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Journal of Traditional Chinese Medicine 2017年第1期37卷 64-75页

作者： Chen Cen wang Fengqin Xiao Wen Xia Zhining Hu Guang wan jianbo Yang Fengqing School of Chemistry and Chemical Engineering Chongqing University Chongqing 400030 China School of Pharmacy and Bioengineering Chongqing University of Technology Chongqing 400054 China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macao Macao China

OBJECTIVE: To evaluate the anti-platelet aggregation effects of extracts from 31 Traditional Chinese Medicines(TCM) with the property of activating blood and resolving stasis in terms of TCM ***: The 31 TCMs extracts were prepared using water, 90% ethanol and ethyl acetate., and the effects on anti-platelet aggregation were tested on a platelet aggregation analyzer in vitro with adenosine 5'-diphosphate, bovine thrombin and arachi-donic acid(AA) as aggregation inducers, respectively. Aspirin was the positive ***: Lots of the tested TCMs had inhibitory effects with concentration-dependent manner on platelet aggregations induced by various ***, some of the TCMs such as Chuanxiong(Rhizoma Chuanxiong), Yanhusuo(Rhizoma Corydalis Yanhusuo) and Danshen(Radix Salviae Miltiorrhizae) showed good anti-platelet aggregation effect similar or higher than that in positive control ***: The study provided scientific references that several TCMs such as Chuanxiong(Rhizoma Chuanxiong), Yanhusuo(Rhizoma Corydalis Yanhusuo) and Danshen(Radix Salviae Miltiorrhizae),possess the property of anti-platelet aggregation.

关键词： Platelet aggregation inhibitors Adenosine diphosphate Thrombin Arachidonic acid Blood activating stasis removing Medicine Chinese traditional

On-line comprehensive two-dimensional hydrophilic interaction liquid chromatography × reversed-phase liquid chromatography coupled with hybrid linear ion trap Orbitrap mass spectrometry for qualitative and quantitative characterization of ginsenosides in

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On-line comprehensive two-dimensional hydrophilic interactio...

联合临床触诊加摄局部点压摄影在乳腺疾病诊断中的价值

2018年中国质谱学术大会（CMSC2018）

作者： Jiliang Cao Lijuan Ma jianbo wan Peng Li State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of Macau

In the present study, a system was developed for the qualitative and quantitative analysis of ginsenosides in the leaves of Panax notoginseng(PNL) using online comprehensive two-dimensional hydrophilic interaction chromatography and reversed-phase liquid chromatography coupled to a DAD detector and hybrid linear ion trap-Orbitrap mass spectrometry(HILIC×RP-DAD-ESI/HRMS/MSn). The system was configured based on the combination of an XBridge Amide column(150 mm × 2.1 mm, 2.5 μm) and Accucore Phenyl-Hexyl(50 mm × 4.6 mm, 2.6 μm) for the first and second dimensions, respectively. An additional water phase was optimized to dilute the eluent from the first dimension to decrease its elution strength in the second dimension. A back-flush trap column was selected as an interface to make up for the loss of efficiency and resolution due to the online dilution. Under the optimized conditions, a total of 235 ginsenosides were discovered from PNL, including 95 potentially novel ginsenosides, using the developed online HILIC×RP system. Moreover, the LC×LC-LTQ-MS system was validated for the quantitative analysis of 24 ginsenosides using the EIC contour plot, exhibiting satisfactory linearity(r≥0.9991). The online combination of HILIC×RP and HRMS system proved to be sufficiently powerful to provide unparalleled separation and identification of target analytes in samples with complex matrices.

关键词： Online HILIC×RPLC Interfaces LTQ-Orbitrap mass spectrometry Ginsenosides Leaves of Panax notoginseng

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现代医用影像学 2021年第4期30卷 654-657页

作者：万剑波盐城市大丰中医院影像科江苏盐城224100

目的:探讨常规乳腺摄影后联合触诊加摄局部点压摄影对乳腺疾病的诊断价值。方法:常规乳腺摄影后,对40例触诊异常或不能鉴别良恶性的病例加摄局部点压摄影,获得的图像结合触诊特点进行分析诊断,并对比评价常规摄影与局部点压摄影对疾病... 详细信息

目的:探讨常规乳腺摄影后联合触诊加摄局部点压摄影对乳腺疾病的诊断价值。方法:常规乳腺摄影后,对40例触诊异常或不能鉴别良恶性的病例加摄局部点压摄影,获得的图像结合触诊特点进行分析诊断,并对比评价常规摄影与局部点压摄影对疾病的诊断。结果:联合触诊加摄的局部点压摄影病变全部检出,远高于常规摄影的病变检出率(80%),且正确诊断率(87.5%)也明显高于常规摄影(60.9%)。40例病例中,其中4例因病灶位置较高较深、紧贴胸壁未能显示完全,局部点压后显示基本满意,3例局灶性非对称致密影经局部点压后显示小肿块伴边缘短小毛刺,结合触诊特点诊断更加明确。结论:在常规乳腺摄影的基础上联合临床触诊加摄局部点压摄影可以显著提高乳腺病变的检出率和正确诊断率。

关键词：乳腺X线触诊局部点压乳腺疾病

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环境艺术设计与中国传统元素的融合路径探究

鞋类工艺与设计 2024年第16期4卷 93-95页

作者：万剑波江西外语外贸职业学院江西南昌330200

中华文化源远流长、博大精深,在历史长河中传统元素不断扩张、种类丰富,不仅是优秀文化的体现与象征,更是精神文明与艺术创造的重要支撑。尤其在艺术设计领域,传统元素发挥着重要作用,可以使艺术作品被赋予文化意境的同时,凸显艺术作品... 详细信息

中华文化源远流长、博大精深,在历史长河中传统元素不断扩张、种类丰富,不仅是优秀文化的体现与象征,更是精神文明与艺术创造的重要支撑。尤其在艺术设计领域,传统元素发挥着重要作用,可以使艺术作品被赋予文化意境的同时,凸显艺术作品的视觉传达效果。如今,艺术设计领域愈加重视传统元素在作品中的应用效果。就环境艺术设计领域而言,只有把握好传统元素融合路径,才能够更好地发挥传统元素价值,提高环境艺术设计水平。本文先后围绕环境艺术设计与中国传统元素的融合原则和融合路径展开了相关探讨,以供参考。

关键词：环境艺术设计中国传统元素融合路径

加压溶剂提取与液相色谱-电喷雾质谱联用技术分析三七中皂苷类成分

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中药材 2005年第10期28卷 26-31页

作者：万建波黎畅明李绍平孔令义王一涛澳门大学中华医药研究所中国药科大学天然药物化学教研室南京210039

目的:建立三七药材的皂苷类成分LC-ESI-MS定性分析方法。方法:三七药材经加压溶剂提取技术处理后,利用负离子检测和多级反应检测(MRM)模式,采集三七药材的总离子色谱和MRM谱,并对其进行深入的分析。结果:该类化合物分子在电喷雾质谱下... 详细信息

目的:建立三七药材的皂苷类成分LC-ESI-MS定性分析方法。方法:三七药材经加压溶剂提取技术处理后,利用负离子检测和多级反应检测(MRM)模式,采集三七药材的总离子色谱和MRM谱,并对其进行深入的分析。结果:该类化合物分子在电喷雾质谱下的裂解特征,有助于其分子量的确定和结构鉴定,检识出10种皂苷类成分。结论:建立的液相色谱-质谱联用方法可用于三七中皂苷类成分的定性分析,为三七质量控制提供了依据。

关键词：三七加压溶剂提取电喷雾质谱人参皂苷多级反应检测

Synergistic effect of bonding heterogeneity and phonon localization in introducing excellent thermoelectric properties in layered heteroanionic NdZnSbO material

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Journal of Energy Chemistry 2025年第1期100卷 259-272页

作者： Da wan Shuwei Tang Shulin Bai Xiaodong Li Peng Ai wanrong Guo Tuo Zheng College of Materials Science and Engineering Liaoning Technical University Faculty of Chemistry Northeast Normal University

Layered rare-earth metal oxides, harnessing the dual properties of oxides and two-dimensional layered materials, exhibit remarkable thermal stability and quantum confinement effects. Therefore, this work adopts the first-principles calculation combined with the Boltzmann transport theory to predict the thermoelectric properties of NdZnSbO compound. The coexistence of weak interlayer van der Waals interactions, robust intralayer ionic bonding, and partial covalent bonding leads to remarkable bonding heterogeneity, which engenders pronounced phonon scattering and imposes constraints on thermal transport along the out-of-plane direction. The weakened chemical bonds induced by the antibonding states, together with the rattling-like behavior of the Zn atom, culminate in the profound anharmonicity in the layered NdZnSbO compound. The weakening bond and heavy element contribute to the softness of phonon modes, which significantly diminishes the phonon group velocity. The redistribution-dominated four-phonon scattering process spans a large optical gap, which effectively reduces the lattice thermal conductivity. The NdZnSbO compound exhibits direct semiconductor characteristic with a bandgap of 0.73 e V by adopting the Heyd-Scuseria-Ernzerhof(HSE06) functional in combination with spin–orbit coupling(SOC) effect. The multi-valley feature of NdZnSbO compound augur favorably for band degeneracy, thus amplifying the power factor. Consequently, an optimal figure-of-merit(ZT) of 3.40 at 900 K is achieved for the n-type NdZnSbO compound. The present study delves deeply insights into the origins for the low thermal conductivity of NdZnSbO compound and proposes an optimization scheme to enhance overall thermoelectric performance.

关键词： Bond strength (chemical)

海底管道外防护层清理设备的电气控制系统研制

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石油工程建设 2018年第3期44卷 31-36页

作者：王徽万箭波冯天贺孙旭恒天津市精研工程机械传动有限公司天津300409

对海底管道进行水下维修,传统做法是由潜水员携带便携式高压水枪或液压圆环锯对管道外表面进行切割并剥离,这种方法效率低,风险大。因此需要研制一种可以智能高效地清理海底管道外防护层的设备。结合前期设计的设备总体组成及设备作业工... 详细信息

对海底管道进行水下维修,传统做法是由潜水员携带便携式高压水枪或液压圆环锯对管道外表面进行切割并剥离,这种方法效率低,风险大。因此需要研制一种可以智能高效地清理海底管道外防护层的设备。结合前期设计的设备总体组成及设备作业工况,配套设计了设备的电气控制系统方案。首先简要介绍了研制任务概况,而后较为详细地论述了设备总体设计方案、控制系统的软硬件设计方案、研制的海底管道外涂层清理设备的工程应用验证。实践表明,研制的设备可满足水深达100 m的水下施工工况,可代替以往潜水员下水人工作业的方式。

关键词：海底管道外防护层清理电气控制硬件设计软件设计

Panax notoginseng saponins protect against chronic ethanol-induced hepatic steatosis

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Journal of Chinese Pharmaceutical Sciences 2014年第6期23卷 361-368页

作者：丁仁博鲍娇琳曹怡纬何承伟王一涛万建波澳门大学中药质量研究国家重点实验室中华医药研究院中国澳门999078

Chronic alcohol consumption induces hepatic steatosis, the early stage of alcoholic liver disease （ALD）. The aim ofpresent study is to investigate the protective effect ofPanax notoginseng saponins （PNS） against chronic ethanol-induced hepaticsteatosis in vivo. Mice were pair-fed a modified Lieber-DeCarli liquid diet containing alcohol or isocaloric maltose dextrin ascontrol diet with or without PNS （200 mg/kg, BW） for 8 weeks. Animals supplemented with PNS were protected against hepaticlipid accumulation induced by chronic ethanol exposure. Accordingly, PNS could significantly decrease the elevation of plasmatriglyceride, plasma enzyme activities, i.e. alanine aminotransferase （ALT） and aspartate aminotransferase （AST）, and hepaticTNF-ct and IL-6 levels which were induced by chronic alcohol exposure. In addition, PNS markedly reduced the lipolysis ofwhite adipose tissue （WAT） that stimulated by alcohol feeding through the inhibiting protein expression of phosphorylation ofhormone-sensitive lipase （p-HSL）, rather than total HSL. Furthermore, alcohol exposure also enhanced fatty acid uptake capacityin liver by elevated hepatic CD36 expression, which could attenuated by PNS treatment. These results demonstrate that PNSsupplementation protects against chronic ethanol-induced hepatic steatosis, which is associated with ameliorating dysfunctionallipid metabolism of WAT and the reduced inflammatory cytokines. Our findings suggested that PNS might be potential to bedeveloped as an effective agent for the treatment of chronic alcoholic steatosis.

关键词： Alcoholic fatty liver Panax notoginseng saponins Lipolysis InflammationCLC number: R96 Document code: A Article ID: 1003-1057(2014)6-361-08

Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

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Neural Regeneration Research 2025年第4期20卷 1015-1030页

作者： Ruoyu Huang Qiuyu Pang Lexin Zheng Jiaxi Lin Hanxi Li Lingbo wan Tao wang Department of Forensic Science School of Basic Medicine and Biological SciencesSuzhou Medicine College of Soochow UniversitySuzhouJiangsu ProvinceChina

Cholesterol is an important component of plasma membranes and participates in many basic life functions,such as the maintenance of cell membrane stability,the synthesis of steroid hormones,and *** plays a key role in the establishment and maintenance of the central nervous *** brain contains 20%of the whole body’s cholesterol,80%of which is located within myelin.A huge number of processes(e.g.,the sterol regulatory element-binding protein pathway and liver X receptor pathway)participate in the regulation of cholesterol metabolism in the brain via mechanisms that include cholesterol biosynthesis,intracellular transport,and *** brain injuries or diseases involving crosstalk among the processes above can affect normal cholesterol metabolism to induce detrimental ***,we hypothesized that cholesterol-related molecules and pathways can serve as therapeutic targets for central nervous system *** hemorrhage is the most severe hemorrhagic stroke subtype,with high mortality and *** cholesterol levels are associated with the risk of intracerebral ***,secondary pathological changes after intracerebral hemorrhage are associated with cholesterol metabolism dysregulation,such as neuroinflammation,demyelination,and multiple types of programmed cell *** cholesterol accumulation in the brain has been found after intracerebral *** this paper,we review normal cholesterol metabolism in the central nervous system,the mechanisms known to participate in the disturbance of cholesterol metabolism after intracerebral hemorrhage,and the links between cholesterol metabolism and cell *** also review several possible and constructive therapeutic targets identified based on cholesterol metabolism to provide cholesterol-based perspectives and a reference for those interested in the treatment of intracerebral hemorrhage.

关键词： cell death cholesterol metabolism intracerebral hemorrhage myelination therapeutic target

Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-Wei Li Jian-Hong Shi Tan Li wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs