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Dysfunction of hippocampal interneurons in epilepsy

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Neuroscience Bulletin 2014年第6期30卷 985-998页

作者： Yu-Qiang liu Fang Yu wan-hong liu Xiao-Hua He Bi-Wen Peng Department of Physiology School of Basic Medical SciencesWuhan University Department of Pathology Zhongnan Hospital of Wuhan University Department of Immunology School of Basic Medical SciencesWuhan University Department of Pathophysiology School of Basic Medical SciencesWuhan University

Gamma-amino-butyric acid（GABA）-containing interneurons are crucial to both development and function of the brain. Down-regulation of GABAergic inhibition may result in the generation of epileptiform activity. Loss, axonal sprouting, and dysfunction of interneurons are regarded as mechanisms involved in epileptogenesis. Recent evidence suggests that network connectivity and the properties of interneurons are responsible for excitatory-inhibitory neuronal circuits. The balance between excitation and inhibition in CA1 neuronal circuitry is considerably altered during epileptic changes. This review discusses interneuron diversity, the causes of interneuron dysfunction in epilepsy, and the possibility of using GABAergic neuronal progenitors for the treatment of epilepsy.

关键词： interneuron diversity therapy GABA progenitor cell

Complement C3 Aggravates Post-epileptic Neuronal Injury Via Activation of TRPV1

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Neuroscience Bulletin 2021年第10期37卷 1427-1440页

作者： Guang-Tong Jiang Lin Shao Shuo Kong Meng-liu Zeng Jing-Jing Cheng Tao-Xiang Chen Song Han Jun Yin wan-hong liu Xiao-Hua He Yu-Min liu Lanzi Gongga Bi-Wen Peng Department of Physiology Hubei Provincial Key Laboratory of Developmentally Originated DiseaseSchool of Basic Medical SciencesWuhan UniversityWuhan 430071China Department of Pathophysiology School of Basic Medical SciencesWuhan UniversityWuhan 430071China Department of Immunology School of Basic Medical SciencesWuhan UniversityWuhan 430071China Department of Neurology Zhongnan HospitalWuhan UniversityWuhan 430071China Medical College Tibet UniversityLhasa 850013China

Epilepsy is a brain condition characterized by the recurrence of unprovoked *** studies have shown that complement component 3(C3)aggravate the neuronal injury in *** our previous studies revealed that TRPV1(transient receptor potential vanilloid type 1)is involved in *** complement C3 regulation of neuronal injury is related to the activation of TRPV1 during epilepsy is not fully *** found that in a mouse model of status epilepticus(SE),complement C3 derived from astrocytes was increased and aggravated neuronal injury,and that TRPV 1-knockout rescued neurons from the injury induced by complement *** RNAs are abundant in the brain,and the reduction of circRad52 caused by complement C3 promoted the expression of TRPV 1 and exacerbated neuronal ***,disorders of neuron-glia interaction mediated by the C3-TRPV1 signaling pathway may be important for the induction of neuronal *** study provides support for the hypothesis that the C3-TRFV1 pathway is involved in the prevention and treatment of neuronal injury and cognitive disorders.

关键词： TRPV 1 Complement C3 Epilepsy CircRad52 Cognitive disorder

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综合治疗儿童屈光参差性弱视的临床分析

国际眼科杂志 2010年第12期10卷 2365-2366页

作者：彭芬刘万红武汉大学基础医学院中国湖北省武汉市430071 湖北民族学院附属医院儿科中国湖北省恩施州445000

目的:评价综合治疗儿童屈光参差性弱视的临床疗效。方法:选择2005-01/2010-01确诊为屈光参差性弱视的儿童患者48例,随机分为两组,其中试验组24例,采用综合治疗的方法进行治疗,对照组24例,仅采用矫正屈光不正及传统的遮盖疗法进行治疗,... 详细信息

目的:评价综合治疗儿童屈光参差性弱视的临床疗效。方法:选择2005-01/2010-01确诊为屈光参差性弱视的儿童患者48例,随机分为两组,其中试验组24例,采用综合治疗的方法进行治疗,对照组24例,仅采用矫正屈光不正及传统的遮盖疗法进行治疗,观察记录并比较两组患儿的视力恢复情况、立体视觉情况等。结果:试验组疗效与对照组比较P=0.007,其差异具有统计学意义;试验组显效时间与对照组比较P=0.005,其差异具有统计学意义;试验组立体视觉恢复情况与对照组比较P=0.022,其差异具有统计学意义。结论:综合治疗儿童屈光参差性弱视疗效肯定、显效时间短且对立体视觉的恢复具有积极的意义。

关键词：综合治疗儿童屈光参差性弱视

Selective inhibition of CCR7- TEM cells activation by a novel peptide targeting Kv1.3 in a rat EAE model

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Selective inhibition of CCR7- TEM cells activation by a nove...

拔贡水电站改扩建工程水轮机的性能和结构特点

第八届全国免疫学学术大会

作者： Zhi Li wan-hong liu Song Han Bi-Wen Peng Jun Yin Ying-Liang Wu Xiao-Hua He Wen-Xin Li Hubei Province Key Laboratory of Allergy and Immunology School of Basic Medical Sciences Wuhan University State Key Laboratory of Virology College of Life Sciences Wuhan University

The voltage-gated Kv1.3 K+ channel in effector memory T cells(TEM) serves as a new therapeutic target for multiple sclerosis(MS).In our previous studies, the novel peptide ADWX-1 was designed and synthesized as a specific Kv1.3 blocker, and this peptide exhibited high potency and selectivity toward Kv1.3 over the related Kv1.1 and Kv1.2 ***, it is unclear if and how ADWX-1 alleviates experimental autoimmune encephalomyelitis(EAE), a model for *** this study, the administration of ADWX-1 significantly ameliorated the rat EAE model by selectively inhibiting CCR7- phenotype TEM cell ***, ADWX-1, a selective modulator of TEM cell activation, preferentially inhibited the activation of effector CD4+CCR7- cells through regulating both IL-2 signaling and the expression of *** contrast,the Kv1.3-specific peptide had little effect on nave and memory CD4+CCR7+ cells, therefore limiting side ***, we determined that ADWX-1 is involved in the regulation of NF-κB signaling through upstream protein kinase C-θ(PKCθ) in the IL-2 pathway of CD4+CCR7- *** elevated expression of Kv1.3 mRNA and protein in activated CD4+CCR7- cells was reduced by ADWX-1 engagement;however, an apparent alteration in CD4+CCR7+ cells was not ***, the selective regulation of the Kv1.3 channel gene expression pattern by ADWX-1 provided a further and sustained inhibition of the CD4+CCR7-phenotype, which depends on the activity of Kv1.3 to modulate its activation ***, the selective effects of ADWX-1 on sorted CD8+CCR7- and CD8+CCR7+ cell activation were observed in *** addition, ADWX-1 mediated the activation of differentiated Th17 cells through the CCR7- *** conclusion, these results indicate that ADWX-1 is a novel potent candidate therapeutic drug for *** efficacy of ADWX-1 is supported by multiple functions, which are based on a Kv1.3high CD4+CCR7- T cell selectivity through two different pathways inclu

关键词： Kv1.3 TEM ADWX-1 cell selectivity MS

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红水河 2013年第6期32卷 73-76页

作者：万柳红广西电力工业勘察设计研究院广西南宁530023

拔贡水电站改扩建工程安装2台10.5 MW灯泡贯流式水轮发电机组,转轮直径3.75 m。文中介绍机组的技术参数及结构特点,为小型灯泡贯流式水轮发电机组的设计、制造、安装积累了一定的经验,起到一定的参考借鉴作用。

关键词：水轮机灯泡贯流式水轮发电机组拔贡水电站改扩建工程

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洞巴水电站转轮空蚀介绍及原因分析

红水河 2010年第3期29卷 50-53页

作者：万柳红广西电力工业勘察设计研究院广西南宁530023

水轮机空蚀严重影响、威胁着机组的安全运行。洞巴水电站3台立轴混流式水轮机自2007年5月全部投入运行后,转轮、尾水管空蚀非常严重。文章对导致转轮空蚀的原因逐一进行分析,最终得出实际运行尾水位过低是主要原因,为今后水轮机选型设... 详细信息

水轮机空蚀严重影响、威胁着机组的安全运行。洞巴水电站3台立轴混流式水轮机自2007年5月全部投入运行后,转轮、尾水管空蚀非常严重。文章对导致转轮空蚀的原因逐一进行分析,最终得出实际运行尾水位过低是主要原因,为今后水轮机选型设计及电站运行提供了宝贵经验。

关键词：水轮机空蚀洞巴水电站

Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai Feng Juanji Li Tingting liu Shiqi Huang Xiangliang Chen Shen liu Junshan Zhou hongdong Zhao Ye hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen Gao Jing-Wen Li Hui Ye Xue-Zhi Zhang Jian-Xiang liu hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

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Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun Shuai wang Yanbo Liang Chao wang Yunhong Zhang hong liu Yu Zhang Lin Han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor