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Hepatic and renal effects of oral stingless bee honey in a streptozotocin-induced diabetic rat model

World Journal of Experimental Medicine 2024年第1期14卷 113-123页

作者： Suriati Mohd Nasir Anis Farihan Ismail Tuan Salwani Tuan Ismail wan Faiziah wan Abdul Rahman wan amir nizam wan ahmad Tengku ahmad Damitri Al-Astani Tengku Din Kuttulebbai Nainamohammed Salam Sirajudeen Department of Chemical Pathology School of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Endocrinology Laboratory Department of Chemical PathologySchool of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Department of Pathology School of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Biomedicine Program School of Health SciencesHealth CampusUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Department of Basic Medical Sciences Kuliyyah of MedicineInternational Islamic University MalaysiaBandar Indera MahkotaKuantan 25200PahangMalaysia

BACKGROUND Diabetes is known damage the liver and kidney,leading to hepatic dysfunction and kidney *** is believed to help in lowering the blood glucose levels of diabetic patients and reducing diabetic ***,the effect of stingless bee honey(SBH)administration in relieving liver and kidney damage in diabetes has not been *** To investigate the effect of SBH administration on the kidney and liver of streptozotocin-induced(STZ;55 mg/kg)diabetic Sprague Dawley *** The rats were grouped as follows(n=6 per group):non-diabetic(ND),untreated diabetic(UNT),metformin-treated(MET),and SBH+metformin-treated(SBME)*** successful diabetic induction,ND and UNT rats were given normal saline,whereas the treatment groups received SBH(2.0 g/kg and/or metformin(250 mg/kg)for 12 *** biochemical parameters and histological changes using hematoxylin and eosin(H&E)and periodic acid–Schiff(PAS)staining were *** On H&E and PAS staining,the ND group showed normal architecture and cellularity of Bowman’s capsule and tubules,whereas the UNT and MET groups had an increased glomerular cellularity and thickened basement *** SBH-treated group showed a decrease in hydropic changes and mild cellularity of the glomerulus vs the ND group based on H&E staining,but the two were similar on PAS ***,the SBME-treated group had an increase in cellularity of the glomerulus on H&E staining,but it was comparable to the SBH and ND groups on PAS *** diabetic rats had tubular hydropic tubules,which were smaller than other *** fatty vacuole formation and dilated blood sinusoids in liver tissue were seen in the SBH ***,the UNT group had high glucose levels,which subsequently increased MDA levels,ultimately leading to liver *** treatment reduced this damage,as evidenced by having the lowest fasting glucose,serum alanine transaminase,aspartate transaminase,and alkaline phosphatase l

关键词： Diabetes Streptozotocin Stingless bee honey Hematoxylin and eosin Periodic acid-Schiff Liver Kidney

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The coastal medicinal plant Vitex rotundifolia: a mini-review on its bioactive compounds and pharmacological activity

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Traditional Medicine Research 2021年第2期6卷 1-10页

作者： Nurul Husna Azizul wan amir nizam wan ahmad Nurul Laili Rosli Muhammad Aniq Hamzah Mohd Azmi Choo En Liang Noor Wini Mazlan Suvik Assaw Biomedicine Program School of Health SciencesUniversiti Sains MalaysiaKubang Kerian 16150KelantanMalaysia Faculty of Science and Marine Environment Universiti Malaysia TerengganuKuala Nerus 21030TerengganuMalaysia

Humans have long used natural remedies like plants and herbs to treat ***,research has been ongoing to find alternative pharmaceutical drugs based on traditionally used plants,as natural products show fewer side effects compared to synthetic *** plants have long been targeted in drug development due to their bioactive compounds like alkaloids,flavonoids,and *** is not only the case for terrestrial plants,but marine environments also provide a larger diversity of flora and fauna with medicinal bioactive *** rotundifolia,also known as Beach Vitex,is a coastal plant that has been traditionally used to treat a variety of diseases including premenstrual syndrome,headaches,migraines,colds,and eye *** have been many review papers on ***,emphasizing its taxonomy,distribution,and biological *** current mini-review not only summarizes the pharmacology and bioactivity of ***,but it also provides new information on the main bioactive compounds of *** such as flavonoids,phenolic acid,and terpenes and their current pharmacological activity in vitro and in vivo *** information can be useful for developing new pharmaceutical and nutraceutical agents to treat and manage disease.

关键词： Vitex rotundifolia Fructus viticis Marine plants Anti-inflammation Anti-nociception Antioxidant

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Immunomodulatory effects and structure-activity relationship of botanical pentacyclic triterpenes:A review

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Chinese Herbal Medicines 2020年第2期12卷 118-124页

作者： Nurul Hikmah Harun Abdi Wira Septama wan amir nizam wan ahmad Rapeah Suppian School of Health Sciences Heath CampusUniversiti Sains MalaysiaKubang Kerian 16150Malaysia School of Biomedicine Faculty of Health SciencesUniversiti Sultan Zainal AbidinKuala Nerus 21300Malaysia Research Center for Chemistry Indonesian Institute of SciencesKawasan Puspitek SerpongTangerang Selatan 15314Indonesia

Botanical pentacyclic triterpenes possessed a broad range of pharmacological activities such as antioxidant,anti-tumor,anti-microbial and anti-inflammatory *** is believed that the mechanisms involved in these bioactivities are due to the modulation of immune ***,the pharmacological validation on immunomodulatory of pentacyclic triterpenes derived from higher plants is very limited and several existence review papers related for this group of compound have not been focused for this *** this review,we have highlighted several studies on immunomodulatory potential of botanical pentacyclic triterpenes isolated from wide array of different species of medicinal plants and herbs based on various preclinical in vitro and animal *** review also attempts to discuss on bioactivities of compouns related with their structure-activity ***,the evaluation of pentacyclic triterpenes offers a great opportunity to discover adjuvants and novel therapeutic agents that presented beneficial immunomodulatory properties.

关键词： botanical immunomodulatory pentacyclic triterpenes structure activity relationship

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Textural characteristics,surface chemistry and oxidation of activated carbon

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Journal of Natural Gas Chemistry 2010年第3期19卷 267-279页

作者： wan Mohd Ashri wan Daud amir Hossein Houshamnd Department of Chemical Engineering Faculty of EngineeringUniversity of Malaya

Numerous researches were reviewed and interpreted to depict a comprehensive illustration of activated carbon and its behavior towards *** carbon as one of the most important adsorbents is tried to be described in this review paper by terms of its＂Textural Characteristics＂and＂Surface Chemistry＂.These two terms,coupled with each other,are responsible for behavior of activated carbon in adsorption processes and in catalytic *** as-prepared activated carbons are usually nonselective and their surfaces suffer from lack of enough reactive groups,their different aspects may be improved and developed by diverse types of *** is one of the most conventional modifications used for activated *** may be used as a final modification or as a pre-modification followed by further *** this paper,methods of oxidation of activated carbon and other graphene-layer carbon materials are introduced and wet oxidation as an extensively-used category of oxidation is discussed in more detail.

关键词： activated carbon graphene-layer carbon surface chemistry textural characteristics oxidation

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Breaking piezoelectric limits of molecules for biodegradable implants

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BMEMat(BioMedical Engineering Materials) 2024年第2期2卷 1-3页

作者： Jianhua Hao Nik ahmad nizam Nik Malek wan Hairul Anuar Kamaruddin Jianhua Li Department of Applied Physics Department of Biomedical Engineeringand Research Centre for Nanoscience and NanotechnologyThe Hong Kong Polytechnic UniversityHong KongChina Centre for Sustainable Nanomaterials Universiti Teknologi MalaysiaJohor BahruMalaysia Department of Biosciences Faculty of ScienceUniversiti Teknologi MalaysiaJohor BahruMalaysia Laboratories Center&Physics Department PPMUUniversiti Teknologi MalaysiaJohor BahruMalaysia Department of Biomaterials School and Hospital of StomatologyCheeloo College of MedicineShandong UniversityJinanChina

In the quest for optimizing biodegradable implants,the exploration of piezoelectric materials stands at the forefront of biomedical engineering *** piezoelectric materials often suffer from limitations in biocompatibility and biodegradability,significantly impeding their in vivo study and further biomedical *** leveraging molecular engineering and structural design,a recent innovative approach transcends the conventional piezoelectric limits of the molecules designed for biodegradable *** biodegradable molecular piezoelectric implants may open new avenues for their applications in bioenergy harvesting/sensing,implanted electronics,transient medical devices and tissue regeneration.

关键词： biodegradable implants molecular ferroelectric piezoelectric biosensors self-powered electronics transient bioelectronics

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The Spatial Structure of Zooplankton Communities of Pedu Reservoir,Malaysia

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湿地科学 2012年第4期10卷 423-428页

作者： amir Shah Ruddin Md Shah Johan Ismail Diana Latief wan Maznah wan Omar School of Biological Sciences Universiti Sains MalaysiaMinden11800 PenangMalaysia Department of Animal Science and Fishery Faculty of Agriculture and Food SciencesUniversiti Putra MalaysiaUPM Bintulu Campus97008 BintuluSarawakMalaysia

A total of 22 species of zooplankton were identified from 8 sampling stations located in the limnetic zone of Pedu *** zooplankton community was dominated by rotifers (11 species),followed by cladocerans (9 species) and copepods (2 species).Four species of zooplankton comprised of 3 rotifers,Brachionus quadridentata,Brachionus caudatus and Keratella cochlearis and one cladoceran,Ceriodaphnia cornuta were present at all sampling *** richness was highest at Station 2 (17 species) followed by Station 4 and Station 8 (14 species),Station 5 (15 species),Station 7 (11 species),Station 6 (10 species),Station 3 (9 species) and Station 1 (7 species).With an exception of water transparency,all other water quality parameters such as temperature,dissolved oxygen,conductivity,pH and total dissolved solids were not significant when compared between sampling *** study found that station 5 which was located in a calm strait,protected from strong wave and wind was a suitable area for zooplankton growth and *** supporting the findings included highest water transparency (3.4 m),rich in species numbers (15 species),high diversity index (0.950) and evenness index (0.808).

关键词：水生生物学研究方法演化浮游生物

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Methanolic extract of Abrus precatorius promotes breast cancer MDA-MB-231 cell death by inducing cell cycle arrest at G0/G1 and upregulating Bax

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Asian Pacific Journal of Tropical Biomedicine 2019年第6期9卷 249-256页

作者： wan Suriyani wan-Ibrahim Norzila Ismail Siti Farhanah Mohd-Salleh Aidy Irman Yajid Michael Pak-KaiWong Mohd nizam Md Hashim Department of Pharmacology School of Medical SciencesUniversiti Sains Malaysia16150Kubang KerianKelantanMalaysia Department of Pathology School of Medical SciencesUniversiti Sains Malaysia16150Kubang KerianKelantanMalaysia Department of Surgery School of Medical SciencesUniversiti Sains Malaysia16150Kubang KerianKelantanMalaysia

Objective:To determine the anti-proliferative activity of Abrus precatorius(***)leaf extracts and their effect on cell ***:*** leaves were extracted successively with hexane,ethyl acetate and methanol by Soxhlet *** extract was prepared by decoction at 50 ℃.Extracts of *** leaves were used to treat selected cancer and normal cell lines for72 ***,3-(4,5-dimethyl thiazol-2-yl)2,5-diphenyl tetrazolium bromide assay was performed to determine cell *** of cell cycle arrest,apoptosis assay and apoptosis protein expressions were determined by flow ***:Methanolic extract of *** leaves showed the lowest IC50 on MDA-MB-231 cells at(26.40±5.40)μg/*** cytometry analysis revealed that cell arrest occurred at G0/G1 phase and the apoptosis assay showed the occurrence of early apoptosis at 48 h in MDAMB-231 cells treated with methanolic extract of *** *** extract of *** leaves induced apoptosis by upregulation of Bax,p53 and caspase-3 and downregulation of ***:Methanolic extract of A precatorius leaves promotes MDA-MB-231 cell death by inducing cell cycle arrest and apoptosis possibly via the mitochondrial-related pathway.

关键词： Abrus precatorius MDA-MB-231 Apoptosis Cell cycle Breast cancer

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Magnetic hydroxyapatite nanobelt-stem cell hybrid spheroids for remotely patterning bone tissues

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BMEMat(BioMedical Engineering Materials) 2024年第1期2卷 146-159页

作者： Min Hao Wenhan wang Anil Kumar wan Hairul Anuar Kamaruddin Syafiqah Saidin Nik ahmad nizam Nik Malek Jerome Claverie Hong Liu State Key Laboratory of Crystal Materials Shandong UniversityJinanChina The Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of TechnologyAtlantaGeorgiaUSA Department of Chemistry University of GeorgiaAthensGeorgiaUSA Universiti Teknologi Malaysia Johor BahruJohorMalaysia Department of Chemistry Universitéde SherbrookeSherbrookeQuebecCanada

The low survival rate and poor differentiation efficiency of stem cells,as well as the insufficient integration of implanted stem cells,limit the regeneration of bone ***,we have developed magnetic ferroferric oxidehydroxyapatitepolydopamine(Fe_(3)O_(4)-HAp-PDA)nanobelts to assemble mesenchymal stem cells(MSCs)into a three-dimensional hybrid spheroid for patterning bone *** nanobelts,which are featured by their highaspect ratio and contain Fe_(3)O_(4) nanospheres with a PDA coating,can be manipulated by a magnetic field and foster enhanced cell-nanobelt *** strategy has been demonstrated to be effective for both bone marrow mesenchymal stem cells and adipose-derived mesenchymal stem cells,enabling remote manipulation of stem cell spheroids and efficient spheroid fusion,which in turn accelerates osteogenic ***,this methodology serves as an efficient and general tool for bone tissue printing and can potentially overcome the low survival rate and poor differentiation efficiency of stem cells,as well as mismatched interface fusion issues.

关键词： hybrid spheroid hydroxyapatite nanobelt mesenchymal stem cells osteogenesis differentiation tissue printing

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Phytocompounds of Anonna muricata leaves extract and cytotoxic effects on breast cancer cells

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Asian Pacific Journal of Tropical Medicine 2018年第12期11卷 659-665页

作者： Husna Syakirah Ab Rahman wan Suriyani wan-Ibrahim Norzila Ismail Tuan Nadrah Naim Tuan Ismail Siti Farhanah Mohd-Salleh Michael Pak-Kai Wong Mohd Ridzuan Abdul Samad Mohd nizam Md Hashim Department of Surgery School of Medical Sciences Universiti Sains Malaysia Department of Pharmacology School of Medical Sciences Universiti Sains Malaysia School of Dental Sciences Universiti Sains Malaysia

Objective: To identify the phytochemical compounds from Annona muricata(A. muricata) and to determine their in vitro anti-proliferative activities against breast cancer cells, MCF7 and MDA-MB-231. Methods: A. muricata leaves were successively extracted by soxhlet method using n-hexane, ethyl acetate and methanol, and decocted with water. Each extract was analysed by gas chromatography mass spectrometry(GCMS) and characterized with Wiley and NIST library searches. Anti-proliferative activity of each extract was evaluated on MCF7 and MDA-MB-231 breast cancer cells using MTT assay. Results: The GCMS analysis of different solvent extracts of A. muricata leaves showed presence of different chemical groups of compounds such as steroids, terpenoids, phenolic compounds, sugars, sugars alcohol and others including vitamin E. Ethyl acetate leaves extract exhibited the lowest IC_(50) value on the MDA-MB-231 breast cancer cell and n-hexane leaves extract showed the the lowest IC_(50) value on the MCF-7 breast cancer cell. Conclusion: Steroids and phenolic compounds were the main phytocompound groups identified from all A. muricata leaves extracts. The antiproliferative activity of n-hexane and ethyl acetate extract towards breast cancer MCF7 and MDA-MB-231 respectively might be due to the presence of biologically active compounds in the extracts, hence, providing some scientific evidences of the effectiveness of its traditional usages.

关键词： Annona muricata GCMS Anti-proliferative Breast cancer Graviola

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A Multidisciplinary Approach in Management of Breast Cancer: Case Study and Literature Reviews

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Journal of Cancer Therapy 2013年第7期4卷 7-11页

作者： Andee Dzulkarnaen Zakaria Nur Farhana Abd Salam wan Zainira wan Zain Mohd nizam Hashim School of Medical Sciences Universiti Sains Malaysia Kubang Kerian Kelantan Malaysia

The diagnosis of breast cancer can cause a significant anxiety in someone’s life. The care of the breast cancer patient requires in many centres. The care of breast cancer patient is undertaken as a joint venture between the surgeon, medical oncologist, radiotherapist, pathologist and allied health professionals such as the clinical nurse specialist as well as counsellors. This is a case of a 39-years-old Malay woman presented to HUSM with a history of ulcerating breast lump with bloody pus discharge on the right breast. An initial mammogram study showed lesion suspicious of malignancy, and histopathological examination was consistent with invasive ductal carcinoma. She received neoadjuvant chemotherapy before proceeding to right modified radical mastectomy with axillary clearance and immediate chest wall reconstruction. Detailed discussion on the diagnosis, treatment, surgical intervention and progress of the patient with reference to available literature reviews are presented.

关键词： Breast Cancer Multidisciplinary Approach Reconstructive Surgery

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