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Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： ling-Xiao Yi Hui Ren Woon Genevieve Saw li Zeng Eng King Tan Zhi dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

Overview of in-situ oxygen production technologies for lunar resources

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 233-255页

作者： Youpeng Xu Sheng Pang liangwei Cong Guoyu Qian dong wang Laishi li Yusheng Wu Zhi wang College of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China CAS Key Laboratory of Green Process and Engineering National Engineering Research Center for Green Recycling of Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

The rich resources and unique environment of the Moon make it an ideal location for human expansion and the utilization of extraterrestrial ***,crucial for supporting human life on the Moon,can be extracted from lunar regolith,which is highly rich in oxygen and contains polymetallic *** oxygen and metal extraction can be achieved using existing metallurgical ***,the ample reserves of water ice on the Moon offer another means for oxygen *** paper offers a detailed overview of the leading technologies for achieving oxygen production on the Moon,drawing from an analysis of lunar resources and environmental *** delves into the principles,processes,advantages,and drawbacks of water-ice electrolysis,two-step oxygen production from lunar regolith,and one-step oxygen production from lunar *** two-step methods involve hydrogen reduction,carbothermal reduction,and hydrometallurgy,while the one-step methods encompass fluorination/chlorination,high-temperature decomposition,molten salt electrolysis,and molten regolith electrolysis(MOE).Following a thorough comparison of raw materials,equipment,technology,and economic viability,MOE is identified as the most promising approach for future in-situ oxygen production on the *** the corrosion characteristics of molten lunar regolith at high temperatures,along with the Moon's low-gravity environment,the development of inexpensive and stable inert anodes and electrolysis devices that can easily collect oxygen is critical for promoting MOE technology on the *** review significantly contributes to our understanding of in-situ oxygen production technologies on the Moon and supports upcoming lunar exploration initiatives.

关键词： lunar resources in-situ oxygen production space metallurgy molten lunar regolith electrolysis

Multi-source and multi-temporal remote sensing image classification for flood disaster monitoring

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Global Geology 2025年

作者： li Zhu JIA Zhenyang dong Jing liU Zhenghong College of Earth Sciences Jilin University Dandong No.2 High School

Flood disasters can have a serious impact on people's production and lives, and can cause huge ***-sourceremotesensingdata,thisstudyestablished decision tree classification rules through multi-source and multi-temporal feature fusion, classified ground objects before the disaster and extracted flood information in the disaster area based on optical images during the disaster, so as to achieve rapid acquisition of the disaster situation of each disaster bearing *** the case of Qianliang Lake, which suffered from flooding in 2020, the results show that decision tree classification algorithms based on multi-temporal features can effectively integrate multi-temporal and multispectral information to overcome the shortcomings of single-temporal image classification and achieve ground-truth object classification.

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精益设计在船舶企业中的实施

船舶工程 2014年第S1期36卷 214-216,238页

作者：赵任张王小峰邹东怡李万冬龚爱军江苏熔盛重工有限公司江苏南通226532

从精益企业的概念出发,结合江苏熔盛重工有限公司设计院的实际情况,阐述了在提高设计管理水平及精益设计方面的想法,介绍了怎样实施精益设计,以为船舶企业实施精益设计提供参考。

关键词：精益企业精益设计 AVEVA

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong dong Bin Zhang Baiyun liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

2,4-表油菜素内酯和赤霉素互作对羊草种子萌发及幼苗生长的影响

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草业科学 2014年第6期31卷 1097-1103页

作者：郭慧琴任卫波李平武自念万东莉内蒙古农业大学生命科学学院内蒙古呼和浩特010018 中国农业科学院草原研究所内蒙古呼和浩特010010

羊草(Leymus chinesis)是我国北方草原区优势种之一,具有重要的经济价值和生态价值。然而,种子休眠严重、发芽率低是当前困扰羊草建植与利用的关键问题。2,4-表油菜素内酯(EBR)是常用的植物调节剂,可以促进种子萌发和种苗生长。本研究... 详细信息

羊草(Leymus chinesis)是我国北方草原区优势种之一,具有重要的经济价值和生态价值。然而,种子休眠严重、发芽率低是当前困扰羊草建植与利用的关键问题。2,4-表油菜素内酯(EBR)是常用的植物调节剂,可以促进种子萌发和种苗生长。本研究以采集的野生羊草种子为材料,采用2,4-表油菜素内酯和赤霉素(GA3)溶液浸泡法,开展激素处理效应研究。结果表明,2,4-表油菜素内酯对羊草种子萌发及种苗根伸长有显著促进作用(P<0.05)。与对照相比,2,4-表油菜素内酯处理后羊草种子发芽率提高2~4倍,种苗根长增加35%~40%,而且不同浓度间存在显著差异(P<0.05)。与此同时,还发现2,4-表油菜素内酯和赤霉素(GA3)之间存在显著正互作效应(P<0.05)。与单一的赤霉素和油菜素内酯处理相比,2,4-表油菜素内酯0.10μg·g-1+GA3200μg·g-1组合处理后羊草种子发芽率可提高30%,种苗长度增加49.14%,根长增加51.34%。以上结果说明,2,4-表油菜素内酯对羊草种子萌发及其种苗生长有显著促进作用(P<0.05),而且2,4-表油菜素内酯与赤霉素存在互作效应,适宜配合使用后效果更好,综合考虑萌发率、种苗等因素,以2,4-表油菜素内酯0.10μg·g-1+GA3200μg·g-1和2,4-表油菜素内酯0.01μg·g-1+GA3200μg·g-1效果最好。

关键词：羊草 2,4-表油菜素内酯赤霉素种子萌发

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论医院的腐败与医院管理

医学与哲学 2019年第18期40卷 41-44页

作者：李江李万冬丁维光锦州医科大学人文管理学院辽宁锦州121001 中国医科大学口腔医学院辽宁沈阳110001 锦州医科大学辽宁锦州121001

公共选择理论和委托-代理理论可以作为解析我国公立医院非伦理现象的理论基础,在此框架下从医院内部管理架构上系统分析医院管理不力导致或加剧医疗腐败的两个方面具体表现和行为成因,即对内部管理不够重视,管理体系不健全,现行宏观管... 详细信息

公共选择理论和委托-代理理论可以作为解析我国公立医院非伦理现象的理论基础,在此框架下从医院内部管理架构上系统分析医院管理不力导致或加剧医疗腐败的两个方面具体表现和行为成因,即对内部管理不够重视,管理体系不健全,现行宏观管理体制造成公立医院内部管理功能不完备或弱化。内部管理的基本构造不健全导致对腐败的制约监管乏力。一些医院价值取向偏差给腐败可乘之机。具体防控措施不力难以遏制腐败,如思想反腐不力,医德医风建设弱化;制度反腐软弱,内部控制不到位;正面防腐不到位,激励机制不合理。

关键词：医疗腐败公立医院医院管理公共选择委托-代理理论

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统一战线与构建社会主义和谐社会

学理论 2010年第7期 11-12页

作者：李万冬郑志博中国医科大学校长办公室中国医科大学

构建和谐社会需要天时、地利、人和,要克服各种特殊的困难,需要激发一切创造力,调动一切积极因素,汇集一切发展资源。爱国统一战线在这一进程中是一支不可或缺的重要力量,因此,将在构建社会主义和谐社会过程中发挥越来越重要的作用。

关键词：统一战线构建和谐社会

Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-li Kang Yi Jiang Hua-Wei Zhang Xiao-Mei Song Yu-Ze li Wen-li Huang dong-dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC