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Interleukin-34 promotes the proliferation and epithelial-mesenchymal transition of gastric cancer cells

World Journal of Gastrointestinal Oncology 2022年第10期14卷 1968-1980页

作者： Chuan-Hong Li Zhang-Ming Chen Pei-Feng Chen Lei Meng wan-nian sui Song-Cheng Ying A-Man Xu Wen-Xiu Han Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Immunology College of Basic MedicineAnhui Medical UniversityHefei 230022Anhui ProvinceChina

BACKGROUND Interleukin(IL)-34 is a pro-inflammatory cytokine involved in tumor development.The role of IL-34 in the proliferation and epithelial-mesenchymal transition(EMT)of gastric cancer(GC)remains to be investigated.AIM To investigate whether and how IL-34 affects the proliferation of GC cells and EMT.METHODS Using immunohistochemical staining,the expression of IL-34 protein was detected in 60 paired GC and normal paracancerous tissues and the relationship between IL-34 and clinicopathological factors was analyzed.The expression of IL-34 mRNA and protein in normal gastric epithelial cell lines and GC was detected using quantitative real-time polymerase chain reaction(qRT-PCR)and western blotting,respectively.Stable IL-34 knockdown and overexpression in AGS cell lines were established by lentiviral infection and validated by qRT-PCR and western blotting.The cholecystokinin-8 assay,clone formation assay,cell scratch assay,and transwell system were used to detect GC cell proliferation,clone formation,migration,and invasion capacity,respectively.The effects of IL-34 on the growth of GC transplant tumors were assessed using a subcutaneous transplant tumor assay in nude mice.The effects of IL-34 on the expression level of EMT-associated proteins in AGS cells were examined by western blotting.RESULTS Expression of IL-34 protein and mRNA was higher in GC cell lines than in GES-1 cells.Compared to matched normal paraneoplastic tissues,the expression of IL-34 protein was higher in 60 GC tissues,which was correlated with tumor size,T-stage,N-stage,tumor,node and metastasis stage,and degree of differentiation.Knockdown of IL-34 expression inhibited the proliferation,clone formation,migration,and invasion of AGS cells,while overexpression of IL-34 promoted cell proliferation,clone formation,migration,and invasion.Furthermore,the reduction of IL-34 promoted the expression of E-cadherin in AGS cells but inhibited the expression of vimentin and N-cadherin.Overexpression of IL-34 inhibited E-cadherin expression but promoted e

关键词： Gastric cancer Interleukin-34 Proliferation Epithelial-mesenchymal transition Metastasis

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Correction to “Interleukin-34 promotes the proliferation and epithelial-mesenchymal transition of gastric cancer cells”

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World Journal of Gastrointestinal Oncology 2023年第9期15卷 1673-1674页

作者： Chuan-Hong Li Zhang-Ming Chen Pei-Feng Chen Lei Meng wan-nian sui Song-Cheng Ying A-Man Xu Wen-Xiu Han Department of General Surgery First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Immunology College of Basic MedicineAnhui Medical UniversityHefei 230022Anhui ProvinceChina

Correction to“Interleukin-34 promotes the proliferation and epithelialmesenchymal transition of gastric cancer cells”.In this article,we found the following error in Figure 3A:The panel image"24 h,sh-RNA1"in the AGS cells wound healing assay was incorrectly inserted during the preparation of the submission;the correct figure is provided in this correction.

关键词： Correction Gastric cancer Interleukin-34 Proliferation Epithelialmesenchymal transition Metastasis

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Isolation of exogenous fungi from Notoginseng Radix et Rhizoma and preliminary analysis of toxigenic fungi

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Journal of Future Foods 2024年第2期4卷 179-182页

作者： Lei Zhou Xiangsheng Zhao Xiaomin Liu Hefang wan Chun sui Xuyu Chen Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of EducationNational Engineering Laboratory for Breeding of Endangered Medicinal MaterialsInstitute of Medicinal Plant Development(IMPLAD)Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine Hainan Branch of the Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeHaikou 570311China

Notoginseng Radix et Rhizoma(Sanqi in Chinese)is a precious traditional Chinese herbal medicine.It has the effect of dispersing blood stasis and stopping bleeding,reducing swelling and fixing pain.However,it tends to contaminate with harmful fungi during storage,which may make it much less effective.In order to understand the fungal contamination of Notoginseng Radix et Rhizoma and master its composition of the exogenous fungi.The surface fungi of Notoginseng Radix et Rhizoma samples collected from six Chinese provinces and districts were investigated by using dilution plate method.Detection of aflatoxins by UPLC-MS/MS.The results showed that Penicillium citrinum was dominantly isolated from Notoginseng Radix et Rhizoma samples from No.1 to No.4.Aspergillus flavus,which produces aflatoxin,was dominantly isolated from Notoginseng Radix et Rhizoma samples from No.5 and No.6.In addition,kinds of mycotoxin were assayed which were produced by three of those identified A.flavus.All three fungi strains produced aflatoxin B1(AFB1)and one strain HBSQ1-5 additionally produced other three kinds of mycotoxin,AFB2,AFG1 and AFG2.It is the results implied that it will be very important to take serious cautions when using Notoginseng Radix et Rhizoma.As well as,understanding the composition of the exogenous fungi of Notoginseng Radix et Rhizoma and the strains of toxin-producing fungi,which can play an important role in guiding the storage of Notoginseng Radix et Rhizoma.

关键词： Notoginseng Radix et Rhizoma Exogenous fungal Amplicon sequencing Mycotoxin

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Multiphysical contact of functionally graded magneto-electroelastic material with imperfect bonding interface

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Friction 2024年第4期12卷 632-654页

作者： Yijin sui Haibo ZHANG Jieliang ZHAO Wenzhong wanG School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China

Three-dimensional(3D)frictional contact model of functionally graded magneto-electro-elastic(FGMEE)material with a conducting spherical punch under electromagnetic fields is presented.Two types of imperfect bonding interface of layers,dislocation-like interface and force-like interface,are considered.Frequency response functions(FRFs)for multilayered MEE material with imperfect interface subjected to unit mechanical,electric,and magnetic loads are derived.The FRFs are used with the semi-analytical method(SAM)to solve present multiphysical contact problem.The present model is verified by comparing with literatures and the finite element method(FEM)and used to study the contact problem of FGMEE film imperfectly bonded on homogenous MEE half-space under electromagnetic fields.Parametric studies are conducted to reveal the effects of imperfect interfaces and also film properties including gradient index and thickness.

关键词： frictional contact magneto-electro-elastic material imperfect interface functionally graded electromagnetic fields

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Peptide drugs: a new direction in cancer immunotherapy

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Cancer Biology & Medicine 2024年第3期21卷 198-203页

作者： Xinghua sui Xiaoshuang Niu Xiuman Zhou Yanfeng Gao School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China

Cancer immunotherapy has emerged as a promising approach in cancer treatment and is considered a major advancement after surgical interventions, radiotherapy, chemotherapy, and targeted therapy. The clinical use of im... 详细信息

关键词： drugs immunotherapy cancer

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Surface engineering with ionic polymers on membranes for boron removal

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Frontiers of Chemical Science and Engineering 2024年第5期18卷 61-69页

作者： Xiting Zhang Chenyi Fang J Paul Chen sui Zhang Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117576Singapore Department of Civil and Environmental Engineering National University of SingaporeSingapore 119260Singapore College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China

Removal of boric acid from seawater and wastewater using reverse osmosis membrane technologies is imperative and yet remains inadequately addressed by current commercial membranes.Existing research efforts performed post-modification of reverse osmosis membranes to enhance boron rejection,which is usually accompanied by substantial sacrifice in water permeability.This study delves into the surface engineering of low-pressure reverse osmosis membranes,aiming to elevate boron removal efficiency while maintaining optimal salt rejection and water permeability.Membranes were modified by the self-polymerization and co-deposition of dopamine and polystyrene sulfonate at varying ratios and concentrations.The surfaces became smoother and more hydrophilic after modification.The optimum membrane exhibited a water permeability of 9.2±0.1 L·m^(-2)·h^(-1)·bar^(-1),NaCl rejection of 95.8%±0.3%,and boron rejection of 49.7%±0.1%and 99.6%±0.3%at neutral and alkaline pH,respectively.The water permeability is reduced by less than 15%,while the boron rejection is 3.7 times higher compared to the blank membrane.This research provides a promising avenue for enhancing boron removal in reverse osmosis membranes and addressing water quality concerns in the desalination process.

关键词： membrane low-pressure reverse osmosis boron surface engineering

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Characteristics of turbulent flow in 3-D pools in the presence of submerged rigid vegetation in channel bed

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Journal of Hydrodynamics 2024年第1期36卷 158-169页

作者： Kourosh Nosrati Hossein Afzalimehr Jueyi sui Hamid Reza Reisifar Natural Disasters Prevention Research Center Faculty of Civil EngineeringIran University of Science and TechnologyTehranIran School of Engineering University of Northern British ColumbiaPrince GeorgeCanada

In this study,the interaction between 3-D bedforms and submerged rigid vegetation has been investigated.Various laboratory experiments were conducted to study the distribution of flow velocity,Reynolds shear stress,turbulent kinetic energy,and skewness coefficients for a constant density of vegetation.Results showed that the velocity profile in the pool section deviates from those in the upstream section of the pool.It has been found that the dip parameter varied between 0.6H and 0.9H depending on various factors including bed roughness,vegetation distribution,and pool entrance/exit slopes.However,scattered vegetation in the pool and differences in slopes created non-uniform flow conditions.Also,in the wake region behind each vegetated element,flow velocity reduced significantly,and small-scale eddies are formed,causing increased perturbations.By decreasing the entrance slope and bed roughness,relatively uniform flow and weaker turbulence was resulted,but the random distribution of vegetated elements counteracted this balance and intensified turbulence.With the decrease in the pool entrance slope,the contribution of sweep event decreased and the contribution of ejection event increased.

关键词： Submerged rigid vegetation 3-D pool Reynolds shear stress skewness coefficients

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What induced the trend shift of mixed-layer depths in the Antarctic Circumpolar Current region in the mid-1980s?

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Acta Oceanologica Sinica 2024年第1期43卷 11-21页

作者： Shan Liu Jingzhi Su Huijun wang Cuijuan sui Key Laboratory of Marine Hazards Forecasting National Marine Environmental Forecasting CenterMinistry of Natural ResourcesBeijing 100081China Center for Earth System Modeling and Prediction of CMA Beijing 100081China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing 210044China Nansen-Zhu International Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

An obvious trend shift in the annual mean and winter mixed layer depth(MLD)in the Antarctic Circumpolar Current(ACC)region was detected during the 1960–2021 period.Shallowing trends stopped in mid-1980s,followed by a period of weak trends.The MLD deepening trend difference between the two periods were mainly distributed in the western areas in the Drake Passage,the areas north to Victoria Land and Wilkes Land,and the central parts of the South Indian sector.The newly formed ocean current shear due to the meridional shift of the ACC flow axis between the two periods is the dominant driver for the MLD trends shift distributed in the western areas in the Drake Passage and the central parts of the South Indian sector.The saltier trends in the regions north to Victoria Land and Wilkes Land could be responsible for the strengthening mixing processes in this region.

关键词： mixed layer depth trend shift Antarctic Circumpolar Current(ACC) flow axis

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Molecular mechanisms of stress resistance in sorghum: Implications for crop improvement strategies

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Journal of Integrative Agriculture 2024年第3期23卷 741-768页

作者： Hongxiang Zheng Yingying Dang Xianmin Diao Na sui Shandong Provincial Key Laboratory of Plant Stress/College of life Sciences Shandong Normal UniversityJinan 250014China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China

Abiotic stresses, such as drought, salt, extreme temperatures, and heavy metal pollution, are the main environmental factors that limit crop growth and yield. Sorghum, a C4 grass plant with high photosynthetic efficiency, can grow in adverse environmental conditions due to its excellent stress resistance characteristics. Therefore, unraveling the stress-resistance mechanism of sorghum could provide a theoretical basis for developing and cultivating various stress-resistant crops. This understanding could also help to create a conducive environment for using marginal soil in agriculture and ensuring food security. In this review, we discuss the adaptation mechanisms of sorghum under drought, salinity, temperature, and soil heavy metal stresses, the specific response to stress, the screening of sorghum-resistant germplasm, and the identification and functional analysis of the relevant genes and quantitative trait loci(QTL). In addition, we discuss the application potential of different stress-tolerant sorghum germplasms reported to date and emphasize the feasibility and potential use in developing and promoting highly stress-tolerant sorghum in marginal soil.

关键词： abiotic stress C4 plants QTL sorghum stress resistance yield stability

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Non-equilibrium kinetic separation of thulium,yttrium and erbium on the surface of freely rising oil droplets

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Journal of Rare Earths 2024年第1期42卷 200-209,I0007页

作者： Na sui Shukai Miao Kaihui Cui Fancheng Meng Kun Huang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Green Recovery and Extraction of Rare and Precious Metals University of Science and Technology BeijingBeijing100083China Key Laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China

It is difficult to achieve selective separation and enrichment of different rare earths from high abundance yttrium ores efficiently only dependent on their discrepancy in thermodynamic properties.The present work suggests a new strategy based on non-equilibrium kinetic separation of Er and Tm on the surface of freely rising oil droplets to control the separation order of Y.It is revealed that the mutual separation of Er/Tm is significantly promoted with the separation coefficient of 2.89 during the non-equilibrium extraction with the addition of diethylenetriaminepentaacetic acid(DTPA).The extraction sequence of Tm,Er and Y can be controlled as Tm>Y>Er,thus Y can be selectively enriched during the process of separation of Er and Tm,Such a sequence is subject to the controllable dissociation rates of RE(Ⅲ)-DTPA complexes and extraction abilities of P507 with the three RE(Ⅲ)ions.The dissociation rate is dependent on the stabilities of RE(Ⅲ)-DTPA complexes and follows the sequence ofY(Ⅲ)—DTPA Er>Y to Tm>Y>Er.

关键词： DTPA Interface interaction Non-equilibrium kinetic separation Rare earths P507

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