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Bevacizumab for neovascular age-related macular degeneration in Chinese patients in a clinical setting

International Journal of Ophthalmology(English edition) 2016年第3期9卷 424-430页

作者： Danny Siu-Chun Ng Alvin Kwan-Ho Kwok Justin Man-Kit Tong Clement wai-Nang Chan walton wai-tat li Department of Ophthalmology & Visual Sciences the Chinese University of Hong Kong Department of Ophthalmology Hong Kong Sanatorium and Hospital Department of Ophthalmology United Christian Hospital

AIM：To determine the outcome of non-investigational treatment with intravitreal bevacizumab（IVB） in neovascular age-related macular degeneration（AMD）patients.· METHODS：Retrospective chart review of 81 eyes with neovascular AMD followed-up for at least 12 mo and received 3-monthly loading IVB ***-treat was based upon the individual clinician＇s *** visual acuity（BCVA） and optical coherence tomography measurements of central foveal thickness outcomes were evaluated at 12,24 mo.· RESULTS：Eighty-one eyes（of 75 patients） completed12 mo of follow-up and 44 eyes（of 41 patients） completed24 mo of *** mean baseline logMAR BCVA significantly improved from 0.94±0.69 to 0.85±0.68 at12mo（P〈0.001） and from 0.91±0.65 to 0.85±0.60（P=0.004）at 24 *** proportion of eyes that lost 〈15 logMAR letters at 12 mo was 90.1%and at 24 mo was 81.8%.IVB was effective in improving visual acuity in both treatment naive and previous photodynamic therapy（PDT）-treated *** naive patients required significantly fewer injections than patients with prior *** regression analysis identified that poorer baseline visual acuity was associated with greater improvement in visual acuity（P=0.015）.· CONCLUSION：Fewer injections in clinical practice may result in suboptimal visual outcomes compared with clinical trials of IVB in neovascular AMD *** baseline visual acuity and prior PDT treatment may also improve vision after *** safety and durability of effect was maintained at 24 mo.

关键词： bcvacizumab age-related maculardegeneration Chinese

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Mitigation of Deane and Hamill phenomenon in gallium nitride high-voltage power supply for electric propulsion system application

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High Voltage 2024年第1期9卷 252-265页

作者： Minghai Dong Hui li Shan Yin Kye Yak See Yingzhe Wu Xiong Xin School of Aeronautics&Astronautics University of Electronic Science and Technology of ChinaChengduChina School of Electrical&Electronic Engineering Nanyang Technological UniversitySingaporeSingapore School of Automation Engineering University of Electronic Science and Technology of ChinaChengduChina Innoscience(Shenzhen)Semiconductor Co.Ltd. ShenzhenChina

The step-up resonant converters are widely adopted to provide high voltage in kV-level for electric propulsion system due to their high efficiency,low mass,modularisation,and high-power *** bipolar Cockcroft-walton voltage multiplier(BiCWVM)is a major circuit that steps up the voltage in the resonant ***,the diode nonlinearity in BiCWVM can introduce self-sustained quasi-periodic oscillations in the voltage and current waveforms,which is commonly known as the Deane and Hamill(DH)*** oscillation can lead to higher magnetic loss and control failure,and it is more likely to present in the gallium nitride-based converter due to the highfrequency *** authors aim to investigate and mitigate the DH phenomenon systematically so that proper mitigation can be *** facilitate the investigation,the circuit before the BiCWVM in the converter is derived and modelled as a voltage source v_(m)and a series inductor L_(sy).Also,the reverse recovery process of the diode in the BiCWVM can be represented by a piecewise-linear(PWL)model,with the simplified circuit and PWL model,the relationship between voltage and current under different operating conditions can be determined with *** relationship allows to understand the mechanism of diode reverse recovery in BiCWVM that leads to DH ***,a hybrid-/full-silicon carbide(SiC)design is proposed to mitigate the DH phenomenon,which is verified experimentally for a 300-kHz,5-W,20-V/1.5-kV GaN-based step-up resonant converter.

关键词： power resonant high

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“扮假作真”何以可能?——“后室游戏”及其想象生成机制

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文化艺术研究 2024年第3期17卷 34-46,113页

作者：李苒中国社会科学院大学文学院北京102400

类型游戏“后室游戏”因其画面视觉拟真度低、场景与形象单一等“弱游戏性”而区别于市面流行的“3A大作”,缺乏一般意义上的“行动者网络性”或“重复可玩性”。其现实关涉性及交互性主要发生于玩家的心理想象和审美体验层面:玩家借助... 详细信息

类型游戏“后室游戏”因其画面视觉拟真度低、场景与形象单一等“弱游戏性”而区别于市面流行的“3A大作”,缺乏一般意义上的“行动者网络性”或“重复可玩性”。其现实关涉性及交互性主要发生于玩家的心理想象和审美体验层面:玩家借助集体记忆与文化惯例这一前置道具,通过游戏画面的增强效果,得以从个体审美体验进入公共性虚构世界,又从给定条件中生成新的个人想象并以此充实游戏所指。“再现”在此从某种符合论标准与道德性要求,转向了被审美感知效果所决定和选择的“自动机制”,以此走向一种有别于模仿论或媒介论、整合当代艺术实践诸层面的“规则论”批评思路。

关键词：后室游戏沃尔顿道具虚构再现

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Stabilization-based soil remediation should consider longterm challenges

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Frontiers of Environmental Science & Engineering 2018年第2期12卷 1-3页

作者： Zhengtao Shen Zhen li Daniel S. Alessi Department of Earth and Atmospheric Sciences University of Alberta Edmonton AB T6G 2E3 Canada College of Resources and Environmental Sciences Nanjing Agricultural University Nanjing 210095 China

Soil remediation is of increasing importance globally, especially in developing countries. Among available remediation options, stabilization, which aims to immobilize contaminants within soil, has considerable advantages, including that it is cost-effective, versatile, sustainable, rapid, and often results in less secondary pollution. However, there are emerging challenges regard- ing the long-term performance of the technology, which may be affected by a range of environmental factors. These challenges stem from a research gap regarding the development of accurate, quantitative laboratory simula- tions of long-term conditions, whereby laboratory accel- erated aging methods could be normalized to real field conditions. Therefore, field trials coupled with long-term monitoring are critical to further verify conditions under which stabilization is effective. Sustainability is also an important factor affecting the long-term stability of site remediation. It is hence important to consider these challenges to develop an optimized application of stabilization technology in soil remediation.

关键词： Stabilization Soil remediation Long-term,Trace metals

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用于行星原位分析的微型微焦斑X射线激发源

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光学学报 2023年第14期43卷 329-335页

作者：曹阳桑鹏李保权牟欢李海涛王欢李帆刘亚宁中国科学院国家空间科学中心复杂航天系统电子信息技术重点实验室北京100190 中国科学院大学北京100049

基于微型X射线闭管的X射线荧光谱仪是深空探测新一代元素就位分析技术,研制了一款微型微焦斑X射线闭管作为X射线荧光分析的激发源。设计了一种新型的单极静电聚焦透镜,仿真模拟了电子聚焦光学结构尺寸对电子束运动轨迹的影响,并对静电... 详细信息

基于微型X射线闭管的X射线荧光谱仪是深空探测新一代元素就位分析技术,研制了一款微型微焦斑X射线闭管作为X射线荧光分析的激发源。设计了一种新型的单极静电聚焦透镜,仿真模拟了电子聚焦光学结构尺寸对电子束运动轨迹的影响,并对静电聚焦结构的形状和尺寸进行了优化。完成了微型一体化X射线源的加工和装调,搭建了X射线源性能测试装置。微型一体化X射线源工作电压2~50 kV、X射线强度不稳定性为0.3%、高压不稳定性为0.21%。在高压50 kV、电子电流50μA的情况下,微型一体化X射线源的总功耗5 W,焦斑尺寸177μm×451μm,可以满足深空探测行星表面物质成分原位分析需求。

关键词：元素原位分析微型X射线闭管微焦斑静电聚焦透镜

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γ"variant-sensitive deformation behaviour of Inconel 718 superalloy

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Journal of Materials Science & Technology 2022年第31期126卷 169-181页

作者： R.Y.Zhang H.L.Qin Z.N.Bi Y.T.Tang J.Araújo de Oliveira T.L.Lee C.Panwisawas S.Y.Zhang J.Zhang J.li H.B.Dong Centre of Excellence for Advanced Materials Dongguan 523808China School of Engineering University of LeicesterUniversity RoadLeicester LE17RHUnited Kingdom Beijing Key Laboratory of Advanced High Temperature Materials Central Iron and Steel Research InstituteBeijing 100081China Department of Materials University of OxfordParks RoadOxford OX13PHUnited Kingdom StressMap Engineering and Innovation DepartmentThe Open UniversityWalton HallMilton Keynes MK76AAUnited Kingdom ISIS Neutron Source Rutherford Appleton LaboratoryHarwell Science and Innovation CampusChiltonOxfordshire OX110QXUnited Kingdom School of Material Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Strengthening in Inconel 718 superalloy is derived from dislocation interaction withγ"precipitates,which exist in disk-shaped three possible orientation variants with their{100}habit plane normal to each *** interactions between dislocations andγ"precipitates vary according to theγ"orienta-tion variants,which makes the deformation behaviour complicated and difficult to reveal *** this work,γ"variant distributions of Inconel 718 samples were tailored by ageing heat treatment under either tensile or compressive ***γ"variant-sensitive deformation behaviours were then studied by in situ tensile tests via neutron diffraction at room *** is demonstrated that yield-ing first takes place in grains oriented withparallel to the loading *** identical lattice strain response to applied stress of both theγmatrix and theγ"precipitates was observed during yield-ing,suggesting that dislocations shearing through theγ"precipitates is predominant at this ***-ations in yield strength for samples with differentγ"variant distributions were observed,which can be attributed to different strengthening that arises from interactions between dislocation and differentγ"variants.

关键词： Ni-base superalloys Precipitation strengthening Neutron diffraction Lattice strains Plastic deformation

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肢带型肌营养不良R1型下肢肌肉MRI特点分析

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中华神经医学杂志 2023年第4期22卷 355-360页

作者：宋佳李刚庞咪高丽张杰文马明明河南省人民医院暨郑州大学人民医院神经内科郑州450003 河南省人民医院暨郑州大学人民医院影像科郑州450003

目的探讨肢带型肌营养不良R1型(LGMDR1)患者下肢肌肉MRI特点及MRI脂肪化总评分与其他临床特征的相关性。方法回顾性分析河南省人民医院暨郑州大学人民医院神经内科自2016年5月至2021年11月收治的经基因检测确诊为LGMDR1的8例患者资料。... 详细信息

目的探讨肢带型肌营养不良R1型(LGMDR1)患者下肢肌肉MRI特点及MRI脂肪化总评分与其他临床特征的相关性。方法回顾性分析河南省人民医院暨郑州大学人民医院神经内科自2016年5月至2021年11月收治的经基因检测确诊为LGMDR1的8例患者资料。应用Gardner-Medwin和walton(GM-W)评分评估肌无力严重程度,观察肌肉病理染色结果,通过MRI T1WI序列、短时间反转恢复序列(STIR)观察肌肉脂肪化情况及水肿程度,并采用Mercuri’s评分对下肢肌肉进行评分;最后采用Spearman相关分析检验下肢肌群脂肪化总评分与年龄、起病年龄、病程、GM-W评分及肌酸激酶(CK)水平的相关性。结果8例LGMDR1患者中7例出现下肢近端肌力下降,其中4例伴下肢远端肌力下降;骨骼肌病理均呈肌营养不良样病理改变。所有患者下肢肌肉均出现不同程度脂肪化,在大腿层面脂肪化最重的是大收肌、股二头肌长头、半膜肌、半腱肌和长收肌(平均分≥4分),缝匠肌和股直肌相对保留;小腿层面脂肪化最重的是腓肠肌内头,其次是比目鱼肌,胫骨后肌和前部肌群相对保留。7例患者伴有肌肉水肿,水肿程度普遍较轻,较易出现水肿及水肿程度相对较高的肌肉为小腿腓肠肌外头及大腿股四头肌。LGMDR1下肢肌群脂肪化总评分与GM-W评分呈正相关关系(r=0.872,P=0.005),与CK水平呈负相关关系(r=-0.929,P=0.001),与年龄、发病年龄及病程均无相关性(r=0.635,P=0.091;r=0.571,P=0.139;r=0.551,P=0.157)。结论LGMDR1患者下肢重度脂肪化肌肉不易出现水肿,肌肉脂肪化程度可用于评估疾病进展。下肢肌肉MRI受累模式有助于诊断与鉴别诊断LGMDR1。

关键词：肢带型肌营养不良R1型磁共振成像下肢肌肉

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突发公共卫生事件中应急救援的研究热点分析

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医学研究生学报 2022年第12期35卷 1317-1319页

作者：刘影刘玉秀嵇小倩麻丽徐晓莉江苏大学管理学院镇江212013 东部战区总医院(原南京军区南京总医院)重症医学科南京210002 东部战区总医院(原南京军区南京总医院)卫勤部南京210002 解放军联勤保障部队第九〇〇医院院部福州350025

目的应急救援能力已经成为国家和社会的重点关注内容。文章探讨国内外突发公共卫生事件中应急救援的研究热点,为后续研究提供参考。方法检索Web of Science、中国知网(CNKI)2011年-2021年突发公共卫生事件中应急救援的相关文献,利用... 详细信息

目的应急救援能力已经成为国家和社会的重点关注内容。文章探讨国内外突发公共卫生事件中应急救援的研究热点,为后续研究提供参考。方法检索Web of Science、中国知网(CNKI)2011年-2021年突发公共卫生事件中应急救援的相关文献,利用文献计量学研究方法和VOSviewer对国家、作者、关键词等进行共现分析。结果共纳入311篇中文文献、869篇英文文献。美国是发文量最高的国家;作者Cnningham Rebecca m和walton Maureen a发文量最高;关键词共现分析得到国内外在该领域研究热点上存在一定差异。结论文章对国内外研究热点及趋势进行分析总结,揭示该领域未来的发展方向。

关键词：突发公共卫生事件应急救援 VOSviewer

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温和的形式主义是否可能——兼论形式主义与反形式主义之争

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中国文学研究 2023年第1期 17-24页

作者：李伟湖南大学中国语言文学学院湖南长沙410082

形式主义与反形式主义之争是当代分析美学中的重要议题。赞威尔的温和形式主义代表了当代分析美学中形式主义发展的最新动向。温和的形式主义主要针对沃尔顿的反形式主义展开。沃尔顿认为审美判断依赖于范畴,而温和的形式主义认为审美... 详细信息

形式主义与反形式主义之争是当代分析美学中的重要议题。赞威尔的温和形式主义代表了当代分析美学中形式主义发展的最新动向。温和的形式主义主要针对沃尔顿的反形式主义展开。沃尔顿认为审美判断依赖于范畴,而温和的形式主义认为审美判断仍然只与对象的形式相关。然而温和的形式主义包含了两个基本教条:对象的审美属性仅仅依赖于形式本身、审美属性不会随着外在语境的变化而变化。这两个教条仍然存在着困难,并且截断了语词与生活之流之间的关联,从而陷入一种私有语言之中。

关键词：形式主义反形式主义审美属性范畴语境

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The enhanced X-ray Timing and Polarimetry mission—eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 3-27页

作者： ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang li MaoShun li Xian li Wei li ZhengWei li Olivier limousin HongWei liu XiaoJing liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen liZhi Sheng JiangBo Song liMing Song Carmelo Sgro liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms Shaolin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang Xiaoli Zhang Ziliang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences Institut für Astronomie und Astrophysik Eberhard Karls Universität INAF-Istituto di Astrofisica e Planetologia Spaziali INFN-Roma Tor Vergata Via della Ricerca Scientifica 1 Department of Engineering Physics and Center for Astrophysics Tsinghua University DTU Building 327DK-2800 Kongens Institute of Space Sciences 08193 Cerdanyola del Valles Institut d’Estudis Espacials de Catalunya Sezione di Pisa Istituto Nazionale di Fisica NucleareLargo Bruno Pontecorvo3 Department of Astronomy University of Genevachemin d’Ecogia 16 Osservatorio di Astrofisica e Scienza Dello Spazio di Bologna Istituto Nazionale di Astofisica Astronomical Institute Czech Academy of Sciences Max Planck Institute for Extraterrestrial Physics Giessenbachstr.1 CEA Paris-Saclay/IRFU Beijing Institute of Spacecraft System Engineering CAST Osservatorio Astronomico di Brera Istituto Nazionale di Astofisica Space Research Center Polish Academy of Sciences Key Laboratory of Advanced Material Microstructure of Education Ministry of China Institute of Precision Optical EngineeringSchool of Physics Science and EngineeringTongji University Department of Physics and Center for Astrophysics Tsinghua University Universita’degli Studi di Udine Via delle Scienze 206 Mullard Space Science Laboratory University College London Department of Nuclear and Particle Physics University of Geneva SRON Netherlands Institute for Space Research Politecnico di Milano Sezione di Perugia Istituto Nazionale di Fisica Nucleare Dipartimento di Fisica e Chimica Fondazione Bruno Kessler Dr.Karl Remeis-Observatory and Erlangen Centre for Astroparticle Physics Universität Erlangen-Nürnberg University of Pavia Department of ElectronicsInformation and Biomedical Engineering and INFN Pavia Sezione di Torino Istituto Nazionale di Fisica NucleareVia Pietro Giuria1 Department of Physics and Astronomy University of Leicester Sezione di Trieste Istituto Nazionale di Fisica Nucleare

In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave *** paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment.

关键词： X-ray instrumentation X-ray polarimetry X-ray timing space mission:eXTP

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