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反复妊娠丢失中同种免疫功能异常机制的研究进展

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生殖医学杂志 2024年第6期33卷 817-823页

作者：付琬婷胡琳莉郑州大学第一附属医院生殖医学中心郑州450052

反复妊娠丢失(RPL)在育龄妇女中发病率达2%~5%,是一种多病因导致的严重危害患者身心健康的生殖疾病。越来越多的研究表明,同种免疫功能紊乱通过影响母胎界面的免疫平衡耐受、子宫内膜蜕膜化、滋养层细胞的凋亡、胎盘血管生成参与了RPL... 详细信息

反复妊娠丢失(RPL)在育龄妇女中发病率达2%~5%,是一种多病因导致的严重危害患者身心健康的生殖疾病。越来越多的研究表明,同种免疫功能紊乱通过影响母胎界面的免疫平衡耐受、子宫内膜蜕膜化、滋养层细胞的凋亡、胎盘血管生成参与了RPL的发生。包括自然杀伤细胞、巨噬细胞和树突状细胞的数量及活性异常在内的固有免疫异常,和包括CD4+辅助性T细胞(Th1、Th2和Th17)、CD4+CD25+Foxp3+调节性T细胞、CD8+T细胞、γδ-T细胞、CD19+调节性B细胞和细胞因子数量及活性异常在内的适应性免疫异常,共同构成了同种免疫性RPL的免疫紊乱模式,但具体机制需要进一步研究和探讨。本文就目前RPL的同种免疫源性的病因机制研究及进展进行综述。

关键词：反复妊娠丢失流产同种免疫固有免疫适应性免疫

Review of optical fibre sensors for electrical equipment characteristic state parameters detection

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High Voltage 2019年第4期4卷 271-281页

作者： Weigen Chen Jianxin wang fu wan Pinyi wang State Key Laboratory of Power Transmission Equipment&System Security and New Technology Chongqing UniversityChongqing 400044People's Republic of China

Optical fibre sensing technology is a powerful method for long-term reliable sensing in harsh environments,which means it is particularly suitable for the detection of electrical equipment characteristic state parameters,including characteristic gases,abnormal vibration,ultrasonic produced by partial discharge,and abnormal temperature *** paper reviews several individual optical fibre sensors for different state parameters detection,discusses the advantages,limitations and possible improvement methods,and finally presents the most promising optical fibre sensor for each state parameter.

关键词： fibre state electrical

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单向特斯拉环形密封泄漏控制方法研究

热能动力工程 2024年第2期39卷 41-49页

作者：杨众杰黄锦辉曾辉张万福华东天荒坪抽水蓄能有限责任公司浙江安吉313302 上海理工大学能源与动力工程学院上海200093

针对透平机械动静间隙工质泄漏问题,提出新型单向特斯拉环形密封,建立特斯拉环形密封三维模型,采用计算流体力学方法研究特斯拉喷嘴几何结构(轴向数量、分流角、回转直径、喷嘴直径)与运行参数(压比、转速)对密封泄漏特性的影响。结果表... 详细信息

针对透平机械动静间隙工质泄漏问题,提出新型单向特斯拉环形密封,建立特斯拉环形密封三维模型,采用计算流体力学方法研究特斯拉喷嘴几何结构(轴向数量、分流角、回转直径、喷嘴直径)与运行参数(压比、转速)对密封泄漏特性的影响。结果表明:特斯拉环形密封可以有效降低密封出口流速,抑制密封泄漏,最高可使泄漏量降低15.7%;高压比、高转速下特斯拉环形密封抑制泄漏效果更佳;轴向数目和喷嘴直径都存在一个最佳值,使特斯拉环形密封出口流速最小,泄漏量最低;随分流角减小,特斯拉环形密封出口流速与泄漏量减小;回转直径较小时,对特斯拉环形密封出口流速与泄漏量影响小,但超过喷嘴直径2倍后会使出口流速与泄漏量小幅回升。

关键词：特斯拉环形密封计算流体力学泄漏特性稳定性

Effect of ERBB2 expression on invasiveness of glioma TJ905 cells

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Asian Pacific Journal of Tropical Medicine 2013年第12期6卷 964-967页

作者： Gao-Feng Xu wan-fu Xie Department of Neurosurgery First Hospital of Xi'an Jiaotong University

Objective:To investigate the influence and possible mechanism of ERBB2 expression on the invasiveness of glioma ***:Glioma TJ905 cells were separated and ***2shRNA and overexpressing vectors were constructed,which were then *** ERBB2expression was up-regulated or *** of invasiveness of TJ905 cells were detected by Transwell assay,and the expressions of matrix metalloprotease(MMP)-2 and MMP-9were measured by Western ***:ERBB2 shRNA transfection vector could effectively inhibit expression of ERBB2:while ERBB2 overexpressing vector transfection could significantly improve the expression of ERBB2 in TJ905 *** assay showed that when ERBB2expression was down-regulated,the invasiveness of TJ905 cells was notably decreased;when ERBB2 expression was up-regulated,the invasiveness of TJ905 cells was markedly *** blot indicated that down-regulating ERBB2 inhibited the expression of MMP-2 and MMP-9,while up-regulating ERBB2 enhanced their ***:ERBB2 expression is closely related in the invasiveness of glioma TJ905 cells.

关键词： Glioma Stem cells Invasiveness

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建造标准:EPC项目技术管理的有效工具

工程建设与设计 2024年第5期 251-253页

作者：席靖雅沈万夫中水北方勘测设计研究有限责任公司天津300222 中信建设有限责任公司北京100020

针对项目建设目标、质量和成本管理、风险控制等方面的具体问题,论文进一步通过建造标准的应用场景、界面管理、编制过程,展开说明该管理工具的应用,结合实例展开详细说明了建造标准的各个控制项目如何具体化、可实施化,并指导工程实践。

关键词： EPC项目技术管理成本管理建造标准

Raman spectrum feature extraction and diagnosis of oil-paper insulation ageing based on kernel principal component analysis

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High Voltage 2021年第1期6卷 51-60页

作者： Dingkun Yang Chen Weigen Shi Haiyang wan fu Zhou Yongkuo State Key Laboratory of Power Transmission Equipment&System Security and New Technology Chongqing UniversityShapingba DistrictChongqingChina

Raman spectroscopy, with its specific ability to generate a unique fingerprint‐like spec-trum of certain substances, has attracted much attention in diagnosing the ageing degree of oil-paper insulation. In this study, the feature extraction and ageing diagnosis methods of oil-paper insulation Raman spectroscopy data are further studied. Based on the non‐linear analysis of Raman spectra of different ageing samples, kernel principal component analysis was applied to extract the spectral features, and the back‐propagation neural network was used to build a diagnosis model with high diagnostic accuracy. The results show that Raman spectroscopy combined with kernel principal component analysis and the back‐propagation neural network can diagnose the ageing state of oil-paper insu-lation, with a diagnostic accuracy of 91.43% (64/70). The proposed method provides an effective and feasible method for the ageing assessment of oil‐immersed electrical equipment.

关键词： insulation analysis component

基于自适应变分模态分解的滚动轴承故障特征提取方法研究

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热能动力工程 2024年第2期39卷 194-204页

作者：俎海东李晓波张万福杨建刚内蒙古电力科学研究院分公司内蒙古呼和浩特010020 上海理工大学能源与动力工程学院上海200093 东南大学能源与环境学院江苏南京210096

针对滚动轴承微弱故障特征易被噪声和强故障成分淹没导致漏诊或误诊问题,基于互信息与信息熵构建多目标适应度函数,形成面向故障诊断的自适应变分模态分解算法(Diagnosis Oriented Adaptive Variational Mode Decomposition,DOA-VMD),... 详细信息

针对滚动轴承微弱故障特征易被噪声和强故障成分淹没导致漏诊或误诊问题,基于互信息与信息熵构建多目标适应度函数,形成面向故障诊断的自适应变分模态分解算法(Diagnosis Oriented Adaptive Variational Mode Decomposition,DOA-VMD),有效提取信息以传达故障特征且不产生异常模态干扰;并采用NSGA-II算法对多目标适应度函数搜寻最优Pareto解集;然后考虑峭度是反应冲突的有效指标,以最大峭度值为目标,筛选解集中最优结果实现DOA-VMD参数的确定和特征提取;基于齿轮箱轴承内圈损伤数据验证提出方法的可靠性。结果表明:DOA-VMD可剔除含噪分量并保留具有最显著冲击信号的特征,且该特征较传统VMD方法更能凸显故障特征频率。

关键词：滚动轴承互信息信息熵变分模态分解

Phase Stability,Elastic,Thermo-physical and Electronic Properties of Hexa-(Mo,Cr,W)_2C from First-principles Calculations

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Journal of Iron and Steel Research International 2016年第10期23卷 1096-1103页

作者： Di WU wan-tang fu Yong LI Chun-xu wanG Jing-lin TANG College of Mechanical Engineering Yanshan University Institute for Structural Materials Central Iron and Steel Research Institute State Key Laboratory of Metastable Materials Science and Technology Yanshan University

Phase stability,elastic properties,thermo-physical properties,as well as electronic properties of hexa-（Mo,Cr,W）2C carbides were investigated by first-principles *** results indicated that the Mo8C4,Mo7Cr1C4,Mo7W1C4,Mo6W2C4,and Mo6W1Cr1C4 are stable and the stability follows the sequence：Mo6W1Cr1C4〉Mo7W1C4〉Mo7Cr1C4〉 Mo6W2C4〉 ***6W1Cr1C4 shows the highest stability,deformation resistance and hardness.G/B（shear modulus/bulk modulus）and Poisson′s ratio of the stable hexa-（Mo,Cr,W）2C are all larger than 1.75 and 0.26,respectively,which indicates that they are all *** anisotropies are mainly due to the different Vogit shear modulus/Reuss shear modulus;the mechanical anisotropy of Mo7Cr1C4 is the largest,and that of Mo8C4 is the ***,the obtained Debye temperatureΘDand heat capacity Cpindicate that Mo6W2C4 possesses the best thermal conductivity（ΘD=497.72K）,while Mo7Cr1C4 and Mo6W2C4possess the largest heat capacity when the temperature is in the range of 0-10 Kand larger than 10 K,*** the electronic property analysis,the doped Cr and W atoms can not only participate in orbitals hybridization themselves but also enhance the orbitals hybridization between Mo and C atoms,which can reinforce the interatomic interactions.

关键词： hexa (Mo,Cr, W)2C carbide elastic property electronic structure thermo-physical property first-principles calculation

宽厚板轧机用Cr3钢支承辊淬硬层深度的理论预测与实验验证

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材料热处理学报 2024年第9期45卷 221-228页

作者：白兴红傅万堂郭峰赵席春王大鹏赵德利燕山大学亚稳材料制备技术与科学国家重点实验室材料科学与工程学院河北秦皇岛066004 天津重型装备工程研究有限公司天津300457 中国第一重型机械股份公司黑龙江齐齐哈尔161041

差温热处理是决定支承辊工作层组织、应力分布和使用性能的关键工序。为精准控制宽厚板轧机用Cr3钢支承辊辊身淬硬层深度以进一步提高其寿命周期内的服役性能,利用ABAQUS有限元模拟软件计算了支承辊在差温热处理过程中的温度场分布,分... 详细信息

差温热处理是决定支承辊工作层组织、应力分布和使用性能的关键工序。为精准控制宽厚板轧机用Cr3钢支承辊辊身淬硬层深度以进一步提高其寿命周期内的服役性能,利用ABAQUS有限元模拟软件计算了支承辊在差温热处理过程中的温度场分布,分析了距离辊身不同深度处的温度与显微组织演变,预测了差温处理过程中辊身淬硬层的深度。结果表明:当加热温度达到840℃及以上时,Cr3钢可获得耐磨性较佳的非珠光体组织;Cr3钢支承辊实验件的淬硬层深度达110 mm,表面硬度达到55 HSD以上,且距离表面110 mm深处的硬度降低不大于4 HSD;淬硬层深度的理论预测结果与实测结果吻合较好,可以实现支承辊淬硬层深度的精确控制,指导Cr3钢支承辊差温热处理工艺制定。

关键词： Cr3钢支承辊差温热处理温度场淬硬层深度