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Solar Radiation, Perelman Entropy Mapping, DNA, Viruses etc.

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Open Journal of Biophysics 2020年第2期10卷 54-58页

A short note based on the homogeneous 5D space-time topological mappings is extended to cover DNAs of viruses and how the body’s immune system can be enhanced to recognize and remove it.

关键词： 5D Homogeneous Space-Time and Perelman Mappings Nitrogenous Bases DNA Viruses Coronavirus Immune System

Prevalence and risk.factors for impaired renal function among Asian patients with nonalcoholic fatty liver disease

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 241-248页

作者： Chao Sun George Boon-Bee Goh wan-Cheng chow Wah-k.eong Chan Grace Lai-Hung Wong Wai-k.y Seto Yi-Hsiang Huang Han-Chieh Lin I-Cheng Lee Hye Won Lee Seung Up k.m Vincent Wai-Sun Wong Jian-Gao Fan Center for Fatty Liver Disease Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghai 200092China Department of Gastroenterology&Hepatology Singapore General HospitalSingaporeSingapore Gastroenterology and Hepatology Unit Department of MedicineFaculty of MedicineUniversity of MalayaKuala LumpurMalaysia Department of Medicine and Therapeutics and State k.y Laboratory of Digestive Disease The Chinese University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina Institute of Clinical Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Division of Gastroenterology and Hepatology Taipei Veterans General HospitalTaipeiTaiwanChina Faculty of Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Department of Internal Medicine Yonsei University College of MedicineSeoulKorea

Back.round:Nonalcoholic fatty liver disease(NAFLD)is associated with impaired renal function,and both diseases often occur alongside other metabolic ***,the prevalence and risk.factors for impaired renal function in patients with NAFLD remain *** objective of this study was to identify the prevalence and risk.factors for renal impairment in NAFLD ***:All adults aged 18-70 years with ultrasound-diagnosed NAFLD and transient elastography examination from eight Asian centers were enrolled in this prospective *** fibrosis and cirrhosis were assessed by FibroScan-aspartate aminotransferase(FAST),Agile 3+and Agile 4 *** renal function and chronic k.dney disease(Ck.)were defined by an estimated glomerular filtration rate(eGFR)with value ofk.-Epidemiology Collaboration(Ck.-EPI)***:Among 529 included NAFLD patients,the prevalence rates of impaired renal function and Ck. were 37.4%and 4.9%,*** multivariate analysis,a moderate-high risk.of advanced liver fibrosis and cirrhosis according to Agile 3+and Agile 4 scores were independent risk.factors for Ck.(Pk.ly to have impaired renal function(Pk.of *** glycemic control in the prediabetic stage might have a potential renoprotective role in these patients.

关键词： Nonalcoholic fatty liver disease Impaired renal function Agile 3+ Agile 4 Metabolic syndrome

Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G

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Virologica Sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin Ng Grace Lui Lowell Ling Agnes S.Y.Leung Chit chow Siaw Shi Boon Wendy C.S.Ho Maggie Haitian wang Renee wan Yi Chan Albert Martin Li David Shu Cheong Hui Paul k.y Sheung Chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jock.y Club School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The SARS-CoV-2 Omicron variants are notorious for their transmissibility,but little is k.own about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate mark.r allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus SARS-CoV-2 Omicron BA.2 Non-VOC-D614G RNA-seq Subgenomic RNA(sgRNA)

Linewidth narrowing in self-injection-lock.d on-chip lasers

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Light(Science & Applications) 2023年第10期12卷 2074-2083页

作者： Emad Alk.azraji Weng W.chow Frédéric Grillot John E.Bowers Yating wan Integrated Photonics Lab King Abdullah University of Science and TechnologyThuwal 23955Saudi Arabia Sandia National Laboratories AlbuquerqueNM 87185-1086USA LTCI Télécom ParisInstitut Polytechnique de Paris91120 PalaiseauFrance Department of Electronic and Computer Engineering University of California-Santa BarbaraSanta BarbaraCA 93106USA

Stable laser emission with narrow linewidth is of critical importance in many applications,including coherent communications,LIDAR,and remote *** this work.the physics underlying spectral narrowing of self-injection-lock.d on-chip lasers to Hz-level lasing linewidth is investigated using a composite-cavity *** integrated III–V/SiN lasers operating with quantum-dot and quantum-well active regions are analyzed with a focus on the effects of carrier quantum *** intrinsic differences are associated with gain saturation and carrier-induced refractive index,which are directly connected with 0-and 2-dimensional carrier densities of *** from parametric studies are presented for tradeoffs involved with tailoring the linewidth,output power,and injection current for different device *** both quantum-well and quantum-dot devices show similar linewidth-narrowing capabilities,the former emits at a higher optical power in the self-injection-lock.d state,while the latter is more ***,a multi-objective optimization analysis is provided to optimize the operation and design *** the quantum-well laser,minimizing the number of quantum-well layers is found to decrease the threshold current without significantly reducing the output *** the quantum-dot laser,increasing the quantum-dot layers or density in each layer increases the output power without significantly increasing the threshold *** findings serve to guide more detailed parametric studies to produce timely results for engineering design.

关键词： narrowing injection quantum

Numerical Studies on Fire-induced Thermal Plumes

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Journal of Thermal Science 2005年第4期14卷 374-381页

作者： Junmei LI Yanfeng LI wan k. chow Huairong HUANG The College of Architecture and Civil Engineering Beijing University of Technology Beijing 100022China Department of Building Services Engineering The Hong Kong Polytechnic University Hong Kong China

大多数描述羽毛在文学报导了的火的表情被知道基于实验。由于不同试验性的方法，火来源的几何学，燃料类型和包围条件，根据存在理论工作与它的温度和速度地导出一根羽毛的一幅全面图画是困难的。计算液体动力学(CFD ) 在由专家设计的... 详细信息

大多数描述羽毛在文学报导了的火的表情被知道基于实验。由于不同试验性的方法，火来源的几何学，燃料类型和包围条件，根据存在理论工作与它的温度和速度地导出一根羽毛的一幅全面图画是困难的。计算液体动力学(CFD ) 在由专家设计的火被认为是一个实际工程工具，肯定能在各种各样的状况下面给羽毛行为的更多的细节。为导致 thermally 的羽毛的气体动力学将与 CFD 数字地被学习。四个典型 axisymmetric 羽毛方程将在这篇论文被估计，并且调查将为在以一种买得起的方式设计烟管理系统的火工程师是有用的。这是在实现设计基于表演的火代码的一个批评的点。关键词热羽毛 - 开火 - CFD - 烟管理 CLC 数字 O643.

关键词： CFD 计算动态流程燃烧过程烟雾处理

Development of a Low-cost Polymerase Chain Reaction-based Method for Studying Differentially Expressed Genes in Developing Rice Leaves

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Journal of Integrative Plant Biology 2009年第6期51卷 614-621页

作者： Yin-wan Wendy Fung Hoi Yee chow Tik.wan Law Biao Dong Hoi Shan k.0} Faculty of Science The Chinese University of Hong Kong Shatin Hong Kong SAP China Department of Biology The Chinese University of Hong Kong Shatin Hong Kong SAR China

Gene expression studies are important for revealing gene functions putatively involved in biological processes. We were interested in identifying differentially expressed genes during leaf development in rice. We combined the RNA arbitrarily primed-polymerase chain reaction （***） and dot blot hybridization methods to screen a rice leaf primordium cDNA library. Three developmental stages during vegetative growth were examined. The cDNA clones showing different hybridization patterns were further analyzed and verified. Here we demonstrate that the combination of RAP-PCR and dot blot hybridization could provide an efficient and relatively low-cost cDNA library screening approach to discover genes not previously k.own to be associated with leaf development in rice, We believe that the findings described here will help to elucidate the molecular mechanism（s） underlying the developmental processes of rice leaf

关键词： cDNA clones development dot blot hybridization primordium RNA arbitrarily primed-polymerase chain reaction.

Numerical studies on swirling of internal fire whirls with experimental justifications

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Building Simulation 2021年第5期14卷 1499-1509页

作者： Zheming Gao S.S.Li Y.Gao H.Y.Hung wan-k. chow Midea Residential Air Conditioner Division FoshanGuangdongChina College of Aerospace and Civil Engineering Harbin Engineering UniversityHarbinHeilongjiangChina Department of Building Services Engineering The Hong Kong Polytechnic UniversityHunghomKowloonHong KongChina

Numerical studies on internal fire whirls(IFW)generated in a vertical shaft model with a single corner gap were reported in this *** generation of IFW,burning rate of fuel and temperature were studied experimentally *** simulations on medium-scale IFW were carried out using a fully-coupled large eddy simulation incorporating subgrid scale turbulence and a fire source with heat release rates compiled from experimental *** transient flame shape was studied and then simulated numerically by using *** dynamic phenomena of generation and development of IFW were simulated and then compared with experimental *** predicted results were validated by comparing with experimental data,which demonstrated that an IFW can be simulated by Computational Fluid *** results for flame surface,temperature,and flame length agreed well with the experimental *** IFW flame region and intermittent region were longer than those for an ordinary pool *** modified empirical formula for centerline temperature was *** of vertical and tangential velocity in axial and radial directions were also *** vortex core radius was found to be determined by the fuel bed *** field was not measured extensively due to resources *** measured temperature distribution with predictions is acceptable because temperature is related to the heat release rate,air flow and pressure gradient.

关键词： internal fire whirl large eddy simulation vertical structure flame surface

Change in model for end-stage liver disease score at two week.,as an indicator of mortality or liver transplantation at 60 days in acute-on-chronic liver failure

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Gastroenterology Report 2015年第2期3卷 122-127页

作者： Rajneesh k.mar Thinesh Lee k.ishnamoorthy Hiang k.at Tan Hock.Foong Lui wan Cheng chow Department of Gastroenterology and Hepatology Singapore General HospitalSingapore

Back.round:Acute-on-chronic liver failure(ACLF)is characterised by a sudden deterioration of underlying chronic liver disease,resulting in increased rates of mortality and liver *** prognostication can benefit optimal allocation of ***:ACLF was defined as per the disease criteria of the Asian Pacific Association for the Study of the *** discharge summaries from between January 2001 and April 2013 were *** primary outcome was mortality or liver transplantation within 60 days from onset of ***‘model for end-stage liver disease’(MELD)score and change in MELD at Week. 1,2 and 4 were reviewed in order to identify the earliest point for prediction of mortality or liver ***:Clinical data were collected on 53 subjects who fulfilled the inclusion and exclusion *** 60 days from presentation,20 patients(37.7%)died and 4(7.5%)underwent liver *** MELD of-2 after 2 week. was 75.0%sensitive and 75.9%specific for predicting mortality or liver *** the MELD score did not increase at 2 week.,predictive chance of survival was 93.8%over the next 60 *** change at 1 week.showed poor sensitivity and *** at 4 week. was too late for ***:Change in MELD score at 2 week. provides an early opportunity for prognostication in ACLF.A MELD score that does not deteriorate by Week.2 would predict 93.8%chance of survival for the next 60 *** finding warrants further validation in larger cohort studies.

关键词： acute-on-chronic liver failure model for end-stage liver disease(MELD)score liver transplantation mortality

The Hong k.ng consensus recommendations on the diagnosis and management of pancreatic cystic lesions

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 715-735,I0019-I0020页

作者： Tan-To Cheung Yuk.Tong Lee Raymond Shing-Yan Tang Wong Hoi She k.i Chi Cheng Chin Cheung Cheung k.ith wan Hang Chiu k.nneth Siu Ho Chok.Wing Sun chow Tak.Wing Lai Wai-k.y Seto Thomas Yau Department of Surgery Queen Mary HospitalThe University of Hong KongHong KongChina Gastroenterologist in private practice Hong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Department of Surgery Kwong Wah HospitalHong KongChina Department of Surgery Tuen Mun HospitalHong KongChina Department of Radiology&Imaging Queen Elizabeth HospitalHong KongChina Department of Medicine The University of Hong KongHong KongChina Department of Surgery Princess Margaret HospitalHong KongChina Department of Medicine School of Clinical MedicineThe University of Hong KongHong KongChina State k.y Laboratory of Liver Research The University of Hong KongHong KongChina

Back.round:The finding of pancreatic cystic lesions(PCL)on incidental imaging is becoming increasingly *** studies report a prevalence of 2.2-44.7%depending on the population,imaging modality and indication for imaging,and the prevalence increases with *** with PCL are at risk.of developing pancreatic cancer,a disease with a poor *** publication summarizes recommendations for the diagnosis and management of PCL and post-operative pancreatic exocrine insufficiency(PEI)from a group of local ***:Clinical evidence was consolidated from narrative reviews and consensus statements formulated during two online meetings in March *** expert panel included gastroenterologists,hepatobiliary surgeons,oncologists,radiologists,and ***:Patients with PCL require careful investigation and follow-up due to the risk.of malignant transformation of these *** should undergo clinical investigation and pancreas-specific imaging to classify lesions and understand the risk.profile of the *** indicated,patients should undergo pancreatectomy to excise *** pancreatectomy,patients are at risk.of PEI,leading to gastrointestinal dysfunction and ***,such patients should be monitored for symptoms of PEI,and promptly treated with pancreatic enzyme replacement therapy(PERT).Patients with poor response to PERT may require increases in dose,addition of a proton pump inhibitor,and/or further investigation,including tests for pancreatic *** are also at risk.of new-onset diabetes mellitus after pancreatectomy;they should be screened and treated with insulin if ***:These statements are an accurate summary of our approach to the diagnosis and management of patients with PCL and will be of assistance to clinicians treating these patients in a similar clinical landscape.

关键词： Pancreatic cystic lesions pancreatic endocrine insufficiency pancreatic enzyme replacement therapy