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Efficacy and Safety of Teriflunomide in Chinese Patients with Relapsing Forms of Multiple Sclerosis: A Subgroup Analysis of the Phase 3 TOWER Study

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Chinese Medical Journal 2018年第23期131卷 2776-2784页

作者： Wei Qiu De-Hui Huang Shi-Fang Hou Mei-Ni Zhang Tao Jin Hui-Qing dong Hua Peng Chao-dong Zhang Gang Zhao Yi-Ning Huang dong Zhou Wei-Ping Wu Bao-Jun wang Ji-Mei li Xing-Hu Zhang Yan Cheng Hai-Feng li ling li Chuan-Zhen Lu Xu Zhang Bi-Tao Bu wan-li dong dong-Sheng Fan Xue-Qiang Hu Xian-Hao Xu Department of Neurology The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510000China Department of Neurology Peking University First HospitalBeijing 100034China Department of Neurology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Neurology Baotou Central HospitalBaotouInner Mongolia 014040China Department of Neurology Beijing Friendship HospitalCapital Medical UniversityBeijing 100000China Department of Neurology Beijing Tian Tan HospitalCapital Medical UniversityBeijing 100050China Department of Neurology Tianjin Medical University General HospitalTianjin 300052China Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong 266003China Department of Neurology Hebei General HospitalShijiazhuangHebei 050051China Department of Neurology Hua Shah Hospital of the Shanghai Fudan University Medical CollegeShanghai 200040China Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China Department of Neurology Chinese People's Liberation Army General HospitalBeijing 100853China Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Neurology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215000China Department of Neurology Beijing HospitalNational Center of GerontologyBeijing 100083China Qilu Hospital of Shandong University JinanShandong 250012China Department of Neurology Beijing HospitalBeijing 100730China Department of Neurology The First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Neurology The First Hospital of Jilin UniversityChangchunJilin 130012China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Neurology Shanghai Chang Zheng HospitalShanghai 200003China Department of Neurology The First Hospital of China Medical UniversityShenyang

Background:Disease-modifying therapy is the standard treatment for patients with multiple sclerosis (MS)in *** primary objective of the current analysis was to assess the efficacy and safety of two teriflunomide doses (7mg and 14mg)in the subgroup of Chinese patients with relapsing MS included in the TOWER study. Methods:TOWER was a multicenter,multinational,randomized, double-blind,parallel-group (three groups),placebo-controlled *** subgroup analysis includes 148 Chinese patients randomized to receive either teriflunomide 7mg (n =51), teriflunomide 14mg (n=43),or placebo (n=54). Results:Of the 148patients in the intent-to-treat population, adjusted annualized-relapse rates were 0.63(95% confidence interval [CI]:0.44,0.92)in the placebo group,0.48(95%CI:0.33, 0.70)in the teriflunomide 7mg group,and 0.18(95%CI:0.09,0.36)in the terifltmomide 14mg group;this corresponded to a significant relative risk reduction in the teriflunomide 14mg group versus placebo (-71.2%,P =0.0012).Terifiunomide 14mg also tended to reduce 12-week confirmed disability worsening by 68.1% compared with placebo (hazard ratio:0.319,P =0.1194).There were no differences across all treatment groups in the proportion of patients with treatment-emergent adverse events (TEAEs;72.2% in the placebo group,74.5%in the teriflunomide 7mg group,and 69.8% in the teriflunomide 14mg group);corresponding proportions for serious adverse events were 11.1%,3.9%,and 11.6%,*** most frequently reported TEAEs with teriflunomide versus placebo were neutropenia,increased alanine aminotransferase,and hair thinning. Conclusions:Teriflunomide was as effective and safe in the Chinese subpopulation as it was in the overall population of patients in the TOWER *** has the potential to meet unmet medical needs for MS patients in China.

关键词： Chinese Patients Efficacy Phase 3 Relapsing Multiple Sclerosis Safety Teriflunomide TOWER

Effect of lamellarization on the microstructure and mechanical properties of marine 10Ni5CrMoV steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 402-413页

作者： Tao Zou Yanwu dong Zhouhua Jiang Shuyang Du Yushuo li School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Key Laboratory for Ecological Metallurgy of Multimetallic Ores(Ministry of Education) Northeastern UniversityShenyang 110819China

Multistage heat treatment involving quenching(Q),lamellarizing(L),and tempering(T)is applied to marine 10Ni5CrMoV *** microstructure and mechanical properties were studied by multiscale characterizations,and the kinetics of reverse austenite transformation,strain hardening behavior,and toughening mechanism were further *** lamellarized specimens possess low yield strength but high toughness,especially cryogenic *** leads to the development of film-like reversed austenite at the martensite block and lath boundaries,refining the martensite structure and lowering the equivalent grain *** analysis of austenite reversion based on the JMAK model shows that the isothermal transformation is dominated by the growth of reversed austenite,and the maximum transformation of reversed austenite is reached at the peak temperature(750℃).The strain hardening behavior based on the modified Crussard-Jaoul analysis indicates that the reversed austenite obtained from lamellarization reduces the proportion of martensite,significantly hindering crack propagation via martensitic transformation during the *** a consequence,the QLT specimens exhibit high machinability and low yield *** with the QT specimen,the ductile-brittle transition temperature of the QLT specimens decreases from-116 to-130℃due to the low equivalent grain size and reversed austenite,which increases the cleavage force required for crack propagation and absorbs the energy of external load,*** work provides an idea to improve the cryogenic toughness of marine 10Ni5CrMoV steel and lays a theoretical foundation for its industrial application and comprehensive performance improvement.

关键词： 10Ni5CrMoV steel lamellarizing reversed austenite cryogenic toughness ductile-brittle transition temperature

基于Er^(3+)∶YAlO_3/TiO_2的可见光催化降解室内甲醛

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发光学报 2015年第7期36卷 769-774页

作者：周娴董山山董双石刘耀辉万立东吉林大学地下水资源与环境教育部重点实验室吉林长春130021

为使TiO2能够在可见光下发挥其于紫外激发的高光催化活性降解室内甲醛,采用水热处理法将TiO2与掺杂稀土离子Er3+的上转换发光剂Er3+∶YAlO3结合,制备具有可见光响应的Er3+∶YAlO3/TiO2光催化剂,并对其进行了表征分析。结果表明,TiO2以... 详细信息

为使TiO2能够在可见光下发挥其于紫外激发的高光催化活性降解室内甲醛,采用水热处理法将TiO2与掺杂稀土离子Er3+的上转换发光剂Er3+∶YAlO3结合,制备具有可见光响应的Er3+∶YAlO3/TiO2光催化剂,并对其进行了表征分析。结果表明,TiO2以锐钛矿为主,且Er3+∶YAlO3可有效地将可见光上转换至可激发TiO2的紫外光。在箱式反应器中进行光催化降解气态甲醛,研究了甲醛初始浓度与催化剂用量对甲醛降解效率的影响。结果表明,该光催化反应的假一级反应速率常数(kapp)与甲醛初始浓度成正相关,而随催化剂用量的增加先升高后降低。当甲醛初始浓度为0.058 mg/m3、催化剂用量为0.122 4 g/L时,kapp最大为3.65×10-3min-1。该反应符合Langmuir-Hinshelwood模型,反应速率常数为5×10-8mg/(L·min)。

关键词：上转换发光剂 TiO2 可见光催化甲醛

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桡尺远侧关节不稳的研究进展

中国临床解剖学杂志 2017年第5期35卷 596-598页

作者：兰万利黄东南华大学附属广东省第二人民医院广州510317

桡尺远侧关节（distal radioulnar joint,DRUJ）又称远端尺桡关节,是由桡骨的乙状切迹和尺骨小头、尺骨小头和三角纤维软骨复合体（triangular fibrocartilage complex,TFCC）组成的双枢滑膜关节。和近端桡尺关节、前臂骨间膜共同连接... 详细信息

桡尺远侧关节（distal radioulnar joint,DRUJ）又称远端尺桡关节,是由桡骨的乙状切迹和尺骨小头、尺骨小头和三角纤维软骨复合体（triangular fibrocartilage complex,TFCC）组成的双枢滑膜关节。和近端桡尺关节、前臂骨间膜共同连接尺、桡骨,承担前臂旋转活动和腕关节桡尺偏的侧方活动,还能传导关节间的负荷。DRUJ不稳是一个常见的临床问题,本文总结国内外文献的相关研究，对DRUJ的解剖基础、诊断依据、损伤分型、治疗进展及问题与展望作一综述。

关键词：桡尺远侧关节关节不稳三角纤维软骨复合体尺骨小头前臂骨间膜尺桡关节乙状切迹滑膜关节

Microstructural evolution during the progressive transformation-induced plasticity effect in a Fe-0.1C-5Mnmedium manganese steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 369-379页

作者： Mei Zhang Wenhao li Yangfei Chen Yang Jiang Xiaofei Guo Han dong School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile ***-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation *** findings were discussed with the local strain measurements via digital image *** results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of *** small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier *** volume fraction of RA gradually decreased from 26.8%to 8.2%prior to *** the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.

关键词： medium-Mn steel retained austenite progressive transformation-induced plasticity effect local strain fracture initiation

A Strong Robust Watermarking Algorithm Based on Twice Arnold Transform in DCT Domain

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A Strong Robust Watermarking Algorithm Based on Twice Arnold...

Low-temperature chlorination roasting technology for the simultaneous recovery of valuable metals from spent liCoO_(2)cathode material

教育部中南地区高等学校电子电气基础课教学研究会第二十届...

作者： Chen wan-li~1,Yang dong~2 (College of Information Engineering,Huanghe S&T College,China)

In this paper,a new kind of robust watermarking algorithm based on twice Arnold Transform in DCT domain of image is *** algorithm makes use of twice Arnold Transform(AT),one applied to the carrier image and the other to the digital watermarking *** how many times twice AT process respectively can be obtained by offering to AT periods listed in *** first AT on carrier image is to enhance the texture and then the DCT coefficients can be increased *** can efficiently improve the robustness of watermark *** the same time,this process also increases *** second one on watermarking image is to scramble it to improve *** dividing the carrier image into blocks and implementing DCT transform to each block,the watermark is embedded into the appropriate frequency *** the watermarking image from the watermarked image is a reverse *** the secret key must be obtained *** results indicate that this algorithm can keep invisibility of the watermarking and can also strengthen the robustness of watermarking against generalimage attacks,such as noise’addition,filtering,JPEG compression and so *** addition,we use PSNR(Peak Signal Noise Ratio) to evaluate the invisibility and NC(Normalized Correlation) to evaluate the effect of watermarking extraction.

关键词： algorithm digital watermarking DCT transform

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 80-91页

作者： Junjie Shi Changle Hou Jingjing dong dong Chen Jianzhong li Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

With the continuous increase in the disposal volume of spent lithium-ion batteries(liBs),properly recycling spent liBs has become essential for the advancement of the circular *** study presents a systematic analysis of the chlorination roasting kinetics and proposes a new two-step chlorination roasting process that integrates thermodynamics for the recycling of liB cathode *** activation energy for the chloride reaction was 88.41 kJ/mol according to thermogravimetric analysis–derivative thermogravimetry data obtained by using model-free,model-fitting,and Z(α)function(αis conversion rate).Results indicated that the reaction was dominated by the first-order(F1)model when the conversion rate was less than or equal to 0.5 and shifted to the second-order(F2)model when the conversion rate exceeded *** conditions were determined by thoroughly investigating the effects of roasting temperature,roasting time,and the mass ratio of NH_(4)Cl to liCoO_(2).Under the optimal conditions,namely 400℃,20 min,and NH_(4)Cl/liCoO_(2)mass ratio of 3:1,the leaching efficiency of li and Co reached 99.43% and 99.05%,*** of the roasted products revealed that valuable metals in liCoO_(2)transformed into CoCl_(2) and ***,the reaction mechanism was elucidated,providing insights for the establishment of a novel low-temperature chlorination roasting technology based on a crystal structure *** technology can guide the development of liB recycling processes with low energy consumption,low secondary pollution,high recovery efficiency,and high added value.

关键词： spent lithium-ion battery thermodynamics chlorination roasting kinetics circular economy

试论开展城市亚健康人群健康状态的社会预警监测

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中国医科大学学报 2009年第1期38卷 68-69页

作者：李万冬王涛王昕中国医科大学校长办公室沈阳110001 中国医科大学学报编辑部沈阳110001 中国医科大学社会科学部沈阳110001

目的探讨建立亚健康状态的社会预警机制的必要性及其重大意义。方法选择城市不同职业人群作为研究对象,将年龄、职业、职业因素、生活因素和生活事件等影响因素作为重要参数,观察城市亚健康人群的生命质量。通过调查城市亚健康人群生命... 详细信息

目的探讨建立亚健康状态的社会预警机制的必要性及其重大意义。方法选择城市不同职业人群作为研究对象,将年龄、职业、职业因素、生活因素和生活事件等影响因素作为重要参数,观察城市亚健康人群的生命质量。通过调查城市亚健康人群生命质量,分析不同职业亚健康人群所处的"健康"状态,确定亚健康人群生命质量的量化分级标准,健康状态—亚健康状态-疾病状态。结果建立城市亚健康人群生命质量多级预警模型超越了对传统亚健康概念的界定,是从新角度对亚健康问题的再审视。亚健康状态的社会预警机制的建立将为今后开展健康干预研究提供重要信息,为合理分配卫生资源提供科学依据。结论全社会高度重视城市亚健康人群的生命质量状态,把包括卫生资源在内的社会资源合理应用于亚健康人群,竭力避免和降低"亚健康"向疾病方向移行或重叠。

关键词：亚健康预警监测城市人群

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北京市院前急救患者流行病学分析

中华急诊医学杂志 2007年第5期16卷 551-553页

作者：万立东李贝刘小龙北京急救中心急诊科北京100031

目的了解北京市院前急救患者流行病学特点。方法采用前瞻性资料收集的方法,对2005年度北京"120"受理出诊患者的性别、年龄、出诊目的主诉等进行调查,并统计分析。结果本组资料是全年"120"受理后出诊患者。男女比例1.93:1。高发年龄为70... 详细信息

目的了解北京市院前急救患者流行病学特点。方法采用前瞻性资料收集的方法,对2005年度北京"120"受理出诊患者的性别、年龄、出诊目的主诉等进行调查,并统计分析。结果本组资料是全年"120"受理后出诊患者。男女比例1.93:1。高发年龄为70岁以上。心脑血管疾病患者占第一位(28.23%)。7、8、11、12、1月份出诊患者最多。8:00～24:00为出诊高峰时间。结论(1)要重视民众心脑血管疾病的预防保健教育。(2)提高院前救治技术和仪器装备水平。(3)建立心脑血管疾病院前急救与院内急诊抢救绿色通道势在必行。(4)根据呼叫出诊密度,科学合理安排工作。(5)完善救援应急预案,装备应对不同类灾种的救援器材。

关键词：患者院前急救流行病学