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New Interpretation of Neonatal Outcomes by Phenotypically Classified Preterm Syndrome:A Retrospective Cohort Study

当代医学科学(英文) 2023年第4期43卷 811-821页

作者： Dan LV Yan-ling ZHANG Yin XIE Fang YE Xiao-lei ZHANG He-ze XU Ya-nan SUN Fan-fan LI Meng-zhou HE Yao FAN Wei LI wan-jiang ZENG Su-hua CHEN Ling feng Xing-guang LIN Dong-rui DENG Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Occupational&Environmental Health School of Public HealthTongji Medical CollegeHuazhong University ofScience and TechnologyWuhan 430030China Key Laboratory of Environment and Health Ministry of Education&Ministry of Environmental Protectionand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Obstetrics and Gynaecology Shengjing Hospital of China Medical UniversityShenyang 110004China

Objective:The global aim to lower preterm birth rates has been hampered by the insufficient and incomplete understanding of its etiology,classification,and *** study was designed to evaluate the association of phenotypically classified preterm syndromes with neonatal outcomes;to what extent would these outcomes be modified after the obstetric interventions,including use of glucocorticoid,magnesium sulfate,and ***:This was a retrospective cohort study conducted at Tongji Hospital(composed of Main Branch,Optical Valley Branch and Sino-French New City Branch)in Wuhan.A total of 900 pregnant women and 1064 neonates were retrospectively *** outcomes were the distribution of different phenotypes among parturition signs and pathway to delivery,the association of phenotypically classified clusters with short-term unfavorable neonatal outcomes,and to what extent these outcomes could be modified by obstetric ***:Eight clusters were identified using two-step cluster analysis,including premature rupture of fetal membranes(PPROM)phenotype,abnormal amniotic fluid(AF)phenotype,placenta previa phenotype,mixed condition phenotype,fetal distress phenotype,preeclampsia-eclampsia&hemolysis,elevated liver enzymes,and low platelets syndrome(PE-E&HELLP)phenotype,multiple fetus phenotype,and no main condition *** for no main condition phenotype,the other phenotypes were associated with one or more complications,which conforms to the clinical *** with no main condition phenotype,some phenotypes were significantly associated with short-term adverse neonatal *** AF phenotype,mixed condition phenotype,PE-E&HELLP phenotype,and multiple fetus phenotype were risk factors for neonatal small-for gestation age(SGA);placenta previa phenotype was not associated with adverse outcomes except low APGAR score being 0-7 at one min;mixed condition phenotype was associated with low APGAR scores,SGA,mechanical vent

关键词： preterm phenotype two-step cluster analysis neonatal outcomes obstetric intervention

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Roles of lncRNAs in pancreatic ductal adenocarcinoma: Diagnosis,treatment, and the development of drug resistance

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Hepatobiliary & Pancreatic Diseases International 2023年第2期22卷 128-139页

作者： Xiao-Yin jiang Qi-Cong Zhu Xiao-Jian Zhang Ting Duan Jiao feng Xin-Bing Sui Xue-Ni Sun Yi-Ping Mou The National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals Zhejiang University of TechnologyHangzhou 310014China Department of Gastrointestinal and Pancreatic Surgery Key Laboratory of Gastroenterology of Zhejiang ProvinceZhejiang Provincial People’s HospitalAffiliated People’s Hospital of Hangzhou Medical CollegeHangzhou 310014China School of Pharmacy Hangzhou Normal UniversityHangzhou 311121China

Background: Pancreatic ductal adenocarcinoma(PDAC) is one of the most lethal cancers, primarily due to its late diagnosis, high propensity to metastasis, and the development of resistance to chemo-/radiotherapy. Accumulating evidence suggests that long non-coding RNAs(lnc RNAs) are intimately involved in the treatment resistance of pancreatic cancer cells via interacting with critical signaling pathways and may serve as potential diagnostic/prognostic markers or therapeutic targets in PDAC. Data sources: We carried out a systematic review on lnc RNAs-based research in the context of pancreatic cancer and presented an overview of the updated information regarding the molecular mechanisms underlying lnc RNAs-modulated pancreatic cancer progression and drug resistance, together with their potential value in diagnosis, prognosis, and treatment of PDAC. Literature mining was performed in Pub Med with the following keywords: long non-coding RNA, pancreatic ductal adenocarcinoma, pancreatic cancer up to January 2022. Publications relevant to the roles of lnc RNAs in diagnosis, prognosis, drug resistance, and therapy of PDAC were collected and systematically reviewed. Results: Lnc RNAs, such as HOTAIR, HOTTIP, and PVT1, play essential roles in regulating pancreatic cancer cell proliferation, invasion, migration, and drug resistance, thus may serve as potential diagnostic/prognostic markers or therapeutic targets in PDAC. They participate in tumorigenesis mainly by targeting mi RNAs, interacting with signaling molecules, and involving in the epithelial-mesenchymal transition process. Conclusions: The functional lnc RNAs play essential roles in pancreatic cancer cell proliferation, invasion, migration, and drug resistance and have potential values in diagnosis, prognostic prediction, and treatment of PDAC.

关键词： Long non-coding RNA Pancreatic ductal adenocarcinoma Drug resistance Diagnostic indicator Therapeutic targets Molecular mechanism

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Complexation of sym-bis(benzimidazole)-2,2'-ethylene salts with cucurbit[6]uril derivatives:A potential axle molecule for pseudorotaxanes

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Chinese Chemical Letters 2013年第5期24卷 362-366页

作者： Jun-Ming Yi Xin-Long Ni Xin Xiao Li-Bing Lu Sai-feng Xue Qian-jiang Zhu Zhu Tao Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province Guizhou University

Sym-bis（benzimidazole）-2,2＇-ethylene cations act as a new axle template for threading cucurbit[6]uril derivatives on,forming[2]pseudorotaxane and[3]*** new complexes have been studied using 1 H NMR,UV-vis absorption spectroscopy and X-ray *** in the 1 H NMR spectra indicate that the two types of pseudorotaxane can be formed by varying the host concentration. UV-vis absorption titration experiments at different pH values demonstrate that interesting pK_a shifts of the bis-benzimidazole derivatives can be induced by the host-guest *** associated constants were calculated to be 2.81×10^4 L/mol and 9.06×10^6 L/mol for the[2]pseudorotaxanes and ｜3]pseudorotaxanes,***,X-ray diffraction studies of the solid state structures provide unequivocal proof of the host concentration dependent pseudorotaxane,which is strongly in line with the evidences in solution.

关键词： Cucurnituril derivatives Bis(benzimidazole) derivatives Pseudorotaxane Crystal structure

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填充毛细管液相色谱-毛细管气相色谱在线联用技术

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高等学校化学学报 1998年第4期19卷 520-525页

作者：江涛关亚风中国科学院大连化学物理研究所

建立了一套填充毛细管液相色谱－毛细管气相色谱在线联用的二维色谱分离体系．联用接口由十通阀和多位阀构成，将经填充毛细管液相色谱分离后的样品各馏分在线准确切割和储存，并在线无损失输送至ＧＣ分析，从而实现了复杂样品的一次进... 详细信息

建立了一套填充毛细管液相色谱－毛细管气相色谱在线联用的二维色谱分离体系．联用接口由十通阀和多位阀构成，将经填充毛细管液相色谱分离后的样品各馏分在线准确切割和储存，并在线无损失输送至ＧＣ分析，从而实现了复杂样品的一次进样全组分的分离分析．本文对该体系的各部件及操作条件进行了详细的考察和优化，并以柴油和变压器油为例进行了分析，结果表明，该联用体系分离分析复杂样品效果良好．

关键词： PC-HPLC CGC 联用在线联用柴油变压器油

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Analysis of clinical manifestations and treatment in 26 children with fibrodysplasia ossificans progressiva in China

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World Journal of Pediatrics 2020年第1期16卷 82-88页

作者： Jun-Mei Zhang Cai-feng Li Shuang-Ying Ke Yu-Rong Piao Tong-Xin Han Wei-Ying Kuang jiang wang jiang-Hong Deng Xiao-Hua Tan Chao Li Department of Rheumatology and Immunology Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthNan Li Shi Road No.56Beijing 100045China

Background Fibrodysplasia ossificans progressiva(FOP)is a rare and disabling heritable connective tissue disease that is difficult to *** study seeks to explore the clinical characteristics,clinical manifestations,treatment and prognosis of FOP to provide a clinical basis for its early diagnosis and *** Twenty-six children with FOP were retrospectively analyzed in terms of their onset,clinical manifestations,auxiliary examinations and *** Among the 26 cases,the youngest age of manifestation of mass was 8 days after birth,and the average age was 3 years and 2 *** peak age was 2-5 years *** mass and toe-finger deformity are the main early clinical manifestations of the *** inflammatory masses often lead to hard osteogenic deposits that initially mainly involve the central axis,such as the neck(22/26,84.6%),back(20/26,76.9%),and head(13/26,50%).Toe-finger deformity mainly manifests as symmetrical great toe deformity,or short and deformed thumb and little *** diagnosis of FOP requires typical clinical manifestations or ACVR1 gene *** main therapeutic drugs for FOP include glucocorticoids and non-steroidal anti-inflammatory *** not compliant with the recommended medical management of FOP,in our clinical practice children with uncontrollable illness could be treated using a variety of immunosuppressive agents in *** FOP is a rare autosomal dominant heritable *** main clinical manifestations observed in this study were recurrent inflammatory mass and toe-finger *** the diagnosis and treatment are not performed in a timely manner,serious complications are likely to affect the ***,early diagnosis and active treatment should be performed.

关键词： Clinical manifestation Fibrodysplasia ossificans progressiva Inflammatory mass Treatment

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Microstructure and properties of Al-Mg-(Sc, Zr) welded joint

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Journal of Central South University of Technology 2005年第Z1期12卷 23-27页

作者： jiang feng CHEN Su-li HUANG Bai-yun YIN Zhi-min HE Yue-hui School of Materials Science and Engineering Central South University Changsha 410083 China State Key Laboratory of Powder Metallurgy Central South University Changsha 410083 China School of Materials Science and Engineering Central South University Changsha 410083 China State Key Laboratory of Powder Metallurgy Central South University Changsha 410083 China School of Materials Science and Engineering Central South University Changsha 410083 China State Key Laboratory of Powder Metallurgy Central South University Changsha 410083 China

Mechanical properties and microstructure of Al-Mg-(Sc, Zr) welded joint prepared by manual labor melt inert gas(MIG) welding method using Al-Mg and Al-Mg-Sc weld wire as filling materials were studied comparatively. The results show that the apparent recrystallization does not happen in heat-affected zone. It proves that Al-Mg(Sc,Zr) alloy has a high capability of resistance to welding heat-soften. Using Al-Mg-Sc welding wire as filling material can obviously refine the grains of weld seam and improve its strength. The layer of small equal-axe grains in fusion area improves the joint strength between welded metal and base metal. The coefficients of welded joints when Al-Mg-Sc and Al-Mg welding wire are used as filling material are greater than 0. 90, respectively. The yield strength of welded joints with Al-Mg welding wire is only 187 MPa, one is as high as 287 MPa with A1-Mg-Sc welding wire, thus the working strength of the welded unit is greatly improved.

关键词： Al-Mg-Sc alloy welding welding wire microstructure and properties of welded seam

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JAK2 V617F, MPL W515L and JAK2 Exon 12 Mutations in Chinese Patients with Primary Myelofibrosis

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Chinese Journal of Cancer Research 2012年第1期24卷 72-76页

作者： Jun Xia Mi-ze Lu Yuan-qiang jiang Guo-hua Yang Yun Zhuang Hong-li Sun Yun-feng Shen Department of Hematology Wuxi People's HospitalNanjing Medical UniversityWuxi 214023China

Objective： JAK2 V617F, MPL W515L and JAK2 exon 12 mutations are novel acquired mutations that induce constitutive cytokine-independent activation of the JAK-STAT pathway in myeloproliferative disorders （MPD）. The discovery of these mutations provides novel mechanism for activation of signal transduction in hematopoietic malignancies. This research was to investigate their prevalence in Chinese patients with primary myelofibrosis （PMF）. Methods： We introduced allele-specific PCR （AS-PCR） combined with sequence analysis to simultaneously screen JAK2 V617F, MPL W515L and JAK2 exon 12 mutations in 30 patients with PMF. Results： Fifteen PMF patients （50.0%） carried JAK2 V617F mutation, and only two JAK2 V617F-negative patients （6.7%） harbored MPL W515L mutation. None had JAK2 exon 12 mutations. Furthermore, these three mutations were not detected in 50 healthy controls. Conclusion： MPL W515L and JAK2 V617F mutations existed in PMF patients but JAK2 exon 12 mutations not. JAK2 V617F and MPL W515L and mutations might contribute to the primary molecular pathogenesis in patients with PMF.

关键词： Primary myelofibrosis JAK2 V617F MPL W515L JAK2 exon 12 mutation

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RAF22,ABI1 and OST1 form a dynamic interactive network that optimizes plant growth and responses to drought stress in Arabidopsis

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Molecular Plant 2022年第7期15卷 1192-1210页

作者： Zhihui Sun Zhenkai feng Yanglin Ding Yuanpeng Qi Shan jiang Zhen Li Yu wang Junsheng Qi Chunpeng Song Shuhua Yang Zhizhong Gong State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China Collaborative Innovation Center of Crop Stress Biology Institute of Plant Stress BiologyHenan UniversityKaifeng 475001China School of Life Sciences Institute of Life Science and Green DevelopmentHebei UniversityBaoding 100193China

Plants adapt to their ever-changing environment via positive and negative signals induced by environmental *** stress,for instance,induces accumulation of the plant hormone abscisic acid(ABA),triggering ABA signal ***,the molecular mechanisms for switching between plant growth promotion and stress response remain poorly *** we report that RAF(rapidly accelerated fibrosarcoma)-LIKE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 22(RAF22)in Arabidopsis tha/iana physically interacts with ABA INSENSITIVE 1(ABl1)and phosphorylates ABl1 at Ser416 residue to enhance its phosphatase ***,ABl1 can also enhance the activity of RAF22 through dephosphorylation,reciprocally inhibiting ABA signaling and promoting the maintenance of plant growth under normal *** drought stress,however,the ASA-activated OPEN STOMATA1(OST1)phosphorylates the Ser81 residue of RAF22 and inhibits its kinase activity,restraining its enhancement of ABl1 *** together,our study reveals that RAF22,ABl1,and OST1 form a dynamic regulatory network that plays crucial roles in optimizing plant growth and environmental adaptation under drought stress.

关键词： ABA signaling RAF22 ABl1 OST1 phosphorylation

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Multielectron transportation of polyoxometalate-grafted metalloporphyrin coordination frameworks for selective CO2-to-CH4 photoconversion

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National Science Review 2020年第1期7卷 53-63页

作者： Qing Huang jiang Liu Liang feng Qi wang Wei Guan Long-Zhang Dong Lei Zhang Li-Kai Yan Ya-Qian Lan Hong-Cai Zhou jiangsu Collaborative Innovation Centre of Biomedical Functional Materials Jiangsu Key Laboratory of New Power Batteries School of Chemistry and Materials Science Nanjing Normal University Department of Chemistry Texas A&M University College Station Department of Chemistry Northeast Normal University

Photocatalytic CO2reduction into energy carriers is of utmost importance due to the rising concentrations of CO2and the depleting energy resource. However, the highly selective generation of desirable hydrocarbon fuel, such as methane（CH4）, from CO2remains extremely challenging. Herein, we present two stable polyoxometalate-grafted metalloporphyrin coordination frameworks（POMCFs）, which are constructed with reductive Zn-ε-Keggin clusters and photosensitive tetrakis（4-carboxylphenyl）porphyrin（H2TCPP） linkers, exhibiting high selectivity（>96%） for CH4formation in a photocatalytic CO2-reduction system. To our knowledge, the high CH4selectivity of POMCFs has surpassed all of the reported coordination-framework-based heterogeneous photocatalysts for ***, the introduction of a Zn-ε-keggin cluster with strong reducing ability is the important origin for POMCFs to obtain high photocatalytic selectivity for CH4formation, considering that eight MoVatoms can theoretically donate eight electrons to fulfill the multielectron reduction process of CO2-to-CH4transformation.

关键词： reductive polyoxometalate coordination frameworks CO2 photoreduction high selectivity methane

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Screening ofα-glucosidase inhibitors in large-leaf yellow tea by offline bioassay coupled with liquid chromatography tandem mass spectrometry

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Food Science and Human Wellness 2022年第3期11卷 627-634页

作者： You Wu Zisheng Han Mingchun Wen Chi-Tang Ho Zongde jiang Yijun wang Na Xu Zhongwen Xie Jinsong Zhang Liang Zhang Xiaochun wan State Key Laboratory of Tea Plant Biology and Utilization Anhui Agricultural UniversityHefei 230036China International Joint Laboratory on Tea Chemistry and Health Effects of Ministry of Education Anhui Agricultural UniversityHefei 230036China Department of Food Science Rutgers UniversityNew BrunswickNJ 08901USA

Larger-leaf yellow tea(LYT)is a characteristic type of Chinese tea produced in Huoshan County,Anhui Province,which is made by mature leaves with *** to recent report,LYT showed competitive effects in anti-hyperglycemia in comparison to other teas such as green or black ***,the bioactive compounds of LYT are still undiscovered so *** this purpose,5 fractions of LYT were prepared by sequential *** in vitro bioassay results indicated that the ethyl acetate fraction of LYT had the strongest inhibitory effects onα-glucosidase andα-***-quenching analysis and proteinbinding test revealed that the compounds of ethyl acetate fraction could inhibitα-glucosidase andα-amylase activities through binding to enzymes or other *** chromatographic peaks of high-performance liquid chromatography(HPLC)of ethyl acetate fraction were separated and *** purified compounds were identified by liquid chromatography-mass spectrometry(LC-MS),and subsequently screened by calculating their inhibition ratio onα-glucosidase at the real concentration in LYT *** results showed that(-)-epigallocatechin gallate,(-)-gallocatechin gallate,caffeine,N-ethyl-2-pyrrolidone-substituted flavan-3-ols were effective inhibitors forα-glucosidase.

关键词： Larger-leaf yellow tea Anti-hyperglycemia α-Glucosidase Mass spectrometry Separation

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