系因不同类群和验证方法而异,随分类阶元的增大更容易支持Rapoport法则,这可能与不同分类阶元所占据的生态位不同有关;被子植物的平均种域呈单峰分布格局,蕨类植物和裸子植物的种域海拔梯度格局无明显规律;藤本植物平均种域随海拔升高而变宽,灌木能适应不同的环境条件,因此,灌木分布对海拔梯度的变化不敏感.Pagel验证方法最容易支持Rapoport法则,Stevens方法次之,中点法受中域效应的影响物种平均种域分布呈单峰分布格局而不支持Rapoport法则,逐种法受散点图分布格局的影响线性模型拟合结果解释力很低.

关键词：维管植物物种丰富度海拔梯度 Rapoport法则小陇山

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山西省区域经济差异变化研究

科技情报开发与经济 2011年第12期21卷 121-124页

作者：万江丽山西大学环境与资源学院山西太原030006

从时间和空间两个角度对山西省区域经济差异进行了研究。从时间角度研究了1994年以来山西省各个地市人均GDP的相对差异、绝对差异、总体差异及其变化趋势;从空间角度研究了1994年和2008年山西省各个地市的经济差异,并比较了其变化。

关键词：区域经济总体差异基尼系数主成分分析山西省