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Advances in Chemical Engineering and Science 2024年第2期14卷 74-83页

作者： walther b. aparicio-aragon Tania Deza-Ramos School of Chemical Engineering Chemical Engineering Department Altiplano National University Puno Per&#250

Currently a technique widely used for gold extraction is mercury b. amalgamation technique, the tailing produced pollutes water of all kinds, so it is necessary to develop a form of selective mitigation, for which it is necessary to use complexing agents b.sed on calixarene functionalized with mercury sequestering agents. These are immob.lized b. adding supports b.sed on natural silica to form polymers and make them insolub.e in all types of solvents, so that they can b. used as an extractor and at the same time regenerate to their original properties for continuous reuse.

关键词： Extraction Amalgamation Polymer Natural Silicate Calixarene

Effect of the Numb.r of Donor Atoms in Calix[4]arene Derivatives for Selective Complexation and Extraction of Mercury(II) Cations, Thermodynamics and Extraction Studies

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Advances in Chemical Engineering and Science 2021年第2期11卷 165-179页

作者： walther b. aparicio-aragon Tania Deza Ramos Angela F. Danil de Namor School of Chemical Engineering Chemical Engineering Department Altiplano National University Puno Perú School of b.omedical and Molecular Sciences Chemistry Division University of Surrey Guildford UK

Water pollution due to gold mining activity is increasingly worrying. One way to selectively mitigate it is through the use of complexing agents such as calixarenes, which selectively functionalized with soft donor atoms such as sulphur, can selectively remove this pollutant, for the selective complexation of mercury from contaminated water, which was compared by conductimetry and liquid-liquid extraction studies with results that show that the derivative with the highest sulphur atoms is its structure which presents greater selectivity compared to the derivative with the lowest number of sulphur atoms, in both cases, they present very stable complexes.

关键词： Pollutant Calixarene Mercury Selectivity Donor Atoms

Darolutamide:a novel androgen-signaling agent in nonmetastatic castration-resistant prostate cancer

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Asian Journal of Andrology 2020年第1期22卷 76-78页

作者： Jeanny b.aragon-Ching GU Medical Oncology Inova Schar Cancer InstituteFairfaxVA 22031USA

ARAMIS is an international PhaseⅢtrial demonstrating the b.neficial role of darolutamide,a novel anti-androgen that has b.en found to prolong metastasis-free survival in men with nonmetastatic castration-resistant pr... 详细信息

关键词： metastatic metastasis resistant

The emerging role of prostate-specific memb.ane antigen (PSMA) PET-CT in patients with high-risk prostate cancer: moving the b.r in high-risk prostate cancer

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Asian Journal of Andrology 2021年第1期23卷 1-2页

作者： Jeanny b.aragon-Ching GU Medical Oncology Department of OncologyInova Schar Cancer InstituteFairfaxVAUSA

The proPSMA trial is a Phase III multicentric trial that examined the role of gallium-68-prostate-specific memb.ane an tigen(PSMA)-p o sitro n em issio n tomography/computed tomography(PET/CT)scan versus conventional CT and b.ne scan to determine the presence of distant disease prior to curative-intent treatment with surgery or radiation for men with highrisk prostate *** findings showed the superiority of PSMA PET/CT scan with 27%b.tter accuracy and sensitivity at 92%versus conventional CT and b.ne scans.

关键词： PSMA high finding

replications for chemoprevention of prostate cancer with ntake of cruciferous vegetab.es

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Asian Journal of Andrology 2011年第3期13卷 357-358页

作者： Jeanny b.aragon-Ching Division of Hematology and Oncology George Washington University Medical Center Washington DC 20037 USA

Efforts on chemoprevention have b.en an attractive target of investigation for prostate cancer. Since prostate cancer is the most common non-cutaneous malignancy among American men, efforts for chemopreventative strategies make sense. However, such undertaking has b.en wrought with prob.ems and wide-scale efforts to launch drug chemoprevent/on have b.en dampened b. mixed results.

关键词： Cancer (genus) Neoplasms Property Properties Vegetab.es Vegetation

Use of early chemotherapy for hormone-sensitive prostate cancer： time for CHAARTED

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Asian Journal of Andrology 2016年第3期18卷 444-445页

作者： Jeanny b.aragon-Ching Clinical Program Director of Genitourinary Cancers INOVA Dwight and Martha gchar Cancer Institute8505 Arlington Boulevard Suite 100 Pairfax VAUSA.

CHAARTED was an ECOG-led phase III trial looking at early chemotherapy with the use of docetaxel in addition to androgen deprivation therapy （ADT） versus ADT alone in hormone-sensitive prostate cancer. The positive results of the trial showing marked improvement in overall survival in those who received chemotherapy with ADT have revolutionized the treatment of metastatic castration-sensitive prostate cancer.

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ARASENS: making sense out of first-line metastatic hormone-sensitive prostate cancer treatment

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Asian Journal of Andrology 2023年第1期25卷 1-4页

作者： Jeanny b.aragon-Ching GU Medical Oncology Inova Schar Cancer InstituteFairfaxVA 22031USA

ARASENS is an international phase III trial demonstrating the b.neficial role of darolutamide,a novel antiandrogen,when added to docetaxel and androgen deprivation therapy(ADT),with improvement in overall survival in men with metastatic castration-sensitive or hormone-sensitive prostate *** is a nonsteroidal androgen receptor antagonist that has b.en previously shown to improve metastasis-free survival in nonmetastatic castration-resistant prostate *** showed that the risk of death was 32.5%lower in those who received additional darolutamide compared to ADT and docetaxel *** also improved other secondary endpoints including time to castrate-resistant disease,time to pain progression,time to first skeletal-related event,and sub.equent initiation of ***,therefore,shows that darolutamide,in addition to ADT and docetaxel,as a form of upfront systemic intensification of“triplet”therapy for patients deemed chemotherapy-fit,represents a new standard of care for men with metastatic hormone-sensitive or castrate-sensitive prostate cancer and is anticipated to further change the landscape of treatment for this population of patients.

关键词： ARAS treatment chemotherapy metastasis ENS

Further analysis of PREVAIL： enzalutamide use in chemotherapy-naive men with metastatic castration- resistant prostate cancer

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Asian Journal of Andrology 2014年第6期16卷 803-804页

作者： Jeanny b.aragon-Ching Department of Medicine Division of Hematology andOncology George Washington University MedicalCenter 2150 Pennsylvania Avenue NW WashingtonDC 20037 USA.

PREVAIL was a phase III multinational, doub.e-b.ind, placeb.-controlled trial that enrolled chemotherapy-naive men with metastatic castration-resistant prostate cancer （mCRPC）, which showed remarkab.e improvement in co-primary endpoints with an overall 81% reduction in the risk of radiographic progression, as well as 29% reduction in the risk of death in favor of the enzalutamide arm over placeb.. All secondary endpoints including time to sub.equent chemotherapy initiation and prostate specific antigen （PSA） progression were in favor of the enzalutamide arm. The results of PREVAIL shows the utility of enzalutamide that would likely soon expand the indication to asymptomatic or minimally symptomatic men with mCRPC not previously treated with chemotherapy.

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The path forward in prostate cancer therapeutics

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Asian Journal of Andrology 2018年第3期20卷 213-214页

作者： Jeanny b.aragon-Ching Ravi A Madan Department of Genitourinary Medical Oncology Inova Schar Cancer Institute Fairfax VA 22031USA Genitourinary Malignancies b.anch Center for Cancer Research National CancerInstitute National Institutes of Health BethesdaMD. USA

The last decade has seen remarkab.e advances in the treatment of prostatecancer. Until 2010, only docetaxel had demonstrated the ab.lity to improve the survival in metastatic castration-resistant prostate cancer （mC...

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The promising role of poly（ADP-rib.se） polymerase inhib.tors in prostate cancer

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Asian Journal of Andrology 2016年第4期18卷 592-593页

作者： Jeanny b.aragon-Ching Clinical Program Director of Genitourinary Cancers INOVA Schar Cancer Institute 8505 Arlington Bird Suite 100 Faiffax VA USA

The TOPARP study showed the b.neficial utility of olaparib.in a heavily pretreatedpopulation of metastatic castration-resistant prostate cancer who were b.omarker-positive for ab.rrations in DNA repair gene. A higher response rate to olaparib.of 88% （14 out of 16 patients）, time to radiographic progression as well as overall survival, was seen in patients who were b.omarker-positive compared to those who were not. This study showed a promising way of targeting prostate cancer with an enriched population of patients who harb.r these deleterious genes. this paves the way for offering new therapeutic opportunities for men who have otherwise few remaining options.

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