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Elite,transformable haploid inducers in maize

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The Crop Journal 2024年第1期12卷 314-319页

作者： Brent Delzer Dawei Liang David Szwerdszarf Isadora Rodriguez Gonzalo Mardones Sivamani Elumalai Francine Johnson Samson Nalapalli Rachel Egger Erin Burch Kerry Meier Juan Wei Xiujuan Zhang Huaping Gui Huaibing Jin Huan Guo Kun Yu Yubo Liu Becky Breitinger Ana Poets Jason Nichols wan shi David Skibbe Qiudeng Que Timothy Kelliher Seeds Development Syngenta SeedsJanesvilleWI 53546USA Seeds Research Syngenta Biotechnology China Co.Ltd.Beijing 102206China Centro de Investigación de Cultivos Arica Syngenta R&DArica 1000000Chile Syngenta S.A. Proyecto la SoledadGraneros 2880000Chile Seeds Research Syngenta Crop Protection LLCRTPNC 27709USA Seeds Development Syngenta SeedsSlaterIA 50244USA

The introduction of alleles into commercial crop breeding pipelines is both time consuming and *** technologies that are disrupting traditional breeding processes are doubled haploid(DH)breeding and genome editing(GE).Recently,these techniques were combined into a GE trait delivery system called HI-Edit(Haploid Inducer-Edit).In HI-Edit,the pollen of a haploid inducer line is reprogrammed to deliver GE traits to any variety,obviating recurrent *** HI-Edit to operate at scale,an efficient transformable HI line is needed,but most maize varieties are recalcitrant to transformation,and haploid inducers are especially difficult to transform given their aberrant reproductive *** marker assisted selection and a three-tiered testing scheme,we report the development of new Iodent and Stiff Stalk maize germplasm that are transformable,have high haploid induction rates,and exhibit a robust,genetically-dominant anthocyanin native trait that may be used for rapid haploid *** show that transformation of these elite‘‘HI-Edit”lines is enhanced using the BABYBOOM and WUSCHEL morphogenetic ***,we evaluate the HI-Edit performance of one of the lines against both Stiff Stalk and non-Stiff Stalk *** strategy and results of this study should facilitate the development of commercially scalable HI-Edit systems in diverse crops.

关键词： Zea mays L Doubled haploids Transformation Genome editing QTL

Characteristics and genesis of groundwater salinization in coastal areas of the Lower Reaches of Oujiang Basin

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Journal of Groundwater Science and Engineering 2024年第2期12卷 190-204页

作者： Mei-hui Zhang shi-yang Zhou Dan-dan Liu Ying Zhang Yu-xi Zhang Xi Chen Hui-wei wang Bei Li Wei Kang Bing Yi wan-peng shi Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Fujian Provincial Key Laboratory of Water Cycling and Eco–Geological Processes Xiamen 361021FujianChina China University of Geosciences(Beijing) Beijing 100083China Changsha Center of Natural Resources Comprehensive Survey China Geological SurveyChangsha 410600China Hydrogeological Environmental Geological Survey Center of China Geological Survey Tianjin 071501China China University of Geosciences Wuhan 430074China

The coastal areas of the lower reaches of Oujiang River Basin are rich in groundwater ***,the unsustainable exploitation and utilization of groundwater have led to significant changes in the groundwater *** the characteristics and genesis of groundwater salinization is crucial for preventing its deterioration and ensuring sustainable *** this study,a comprehensive approach combining the ion ratio method,mineral saturation index method and multivariate statistical analysis was employed to investigate the hydrochemical characteristics and main controlling factors in the study *** findings reveal that:(1)Groundwater samples in study area exhibit a neutral to slightly alkaline *** predominant chemical types of unconfined water are HCO_(3)-Ca·Na,HCO_(3)·Cl-Na·Ca and HCO_(3)·SO_(4)-Ca·Na,while confined water mainly exhibits Cl·HCO_(3)-Na and Cl-Na types.(2)Salinity coefficients indicate an increase in salinity from unconfined to confined ***,Na^(+)and Cl^(–)concentrations show an increasing trend from mountainous to coastal areas in unconfined water,while confined water displays variability in TDS,Na^(+)and Cl^(–)concentrations.(3)Groundwater salinity is mainly influenced by water-rock interactions,including the dissolution of halite and gypsum,cation exchange,and seawater intrusion ***,human activities and carbonate dissolution contribute to salinity in unconfined *** intrusion is identified as the primary factor leading to higher salinity in confined water compared to unconfined water,with increasing cation exchange and seawater interaction observed from unconfined to confined water.

关键词： Hydrochemical Multivariate statistical analysis Seawater intrusion

Hemolysis attributed to high dose vitamin C:Two case reports

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World Journal of Clinical Cases 2024年第17期12卷 3168-3176页

作者： shi-wan wang Xiao-Wei Zhang Jin-Xiu Qu Yi-Zhong Rao Shuai Lu Bing wang Jia He Yuan Zhao Ben-Qiang Rao Center for Oncology Nutrition and Metabolism Beijing Shijitan HospitalCapital Medical University/Key Laboratory of Cancer FSMP for State Market RegulationBeijing 100038China

BACKGROUND High-dose vitamin C treatment(HVCT)can reduce the adverse effect of chemotherapy and enhance the effect of antitumor therapy,which has been considered one of the safest alternative ***,the severity of its adverse effects may have been *** most serious adverse effect is hemolysis,which may result in acute kidney injury or *** glucose-6-phosphate dehydrogenase(G6PD)deficiency is considered to be the main cause,the probability and pathological mechanism are not completely understood,leading to a lack of effective and standardized treatment *** SUMMARY Two patients with colorectal cancer developed hemolytic anemia after using 1 g/kg *** contrast to previous cases,the lowest hemoglobin level in the two cases was<50 g/L,which was lower than previously *** may be because Case 1 had chronic hepatitis B for many years,which caused abnormal liver reserve function,and Case 2 had grade II bone marrow *** patients improved and were discharged after blood replacement *** cases had the most severe degree of hemolysis but the best prognosis,suggesting that our treatment may be helpful for rescue of drug-induced *** is the first review of the literature on hemolysis caused by HVCT,and we found that all patients with G6PD deficiency developed hemolysis after *** G6PD deficiency should be considered as a contraindication to HVCT,and it is not recommended for patients with bone marrow suppression,moderate-tosevere anemia,hematopoietic abnormalities,or abnormal liver and kidney *** blood purification and steroid therapy may avoid acute kidney injury or death caused by HVCT-related hemolytic anemia.

关键词： Hemolysis Vitamin C Adverse effects Acute kidney injury Cancer Case report

浅析新疆若羌县红水沟- 亮剑峡一带铅锌金多金属矿成矿地质特征

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世界有色金属 2024年第3期 104-106页

作者：王文松石万新疆地矿局第二区域地质调查大队新疆昌吉831100

新疆若羌县红水沟—亮剑峡地区处于塔里木盆地东南缘、阿尔金山脉西南段,位于若羌县西南约125km处,行政区划属新疆若羌县管辖。文中结合实践对新疆若羌县红水沟-亮剑峡一带铅锌金多金属矿成矿地质特征展开探讨,旨在为区内铅锌金多金属... 详细信息

新疆若羌县红水沟—亮剑峡地区处于塔里木盆地东南缘、阿尔金山脉西南段,位于若羌县西南约125km处,行政区划属新疆若羌县管辖。文中结合实践对新疆若羌县红水沟-亮剑峡一带铅锌金多金属矿成矿地质特征展开探讨,旨在为区内铅锌金多金属矿找矿工作提供参考。

关键词：红水沟-亮剑峡一带铅锌金多金属矿地质特征新疆若羌县

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索尔库都克铜矿成矿条件分析及成矿模式研究

世界有色金属 2024年第8期 91-93页

作者：石万王文松新疆地矿局第二区域地质调查大队新疆昌吉831100

索尔库都克铜矿分布在新疆准噶尔盆地北侧区域上沙漠地带,行政区划属新疆富蕴县管辖范围。该矿大地构造位置属准噶尔北缘活动陆缘中的萨吾尔晚古生代岛弧带,索尔库都克铜矿的研究对于东准噶尔地区地质找矿工作能够提供借鉴及科学依据。... 详细信息

索尔库都克铜矿分布在新疆准噶尔盆地北侧区域上沙漠地带,行政区划属新疆富蕴县管辖范围。该矿大地构造位置属准噶尔北缘活动陆缘中的萨吾尔晚古生代岛弧带,索尔库都克铜矿的研究对于东准噶尔地区地质找矿工作能够提供借鉴及科学依据。为此主要针对该矿成矿条件分析及成矿模式进行研究,能够为该区找矿工作提供一些参考作用。

关键词：索尔库都克铜矿成矿条件成矿模式

新疆哈巴河萨尔朔克多金属矿地质特征及成矿模式研究

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世界有色金属 2024年第7期 94-96页

作者：石万王文松新疆地矿局第二区域地质调查大队新疆昌吉831100

萨尔朔克多金属矿位于新疆哈巴河县1°方位、直距30km的萨尔朔克一带,行政区划隶属哈巴河县管辖,南西距阿舍勒铜锌矿床6km。本文在对该矿成矿地质特征进行详细分析研究的基础上,阐述分析该矿矿床成因及成矿模式,能对区内同类型矿床的找... 详细信息

萨尔朔克多金属矿位于新疆哈巴河县1°方位、直距30km的萨尔朔克一带,行政区划隶属哈巴河县管辖,南西距阿舍勒铜锌矿床6km。本文在对该矿成矿地质特征进行详细分析研究的基础上,阐述分析该矿矿床成因及成矿模式,能对区内同类型矿床的找矿工作提供一些借鉴与参考。

关键词：河萨尔朔克多金属矿地质特征成矿模式新疆哈巴河

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新疆若羌县红石崖金矿地质特征及找矿前景

世界有色金属 2024年第5期 46-48页

作者：王文松石万新疆地矿局第二区域地质调查大队新疆昌吉831100

新疆若羌县红石崖金矿位于阿尔金山脉中段,塔里木地块与柴达木地块的结合部位,属藏北高原高山-丘陵-盆岭地貌区,总体地势北高南低,西高东低,海拔4200m~4582m,最高4582m,相对高差200~300余米。通过针对矿区开展详查工作,进一步分析该矿... 详细信息

新疆若羌县红石崖金矿位于阿尔金山脉中段,塔里木地块与柴达木地块的结合部位,属藏北高原高山-丘陵-盆岭地貌区,总体地势北高南低,西高东低,海拔4200m~4582m,最高4582m,相对高差200~300余米。通过针对矿区开展详查工作,进一步分析该矿区成矿地质背景、物化探特征、蚀变带和矿体特征,初步认为该矿床为属中低温热液金矿,并在此基础上探讨该矿找矿前景,以期能对指导该地区同类型金矿的找矿工作提供一些借鉴与参考。

关键词：阿尔金山红石崖金矿地质特征低温热液型

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污泥热干化的研究进展

应用化工 2024年第2期53卷 453-457页

作者：彭雅袁进周印羲余丽吉伟石万太原理工大学环境科学与工程学院山西晋中030600

首先阐述了在热干化过程中污泥的理化性质变化,污泥中大分子有机物分解为小分子有机物,酸溶态、可氧化态、可还原态等重金属形态转变为稳定的残渣态,降低了污泥处置的环境风险。随后,分析了污泥热干化过程出现的问题及其成因,针对污泥... 详细信息

首先阐述了在热干化过程中污泥的理化性质变化,污泥中大分子有机物分解为小分子有机物,酸溶态、可氧化态、可还原态等重金属形态转变为稳定的残渣态,降低了污泥处置的环境风险。随后,分析了污泥热干化过程出现的问题及其成因,针对污泥黏滞问题,总结了干污泥返混、添加降黏性物质及改造干化设备等方法;针对污染气体问题,综述了加入添加剂和降低温度抑制污染气体的释放,采用吸收法、吸附法和生物法处理产生的污染气体;针对设备腐蚀问题,归纳了采用防腐管材、防腐涂层、投加缓蚀剂和降低污泥含砂量的主要措施。最后对污泥热干化技术的研究趋势和发展提出了建议。

关键词：污泥热干化黏滞特性污染气体腐蚀磨损

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吲哚布芬联合氯吡格雷对急性心肌梗死患者PCI术后疗效的临床研究

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中国临床药理学杂志 2024年第4期40卷 497-500页

作者：程辉彭杰成伍万仕胡兴兵苏家凤安徽医科大学附属安庆第一人民医院心血管内科安徽安庆246000

目的探讨吲哚布芬联合氯吡格雷对急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)术后疗效及血小板活性和凝血功能的影响。方法将AMI患者按照队列法分为试验组和对照组,对照组接受阿司匹林0.1 g(qd)+氯吡格雷75 mg(qd)口服治疗;试验... 详细信息

目的探讨吲哚布芬联合氯吡格雷对急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)术后疗效及血小板活性和凝血功能的影响。方法将AMI患者按照队列法分为试验组和对照组,对照组接受阿司匹林0.1 g(qd)+氯吡格雷75 mg(qd)口服治疗;试验组接受吲哚布芬片0.1 g(bid)+氯吡格雷75 mg(qd)口服治疗,2组均服用1个月。比较2组疗效、治疗前后血小板计数(PLT)、平均血小板体积(MPV)、凝血酶原时间(PT)、纤维蛋白原(FIB)、D-二聚体(D-D)和药物不良反应发生率。结果试验组38例,对照组43例。治疗后,试验组和对照组的疗效分别为97.37%和86.05%,在统计学上差异无统计学意义(P>0.05)。治疗后,试验组和对照组PLT分别为(167.89±43.62)×10^(9)·L^(-1)和(183.73±49.81)×10^(9)·L^(-1);MPV分别为(11.86±2.31)和(10.97±2.16)fl;FIB分别为(2.53±0.61)和(2.78±0.72)g·L^(-1);D-D分别为(0.20±0.06)和(0.22±0.07)mg·L^(-1);PT分别为(12.82±2.35)和(12.26±2.28)s,在统计学上差异均无统计学意义(均P>0.05)。试验组和对照组的药物不良反应发生率分别为2.63%和11.63%,在统计学上差异有统计学意义(P<0.001)。结论吲哚布芬联合氯吡格雷的治疗效果与阿司匹林基本一致,均具有较好的抗血小板聚集作用,且吲哚布芬安全性更高,推荐作为AMI患者PCI术后的用药方案。

关键词：吲哚布芬氯吡格雷急性心肌梗死经皮冠状动脉介入治疗临床疗效血小板活性凝血功能