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Genes & Diseases 2022年第2期9卷 429-442页

作者： Min Xu Yu-Meng wang wan-qing li Cheng-Long Huang Jun li Wen-Hua Xie Hong-Xiang Zeng lin-Fen Tao Xi li Biology Science Institutes Chongqing Medical UniversityChongqing 400016PR China

Obesity-induced inflammation,characterized by augmented infiltration and altered balance of macrophages,is a critical component of systemic insulin resistance.Chemokine-chemokine receptor system plays a vital role in the macrophages accumulation.CC-Chemokine Receptor-like 2(Ccrl2)is one of the receptors of Chemerin,which is a member of atypical chemokine receptors(ACKR)family,reported taking part in host immune responses and inflammation-related conditions.In our study,we found ccrl2 expression significantly elevated in visceral adipose tissue(VAT)of high fat diet(HFD)induced obese mice and ob/ob mice.Systemic deletion of Ccrl2 gene aggravated HFD induced obesity and insulin resistance and ccrl2−/−mice showed aggravated VAT inflammation and increased M1/M2 macrophages ratio,which is due to the increase of macrophages chemotaxis in Ccrl2 deficiency mice.Cumulatively,these results indicate that Ccrl2 has a critical function in obesity and obesity-induced insulin resistance via mediating macrophages chemotaxis.

关键词： Ccrl2 Inflammation Insulin resistance Macrophages Obesity

Disclosing the active integration structure and robustness of a pseudo-tri-component electrocatalyst toward alkaline hydrogen evolution

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Journal of Energy Chemistry 2022年第9期31卷 210-216,I0007页

作者： Hong-Hong Zou wan-qing li Cong-Hu Song li-Ming Cao Xue-Feng Zhang Xuan-Yi Zhu Zi-Yi Du Jia Zhang Sheng-liang Zhong Chun-Ting He Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education and College of Life ScienceJiangxi Normal UniversityNanchang 330022JiangxiChina Research Center for Ultrafine Powder Materials College of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang 330022JiangxiChina

Designing multicomponent integration catalysts(MICs)has been a promising strategy for improving electrocatalytic hydrogen evolution reaction(HER)due to the highly active interfaces as well as electronic synergy.Nevertheless,many fundamental questions such as their actual active species and the influence on long-term stability remain to be answered.Herein,we present the structural evolution from a pseudotri-component electrocatalyst of nitrogen-doped carbon supported nickel/vanadium nitride/vanadium oxide(Ni-VN-V_(2)O_(3)/NC)nanorods to the heterostructural nickel/vanadium nitride(Ni-VN/NC)nanosheets during chemical or electrochemical processes.The self-reconstructed Ni-VN/NC exhibits a robust stability under alkaline conditions,while maintaining initial efficient HER activity with a low overpotential of 76 mV at the current density of 10 mA cm^(-2).Theoretical calculations and quasi-in-situ spectroscopic technology unveil the redistribution of electrons on the synergistic active interface,which synchronously optimizes the affinities for hydrogen,hydroxide,and water molecules,thereby remarkably accelerating the HER kinetics by reducing the barrier of Volmer step.

关键词： Hydrogen evolution reaction Multicomponent integration catalysts Structural transformation Electrocatalysis Density functional theory

生物质衍生醇类水相重整制氢研究进展(英文)

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2015年第6期16卷 491-506页

作者： Guan-yi CHEN wan-qing li Hong CHEN Bei-bei YAN School of Environmental Science and Engineering Tianjin University Provincial Key Lab of Forestry and Ecological Environment Beihua University MOE Key Laboratory of Efficient Utilization of Low and Medium Grade Energy Tianjin University

氢气作为一种清洁、高效的可持续能源,近年来得到了广泛关注。水相重整技术以生物质衍生醇类制备氢气,具有来源广泛、反应条件温和、运行成本较低等优点,相较于其他制氢方法更有优势。本文详细阐述生物质衍生醇类水相重整制氢的研究进展... 详细信息

氢气作为一种清洁、高效的可持续能源,近年来得到了广泛关注。水相重整技术以生物质衍生醇类制备氢气,具有来源广泛、反应条件温和、运行成本较低等优点,相较于其他制氢方法更有优势。本文详细阐述生物质衍生醇类水相重整制氢的研究进展,同时讨论不同催化剂的反应机理。Pt系催化剂表现出较高的氢气选择性,但是醇类转化率较低。Ni系催化剂反应活性和转化率均较高,但仍存在氢气选择性和氢气产率较低等问题。

关键词：生物质醇类制氢水相重整制氢反应机理催化剂

Topological magnetoelectric response in ferromagnetic axion insulators

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National Science Review 2024年第2期11卷 8-14页

作者： Yuhao wan Jiayu li Qihang liu Department of Physics and Shenzhen Institute for Quantum Science and Engineering(SIQSE) Southern University of Science and Technology Shenzhen Key Laboratory of Advanced Quantum Functional Materials and Devices Southern University of Science and Technology Guangdong Provincial Key Laboratory for Computational Science and Material Design Southern University of Science and Technology

The topological magnetoelectric effect （TME） is a hallmark response of the topological field theory,which provides a paradigm shift in the study of emergent topological phenomena.However,its direct observation is yet to be realized due to the demanding magnetic configuration required to gap all surface states.Here,we theoretically propose that axion insulators with a simple ferromagnetic configuration,such as the MnBi2Te4/（Bi2Te3）nfamily,provide an ideal playground to realize the TME.In the designed triangular prism geometry,all the surface states are magnetically gapped.Under a vertical electric field,the surface Hall currents give rise to a nearly half-quantized orbital moment,accompanied by a gapless chiral hinge mode circulating in parallel.Thus,the orbital magnetization from the two topological origins can be easily distinguished by reversing the electric field.Our work paves the way for direct observation of the TME in realistic axion-insulator materials.

关键词： topological magnetoelectric effect axion insulator magnetic topological materials

Yiwei Xiaoyu granules for treatment of chronic atrophic gastritis with deficiency syndrome of the spleen and stomach

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World Journal of Clinical Cases 2024年第13期12卷 2201-2209页

作者： wan-Qun Chen qing-Feng Fan Yuan-Jun He Fei li Xin Wu Yan-Ping li Xiao-Jun Yang Department of Gastroenterology Chongqing Hospital of Traditional Chinese MedicineChongqing 400000China

BACKGROUND The Correa sequence,initiated by Helicobacter pylori(H.pylori),commonly progresses to gastric cancer through the stage of chronic atrophic gastritis(CAG).Although eradication of H.pylori only reduces the risk of gastric cancer,it does not eliminate the risk for neoplastic progression.Yiwei Xiaoyu granules(YWXY)are a commonly used composite preparation in Chinese clinics.However,the pursuit of excellence in clinical trials and the establishment of standardized animal experiments are still needed to contribute to full understanding and application of traditional Chinese medicine in the treatment of CAG.AIM To demonstrate the effectiveness of YWXY in patients with CAG and spleenstomach deficiency syndrome(DSSS),by alleviating histological scores,improving response rates for pathological lesions,and achieving clinical efficacy in relieving DSSS symptoms.METHODS We designed a double-blind,randomized,controlled trial.The study enrolled seventy-two H.pylori-negative patients(mean age,52.3 years;38 men)who were randomly allocated to either the treatment group or control group in a 1:1 ratio,and treated with 15 g YWXY or 0.36 g Weifuchun(WFC)tablet combined with the respective dummy for 24 wk.The pre-randomization phase resulted in the exclusion of 72 patients:50 participants did not meet the inclusion criteria,12 participants declined to participate,and 10 participants were excluded for various other reasons.Seven visits were conducted during the study,and histopathological examination with target endoscopic biopsy of narrow-band imaging was requested before the first and seventh visits.We also evaluated endoscopic performance scores,total symptom scores,serum pepsinogen and gastrin-17.RESULTS Six patients did not complete the trial procedures.Treatment with YWXY improved the Operative link on Gastric Intestinal Metaplasia Assessment(OLGIM)stage,compared with WFC(Plief from symptoms of DSSS and better improvement in serum gastric function,compared with WFC(P<0.05).CONCLUSION YWXY

关键词： Chronic atrophic gastritis Yiwei Xiaoyu granules Randomized clinical trial Weifuchun tablet Traditional Chinese medicine Helicobacter pylori

Vibration Control of A Flexible Marine Riser System Subject to Input Dead Zone and Extraneous Disturbances

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China Ocean Engineering 2024年第2期38卷 271-284页

作者： ZHOU li wanG Guo-rong wan Min School of Mechatronic Engineering Southwest Petroleum UniversityChengdu 610500China Energy Equipment Institute Southwest Petroleum UniversityChengdu 610500China National Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China

An observer-based adaptive backstepping boundary control is proposed for vibration control of flexible offshore riser systems with unknown nonlinear input dead zone and uncertain environmental disturbances.The control algorithm can update the control law online through real-time data to make the controller adapt to the environment and improve the control precision.Specifically,based on the adaptive backstepping framework,virtual control laws and Lyapunov functions are designed for each subsystem.Three direction interference observers are designed to track the timevarying boundary disturbance.On this basis,the inverse of the dead zone and linear state transformation are used to compensate for the original system and eliminate the adverse effects of the dead zone.In addition,the stability of the closed-loop system is proven by Lyapunov stability theory.All the system states are bounded,and the vibration offset of the riser converges to a small area of the initial position.Finally,four examples of flexible marine risers are simulated in MATLAB to verify the effectiveness of the proposed controller.

关键词： adaptive backstepping control disturbance observer flexible marine riser input dead zone vibration control

Selective photosynthesis of imines from biomass-derived aldehydes over Ni/TiO_(2)

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Rare Metals 2024年第3期43卷 1116-1124页

作者： Wu-lin li qing-qing Zhang lin Dong Wen-Jun Zhang li-li lin Zu-Peng Chen Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing210037China Institute of Industrial Catalysis State Key Laboratory of Green Chemistry Synthesis TechnologyCollege of Chemical EngineeringZhejiang University of TechnologyHangzhou310014China

Photocatalytic reductive amination of biomass-derived aldehydes is a desirable way to selectively upgrade biomass into value-added nitrogen-containing chemicals under mild conditions.However,it is challenging to produce imines in high selectivity because of the undesirable side reactions caused by the activity of functional groups.Here,we demonstrate the highly reactive and selective production of imines from biomass derived aldehydes via the photocatalytic reductive amination,using a defective TiO_(2)supported nickel catalyst.The employment of methanol as the hydrogen donor and ammonia solution as the nitrogen source avoids the use of high-pressure H_(2)and expensive amines,rendering the current catalytic process safe,economical,and environmentally friendly.In depth investigations attribute the improved separation and transfer of photogenerated charge carriers to the presence of oxygen vacancies and decorated Ni nanoparticles,thereby accelerating the production of imines from benzaldehyde amination(conversion,95.8%;seleetivity,95.2%).Furthermore,the developed system could be easily translated to the photocatalytic conversions of various biomass derived aldehydes,which provided an example of a cost-effective and sustainable approach for the valorization of biomass derived feedstocks.

关键词： Photocatalysis Biomass derivatives Imines Reduction amination Heterogeneous catalyst

lightweight Malicious Code Classification Method Based on Improved Squeeze Net

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Computers, Materials & Continua 2024年第1期78卷 551-567页

作者： li li Youran Kong qing Zhang School of Computer and Control Engineering Northeast Forestry UniversityHarbin150040China

With the growth of the Internet,more and more business is being done online,for example,online offices,online education and so on.While this makes people’s lives more convenient,it also increases the risk of the network being attacked by malicious code.Therefore,it is important to identify malicious codes on computer systems efficiently.However,most of the existing malicious code detection methods have two problems:(1)The ability of the model to extract features is weak,resulting in poor model performance.(2)The large scale of model data leads to difficulties deploying on devices with limited resources.Therefore,this paper proposes a lightweight malicious code identification model lightweight Malicious Code Classification Method Based on Improved SqueezeNet(LCMISNet).In this paper,the MFire lightweight feature extraction module is constructed by proposing a feature slicing module and a multi-size depthwise separable convolution module.The feature slicing module reduces the number of parameters by grouping features.The multi-size depthwise separable convolution module reduces the number of parameters and enhances the feature extraction capability by replacing the standard convolution with depthwise separable convolution with different convolution kernel sizes.In addition,this paper also proposes a feature splicing module to connect the MFire lightweight feature extraction module based on the feature reuse and constructs the lightweight model LCMISNet.The malicious code recognition accuracy of LCMISNet on the BIG 2015 dataset and the Malimg dataset reaches 98.90% and 99.58%,respectively.It proves that LCMISNet has a powerful malicious code recognition performance.In addition,compared with other network models,LCMISNet has better performance,and a lower number of parameters and computations.

关键词： lightweight neural network malicious code classification feature slicing feature splicing multi-size depthwise separable convolution

CBA: multi source fusion model for fast and intelligent target intention identification

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Journal of Systems Engineering and Electronics 2024年第2期35卷 406-416页

作者： wan Shichang li qingshan wanG Xuhua LU Nanhua School of Computer Science and Technology Xidian UniversityXi’an 710071China School of Mathematics and Computer Application Shangluo UniversityShangluo 726000China

How to mine valuable information from massive multisource heterogeneous data and identify the intention of aerial targets is a major research focus at present. Aiming at the longterm dependence of air target intention recognition, this paper deeply explores the potential attribute features from the spatiotemporal sequence data of the target. First, we build an intelligent dynamic intention recognition framework, including a series of specific processes such as data source, data preprocessing,target space-time, convolutional neural networks-bidirectional gated recurrent unit-atteneion (CBA) model and intention recognition. Then, we analyze and reason the designed CBA model in detail. Finally, through comparison and analysis with other recognition model experiments, our proposed method can effectively improve the accuracy of air target intention recognition,and is of significance to the commanders’ operational command and situation prediction.

关键词： intention massive data deep network artificial intelligence

Fusobacterium nucleatum-induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer

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World Journal of Gastroenterology 2024年第14期30卷 2018-2037页

作者： Qi-Long Wu Xiao-Ting Fang Xin-Xin wan qing-Yong Ding Yan-Jun Zhang ling Ji Yong-liang Lou Xiang li School of Laboratory Medicine and life Sciences Wenzhou Medical UniversityKey Laboratory of Laboratory MedicineMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of Health Inspection and Quarantine School of Laboratory Medicine and Life SciencesWenzhou 325035Zhejiang ProvinceChina School of Laboratory Medicine and life Sciences Wenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of General Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina School of Laboratory Medicine and life Sciences Institute of One HealthWenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of Health Inspection and Quarantine School of Laboratory Medicine and Life SciencesInstitute of One HealthWenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina

BACKGROUND Colorectal cancer(CRC)ranks among the most prevalent malignant tumors globally.Recent reports suggest that Fusobacterium nucleatum(F.nucleatum)contributes to the initiation,progression,and prognosis of CRC.Butyrate,a short-chain fatty acid derived from the bacterial fermentation of soluble dietary fiber,is known to inhibit various cancers.This study is designed to explore whether F.nucleatum influences the onset and progression of CRC by impacting the intestinal metabolite butyric acid.AIM To investigate the mechanism by which F.nucleatum affects CRC occurrence and development.METHODS Alterations in the gut microbiota of BALB/c mice were observed following the oral administration of F.nucleatum.Additionally,DLD-1 and HCT116 cell lines were exposed to sodium butyrate(NaB)and F.nucleatum in vitro to examine the effects on proliferative proteins and mitochondrial function.RESULTS Our research indicates that the prevalence of F.nucleatum in fecal samples from CRC patients is significantly greater than in healthy counterparts,while the prevalence of butyrate-producing bacteria is notably lower.In mice colonized with F.nucleatum,the population of butyrate-producing bacteria decreased,resulting in altered levels of butyric acid,a key intestinal metabolite of butyrate.Exposure to NaB can impair mitochondrial morphology and diminish mitochondrial membrane potential in DLD-1 and HCT116 CRC cells.Consequently,this leads to modulated production of adenosine triphosphate and reactive oxygen species,thereby inhibiting cancer cell prolif-eration.Additionally,NaB triggers the adenosine monophosphate-activated protein kinase(AMPK)signaling pathway,blocks the cell cycle in HCT116 and DLD-1 cells,and curtails the proliferation of CRC cells.The combined presence of F.nucleatum and NaB attenuated the effects of the latter.By employing small interfering RNA to suppress AMPK,it was demonstrated that AMPK is essential for NaB’s inhibition of CRC cell proliferation.CONCLUSION F.nucleatum can promote cancer progression through

关键词： Colorectal cancer Fusobacterium nucleatum Butyric acid Gut microbiota Adenosine monophosphate-activated protein kinase signal pathway