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BIOCOMPATIBILITY OF A PDMS-COATED MICRO-DEVICE:BLADDER VOLUME MONITORING SENSOR

Chinese Journal of Polymer Science 2012年第2期30卷 242-249页

作者： Dong Sup Lee Su Jin kim Jun Ho Sohn In Gul kim Sae Woong kim Dong wan Sohn Jong Hyun kim Bumkyoo Choi Department of Urology St.Vincent's HospitalCollege of Medicinethe Catholic University of KoreaSuwonKorea Department of Urology Seoul St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoulKorea Department of Urology Yeouido St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoulKorea Department of Mechanical Engineering Sogang UniversitySeoulKorea

We evaluated the biocompatibility of a dimethylpolysiloxane-coated micro-device which had been designed for monitoring real-time bladder volume in previous studies. The extract assay with dimethylpolysiloxane which had been used for coating the micro-device to measure the bladder volume was performed as an in vitro cytotoxicity test. For in vivo biocompatibility testing, the inflammatory responses around the implantation site of the micro-device in subcutaneous tissue of rat were assessed by light microscope with H＆E stain and fluorescence microscope with ED1 stain and von Willebrand factor stain. The averages of cell viability in dimethylpolysiloxane group were 84.6% and 82.3% at 24 h and 72 h incubation, respectively. The qualitative evaluations with light and fluorescence microscope revealed that the inflammatory changes peaked during 2 weeks but almost disappeared at 4 weeks after implantation of devices. The quantitative evaluations for granulation layer formation and neovascularization showed that the thickness of the layer in dimethylpolysiloxane group peaked during 2 weeks but it came to be stabilized at 4 weeks as thin as at 2 weeks in control group, and the frequency of neovascularization was higher in dimethylpolysiloxane group than in control group but it was not increased with time. The dimethylpolysiloxane-coated micro-device is thought be a reliable bio-medical device.

关键词： Dimethylpolysiloxane Devices Biocompatibility testing.

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Cumulative incidence and risk factors for pouch adenomas associated with familial adenomatous polyposis following restorative proctocolectomy

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World Journal of Gastroenterology 2022年第30期28卷 4152-4162页

作者： Hyo Seon Ryu Chang sik Yu Young Il kim Jong Lyul Lee Chan Wook kim Yong sik Yoon In Ja Park Seok-Byung Lim Jin Cheon kim Division of Colon and Rectal Surgery Department of SurgeryUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND The emergence of restorative total proctocolectomy has significantly reduced the lifetime colorectal cancer risk associated with familial adenomatous polyposis(FAP).However,adenomas may develop in the ileal pouch over time and may even progress to *** evaluated the cumulative incidence,time to development,and risk factors associated with ileal pouch *** To evaluate the cumulative incidence,time to development,and risk factors associated with pouch *** In this retrospective,observational study conducted at a tertiary center,95 patients with FAP who underwent restorative proctocolectomy at our center between 1989 and 2018 were consecutively *** mean follow-up period was 88 *** Pouch adenomas were found in 24(25.3%)patients,with a median time of 52 mo to their first *** adenomas were detected in most patients(95.9%).There were no high-grade dysplasia or *** the 24 patients with pouch adenomas,13 had all detected adenomas *** the 13 patients who underwent complete adenoma removal,four(38.5%)developed *** 11(45.8%)patients with numerous polyps within the pouch,seven(63.6%)exhibited progression of pouch *** cumulative risks of pouch adenoma development at 5,10,and 15 years after pouch surgery were 15.2%,29.6%,and 44.1%,*** colorectal polyposis(with more than 1000 polyps)was a significant risk factor for pouch adenoma development(hazard ratio,2.49;95% confidence interval:1.04-5.96;P=0.041).CONCLUSION Pouch adenomas occur at a fairly high rate in association with FAP after restorative proctocolectomy,and a high colorectal polyp count is associated with pouch adenoma development.

关键词： Adenomatous polyposis coli Familial adenomatous polyposis Adenoma Intestinal polyps Proctocolectomy,restorative Ileal pouch anal anastomosis

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Development of fault section identification technique for low voltage DC distribution systems by using capacitive discharge current

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Journal of Modern Power Systems and Clean Energy 2018年第3期6卷 509-520页

作者： Chul-Ho NOH Chul-Hwan kim Gi-Hyeon GWON Yun-sik OH College of Information and Communication Engineering Sungkyunkwan University

The increasing importance of energy efficiency has led to several studies related to the construction of a reliable low voltage DC(LVDC) distribution ***, studies on a protection scheme that considers the fault characteristics of an LVDC distribution system are essential to improve system reliability. When compared to a conventional distribution system, the most distinct feature of an LVDC distribution system is the existence of a capacitive discharge current from converters under a fault condition that results in the prompt operation of protection devices. Therefore, this study involves proposing a precise and rapid technique to identify the fault section in an LVDC distribution system. The technique involves two stages, namely: an analysis stage to analyze the capacitive discharge current and a decision stage to identify the fault section based on the fault type. A detailed discussion of each step is presented and its feasibility is verified based on the results of simulations with an ElectroMagnetic Transients Program and MATLAB~?.

关键词： Capacitive discharge current Fault section identification Fault type identification Low voltage DC distribution system

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Impression of prognosis regarding pathologic stage after preoperative chemoradiotherapy in rectal cancer

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World Journal of Gastroenterology 2015年第2期21卷 563-570页

作者： Kyungyeon Hwang In Ja Park Chang sik Yu Seok-Byung Lim Jong Lyul Lee Yong sik Yoon Chan Wook kim Jin Cheon kim Department of Colon and Rectal Surgery University of Ulsan College of Medicine and Asan Medical CenterSeoul 138-736South Korea

AIM: To ascertain pathologic stage as a prognostic indicator for rectal cancer patients receiving preoperative chemoradiotherapy(PCRT).METHODS: Patients with mid- and low rectal carcinoma(magnetic resonance imaging- based clinical stage Ⅱ or Ⅲ) between 2000 and 2009 and treated with curative radical resection were identified. Patients were divided into two groups: PCRT and No-PCRT. Recurrence-free survival(RFS) was examined according to pathologic stage and addition of adjuvant ***: Overall, 894 patients were identified. Of these, 500 patients received PCRT. Adjuvant chemotherapy was delivered to 81.5% of the No-PCRT and 94.8% of the PCRT patients. Adjuvant radiotherapy was given to 29.4% of the patients in the No PCRT group. The 5-year RFS for the No-PCRT group was 92.6% for StageⅠ, 83.3% for Stage Ⅱ, and 72.9% for Stage Ⅲ. The 5-year RFS for the PCRT group was 95.2% for yp Stage 0, 91.7% for yp StageⅠ, 73.9% for yp Stage Ⅱ, and 50.7% for yp Stage Ⅲ.CONCLUSION: Pathologic stage can predict prognosis in PCRT patients. Five-year RFS is significantly lower among PCRT patients than No-PCRT patients in pathologic stage Ⅱ and Ⅲ. These results should be taken into account when considering adjuvant treatment for patients treated with PCRT.

关键词： Preoperative Chemoradiotherapy Rectal cancer Patho

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Autopilot Control Synthesis for Path Tracking Maneuvers of Underwater Vehicles

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China Ocean Engineering 2011年第2期25卷 237-249页

作者： Sam-Sang YOU Hyeung-sik CHOI Hwan-Seong kim Han-Il PARK School of Mechanical and Energy Systems Engineering Korea Maritime University Department of Logistics System Engineering Korea Maritime University Department of Ocean Engineering Korea Maritime University

This paper is concerned with the robust control synthesis of autonomous underwater vehicle （AUV） for general path following maneuvers. First, we present maneuvering kinematics and vehicle dynamics in a unified framework. Based on H∞ loop-shaping procedure, the 2-DOF autopilot controller has been presented to enhance stability and path tracking. By use of model reduction, the high-order control system is reduced to one with reasonable order, and further the scaled low-order controller has been analyzed in both the frequency and the time domains. Finally, it is shown that the autopilot control system provides robust performance and stability against prescribed levels of uncertainty.

关键词： underwater vehicle path following 2-DOF control synthesis H∞ loop-shaping plant uncertainty model reduction

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Injection molding of micro patterned PMMA plate

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Transactions of Nonferrous Metals Society of China 2011年第A01期21卷 148-152页

作者： Yeong-Eun YOO Tae-Hoon kim Tae-Jin JE Doo-Sun CHOI Chang-wan kim Sun-Kyung kim Department of Nanomanufacturing Technology KIMM 171 Jang-dong Yusung-gu Daejeon 305-343 Korea Department of Product Design and Manufacturing Seoul National University of Technology

A plastic plate with surface micro features was injection molded to investigate the effect of pressure rise of melt on the replication of the micro structures. Prism pattern, which is used in many optical applications, was selected as a model pattern. The prism pattern is 50 μm in pitch and 108° in the vertical angle. The overall size of the plate was 335 minx213 mm and the thickness of the plate varied linearly from 2.6 mm to 0.7 ram. The prism pattern was firstly machined on the nickel plated core block using micro diamond tool and this machined pattern core was installed in a mold for injection molding of prism patterned plate. Polymethyl methacrylate （PMMA） was used as a molding material. The pressure and temperature of the melt in the cavity were measured at different positions in the cavity and the replication of the pattern was also measured at the same positions. The results show that the pressure or temperature profile through the process depends on the shape and the size of the plate. The replication is affected by the temperature and pressure profiles at the early stage of filling, which is right after the melt reaches the position to be measured.

关键词： micro prism pattern injection molding replication pressure profile temperature profile

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Combined exercise improves gastrointestinal motility in psychiatric in patients

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World Journal of Clinical Cases 2018年第8期6卷 207-213页

作者： Bong Kil Song Yeon Soo kim Hee Soo kim Jung-Woo Oh On Lee Joon-sik kim Health and Exercise Science Laboratory Institute of Sports ScienceSeoul National University Namyangju Hanyang General Hospital

AIM To examine the effect of combined exercise on colonic transit time(CTT) in admitted psychiatric patients. METHODS Over a 6-mo period, consecutive in patients with mental illness were recruited from the Somang Hospital Psychiatry Unit. A combined exercise program that included 60 min per day of exercise 3 d per week for 12 wk was performed. Physical fitness and CTT of the patients were measured twice before and twice after the exercise program. CTT was measured using a multiple marker technique with a radio-opaque marker. Changes in the exercising patients' CTT and weight-,cardiovascular-and fitness-related parameters were statistically *** After the 12-wk combined exercise intervention, decreased intestinal transit time was observed in all CTTs of the exercise group, including the right CTT(exercise: 15.6 ± 15.2 vs 9.2 ± 11.9, control: 13.1 ± 10.4 vs 10.9 ± 18.7), left CTT(exercise: 19.7 ± 23.5 vs 10.4 ± 13.2, control: 19.2 ± 19.0 vs 16.9 ± 19.8), recto-sigmoid CTT(exercise: 14.3 ± 16.7 vs 6.7 ± 7.9, control: 15.0 ± 14.4 vs 19.3 ± 30.3), and total colonic transit time(TCTT)(exercise: 50.2 ± 38.1 vs 27.1 ± 28.0, control: 47.4 ± 34.6 vs 47.3 ± 47.3). After the 12-wk combined exercise period, TCTT was significantly shortened in the exercise group compared with that in the control group. In addition to eating habits, water intake, and fiber intake, the increased physical activity level as a result of the 12-wk combined exercise program reduced the CTT.

关键词： Combined exercise Constipation Colonic transit time Radio-opaque marker Psychiatry unit patient

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Obesity is an important determinant of severity in newly defined metabolic dysfunction-associated fatty liver disease

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Hepatobiliary & Pancreatic Diseases International 2022年第3期21卷 241-247页

作者： Ji Hye Huh Kwang Joon kim Seung Up kim Bong-Soo Cha Byung-wan Lee Division of Endocrinology and Metabolism Department of Internal MedicineHallym University Sacred Heart HospitalAnyang 14068Korea Division of Geriatrics Department of Internal MedicineYonsei University College of MedicineSeoul 03722Korea Division of Endocrinology and Metabolism Department of Internal MedicineYonsei University College of MedicineSeoul 03722Korea Institute of Gastroenterology Department of Internal MedicineYonsei University College of MedicineSeoul 03722Korea

Background: The recently proposed definition of metabolic dysfunction-associated fatty liver disease(MAFLD) is based on the co-existence of hepatic steatosis with other metabolic disorders, including obesity and metabolic risk abnormalities such as hyperglycemia, high blood pressure and dyslipidemia. This study aimed to assess MAFLD severity according to the presence of metabolic abnormalities and obesity. Methods: Using transient elastography, hepatic steatosis and fibrosis severity were assessed by measuring the controlled attenuation parameter and liver stiffness measurement. A total of 1163 patients with MAFLD were categorized into the following four groups according to metabolic risk abnormalities and obesity presence: non-obese without metabolic risk abnormality group(Group 1;reference group);nonobese with metabolic risk abnormality group(Group 2);obese without metabolic risk abnormality group(Group 3);and obese with metabolic risk abnormality group(Group 4). A multiple logistic regression analysis was performed to determine severe hepatic steatosis and fibrosis risk in each group in both unadjusted and adjusted models. Results: In the adjusted model, the odds ratios(ORs) [95% confidence interval(CI)] for severe hepatic steatosis in Groups 2, 3, and 4 were 1.07(0.61-1.88), 2.43(1.44-4.08), and 4.07(2.56-6.48), respectively( P trend < 0.001). For liver fibrosis, compared with Group 1, Group 2 showed no significant increases in OR, whereas Groups 3 and 4(obese groups) showed significant increases(OR = 4.70, 95% CI: 1.24-17.82 and OR = 6.43, 95% CI: 1.88-22.02, respectively). Conclusions: Obesity, rather than metabolic abnormality, is the principal determinant of severe hepatic steatosis and fibrosis in patients with MAFLD.

关键词： Metabolic dysfunction-associated fatty liver disease Metabolically-healthy obesity Liver fibrosis

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Solution-flame hybrid synthesis of defect-enriched mesoporous CuO_(x) nanowires for enhanced electrochemical nitrate-to-ammonia production

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Journal of Energy Chemistry 2024年第12期99卷 475-483页

作者： Li Qu Sungkyu kim Runfa Tan Arumugam Sivanantham Seokgi kim Yoo Jae Jeong Min Cheol kim Seong sik Shin Uk Sim In Sun Cho Department of Materials Science&Engineering Ajou UniversitySuwon 16499Republic of Korea Department of Energy Systems Research Ajou UniversitySuwon 16499Republic of Korea Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea Department of Chemistry Sookmyung Women's UniversitySeoul 04310Republic of Korea Department of Nano Engineering and Department of Nano Science and Technology SKKU Advanced Institute of Nanotechnology(SAINT)Sungkyunkwan UniversitySuwonRepublic of Kore SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwonRepublic of Kore School of Energy Technology Korea Institute of Energy Technology(KENTECH)Jeonnam 58217Republic of Korea

Electrochemical nitrate reduction(ENR)is an economical and eco-friendly method for converting industrial wastewater into valuable ammonia under atmospheric *** main challenge lies in designing and developing highly durable ENR *** study introduces defect-rich mesoporous CuO_(x) nanowires electrocatalyst synthesized using a novel solution-flame(sol-flame)hybrid method to control mesoporosity and introduce surface defects,thereby enhancing the electrochemical nitrate-toammonia production *** found surface defects(oxygen vacancies and Cu^(+))and unique mesoporous nanowire structure composed of tightly interconnected *** sol-flamesynthesized CuO_(x) nanowires(sf-CuO NWs)achieved superior ammonia yield rate(0.51 mmol h^(-1)cm^(-2)),faradaic efficiency(97.3%),and selectivity(86.2%)in 1 M KOH electrolyte(2000 ppm nitrate).This performance surpasses that of non-porous and less-defective CuO NWs and is attributed to the increased surface area and rapid electron transport facilitated by the distinctive morphology and generated *** calculation further suggests oxygen vacancies enhance NO_(3)^(-)adsorption on the sf-CuO NWs’surface and mitigate the competing hydrogen evolution *** study outlines a strategic design and simple synthesis approach for nanowire electrocatalysts that boost the efficiency of electrochemical nitrate-to-ammonia conversion.

关键词： CuO nanowires Solution-flame Mesoporous Oxygen vacancy Electrochemical nitrate reduction Wastewater

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Generation of Discrete Bicubic G^1 B-Spline Ship Hullform Surfaces from a Given Curve Notwork Using Virtual Iso-Parametric Curves

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Journal of Computer Science & Technology 2006年第2期21卷 265-271页

作者： Joong-Hyun Rhim Doo-Yeoun Cho Kyu-Yeul Lee Tao-wan kim EzGragh Co.Ltd.Seoul 135-080 Koren Department of Naval Architecture & Ocean Engincering Seoul National UniversitySeoul 151-744Korea Department of Naval Architecture & Ocean Engincering and Research Institute of Macine Systems Engineering Seoul National University Seoul 151-744Korea

We propose a method that automatically generates discrete bicubic G^1 continuous B-spline surfaces that interpolate the curve network of a ship ***,the curves in the network are classified into two types;boundary curves and ＂reference curves＂,The boundary curves correspond to a set of rectangular（or triangular）topological type that can be representes with tensot-product （or degenerate）B-spline surface ***,in the interior of the patches,surface fitting points and cross boundary derivatives are estimated from the reference curves by constructing ＂virtual＂isoparametric ***,a discrete G^1 continuous B-spline surface is gencrated by a surface fitting *** smooth ship hullform surfaces generated from curve networks corresponding to actual ship hullforms demonstrate the quality of the method.

关键词： curve netowork interpotation discrete G^1 continuous B-spline surface,iso-parametric curve,ship hullform

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