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Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

Neural Regeneration Research 2025年第4期20卷 1015-1030页

作者： Ruoyu Huang Qiuyu Pang Lexin Zheng Jiaxi Lin Hanxi Li Lingbo wan Tao wang Department of Forensic Science School of Basic Medicine and Biological SciencesSuzhou Medicine College of Soochow UniversitySuzhouJiangsu ProvinceChina

Cholesterol is an important component of plasma membranes and participates in many basic life functions,such as the maintenance of cell membrane stability,the synthesis of steroid hormones,and *** plays a key role in the establishment and maintenance of the central nervous *** brain contains 20%of the whole body’s cholesterol,80%of which is located within myelin.A huge number of processes(e.g.,the sterol regulatory element-binding protein pathway and liver X receptor pathway)participate in the regulation of cholesterol metabolism in the brain via mechanisms that include cholesterol biosynthesis,intracellular transport,and *** brain injuries or diseases involving crosstalk among the processes above can affect normal cholesterol metabolism to induce detrimental ***,we hypothesized that cholesterol-related molecules and pathways can serve as therapeutic targets for central nervous system *** hemorrhage is the most severe hemorrhagic stroke subtype,with high mortality and *** cholesterol levels are associated with the risk of intracerebral ***,secondary pathological changes after intracerebral hemorrhage are associated with cholesterol metabolism dysregulation,such as neuroinflammation,demyelination,and multiple types of programmed cell *** cholesterol accumulation in the brain has been found after intracerebral *** this paper,we review normal cholesterol metabolism in the central nervous system,the mechanisms known to participate in the disturbance of cholesterol metabolism after intracerebral hemorrhage,and the links between cholesterol metabolism and cell *** also review several possible and constructive therapeutic targets identified based on cholesterol metabolism to provide cholesterol-based perspectives and a reference for those interested in the treatment of intracerebral hemorrhage.

关键词： cell death cholesterol metabolism intracerebral hemorrhage myelination therapeutic target

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Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-Wei Li Jian-Hong Shi Tan Li wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

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Biodegradation of oil wastewater by free and immobilized Yarrowia lipolytica W29

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Journal of Environmental Sciences 2009年第2期21卷 237-242页

作者： WU Lan ge Gang wan Jinbao College of Life Science Nanchang University Nanchang 330031 China College of Environmental Science and Engineering Nanchang University Nanchang 330031 China

The ability of Yarrowia lipolytica W29 immobilized by calcium alginate to degrade oil and chemical oxygen demand （COD） was examined. The degradation rules of oil and COD by immobilized cells with the cell density of 6.65 × 10^6 CFU/mL degraded 2000 mg/L oil and 2000 mg/L COD within 50 h at 30℃ （pH 7.0, 150 r/min）, similarly to those of free cells, and the degradation efficiencies of oil and COD by immobilized cells were above 80%, respectively. The factors affecting oil and COD degradation by immobilized cells were investigated, the results showed that immobilized cells had high thermostability compared to that of free cells, and substrate concentration significantly affected degrading ability of immobilized cells. Storage stability and reusability tests revealed that the oil degradation ability of immobilized cells was stable after storing at 4~C for 30 d and reuse for 12 times, respectively, the COD degradation rate of immobilized cells was also maintained 82% at the sixth cycle. These results suggested that immobilized Y lipolytica might be applicable to a wastewater treatment system for the removal of oil and COD.

关键词： Yarrowia lipolytica biodegradation oil wastewater calcium alginate

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Electronic and magnetic properties of single-layer and double-layer VX_(2)(X=Cl,Br)under biaxial stress

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Chinese Physics B 2021年第10期30卷 534-540页

作者： Xing Li Yanfeng ge Jun Li Wenhui wan yong Liu State Key Laboratory of Metastable Materials Science and Technology&Key Laboratory for Microstructural Material Physics of Hebei Province School of ScienceYanshan UniversityQinhuangdao 066004China

First-principles calculations and Monte Carlo simulations reveal that single-layer and double-layer VX_(2)(X=Cl,Br)can be tuned from antiferromagnetic(AFM)semiconductors to ferromagnetic(FM)state when biaxial tensile stress is *** ground states are all T *** biaxial tensile stress at the phase transition point of the double-layer VX_(2) is larger than that of the single-layer VX_(2).The direct band gaps can be also manipulated by biaxial tensile stress as they increases with increasing tensile stress to a critical point and then *** Neel temperature(´TN)of double-layer VX_(2) are higher than that of *** the stress increases,the TN of all materials tend to *** magnetic moment increases with the increase of biaxial tensile stress,and which become insensitive to stress after the phase transition *** research provides a method to control the electronic and magnetic properties of VX_(2) by stress,and the single-layer and double-layer VX_(2) may have potential applications in nano spintronic devices.

关键词： first-principles biaxial tensile stress phase transition magnetic properties

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内蒙古阿拉善左旗M_S5.8地震的构造应力场和静态库伦应力变化分析

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华北地震科学 2015年第2期33卷 48-54页

作者：高熹微万永革黄骥超李祥崔华伟防灾科技学院河北三河065201

利用收集的60个震源机制解,应用MSATSI软件反演了2015年4月15日内蒙古阿拉善左旗MS5.8级地震的震中周围地区的构造应力场。结果显示:此次地震是发生在走滑体系的背景下,总体应力场的空间不均匀性表现不明显。总体最大主压应力走向N42±7... 详细信息

利用收集的60个震源机制解,应用MSATSI软件反演了2015年4月15日内蒙古阿拉善左旗MS5.8级地震的震中周围地区的构造应力场。结果显示:此次地震是发生在走滑体系的背景下,总体应力场的空间不均匀性表现不明显。总体最大主压应力走向N42±7°E,主张应力走向为N58±12.6°W,R值约为0.4。相比于前人的结果,该结果与地震发生震源机制的P、T轴方位更加一致。为揭示余震和主震之间的关系,计算了此次地震所造成的静态破裂库仑应力变化。结果表明:M4.0级余震的静态库仑应力变化值分别为0.042 8 MPa,M3.2级余震的静态库伦应力变化值为0.023 MPa,说明此次地震对2次余震有触发作用。

关键词：震源机制解构造应力场静态库仑应力变化

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In situ polymerization of aniline in electrospun microfibers

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Chinese Chemical Letters 2014年第1期25卷 83-86页

作者： Xiao-Qiang Li wan-wan Liu Shui-Ping Liu Meng-Juan Li yong-Gui Li Ming-Qiao ge Key Laboratory of Eco-textiles Ministry of EducationJiangnan University College of Textile & Clothing Jiangnan University

Conductive microfibers with an average diameter of ca. 1.0 μm were prepared by in situ polymerization of aniline, in which poly（vinylchloride-acrylonitrile）（PVC-AN） was used as the filament-material in electrospinning to form precursor microfibers and carry the aniline monomers. Fourier-transform infrared （FTIR） results demonstrated that PANi was successfully polymerized in the microfibers. The morphology of the PVC-AN-PANi microfibers was observed by scanning electron microscopy （SEM）. Results of differential scanning calorimetry indicated that the polymer composite of PVC-AN-PANi formed via molecular interactions. Although the conductivity of PVC-AN-PANi microfibers was still limited （2.2 × 10^-8 S/cm）, this method provided an effective and convenient approach for preparing highly uniform and soft microfibrous electrodes.

关键词： Conductive microfibers Electrospinning Polymer composite Polyaniline

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Equatorial aurora: the aurora-like airglow in the negative magnetic anomaly

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National Science Review 2020年第10期7卷 1606-1615页

作者： Fei He yong Wei Weixing wan Key Laboratory of Earth and Planetary Physics Institute of Geology and Geophysics Chinese Academy of Sciences College of Earth and Planetary Sciences University of Chinese Academy of Sciences

The most fantastic optical phenomena in the Earth’s upper atmosphere are the auroras. They are highly informative indicators of solar activity, geomagnetic activity, upper atmospheric structures and dynamics,and magnetospheric energetic particles. An area where the geomagnetic field differs significantly from the expected symmetric dipole, such as at the South Atlantic Anomaly, where the magnetic field intensity is low,gives rise to stronger precipitation of energetic particles into the upper atmosphere. Impact excitation and the subsequent airglow emissions exhibit aurora-like dynamic signatures. Nomenclatures of nonpolar aurora or equatorial auroras are similar to those used with the polar auroras owing to their similar excitation mechanisms. This paper provides an overview of the knowledge and the challenges concerning auroral activity at the South Atlantic Anomaly, or more generally, at the negative magnetic anomaly. We emphasize systematic investigation of the equatorial auroras to reveal the temporal and spatial evolution of the magnetic anomaly and the behaviour of energetic particles in near-Earth space.

关键词： aurora geomagnetic field South Atlantic Anomaly negative magnetic anomaly energetic particles

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A review on ex situ catalytic fast pyrolysis of biomass

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Frontiers of Chemical Science and Engineering 2014年第3期8卷 280-294页

作者： Shaolong wan yong wanG Center for Biomass Refining School of Chemical Biological and Materials Engineering The University of Oklahoma Norman OK 73019 USA Voiland School of Chemical Engineering and Bioengineering Washington State University Pullman WA 99164 USA

Catalytic fast pyrolysis （CFP） is deemed as the most promising way to convert biomass to transportation fuels or value added chemicals. Most works in literature so far have focused on the in situ CFP where the catalysts are packed or co-fed with the feedstock in the pyrolysis reactor. However, the ex situ CFP with catalysts separated from the pyrolyzer has attracted more and more attentions due to its unique advantages of individually optimizing the pyrolysis conditions and catalyst performances. This review compares the differences between the in situ and ex situ CFP operation, and summarizes the development and progress of ex situ CFP applications, including the rationale and performances of different catalysts, and the choices of suitable ex situ reactor systems. Due to the complex composition of bio-oil, no single approach was believed to be able to solve the problems completely among all those existing technologies. With the increased understanding of catalyst performances and reaction process, the recent trend toward an integration of biomass or bio-oil fractionation with subsequent thermo/biochemical conversion routes is also discussed.

关键词： catalytic fast pyrolysis ex situ catalysts

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Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑Chang Sung Gwang‑Hee Lee Byoungjoon Hwang Sojung Seo Ji‑Hun Seo Dong‑wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

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Stability and Hopf bifurcation of a delayed ratio-dependent predator-prey system

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Acta Mechanica Sinica 2011年第2期27卷 285-296页

作者： wan-yong wang Li-Jun Pei School of Aerospace Engineering and Applied Mechanics Tongji University 200092 Shanghai China Department of Mathematics Zhengzhou University 450001 Zhengzhou China

Since the ratio-dependent theory reflects the fact that predators must share and compete for food, it is suitable for describing the relationship between predators and their preys and has recently become a very important theory put forward by biologists. In order to investigate the dynamical relationship between predators and their preys, a so-called Michaelis-Menten ratio-dependent predator-prey model is studied in this paper with gestation time delays of predators and preys taken into consideration. The stability of the positive equilibrium is investigated by the Nyquist criteria, and the existence of the local Hopf bifurcation is analyzed by employing the theory of Hopf bifurcation. By means of the center manifold and the normal form theories, explicit formulae are derived to determine the stability, direction and other properties of bifurcating periodic solutions. The above theoretical results are validated by numerical simulations with the help of dynamical software WinPP. The results show that if both the gestation delays are small enough, their sizes will keep stable in the long run, but if the gestation delays of predators are big enough, their sizes will periodically fluc-tuate in the long term. In order to reveal the effects of time delays on the ratio-dependent predator-prey model, a ratiodependent predator-prey model without time delays is considered. By Hurwitz criteria, the local stability of positive equilibrium of this model is investigated. The conditions under which the positive equilibrium is locally asymptotically stable are obtained. By comparing the results with those of the model with time delays, it shows that the dynamical behaviors of ratio-dependent predator-prey model with time delays are more complicated. Under the same conditions, namely, with the same parameters, the stability of positive equilibrium of ratio-dependent predator-prey model would change due to the introduction of gestation time delays for predators and preys. Moreover, w

关键词： Time delays · Stability · Hopf bifurcation · Normal form · Center manifold

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