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Effects of miR-214-5p and miR-21-5p in hypoxic endometrial epithelial-cell-derived exosomes on human umbilical cord mesenchymal stem cells

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World Journal of Stem Cells 2024年第11期16卷 906-925页

作者： wan-yu zhang Han-Bi wang Cheng-Yan Deng Department of Obstetrics and Gynecology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Obstetrics and Gynecology Peking Union Medical College HospitalBeijing 100730China

BACKGROUND Thin endometrium seriously affects endometrial receptivity,resulting in a significant reduction in embryo implantation,and clinical pregnancy and live birth rates,and there is no gold standard for *** main pathophysiological characteristics of thin endometrium are increased uterine arterial blood flow resistance,angiodysplasia,slow growth of the glandular epithelium,and low expression of vascular endothelial growth factor,resulting in endometrial epithelial cell(EEC)hypoxia and endometrial tissue *** umbilical cord mesenchymal stem cells(HucMSCs)promote repair and regeneration of damaged endometrium by secreting microRNA(miRNA)-carrying ***,the initiation mechanism of HucMSCs to repair thin endometrium has not yet been *** To determine the role of hypoxic-EEC-derived exosomes in function of HucMSCs and explore the potential *** Exosomes were isolated from normal EECs(EEC-exs)and hypoxia-damaged EECs(EECD-exs),before characterization using Western blotting,nanoparticletracking analysis,and transmission electron *** were cocultured with EEC-exs or EECD-exs and differentially expressed miRNAs were determined using ***-21-5p or miR-214-5p inhibitors or miR-21-3p or miR-214-5p mimics were transfected into HucMSCs and treated with a signal transducer and activator of transcription 3(STAT3)activator or STAT3 *** migration was assessed by Transwell and wound healing *** of HucMSCs into EECs was assessed by detecting markers of stromal lineage(Vimentin and CD13)and epithelial cell lineage(CK19 and CD9)using Western blotting and *** binding of the miRNAs to potential targets was validated by dual-luciferase reporter *** MiR-21-5p and miR-214-5p were lowly expressed in EECD-ex-pretreated ***-214-5p and miR-21-5p inhibitors facilitated the migratory and differentiative potentials of ***-21-5p and miR-214-5p ta

关键词： Endometrial epithelial cells Exosomes Human umbilical cord mesenchymal stem cells MiR-214-5p/miR-21-5p Signal transducer and activator of transcription 3

Intermittent spontaneous ovulation in patients with premature ovarian failure:Three case reports and review of literature

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World Journal of Clinical Cases 2023年第31期11卷 7647-7655页

BACKGROUND Premature ovarian failure(POF)is the end-stage of a decline in ovarian function prior to the age of 40 years that involves symptoms associated with low estradiol(E2)levels and a minimal probability of *** increases the physical and psychological burden experienced by young women of reproductive age,particularly with regards to *** SUMMARY Here,we report three cases(29,22,and 33 years-of-age)diagnosed with POF after experiencing secondary amenorrhea for more than one year,serum levels of follicle-stimulating hormone(FSH)>40 IU/L on two occasions with an interval of more than 4 wk,and negative progesterone withdrawal *** three patients were intermittently administered with drugs to create an artificial *** the subsequent discontinuation period,the patients experienced intermittent follicular growth and spontaneous *** patient experienced two natural pregnancies(both with embryo arrest).CONCLUSION Our findings suggest that young patients with POF can experience unpredictable and intermittent spontaneous follicular development,ovulation,and even natural *** should provide appropriate medical guidance and individualized treatments according to fertility requirements,genetic risks and hypoestrogenic symptoms as soon as possible.

关键词： Premature ovarian failure Follicular development Natural pregnancy Artificial cycle Case report

Incorporation of polyoxometalate-based acid–base pair into a sulfonated MIL-101 for achieving proton-conduction materials with high proton conductivity and high stability

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Tungsten 2022年第2期4卷 130-137页

作者： wan-yu zhang Ying Lu Zhuo Li Yang wang Xiu-Wei Sun Qian wang Zhong zhang Shu-Xia Liu Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education College of ChemistryNortheast Normal UniversityChangchun130024China

Currently,it is of great significance to develop new proton-conduction materials with high proton conductivity,high stability,and good conducting durability to meet the demands of fuel cell and ***,we prepared two composites DETA-HPW@MIL-101-SO_(3)H 1 and TETA-HPW@MIL-101-SO3H 2(DETA=diethylenetriamine,HPW=H_(3)PW_(12))_(4)0·xH_(2)O,MIL=Material Institut Lavoisier,TETA=triethylenetetramine)by encapsulating polyoxometalate(POM)and organic amine into a sulfonated MIL-101 through a step-by-step dipping ***,1 and 2 have high proton conductivities of 6.4×10^(−2) and 2.9×10^(−2) S·cm^(−1) at 65℃ and 95%relative humidity(RH),respectively,which can be attributed to the fast proton transfer among acid–base pairs formed between HPW and organic amine as well between sulfonic acid and organic ***,the time-dependent test in proton conductivity displays that their proton-conduction properties have good stability and durability,which benefit from that the electrostatic interactions among acid–base pairs and the limitation of opening size of MIL-101-SO3H make HPW and organic amine stably exist in the cages of MIL-101-SO_(3)*** remarkable proton-conduction properties(high proton conductivity and high stability)of the two composites make them become promising proton-conduction materials.

关键词： Polyoxometalate Acid-base pair MIL-101-SO3H Proton conduction

Collateral bloodletting at ashi point combined with external application of Sānqī powder for 120 cases of old ankle injury

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World Journal of Acupuncture-Moxibustion 2019年第4期29卷 305-307页

作者： Shao-ren Cai Jin Yong wan-yu zhang Zhong-tang Liao Han-wen Xia Department of Disease Prevention Shenzhen Pingle Orthopaedics and Traumatology HospitalShenzhen 518010Guangzhou ProvinceChina

Objective:To study the clinical effect on old ankle injury treated with collateral bloodletting at ashi point combined with the external application of Sānqī(三七Radix et Rhizoma Notoginseng)***:120 outpatients with old ankle injury were collected from the Department of Disease Prevention of Shenzhen Pingle Orthopaedics and Traumatology *** points were *** threeedged needle or the syringe needle for single use was used to prick the ashi points for 5-10 times till the slight bleeding presented in local ***,the cupping was used at the pricked area for 10-15 min to ensure the complete elimination of stagnant *** therapies were given once a *** the day after the day of bleeding and cuping,Sanqi powder was applied externally,once a *** pain score(visual analogue scale,VAS)and the clinical effect were observed in the ***:A total of 115 patients accomplished the whole procedure of treatment The pain mean score of VAS was(3.2±0.4)points before treatment and it were(0.28±0.5)points after *** them,104 cases were cured completely,8 cases effective significantly and 3 cases ***:The combined treatment with bloodletting therapy at ashi point and the external application of Sanqi powder achieves the satisfactory clinical effect on old ankle injury and this therapy deserves to be promoted in clinical practice.

关键词： Old ankle injury Bloodletting Cupping External application of Sānqīpowder

Clinical research of postpartum pantalgia treated with individualized moxibustion

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World Journal of Acupuncture-Moxibustion 2022年第1期32卷 26-32页

作者： wan-yu zhang Ying DING Bai-pu XU Shenzhen Pingle Orthopedics and Traumatology Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine Shenzhen Municipal Pingshan District Hospital of Traditional Chinese MedicineShenzhen 518118China

Objective:To evaluate the clinical therapeutic effect and safety of individualized moxibustion in treatment of postpartum ***:A total of 99 patients with postpartum pantalgia were divided into three group at the ratio of 1:1:1 according to random number table,*** individualized moxibustion group,a quantitative moxibustion group and a voltaren *** same acupoints were selected in the individualized moxibustion group and the quantitative moxibustion *** the patient in supine,Zhongwǎn(中脘CV12),Guānyuán(关元CV4),bilateral Tiānshū(天枢ST25),bilateral Xuèhǎi(血海SP10),bilateral Yanglingquan(阳陵泉GB34),bilateral Zúsānlǐ(足三里ST36) and bilateral Sānyīnjiāo(三阴交SP6) were *** the patient in prone,Dàzhuī(大椎GV14),bilateral Géshū(膈俞BL17),bilateral Píshū(脾俞BL20),bilateral Shènshū(肾俞BL23),Mìngmén 命门(GV4),bilateral Wěizhōng(委中BL40) and bilateral Yǒngquán(涌泉KI1) were *** the individualized moxibustion group,the moxibusion dose was determined by patient’s constitution and conditions as well as no occurrence of dry throat,thirst and local skin *** the quantitative moxibustion group,the moxibustion dose was fixed as 1 cone at each acupoint in *** these two groups,the treatment was given once every two days,three times a week and the treatment for 2 weeks was as 1 ***,2 courses of treatment were *** the voltaren group,voltaren ointment was used externally at the pain area,once a day,for 4 weeks ***,before treatment,at the end of treatment course and in follow-up,the symptom score of traditional Chinese medicine(TCM),pain score of visual analogue scale(VAS) and patient’s treatment satisfaction score were observed in the patients of the three ***:In comparison within group,TCM symptom score,VAS score and the treatment satisfaction score at the end of treatment were all reduced obviously as compared with those before treatment in each of the three groups(P <0.05).In 4,12 and 24 weeks of followup

关键词： Postpartum pantalgia Moxibustion therapy Individualized moxibustion Randomized controlled trial(RCT)

滇西南西盟群帕可组沉积时代厘定及构造意义:锆石U-Pb年代学及Lu-Hf同位素证据

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矿物岩石地球化学通报 2016年第5期35卷 936-948页

作者：邢晓婉张玉芝中山大学地球科学与地质工程学院广州510275 广州生产力促进中心创新基金服务部广州510091

研究滇西南地区出露的西盟群碎屑岩沉积时限及其古地理属性对了解冈瓦纳大陆东缘的构造演化及其古地理重建具有重要意义。本文对西盟群帕可组3个变质砂岩样品中的碎屑锆石进行了 LA-ICP-MS U-Pb测年和原位 Lu-Hf同位素组成分析，获得样... 详细信息

研究滇西南地区出露的西盟群碎屑岩沉积时限及其古地理属性对了解冈瓦纳大陆东缘的构造演化及其古地理重建具有重要意义。本文对西盟群帕可组3个变质砂岩样品中的碎屑锆石进行了 LA-ICP-MS U-Pb测年和原位 Lu-Hf同位素组成分析，获得样品的最小年龄峰值分别为568Ma、541Ma和560Ma，εHf（t）值为-24.0～26.3。结合前人对帕可组内片麻状花岗岩的研究成果，推测西盟群帕可组沉积于早寒武世—中奥陶世（541～460Ma），而非以往所认为的前寒武纪地层。Lu-Hf同位素组成则表明西盟群帕可组物源为古老地壳物质的再循环并混入新生地壳组分，结合其他区域地质资料推断西盟群物源类似东印度板块，与东冈瓦纳大陆具有亲缘性。

关键词：西盟群帕可组变沉积岩早古生代冈瓦纳大陆锆石 U-Pb年代学 Lu-Hf同位素

Co/Co_(7)Fe_(3)heterostructures with controllable alloying degree on carbon spheres as bifunctional electrocatalyst forrechargeable zinc-air batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 476-487页

作者： Junkang Chen Yongyue Zhuang Yanxin Qiao yu zhang Aihua yuan Hu Zhou School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Exploring efficient and nonprecious metal electrocatalysts of oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is crucial for developing rechargeable zinc-air batteries(ZABs).Herein,an alloying-degree control strategy was employed to fabricate nitrogen-doped carbon sphere(NCS)decorated with dual-phase Co/Co_(7)Fe_(3)heterojunctions(CoFe@NCS).The phase composition of materials has been adjusted by controlling the alloying *** optimal CoFe_(0.08)@NCS electrocatalyst displays a half-wave potential of 0.80 V for ORR and an overpotential of 283 mV at 10 mA·cm^(-2)for OER in an alkaline *** intriguing bifunctional electrocatalytic activity and durability is attributed to the hierarchically porous structure and interfacial electron coupling of highly-active Co_(7)Fe_(3)alloy and metallic Co *** the CoFe_(0.08)@NCS material is used as air-cathode catalyst of rechargeable liquid-state zinc-air battery(ZAB),the device shows a high peak power-density(157 mW·cm^(-2))and maintains a stable voltage gap over 150 h,outperforming those of the benchmark(Pt/C+RuO_(2))-based *** particular,the as-fabricated solid-state flexible ZAB delivers a reliable compatibility under different bending *** work provides a promising strategy to develop metal/alloy-based electrocatalysts for the application in renewable energy conversion technologies.

关键词： bifunctional electrocatalysts oxygen reduction reaction oxygen evolution reaction zinc-air battery metal/alloy carbon sphere

Approach for mechanism of BH3 domain counterpart BH3I-2' inducing colorectal cancer cell apoptosis

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Approach for mechanism of BH3 domain counterpart BH3I-2' ind...

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

两岸三地药理学与临床药理学术会议

作者： FENG wan-yu LIU Yang zhang Zhi-cheng (The First Affiliated Hospital, China Medical University, Shenyang 110001, China)

Objective To discuss mechanism of BH3 domain counterpart BH3I-2’inducing colorectal cancer cell *** Detected inhibition ratio and apoptosis of colorectal cancer cells HCT-116,which were treated by BH3I-2’,with microplate reader and flow *** Inhibition ratio of colorectal cancer cells,which were treated by BH3I-2’,could reach about 50%.Ratio of viable apoptotic cell decreased and that of non-viable apoptotic cell increased as time *** BH3I-2’can induce colorectal can- cer cell apoptosis.

关键词： BH3I-2’ apoptosis colorectal cancer cells flow cytometry

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui yu Yan Xie Jian yu Kun-Ning zhang Zhou-Bo Guo Di wang Zhao-Xian Li Wei-Qi zhang yu-Ying Tan Li zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis