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Association of choroidal thickness with early stages of diabetic retinopathy in type 2 diabetes

International Journal of Ophthalmology(English edition) 2017年第4期10卷 613-618页

作者： Zhi-Jun Shen Xiu-Fen Yang Jun Xu Chong-Yang She Wen-Wen Wei wan-lu zhu Ning-Pu Liu Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology & Visual Science Key Lab Department of Ophthalmology the Friendship HospitalCapital Medical University

AIM：To assess the correlation between choroidal thickness（CT） and the early stages of diabetic retinopathy（DR） in type 2 diabetic ***：We divided 83 diabetic patients（51-80 years of age;50 females） into non diabetic retinopathy group（NDR） and mild/moderate nonproliferative diabetic retinopathy（NPDR） group,and compared them with 26 non-diabetic control subjects（51-78 years of age;16 females）.Subfoveal choroidal thickness（SFCT） and parafoveal choroidal thickness（PFCT） were measured using enhanced depth imaging spectral-domain optical coherence tomography（EDI-OCT）.Ocular health status,disease duration,body mass index,and hemoglobin A1c（Hb A1c） were ***：The mean ages of the NDR,NPDR,and control groups were 68.0±6.9y,67.8±6.4y,and 65.1±6.3y,respectively（P=0.17）.Pearson correlation of the right and left eyes for the control subjects was 0.95 and for the NDR subjects was *** for the right eyes of the controls was 252.77± 41.10 μm,which was significantly thicker than that of the right eyes in NDR group（221.51±46.56 μm） and the worse eyes of the NPDR group（207.18±61.87 μm;ANOVA,P〈0.01）.In the diabetic patients pooled together,age was the only variable significantly associated with SFCT（multiple linear regression analysis,P=0.01）.CONCluSION：CT decreased significantly in the NDR and mild/moderate NPDR eyes compared with the control *** is significantly associated with SFCT in the diabetic *** choroidopathy may be present before clinical retinopathy.

关键词： choroidal thickness diabetic choroidopathy diabetic retinopathy

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Nanoparticles for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di lu Jiuping Wu Fuming Liang Huayi wang Junjie Yang Ganggang Zhang Chen wang Yanlian Yang Ling zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

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Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang Zhenjie lu Yanwen Ding Shujun Liu Zhijie Qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen Sun Liang Xue Wenyao Zhang Pan Xiong Xin wang Junwu zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Ductility

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大悬挑钢结构整体施工技术研究

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建筑技术开发 2023年第12期50卷 61-63页

作者：陈伟夏春阳陆万柱中建科技集团有限公司深圳518000

深圳市坪山区生物医药产业加速器园区项目1号楼超高层存在悬挑钢结构桁架,研究了大悬挑钢结构施工流程、主要施工技术、临时支撑及卸荷技术等内容,以期为类似工程提供参考。

关键词：悬挑钢结构施工流程施工技术临时支撑

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Spatio-temporal patterns and climatic drivers of spring phenology in eight forest communities across the north-south transitional zone of China

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Journal of Geographical Sciences 2025年第1期 17-38页

作者： zhu Wenbin lu Yu Institute of Geographic Sciences and Natural Resources Research CAS School of Geographical Science Nanjing University of Information Science & Technology

The Qinba Mountains are climatically and ecologically recognized as the northsouth transitional zone of *** of its phenology is critical for comprehending the response of vegetation to climatic *** retrieved the start of spring phenology （SOS）of eight forest communities from the MODIS products and adopted it as an indicator for spring *** analysis,partial correlation analysis,and Geo Detector were employed to reveal the spatio-temporal patterns and climatic drivers of *** results indicated that the SOS presented an advance trend from 2001 to 2020,with a mean rate of–0.473 d yr–*** SOS of most forests correlated negatively with air temperature （TEMP） and positively with precipitation （PRE）,suggesting that rising TEMP and increasing PRE in spring would forward and delay SOS,*** dominant factors influencing the sensitivity of SOS to climatic variables were altitude,forest type,and latitude,while the effects of slope and aspect were relatively *** response of SOS to climatic factors varied significantly in space and among forest communities,partly due to the influence of altitude,slope,and aspect.

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Laser assisted phase transformation of carbon-based transition metal oxide electrode for high-performance supercapacitor application

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Science China Chemistry 2025年

作者： Mingzhen Xiu Jianghong Zhang Yu lu Xun Cao Kang Huang Siyu zhu Bowei Zhang Yu Liang Chunwang Zhao Junsheng Wu Yizhong Huang School of Materials Science and Engineering Nanyang Technological University Energy Research Institute Interdisciplinary Graduate Programme Nanyang Technological University Institute of Sustainability for Chemicals Energy and Environment Agency for Science Technology and ResearchSingapore Institute of Advanced Materials and Technology University of Science and Technology Beijing School of Materials Science and Technology Shenyang University of Chemical Technology School of Materials Science and Hydrogen Energy Foshan University

Transitional metal oxides have a wide range of applications due to their superior *** enhanced performance of metal oxide relies on their desirable oxidation states,which is challenging to achieve and requires complex *** study demonstrates a facile strategy enabling rapid phase transformation of transition metal *** approach involves synthesis of a tetragonal Mn3O4/carbon cloth composite using the liquid plasma discharge deposition （LPDD） technique,followed by laser irradiation with the presence of ethylene glycol under an N2gas *** resulting face-centered cubic MnO/carbon cloth electrode exhibits an excellent capacitance of 1,125 F g-1at 2 A g-1,with remarkable capacitance retention of 95%after10,000 *** approach can be extended to other transition metals including Co,Cu,Cr,Fe,Ni,and *** simulations reveal the significance of ethylene glycol and the underlying mechanism associated with the phase transformation of transition metal *** present study offers a powerful technique for the phase transformation of transition metal oxide which can guide the development of new electrode materials with enhanced electrochemical properties for high-performance energy storage applications.

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南宁市居民结核病核心信息知晓率影响因素分析

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医学动物防制 2022年第10期38卷 1000-1004页

作者：黄家运卢永霞陈世艺吴小玲谢柳媛陆婉珠黎舒南宁市疾病预防控制中心广西530023 广西中医药大学广西艺术学院

目的了解南宁市居民结核病核心信息知晓现况,并探讨其影响因素,为相关政府和民间组织等开展结核病防治工作提供理论参考。方法2020年12月—2021年1月,采用多阶段按比例分层随机抽样方法,抽取南宁市2个县区调查点的250名调查对象进行问... 详细信息

目的了解南宁市居民结核病核心信息知晓现况,并探讨其影响因素,为相关政府和民间组织等开展结核病防治工作提供理论参考。方法2020年12月—2021年1月,采用多阶段按比例分层随机抽样方法,抽取南宁市2个县区调查点的250名调查对象进行问卷调查。结果南宁市居民5条主要核心信息总知晓率为88.67%(1064/1200),全部核心信息知晓率为66.25%。单项核心信息知晓情况调查显示,居民对了解结核病是“慢性传染性疾病”知晓率最高(93.33%),对结核病“坚持治疗,大多可治愈”知晓率最低(79.58%)。多因素二元logistic回归分析结果显示,民族、年龄、文化程度为居民结核病防治知识了解程度的影响因素,其中高中及同等学历者对结核病全部核心信息知晓率为文盲与半文盲的18.616倍(OR=18.616,95%CI:5.463~63.441)。结论南宁市居民结核病防治知识了解程度有待进一步提高,应根据不同人群特点紧扣居民需求,采取针对性的、多样化的宣教方式,逐步提高居民对结核病核心信息的认知水平。

关键词：结核病核心信息知晓率问卷调查居民影响因素分析

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实测实量机器人在坪山生物医药产业加速器园区项目中的应用

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工程建设与设计 2022年第17期 163-166页

作者：陆万柱陈伟雷俊田璐璐夏春阳中建科技集团有限公司深圳分公司广东深圳518000

介绍了实测实量机器人的研发思路、创新性能,从项目概况、应用设计、测量过程、测量结果 4方面对实测实量机器人在坪山生物医药产业加速器园区项目中的应用进行详细分析,并对其应用效果进行总结与展望。

关键词：实测实量机器人研发思路创新性能应用效果

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Orbitronics for energy-efficient magnetization switching

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Science China(Information Sciences) 2025年第1期 398-399页

作者： Yuxuan YAO Daoqian zhu Qingtao XIA Jianing LIANG Yuhao JIANG Zhiyang PENG Jiaxu LI Chen XIAO Renyou XU Wenwen wanG Xiantao SHANG Shiyang lu Dapeng zhu Hong-Xi LIU Kaihua CAO Weisheng ZHAO Fert Beijing Institute School of Integrated Circuit Science and Engineering Beihang University National Key Lab of Spintronics Institute of International Innovation Beihang University Qingdao Research Institute Beihang University Truth Memory Corporation

Spin-orbit torque （SOT）,as a promising writing method for magnetic random-access memory （MRAM）,has garnered widespread interest for over a decade [1].Heavy metals,such as β-W,have been broadly adopted as spin current sources,but suffer from phase change at a limited thickness,resulting in a dramatic reduction of the charge-tospin conversion efficiency θSH[2].The thickness limitation leads to stringent etching conditions and large distribution among devices,posing challenges for simultaneously satisfying SOT efficiency,etching-stop margins,and back-end-ofline （BEOL） compatibility.

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生物医药厂房结构施工安全风险管控

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建筑技术开发 2024年第3期51卷 145-147页

作者：陆万柱朱朝聪陈伟夏春阳中建科技集团有限公司深圳分公司广东深圳518118

以坪山生物医药产业加速器园区项目结构施工为例,针对装配式群体结构在施工过程中主要存在的安全隐患进行了识别和判断,介绍了相应的安全管理措施和创新技术,主要包括群塔作业及各类安全防护措施。经项目实际应用,采用的管理措施和技术... 详细信息

以坪山生物医药产业加速器园区项目结构施工为例,针对装配式群体结构在施工过程中主要存在的安全隐患进行了识别和判断,介绍了相应的安全管理措施和创新技术,主要包括群塔作业及各类安全防护措施。经项目实际应用,采用的管理措施和技术手段,在满足现场安全施工的前提下,达到了节约成本的功效。在施工过程中大体量地使用装配式施工技术,实现了已使用的材料可达到多次周转使用的目的,具有绿色环保、安全可靠等特点,更好地保证了本工程施工的顺利进行,可为类似工程提供借鉴。

关键词：装配式结构风险分类安全管理与创新

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