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Novel index for the prediction of significant liver fibrosis and cirrhosis in chronic hepatitis B patients in China

World Journal of Gastroenterology 2022年第27期28卷 3503-3513页

作者： Min-Jun Liao Jun Li Wei Dang Dong-Bo Chen wan-Ying Qin pu Chen Bi-Geng Zhao Li-Ying Ren Ting-feng Xu Hong-Song Chen Wei-Jia Liao Laboratory of Hepatobiliary and Pancreatic Surgery The Affiliated Hospital of Guilin Medical UniversityGuilin 541001Guangxi Zhuang Autonomous RegionChina Guangdong Provincial Key Laboratory of Gastroenterology Department of Gastroenterology and Hepatology UnitNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Genetics and Precision Medicine Laboratory The Affiliated Hospital of Guilin Medical UniversityGuilin 541001Guangxi Zhuang Autonomous RegionChina Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Disease Peking University People’s HospitalBeijing 100044China

BACKGROUND Noninvasive,practical,and convenient means of detection for the prediction of liver fibrosis and cirrhosis in China are greatly *** To develop a precise noninvasive test to stage liver fibrosis and *** With liver biopsy as the gold standard,we established a new index,[alkaline phosphatase(U/L)+gamma-glutamyl transpeptidase(U/L)/platelet(109/L)(AGPR)],to predict liver fibrosis and *** addition,we compared the area under the receiver operating characteristic curve(AUROC)of AGPR,gammaglutamyl transpeptidase to platelet ratio,aspartate transaminase to platelet ratio index,and FIB-4 and evaluated the accuracy of these routine laboratory indices in predicting liver fibrosis and *** Correlation analysis revealed a significant positive correlation between AGPR and liver fibrosis stage(P<0.001).In the training cohort,the AUROC of AGPR was 0.83(95%CI:0.78-0.87)for predicting fibrosis(≥F2),0.84(95%CI:0.79-0.88)for predicting extensive fibrosis(≥F3),and 0.87(95%CI:0.83-0.91)for predicting cirrhosis(F4).In the validation cohort,the AUROCs of AGPR to predict≥F2,≥F3 and F4 were 0.83(95%CI:0.77-0.88),0.83(95%CI:0.77-0.89),and 0.84(95%CI:0.78-0.89),*** The AGPR index should become a new,simple,accurate,and noninvasive marker to predict liver fibrosis and cirrhosis in chronic hepatitis B patients.

关键词： Liver Fibrosis Cirrhosis Prediction Novel noninvasive marker Chronic hepatitis B

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石蜡相分光光度法测定稀土的研究

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冶金分析 2001年第1期21卷 12-13页

作者：郭岚万益群万小芬南昌大学化学系!江西南昌330047

系统研究了稀土 -8 羟基喹啉显色体系在石蜡相中的显色反应。在NH4Cl-NH3·H2 O(pH 9)介质中 ,稀土 -8 羟基喹啉显色络合物可定量被石蜡萃取 ,且固相色阶明显 ,RE2 O3 在 0～ 80 μg/ 5 0mL范围内符合比尔定律 ,从而建立了测量稀土的新... 详细信息

系统研究了稀土 -8 羟基喹啉显色体系在石蜡相中的显色反应。在NH4Cl-NH3·H2 O(pH 9)介质中 ,稀土 -8 羟基喹啉显色络合物可定量被石蜡萃取 ,且固相色阶明显 ,RE2 O3 在 0～ 80 μg/ 5 0mL范围内符合比尔定律 ,从而建立了测量稀土的新的固相分光光度法。大多数干扰离子可通过控制溶液酸度进行萃取分离。方法应用于江西稀土矿中稀土总量的测定 ,结果满意。

关键词：石蜡相分光光度法稀土 8-羟基喹啉

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Efficacy of Yangyin Yiqi Huoxue Granule (养阴益气活血颗粒) in Treatment of Ischemic Stroke Patients with Qi-Yin Deficiency and Blood Stasis Syndrome: A Randomized, Double-Blind, Multicenter, Phase-2 Clinical Trial

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Chinese Journal of Integrative Medicine 2021年第11期27卷 811-818页

作者： wanG Yu YANG Jie-hong wan Hai-tong HE Yu XU Bin Al Chang-shan ZHOU Hui-fen YU Li wan Hao-fang BIE Xiao-dong Institute of Cardio-Cerebrovascular Disease Zhejiang Chinese Medical UniversityHangzhou310053China Neurology Department Xinhua Hospital of Zhejiang ProvinceHangzhou310005China Neurology Department Integrated Medicine Hospital of Jilin ProvinceYanbianJilin Province133001China Chinese Medicine Department the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou310000China

Objective To evaluate the efficacy and safety of Yangyin Yiqi Huoxue Granule(养阴益气活血颗粒,YYHG)in the treatment of ischemic stroke(IS)patients with qi-yin deficiency and blood stasis syndrome(QYDBSS),and to explore its effective *** The total of 288 patients were randomly assigned to the YYHG high-dose,YYHG low-dose,positive control(administered Xiaoshuantong Granule,XSTG,消栓通颗粒),or placebo control(administered inert granule)groups(72 cases per group)by software-drived competitive block *** trial was conducted for a 28-day period,with a 180-day follow-up *** primary outcome was the comprehensive curative evaluation,and secondary outcomes were the National Institute of Health Stroke Scale(NIHSS)score,Barthel activities of daily living(ADL)index score,the quality of life index(QLI)score,and the Chinese medicine syndrome(CMS)*** analyses were done on an intention-to-treat *** clinical safety was also *** The total of 288 participants were recruited between June 1,2008 and September 30,2009,and 287 patients received intervention;the treatment groups were well balanced at *** comprehensive cure rates of YYHG high-dose,low-dose,positive and placebo control groups were 63.38%,31.94%,36.11%and 6.14%,respectively;there was a statistical difference between the two groups(P<0.01),while the high-dose YYHG treatment group was significantly higher than the other 3 groups(P<0.01).The improvement of NIHSS,ADL,QLI and CMS scores of the YYHG high-dose and low-dose groups was significantly better than that of the positive control group and the placebo control group(P<0.05).In terms of improving the classification of the NIHSS scale and the assessment of the ADL scale,the YYHG high-dose group was significantly better than the other three groups(P<0.05),and the YYHG low-dose group was better than the placebo control group(P<0.01).At the same time,except for the QLI score,the high-dose group was better than the low-dose group(P

关键词： stroke qi-yin deficiency and blood stasis syndrome Chinese medicine randomized controlled trial

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Protective Effect of Naoxintong Capsule(脑心通胶嚢)Combined with Guhong Injection(谷红注射液)on Rat Brain Microvascular Endothelial Cells during Cerebral Ischemia-Reperfusion Injury

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Chinese Journal of Integrative Medicine 2021年第10期27卷 744-751页

作者： wanG Hai-yan ZHOU Hui-fen HE Yu YU Li LI Chang YANG Jie-hong wan Hai-tong College of Life Science Zhejiang Chinese Medical UniversityHangzhou(310053)China College of Pharmacy Zhejiang Chinese Medical UniversityHangzhou(310053)China College of Basic Medicine Zhejiang Chinese Medical UniversityHangzhou(310053)China

Objective:To investigate the synergistic effect of Naoxintong Capsule(NXTC,脑心通胶囊)and Guhong Injection(GHI,谷红注射液)on cerebral ischemia-reperfusion(丨/R)***:Forty-eight Sprague-Dawley rats were divided into 6 groups:control group,oxygen and glucose deprivation(OGD)group,nimodipine group(9.375 mg/kg),NXTC group(0.5 g/kg),GHI group(5 mL/kg)and NXTC+GHI group(0.5 g/kg NXTC+5 mL/kg GHI),after the onset of reperfusion and once per day for the following 7 *** was collected 1 h after final administration,and the sera were *** primary rat brain microvascular endothelial cells(rBMECs)were subjected to OGD to establish a cell injury *** rBMECs were used as blank *** cell counting kit-8 assay was used to assess cell viability using the ***(MDA)and superoxide dismutase(SOD)levels were assessed using an enzyme-linked immunosorbent *** was evaluated after Hoechst33342 staining using fluorescence microscopy and flow ***-1 staining was performed to assess changes in mitochondrial membrane ***:Statistical analysis indicated that more than 95%of the cells were *** with the OGD group,the cellular morphology of the all drug delivery groups *** particular,the combined drug group had the most significant *** with the OGD group,all drug intervention groups induced a decrease in the apoptotic rate of rBMECs,increased the SOD levels,and decreased the MDA levels(all P<0.01).Compared with the mono-therapy groups,the NXTC+GHI group exhibited a significant improvement in the number of apoptotic rBMECs(P<0.01).All drug intervention groups showed different degrees of increase in membrane potential,and the NXTC+GHI group was higher than the NXTC or GHI group(P<0.01).Conclusion:The combinationa application of NXTC and GHI on cerebral l/R injury clearly resulted in protective benefits.

关键词： cerebral ischemia/repertusion injury Naoxintong Capsule Guhong Injection brain microvascular endothelial cells apoptosis rat

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Effects of Uniconazole on Nitrogen Metabolism and Grain Protein Content of Rice

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Rice science 2005年第2期12卷 107-113页

作者： XIANG Zu-fen YANG Wen-yu REN wan-jun wanG Xiao-chun Mianyang Agricultural Research Institute Mianyang 621002 China Agronomy College Sichuan Agricultural University Ya ＇an 625014 China

The effects of uniconazole by soaking seeds and spraying leaves at booting stage with different concentrations （0, 20 and 40 mg/kg） on the nitrogen metabolism of flag leaf and grains after flowering, and rice grain protein content and yield were studied with hybrid rice combination Shanyou 63. Under uniconazole treatment, the soluble protein content in flag leaf was increased in early and middle period of grain filling, but this content was nearly the same as or even lower than that of control at maturity; Glutamine synthetase activity in superior and inferior grains and non-protein nitrogen content in superior grains at early stage of grain development were promoted, and moreover, the transforming speed from non-protein nitrogen to protein nitrogen was accelerated; Non-protein nitrogen content was lower than that of control at maturity, but protein nitrogen content at each stage was higher than those of control; Protein nitrogen content in superior and inferior grains and protein nitrogen absolutely accumulative content in a grain both were enhanced and protein content and yield in rice grain were raised. The application of uniconazole by soaking seeds and spraying leaves raised crude protein content by an average of 7.2% and 8.3%, and protein yield by an average of 13.1% and 13.4%, respectively.

关键词： rice uniconazole nitrogen metabolism protein

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中国大型体育赛事融资模式及其创新

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河北大学学报（哲学社会科学版） 2019年第4期44卷 82-88页

作者：裴桂芬张璞河北大学经济学院河北保定071002 国家开发银行河北省分行河北石家庄050051

全球大型体育赛事的融资主要有政府投融资、市场化投融资和混合投融资3种模式,混合投融资模式逐渐占据主流。基于项目分类法来看,公益性项目主要依赖于政府全额投入,准公益性项目一般由政府先期主导,同时吸引社会资本参与,而经营性项目... 详细信息

全球大型体育赛事的融资主要有政府投融资、市场化投融资和混合投融资3种模式,混合投融资模式逐渐占据主流。基于项目分类法来看,公益性项目主要依赖于政府全额投入,准公益性项目一般由政府先期主导,同时吸引社会资本参与,而经营性项目的融资主要由企业自主筹资。从创新方向上看,公益性项目适合于政府投融资模式,但要对部分项目进行以PFI为导向的制度创新;准公益性项目应灵活运用PPP等方式吸引社会资本参与;经营性项目应尝试资产证券化和建立体育产业投资基金。融资模式的创新需要政府从法律法规、人才建设、制度建设等方面加以保障。

关键词：大型体育赛事融资模式公益性项目准公益性项目经营性项目

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Simple,stable and efficient nonlinear pulse compression through cascaded filamentation in air

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High Power Laser Science and Engineering 2023年第6期11卷 193-198页

作者： Tao pu Kan Tian Bo Hu Zhongjun wan Linzhen He Xuemei Yang Han Wu Yang Li Weizhe wang Houkun Liang College of Electronics and Information Engineering Sichuan UniversityChengduChina

Nonlinear compression has become an obligatory technique along with the development of ultrafast lasers in generating ultrashort pulses with narrow pulse widths and high peak *** particular,techniques of nonlinear compression have experienced a rapid progress as ytterbium(Yb)-doped lasers with pulse widths in the range from hundreds of femtoseconds to a few picoseconds have become mainstream laser tools for both scientific and industrial ***,we report a simple and stable nonlinear pulse compression technique with high efficiency through cascaded filamentation in air followed by dispersion *** at a center wavelength of 1040 nm with millijoule pulse energy and 160 fs pulse width from a high-power Yb:CaAlGdO_(4) regenerative amplifier are compressed to 32 fs,with only 2.4% loss from the filamentation *** compressed pulse has a stable output power with a root-meansquare variation of 0.2% over 1 hour.

关键词： femtosecond pulse filamentation nonlinear compression

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Natural Variation of Pto and fen Genes and Marker-Assisted Selection for Resistance to Bacterial Speck in Tomato

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Agricultural Sciences in China 2011年第6期10卷 827-837页

作者： SUN wan-yu ZHAO wan-ying wanG Yuan-yuan PEI Cheng-cheng YANG Wen-cai Department of Vegetable Science College of Agronomy and Biotechnology China Agricultural University Beijing 100193 P.R.China

The resistance in tomato plants to bacterial speck caused by Pseudomonas syringae pv. tomato is triggered by the interactions between the plant resistance protein Pto and the pathogen avirulence proteins AvrPto or AvrPtoB. fen is a gene encoding closely related functional protein kinases as the Pto gene. To investigate the status of resistance to the pathogen and natural variation of Pto and fen genes in tomato, 67 lines including 29 growing in China were subject to disease resistance evaluation and fenthion-sensitivity test. Alleles of Pto and fen were amplified from genomic DNA of 25 tomato lines using polymerase chain reaction （PCR） and sequences were determined by sequencing the PCR products. The results indicated that none of the 29 cultivars/hybrids growing in China were resistant to bacterial speck race 0 strain DC3000. Seven of eight tomato lines resistant to DC3000 were also fenthion-sensitive. Analysis of deduced amino acid sequences identified three novel residue substitutions between Pto and pto, and one new substitution identified between fen and fen. A PCR-based marker was developed and successfully used to select plants with resistance to DC3000.

关键词： tomato bacterial speck Pto fen natural variation marker-assisted selection

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Effects of New Rural Cooperative Medical Scheme on Medical Service Utilization and Medical Expense Control of Inpatients： A 3-year Empirical Study of Hainan Province in China

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Chinese Medical Journal 2016年第11期129卷 1280-1284页

作者： Tao Dai Hong-pu Hu Xu Na Ya-Zi Li Yan-Li wan Li-Qin Xie Center 1or Health Policy and Management institute of Medical Inlormation Chinese Academy ol Medical Sciences Beijing 100020 China

Background： The New Rural Cooperative Medical Scheme （NCMS） has been further adjusted and optimized to reduce the financial burden of rural residents and to achieve universal coverage for them. In this study, we aimed to explore the impact of NCMS on medical service utilization and medical expense of inpatients in recent years. Methods： The research data of Hainan Province were extracted from the Chinese NCMS platform from 2012 to 2014. Detailed information included total expenditure, average inpatients costs, average out-of-pocket payments, actual reimbursement rate, and average annual growth rate of the above indicators. Descriptive analysis was used to gauge the effects of NCMS. Results： In the utilization of medical services, NCMS inpatients in tertiary hospital decreased from 25.49% in 2012 to 20.39% in 2014, inpatients in county hospitals increased from 39.49% to 55.92%, simultaneously. The total expenditure in county hospitals rose steadily from 28.46% to 46.66%, meanwhile, the total expenditure in tertiary hospitals fell from 60.44% to 44.51%.The average out-of-pocket costs of rural inpatients remained stable over the years. Furthermore, the compensation fund ofNCMS inpatients grew significantly. The actual inpatient reimbursement rate at township health centers increased from 76.93% to 84.04%. Meanwhile, the rate at county hospitals and tertiary hospitals increased slightly from 59.37% and 46.10% to 61.25% and 47.71%, respectively. Conclusions： With the improvement of the reimbursement ability, especially after the new health care reform in 2009, the NCMS have been playing a prominent role in alleviating the economic burden of farmers＇ medical treatment. Meanwhile, more patients go to primary hospitals than tertiary hospitals, and the capability of primary hospitals has been greatly improved.

关键词： Hainan Province Medical Expense Control Medical Service Utilization New Cooperative Medical Scheme

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高含水后期非均质油藏W/O型表面活性剂调驱实验研究

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科学技术与工程 2021年第8期21卷 3090-3096页

作者：蒲万芬梅子来辛军西南石油大学油气藏地质与开发工程国家重点实验室成都610500 中国石油川庆钻探工程公司地质勘探开发研究院成都610051

针对常规低界面张力表面活性剂驱在非均质油藏易发生窜流、调驱效果差等问题,选用具有良好乳化增黏性能的W/O型表面活性剂调驱体系HC-2,促使油水两相在地层发生乳化,形成高黏度W/O型乳状液驱,有效驱替油藏低渗区域的残余油,改善高含水... 详细信息

针对常规低界面张力表面活性剂驱在非均质油藏易发生窜流、调驱效果差等问题,选用具有良好乳化增黏性能的W/O型表面活性剂调驱体系HC-2,促使油水两相在地层发生乳化,形成高黏度W/O型乳状液驱,有效驱替油藏低渗区域的残余油,改善高含水后期非均质油藏的开发效果。室内模拟高含水、非均质油藏条件,对W/O型表面活性剂调驱体系HC-2进行了基本性能评价及乳状液驱油研究。研究结果表明,HC-2的乳化增黏性能良好,在水油比小于7∶3时,可促使油水两相完全乳化形成高黏度的W/O型乳状液,且乳化稳定系数SI均在66%以上;同时在X油藏条件下,HC-2可将油水界面张力降低至10-2 mN/m。岩心驱油实验结果表明,在高含水及高含水后期,W/O型表面活性剂HC-2调驱体系可提高原油采收率23%~28.77%;HC-2调驱体系具有较强的非均质性调控能力,在渗透率级差小于7.5时,可有效地增大驱替相黏度,改善高、低渗层吸液剖面,提高原油采收率。

关键词：高含水乳化增黏调驱非均质性

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