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Effect of exogenous spastin combined with polyethylene glycol on sciatic nerve injury

Neural Regeneration Research 2019年第7期14卷 1271-1279页

作者： Yao-Fa Lin Zheng Xie Jun Zhou Hui-Hao Chen Wan-Wan Shao Hao-Dong Lin Department of Orthopedics Changzheng Hospitalthe Second Military Medical University Department of Orthopedics the Second People's Hospital of Karamay

Polyethylene glycol can connect the distal and proximal ends of an injured nerve at the cellular level through axonal fusion to avoid Wallerian degeneration of the injured distal nerve and promote peripheral nerve regeneration.However,this method can only prevent Wallerian degeneration in 10% of axons because the cytoskeleton is not repaired in a timely fashion.Reconstruction of the cytoskeletal trunk and microtubule network has been suggested to be the key for improving the efficiency of axonal fusion.As a microtubule-severing protein,spastin has been used to enhance cytoskeletal reconstruction.Therefore,we hypothesized that spastin combined with polyethylene glycol can more effectively promote peripheral nerve regeneration.A total of 120 male Sprague-Dawley rats were randomly divided into sham,suture,polyethylene glycol,and polyethylene glycol + spastin groups.In suture group rats,only traditional nerve anastomosis of the end-to-end suture was performed after transection of the sciatic nerve.In polyethylene glycol and polyethylene glycol + spastin groups,50 μL of polyethylene glycol or 25 μL of polyethylene glycol + 25 μL of spastin,respectively,were injected immediately under the epineurium of the distal suture.Sensory fiber regeneration distance,which was used to assess early nerve regeneration at 1 week after surgery,was shortest in the suture group,followed by polyethylene glycol group and greatest in the polyethylene glycol + spastin group.Behavioral assessment of motor function recovery in rats showed that limb function was restored in polyethylene glycol and polyethylene glycol + spastin groups at 8 weeks after surgery.At 1,2,4 and 8 weeks after surgery,sciatic functional index values and percentages of gastrocnemius muscle wet weight were highest in the sham group,followed by polyethylene glycol + spastin and polyethylene glycol groups,and lowest in the suture group.Masson staining was utilized to assess the morphology of muscle tissue.Morphological changes in skeletal muscle were detectable in suture,p

关键词： nerve regeneration peripheral nerves Wallerian degeneration polyethylene glycol axonal fusion spastin peripheral nerve injuries Masson staining microtubule neural regeneration

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On the superplastic deformation mechanisms of near-αTNW700 titanium alloy

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Journal of Materials Science & Technology 2022年第13期108卷 173-185页

作者： Lixia Ma Min wan Weidong Li Jie shao Xiaoning Han Jichun Zhang School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China AVIC Manufacturing Technology Institute Beijing 100024China

The new near-αTNW700 titanium alloy is a potential candidate material for high performance ultrasonic/hypersonic aircrafts,which is designed for short-term service at 700℃.This study systematically investigated the superplastic deformation microstructure evolution and mechanism of TNW700 alloy at different strain rates and true strains at 925℃.Results show that TNW700 alloy exhibits excellent superplastic behavior in a constant strain rate range of 0.0005-0.005 s^(-1) with elongation above 400%.The peak stress decreases with decreasing strain rate,which is related to the increase ofβ-phase volume fraction caused by the increase of thermal exposure time.In addition,significant strain hardening is observed in early-middle stage of superplastic deformation,and flow softening is followed in middle-late stage.To rationalize these complex flow behaviors,electron backscatter diffraction(EBSD)and high resolution transmission electron microscopy(HRTEM)were used to characterize the microstructure.Strain hardening is correlated to the synergistic effect ofβgrain growth,dislocation accumulation,silicide precipitate,and solid solution strengthening ofαphase.Continuous dynamic recrystallization(CDRX)induced the fragmentation of primaryαgrains in middle-late stage of superplastic deformation,and the refinement ofαgrains,the increase ofβphase volume fraction and dynamic dislocation recovery are main causes of high strain softening.In addition,EBSD and TEM observations confirmed texture randomization,fine equiaxed primaryαgrains and intragranular dislocation movement,indicating that grain boundary sliding(GBS)accommodated by dislocation sliding/climb is the dominant superplastic deformation mechanism of TNW700 alloy.

关键词： Near-αtitanium alloy Superplastic deformation Strain hardening and flow softening Microstructure evolution Deformation mechanisms

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Six-hierarchy model of accident analysis and its application in coal mine accidents

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Journal of Safety Science and Resilience 2022年第1期3卷 61-71页

作者： Qiuju Ma Mengsai wan Juncheng shao Mingyu Zhong Yuhao Guo Wei wang School of Emergency Management and Safety Engineering China University of Mining and TechnologyBeijing 100083China Shanghai Fire Science and Technology Research Institute of MEM Shanghai 200032China

Accident analysis models play a significant role in accident investigation and analysis.Most traditional models,usually based on a chain of events,have serious limitations when used for complex systems,especially for coal mine accident.HFACS is a widely accepted accident cause model with complex structure and content.Based on HFACS and accident investigation need in China,a new systemic accident analysis method“Six-hierarchy model”is proposed.And the index database of accident causal factors at each hierarchy of coal mine accidents is established.This model provides clear guidance for the prevention of accidents from six levels,which helps to the targeted rectification after accidents and the improvement of safety management level.The source,ap-plication scope,advantages and disadvantages of HFACS and six-hierarchy model are compared.The“2.14”gas explosion accident in Sunjiawan coal mine is analyzed by using HFACS and six-hierarchy model and the safety management suggestions are put forward.The study shows that the Six-hierarchy model provides a clear guide for the prevention of accidents from six levels.And it benefits the targeted rectification after accidents and the continuous improvement of safety management.

关键词： Accident Accident analysis Six-hierarchy Coal mine accident HFACS

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Thermal insulating and fire-retardant Si_(3)N_(4) nanowire membranes resistant to high temperatures up to 1300℃

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Journal of Materials Science & Technology 2023年第24期155卷 82-88页

作者： Yeye Liu Leilei Zhang Ruonan Zhang Siqi shao Lina Sun Xinyi wan Tiantian wang State Key Laboratory of Solidification Processing Shaanxi Key Laboratory of Fiber Reinforced Light Composite MaterialsNorthwestern Polytechnical UniversityXi’an 710072China

Superior thermal insulating and fire-retardant ceramic membranes are urgently demanded in the aerospace,construction,and chemical engineering industries.However,the generic characteristics of ceramic membranes,such as brittleness,structural collapse,and crystallization-induced pulverization behavior,present a great plague to their practical applications.Herein,we report a highly flexible,mechanically stable,fire-retardant,and high-temperature-resistant ceramic membrane based on the interlocked Si_(3)N_(4) nanowires formed by the precursor pyrolysis method.The Si_(3)N_(4) nanowire membrane(SNM)has excellent high-temperature resistance under alcohol lamps and butane spray lance.The thermal insulation with a thermal conductivity as low as 0.056 W m^(-1)K^(-1)can be attributed to the high porosity of SNM,which makes it a desirable candidate for heat insulators under harsh conditions.More importantly,SNM exhibits thermal stability and robust mechanical properties in the range of 25 to 1300℃.The high-temperature resistance of SNM up to 1300℃is achieved by the four stages:Si3 N4 nanowires,Si_(3)N_(4)@SiO_(2) nanowires,SiO_(2) nanowires,and bead-like SiO_(2) nanowires.After heat-treated at 1300℃,the macroscopic size of SNM does not change significantly,and the interlocked structure is still maintained.Furthermore,SNM still maintains excellent mechanical properties,with tensile strength as high as 0.26 MPa.This work provides a facile method for fabricating excellent thermal insulating and fire-retardant ceramic membranes,showing prospective application prospects in the era of thermal insulating materials.

关键词： Silicon nitride nanowires Thermal insulation Fire-resistance High-temperature resistance

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Progress in blood biomarkers of subjective cognitive decline in preclinical Alzheimer’s disease

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Chinese Medical Journal 2023年第5期136卷 505-521页

作者： Xianfeng Yu Kai shao Ke wan Taoran Li Yuxia Li Xiaoqun Zhu Ying Han Department of Neurology Xuanwu Hospital of Capital Medical UniversityBeijing 100053China Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China Department of Neurology Tangshan Central HospitalTangshanHebei 063000China School of Biomedical Engineering Hainan UniversityHaikouHainan 570228China Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijing 100053China National Clinical Research Center for Geriatric Diseases Beijing 100053China.

Alzheimer's disease(AD)is a neurodegenerative disease that gradually impairs cognitive functions.Recently,there has been a conceptual shift toward AD to view the disease as a continuum.Since AD is currently incurable,effective intervention to delay or prevent pathological cognitive decline may best target the early stages of symptomatic disease,such as subjective cognitive decline(SCD),in which cognitive function remains relatively intact.Diagnostic methods for identifying AD,such as cerebrospinal fluid biomarkers and positron emission tomography,are invasive and expensive.Therefore,it is imperative to develop blood biomarkers that are sensitive,less invasive,easier to access,and more cost effective for AD diagnosis.This review aimed to summarize the current data on whether individuals with SCD differ reliably and effectively in subjective and objective performances compared to cognitively normal elderly individuals,and to find one or more convenient and accessible blood biomarkers so that researchers can identify SCD patients with preclinical AD in the population as soon as possible.Owing to the heterogeneity and complicated pathogenesis of AD,it is difficult to make reliable diagnoses using only a single blood marker.This review provides an overview of the progress achieved to date with the use of SCD blood biomarkers in patients with preclinical AD,highlighting the key areas of application and current challenges.

关键词： Alzheimer’s disease Biomarker Blood Evolving technologies Subjective cognitive decline

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Terahertz quantum cascade lasers with sampled lateral gratings for single mode operation

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Frontiers of Optoelectronics 2021年第1期14卷 94-98页

作者： Dixiang shao Chen YAO Zhanglong FU Wenjian wan Ziping LI Juncheng CAO Key Laboratory of Terahertz Solid-State Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China

In this paper,we presented single mode terahertz quantum cascade lasers(THz QCLs)with sampled lateral grating emitting approximately 3.4 THz.Due to strong mode selection,the implementation of sampled lateral grating on THz QCL ridges can result in stable single longitudinal mode emission with a side-mode suppression ratio larger than 20 dB.The measured peak power of the grating laser is improved by about 11.8%compared to the power of devices with uniform distributed feedback gratings.Furthermore,the far-field pattern of the presented device is uninfluenced by grating structures.

关键词： terahertz(THz) quantum cascade laser(QCL) sampled lateral grating

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Metabolomics: A useful tool for ischemic stroke research

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Journal of Pharmaceutical Analysis 2023年第9期13卷 968-983页

作者： Wentao Li Chongyu shao Chang Li Huifen Zhou Li Yu Jiehong Yang Haitong wan Yu He School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou310053China School of Basic Medicine Sciences Zhejiang Chinese Medical UniversityHangzhou310053China

Ischemic stroke(IS)is a multifactorial and heterogeneous disease.Despite years of studies,effective strategies for the diagnosis,management and treatment of stroke are still lacking in clinical practice.Metabolomics is a growing field in systems biology.It is starting to show promise in the identification of biomarkers and in the use of pharmacometabolomics to help patients with certain disorders choose their course of treatment.The development of metabolomics has enabled further and more biological applications.Particularly,metabolomics is increasingly being used to diagnose diseases,discover new drug targets,elucidate mechanisms,and monitor therapeutic outcomes and its potential effect on precision medicine.In this review,we reviewed some recent advances in the study of metabolomics as well as how metabolomics might be used to identify novel biomarkers and understand the mechanisms of IS.Then,the use of metabolomics approaches to investigate the molecular processes and active ingredients of Chinese herbal formulations with anti-IS capabilities is summarized.We finally summarized recent developments in single cell metabolomics for exploring the metabolic profiles of single cells.Although the field is relatively young,the development of single cell metabolomics promises to provide a powerful tool for unraveling the pathogenesis of IS.

关键词： Metabolomics Ischemic stroke Biomarker Precision medicine Single cell metabolomics

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Identification of seven long noncoding RNAs signature for prediction of biochemical recurrence in prostate cancer

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Asian Journal of Andrology 2019年第6期21卷 618-622页

作者： Ning shao Wo Zhu Fang-Ning wan Ding-Wei Ye Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China.

Accumulating evidenee suggested that long noncoding RNAs(IncRNAs)possess a potential role in prostate cancer(PCa)diagnosis and prognosis.Rapid biochemical recurrence(BCR)is considered as a sign for clinical recurrence metastasis and PCa-specific mortality.Hence,the aim of the present study was to identify a IncRNA signature that can predict BCR of PCa accurately.Bioinformatics analysis,Kaplan-Meier analyses,Cox regression analyses,and Gene Set Enrichment Analysis(GSEA)were performed in a publicly available database with 499 PCa tissues and 52 matched normal tissues.A signature was identified.All these IncRNAs were differentially expressed between tumor and normal tissues and differentially expressed between high Gleason score and low Gleason score tissues.Furthermore,we developed a seven IncRNAs signature that can predict PCa BCR.Patients classified into low-risk group showed better BCR survival significantly than the patients in the high-risk group(hazard ratio=0.32,95%Cl:0.20-0.52,concordance index=0.63).The area under the curve was 0.68 for BCR.The signature also had good discrimination for BCR in men with Gleason 7 PCa.In conclusion,our results suggest that the seven IncRNAs signature is a new biomarker of BCR and high risk in PCa.In addition,the in dividual In cRNA warrants further study to un cover the associated mechanisms of PCa progression and the signature could be used to design direct clinical trials for adjuvant therapy.

关键词： biochemical recurrence biomarker high risk Iong noncoding RNA prostate cancer

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Effect of precipitates on high-temperature strength and irradiation behavior of vanadium-based alloys

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Journal of Iron and Steel Research(International) 2018年第12期25卷 1270-1277页

作者： shao-ning Jiang Li-qun Xu Fa-rong wan School of Mechanical and Automotive Engineering Qilu University of Technology (Shandong Academy of Science) Jinan 250353ShandongChina School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China

The formation of precipitates and their effect on mechanical properties and irradiation damage in V-4CraTi alloys have been investigated using transmission electron microscope,high-temperature tensile tests and high-voltage electron microscope (HVEM).V-4Cr-4Ti alloys were aged for 20-40 h at 873 K,and extremely fine precipitates were produced during the aging process,which coarsened with aging time.The results of high-temperature (773,873 and 973 K)tensile tests showed an increase in strength with increasing aging time (i.e:,increasing size of precipitates)while a decrease in the uniform elongation.There was evidence that presence of precipitates strengthened V-4Cr-4Ti alloys.In situ HVEM observations showed that the precipitates restricted the growth rate of dislocation loops induced during electron irradiation at 773 K.The interactions between precipitates and irradiation-induced dislocation loops were discussed.The presence of particles alleviated the increase in irradiation hardening up to an irradiation dose of 3.42 dpa (displacement per atom).The precipitates shrank in size during electron irradiation,which was due to the dissolution of constituent atoms of the precipitates into the alloy matrix.

关键词： Aging Precipitate strengthening Electron irradiation Irradiation defect Dislocation loop

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Association between plasma immunoproteasome and 90-day prognosis after first-ever ischemic stroke

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Neural Regeneration Research 2021年第4期16卷 795-800页

作者： Xing-Yong Chen Ming Fu shao-Fen wan Xu Zhang Yin-Zhou wang Department of Neurology Fujian Provincial HospitalShengli Clinical Medical College of Fujian Medical UniversityFuzhouFujian ProvinceChina

Many blood biomarkers are reportedly helpful for predicting post-stroke cognitive impairment(PSCI),but no biomarkers are widely used in clinical practice.The purpose of this study was to investigate the association between the plasma immunoproteasome and patients’90-day prognosis after first-ever acute ischemic stroke.In our prospective,single-center study,259 patients with first-ever acute ischemic stroke were enrolled from the Department of Neurology,Fujian Provincial Hospital,China,from March to September 2014.Of these,27 patients(10.4%)had unfavorable outcomes as assessed by the Modified Rankin Scale(scores of 3–6).The National Institutes of Health Stroke Scale score on admission,plasma N-terminal pro-B-type natriuretic peptide(NT-pro-BNP)levels,and immunopro-teasome subunit(low molecular mass peptide[LMP]2,LMP5,and LMP7)levels were significantly higher in the unfavorable outcome group than in the favorable outcome group.To predict unfavorable outcomes,the optimal cutoff points were National Institutes of Health Stroke Scale score>12,NT-pro-BNP level>1883.5 pg/mL,and LMP2 level>841.4 pg/mL.Of the 193 patients that were able to complete the Mini-Mental State Examination at 90 days poststroke,66 patients(34.2%)had PSCI.Plasma levels of NT-pro-BNP and LMP2 were higher in patients with PSCI than in those without PSCI.To predict PSCI,the optimal cutoff values were age>70.5 years and LMP2 level>630.5 pg/mL.These findings indicate that plasma LMP2 may serve as a new prognostic biomarker of poor outcome and PSCI at 90 days after stroke.This study was approved by the Ethics Committee of Fujian Provincial Hospital,Provincial Clinical Medical College of Fujian Medical University(approval No.K2014-01-003)on January 15,2014.

关键词： behavior biomarker brain clinical trial cognitive impairment immune function neurological function protein stroke

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