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Predictors of Adverse Pregnancy Outcomes Following Traumatic Injuries

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Current Medical Science 2024年第3期44卷 642-647页

作者： wan-rong LU Ping WU Gong SONG Mei-qi GU Zhe XU Li HE National Clinical Research Center for Gynecology and Obstetrics Cancer Biology Research CenterTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Traumatic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective After traumatic injury in pregnant women,providing timely and appropriate management for high-risk patients is crucial for both pregnant women and *** study aimed to identify risk factors that predict adverse pregnancy outcomes after traumatic *** A retrospective cohort study including 317 pregnant patients who experienced trauma was *** collected data included general demographics,injury mechanisms and adverse pregnancy *** were divided into two subgroups based on the absence or presence of trauma-related adverse pregnancy *** and multivariate logistic regressions were conducted to estimate the associations between clinical variables and adverse pregnancy *** A total of 41(12.93%)patients experienced adverse pregnancy outcomes within the first 24 h *** study revealed that age>35 years(OR=14.995,95%CI:5.024–44.755,P<0.001),third trimester trauma(OR=3.878,95%CI:1.343–11.204,P=0.012),abdominal pain(OR=3.032,95%CI:1.221–7.527,P=0.017),vaginal bleeding(OR=3.226,95%CI:1.093–9.523,P=0.034),positive scan in focused assessment with sonography for trauma(FAST)positive(OR=8.496,95%CI:2.825–25.555,P<0.001),9≤injury severity score(ISS)<16(OR=3.039,95%CI:1.046–8.835,P=0.041)and ISS≥16(OR=5.553,95%CI:1.387–22.225,P=0.015)increased the probability of posttraumatic adverse pregnancy *** age,gestational age at delivery,vaginal bleeding and positive FAST results were risk factors for abnormal *** Advanced maternal age,third trimester,and positive FAST results should alert multidisciplinary trauma teams to closely monitor patients to prevent adverse pregnancy outcomes.

关键词： adverse pregnancy outcomes predictive factors abnormal delivery trauma

Role of brahma-related gene 1/brahma-associated factor subunits in neural stem/progenitor cells and related neural developmental disorders

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World Journal of Stem Cells 2023年第4期15卷 235-247页

作者： Nai-Yu Ke Tian-Yi Zhao wan-rong wang Yu-Tong Qian Chao Liu The First Clinical Medical College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Institute of Stem cells and Tissue Engineering School of Basic Medical SciencesAnhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Histology and Embryology School of Basic Medical SciencesAnhui Medical UniversityHefei 230032Anhui ProvinceChina

Different fates of neural stem/progenitor cells(NSPCs)and their progeny are determined by the gene regulatory network,where a chromatin-remodeling complex affects synergy with other ***,we review recent research progress indicating that the BRG1/BRM-associated factor(BAF)complex plays an important role in NSPCs during neural development and neural developmental *** studies based on animal models have shown that mutations in the BAF complex may cause abnormal neural differentiation,which can also lead to various diseases in *** discussed BAF complex subunits and their main characteristics in *** advances in studies of human pluripotent stem cells and the feasibility of driving their differentiation into NSPCs,we can now investigate the role of the BAF complex in regulating the balance between self-renewal and differentiation of *** recent progress in these research areas,we suggest that three approaches should be used in investigations in the near *** of whole human exome and genome-wide association studies suggest that mutations in the subunits of the BAF complex are related to neurodevelopmental *** insight into the mechanism of BAF complex regulation in NSPCs during neural cell fate decisions and neurodevelopment may help in exploiting new methods for clinical applications.

关键词： Neural stem/progenitor cell BRG1/BRM-associated factor complex Subunit Proliferation Differentiation Neural developmental disorde

Improvement on the Effectiveness of Marine Stock Enhancement in the Artificial Reef Area by a New Cage-Based Release Technique

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Journal of Ocean University of China 2021年第4期20卷 992-998页

作者： ZHANG Junbo HE Yufeng GUO Zhixing JI Shuheng ZHANG Shuo TANG Yanli SHENG Huaxiang wan rong KITAZAWA Daisuke College of Marine Sciences Shanghai Ocean UniversityShanghai 201306China College of Economics and Management Shanghai Ocean UniversityShanghai 201306China Marine Hazard Mitigation Service Ministry of Natural ResourcesBeijing 100194China College of Fisheries Ocean University of ChinaQingdao 266003China National Engineering Research Center for Oceanic Fisheries Shanghai Ocean UniversityShanghai 201306China Institute of Industrial Science the University of Tokyo5-1-5 KashiwanohaKashiwa-shiChiba 277-8574Japan

The release technique,affecting the survival rate of fish species released for stock enhancement,plays a vital role in the effectiveness of the *** order to improve the probability of released fish settling down to bottom,a new cage-based release technique was designed and tested via a water tank with artificial reef *** coral reef fish species,Sebastes schlegelii and Paralichthys olivaceus were assessed using this *** behavior and distribution in water tank were recorded and compared with the traditional release release *** showed that in the case of cage-based release technique:1)when the release process is just finished,the distribution index(DI)of juveniles *** and *** were 97.8%and 98.9%at reef area,40%and 71.1%at release point,respectively,which was higher than those using two alternative techniques;2)its impact duration was less than that in the other two conditions,where the DI within 4 hours was higher after releasing,especially for *** findings indicated that the new cage-based technique could release the fish into the specified location,and has a potential to mitigate the stress reaction of fish caused by releasing process.

关键词： release technique cage-based device distribution patterns distribution index stock enhancement

The Cleavage Effect of Histidyl-Lysine on RNA

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Chinese Chemical Letters 1998年第4期9卷 333-334页

作者： Xiang Hong LI rong wan Qiong ZHANG Yu Fen ZHAO(Department of Chemistry, Tsinghua University, Bejing 100084) Department of Chemistry Tsinghua University Beijing 100084 China

The cleavage activity of histidyl-lysine dipeptide (His-Lys) on RNA was studied and compared with that of histidine. With the addition of the lysine residue, the cleavage activity was increased about 10-fold compared ... 详细信息

关键词： RNA cleavage histidyl-lysine

Hepatitis C virus core proteins derived from different quasispecies of genotype 1b inhibit the growth of Chang liver cells

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World Journal of Gastroenterology 2008年第18期14卷 2877-2881页

作者： Xue-Bing Yan Lei Mei Xia Feng Mei-rong wan Zhi Chen Nicole Pavio Christian Brechot Department of Infectious Diseases the First Affiliated Hospital of Xuzhou Medical College Xuzhou 221002 Jiangsu Province China Changshu No. 2 People's Hospital 68 Haiyu South Road Changshu 215500 Jiangsu Province China Department of Central Labatory the First Affiliated Hospital of Xuzhou Medical College Xuzhou 221002 Jiangsu Province China Institute of Infectious Diseases the First Affiliated Hospital College of Medical Science Zhejiang University Key Lab of Infectious Diseases Ministry of Public Health Hangzhou 310003 Zhejiang Province China Christian Brechot Inserm U785 Villejuif F-94804 France Universite Paris sud Centre Hepato-Biliaire Hopital Paul Brousse Villejuif F-94804 France

AIM: To investigate the influence of different quasispecies of hepatitis C virus (HCV) genotype 1b core protein on growth of Chang liver cells. METHODS: Three eukaryotic expression plasmids (pEGFP-N1/core) that contained different quasispecies truncated core proteins of HCV genotype 1b were constructed. These were derived from tumor (T) and non- tumor (NT) tissues of a patient infected with HCV and C191 (HCV-J6). The core protein expression plasmids were transiently transfected into Chang liver cells. At different times, the cell cycle and apoptosis was assayed by flow cytometry, and cell proliferation was assayed by methyl thiazolyl tetrazolium (MTT) assay. RESULTS: The proportion of S-phase Chang liver cells transfected with pEGFP-N1/core was significantly lower than that of cells transfected with blank plasmid at three different times after transfection (all P NT > C191), and apoptosis was increased in cells transfected with pEGFP-N1/core as the transfection time increased (72 h > 48 h > 24 h). CONCLUSION: These results suggest that HCV genotype 1b core protein induces apoptosis, and inhibits cell- cycle progression and proliferation of Chang liver cells. Different quasispecies core proteins of HCV genotype 1b might have some differences in the pathogenesis of HCV persistent infection and hepatocellular carcinoma.

关键词： Hepatitis C virus Core protein Chang liver cells Cell cycle Apoptosis

Comparison of nominal and standardized catch per unit effort data in quantifying habitat suitability of skipjack tuna in the equatorial Pacific Ocean

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Acta Oceanologica Sinica 2022年第3期41卷 1-10页

作者： Cheng Zhou Yuanyuan Hu Jie Cao Liuxiong Xu Xuefang wang rong wan Yu Xiao Jiangfeng Zhu Hao Tang College of Marine Sciences Shanghai Ocean UniversityShanghai 201306China National Engineering Research Center for Oceanic Fisheries Shanghai 201306China Department of Applied Ecology Center for Marine Sciences and TechnologyNorth Carolina State UniversityMorehead CityNC 28557USA

In the western and central Pacific Ocean,upper strata waters exhibit highly dynamic oceanographic features under ENSO *** has been proved to be responsible for the dynamic change of both abundance and zonal distribution of skipjack tuna(Katsuwonus pelamis).Although causality has been suggested by researchers using physical-biological interaction models,cumulative evidence needs to be obtained and the tenability of assertion needs to be tested from an ecological habitat perspective,based on fisheries *** purse seine fishery,the use of catch per unit effort(CPUE)as an indication of the abundance is confusing because of technical improvements over the whole exploitation history and unbalanced individual fishing characteristic of *** is particularly interesting to discriminate between habitat characteristics in comparative scenarios of CPUE *** study identified habitat traits based on a series of oceanographic factors from a global ocean reanalysis model.A comparison was conducted between two habitat models based on unprocessed purse seine CPUE and standardized CPUE considering fishing *** results suggest that standardized CPUE could model the regular zonal shift of habitat compatible with the observed fishing efforts transfer,and achieved better prediction capacity than unprocessed ***,the habitat of skipjack tuna was also characterized and linked with surface and subsurface thermal environment,ocean current,dissolved oxygen,biotic environment,and ENSO *** monthly-averaged habitat suitable index,derived from the optimal habitat model prediction,showed a significant linear relationship with the southern oscillation index,which suggested that El Ni?o episodes eventually provide more preferable habitat for skipjack tuna under ENSO variability.

关键词： skipjack tuna free-swimming schools habitat characteristics ENSO events CPUE standardization

Enhancing the mechanical and anticorrosion properties of 316L stainless steel via a cathodic plasma electrolytic nitriding treatment with added PEG

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Journal of Materials Science & Technology 2019年第11期35卷 2630-2637页

作者： Tianyi Zhang Junsheng Wu Lei Jin Zhan Zhang wan rong Bowei Zhang Yi wang Yedong He Wei Liu Xiaogang Li Corrosion and Protection Center Key Laboratory for Corrosion and Protection(MOE)University of Science and Technology BeijingBeijing 100083China Department of Materials Application Research China Aviation Manufacturing Technology InstituteBeijing 100024China Northwest Institute for Non-Ferrous Metal Research Xi’an 710016China

A cathodic plasma electrolytic nitriding(CPEN)treatment with a urea aqueous solution was performed on 316L stainless steel to rapidly improve its surface properties in this *** results show that the PEG2000 macromolecules increased the nitriding energy via enhancing the ability to bond the produced gas film to the metal/electrolyte *** cross-sectional morphologies indicate that a thick nitrided layer was obtained when the urea concentration was 543 g I^-1,corresponding to a Vickers hardness 450 HV(0.1),which was 3.5 times larger than that of the *** nitrided layer mainly contained expanded austenite(γN),oxides and iron nitrides(e.g.,Fe3O4 and FeN(0.076)).In terms of its performance,coefficient of friction(COF)of the nitride layer decreased to nearly two-thirds that of the untreated layer,and the passivation current densities of the nitrided sample in a 3.5%NaCl solution decreased by an order of magnitude compared to that of the ***,the approach presented herein provides an attractive way to modify the effect of CPEN in a urea aqueous solution.

关键词： 316L stainless steel Cathodic plasma electrolytic nitriding Coefficient of friction Polarization curves

A facile and precise method for quantifying small–large/light-weighted molecular interaction system

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Nuclear Science and Techniques 2016年第5期27卷 132-139页

作者： wan-rong Li Pei Gong Yu-Xing Ma Hai-Yang Gao Xiao-Ling Yun Ming Yuan Yu-Shuang Liu Feng Zhang Agricultural Nanocenter School of Life SciencesInner Mongolia Agricultural University306 Zhaowuda RoadHohhot 010018China

It is significant to quantify the intermolecular physisorption extent in biomedical *** taking the advantage of a significant difference from either sizes or weights,we introduced a combination of Scatchard equation and either ultracentrifugation or size exclusion chromatography to obtain both the binding constant and the number of binding sites by using bovine serum albumin and eosin B as *** to the photoluminescence quenching-based methods like Stern-Volmer and Hill equations,the introduced method is not only more precise but also simpler and more straightforward for the ***,the protein conformational changes and the corresponding theoretical binding mode with an atomic resolution were also studied by using three-dimensional fluorescence spectroscopy and molecular docking method,*** comparative results could help scientists select right methods to study any interactions between two molecules with significant differences from either sizes or weights.

关键词：相互作用系统分子间定量方法尺寸排阻色谱简便牛血清白蛋白 Hill方程三维荧光光谱

Efficacy and safety profile of two-dose SARS-CoV-2 vaccines in cancer patients:An observational study in China

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World Journal of Clinical Cases 2022年第31期10卷 11411-11418页

作者： Sheng-Wei Cai Jin-Yan Chen rong wan De-Jian Pan Wei-Lin Yang Ren-Gui Zhou Department of Oncology The 904^(th) Hospital of Joint Logistic Support ForceWuxi 214044Jiangsu ProvinceChina Department of Disinfection and Supply The 904^(th) Hospital of Joint Logistic Support ForceWuxi 214044Jiangsu ProvinceChina Department of Quality Control The 904^(th) Hospital of Joint Logistic Support ForceWuxi 214044Jiangsu ProvinceChina

BACKGROUND The new coronavirus severe acute respiratory syndrome coronavirus 2(SARSCoV-2)has produced a global pandemic of coronavirus disease 2019(COVID-19),resulting in modifications to public health policies on a universal ***-2 vaccine has evolved as the most effective and secure way for protecting healthy individuals against *** with cancer were excluded from clinical trials due to their increased COVID-19 risk and current immunosuppressing *** and effectiveness evidence is insufficient for SARS-CoV-2 vaccination in cancer *** To assess the efficacy and safety of two-dose SARS-CoV-2 vaccines in cancer *** A multicenter observational study was performed at ten Chinese hospitals between January 1,2021 and December 31,*** participant in the research received two doses of vaccination.A total of 215 healthy people were screened and 132 eligible patients with cancer were *** order to verify the safety of the second dose of the vaccine,a side-effect report was *** weeks following the second vaccination dose,subjects underwent an analogous questionnaire *** a magnetic particle-based chemiluminescence immunoassay,serum levels of anti-SARS-CoV-2 immunoglobulin G(IgG)antibodies were measured to determine the effectiveness of *** levels≥10 AU/mL were considered *** All the 347 eligible patients completed the follow-up,and anti-SARS-CoV-2 IgG antibodies were *** pain at the injection location was the most common side effect mentioned by all responders,with an increased incidence in cancer patients than the healthy people after the second dose vaccine(17.2%vs 9.1%;P=0.035).There was no significant difference in headache,urticaria,or other adverse reactions between patients with cancer and healthy *** the group of cancer patients,the seropositivity incidence was 83.3%,while it was 96.3%in the group of healthy *** the group of cancer

关键词： SARS-CoV-2 Vaccine Cancer COVID-19 Immunotherapy