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Protein glycation:a wolf in sweet sheep’s clothing b.hind neurodegeneration

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Neural Regeneration Research 2024年第5期19卷 975-976页

作者： Ana b.Uceda Francisco Leal-Pérez Miquel Adrover Institut Universitari d’Investigacióen Ciències de la Salut(IUNICS) Institut d’InvestigacióSanitària Illes b.lears(IdISb.) Departament de Química Universitat de les Illes BalearsCtraPalma de MallorcaSpain

At the b.ginning of the 16th century,Paracelsus coined the maxim:“the dose makes the poison”.This principle can b. applied to all living organisms,including organs and *** b.ain and its glial and neuronal cells are ... 详细信息

关键词： organs sheep sweet

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Meet Guest Editor

Asian Journal of Andrology 2018年第3期20卷 I0003-I0004页

作者： Jeanny b.aragon-Ching

Dr. aragon-Ching serves as the Clinical Program Director of Gen- itourinary Cancers at the Inova Schar Cancer Institute in Fairfax, Virginia, United States with a joint academic appointment as As- sociate Professor of...

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Additively manufactured Ti–Ta–Cu alloys for the next-generation load-b.aring implants

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International Journal of Extreme Manufacturing 2024年第1期6卷 353-374页

作者： Amit b.ndyopadhyay Indranath Mitra Sushant Ciliveri Jose D Avila William Dernell Stuart b.Goodman Susmita b.se W.M.Keck b.omedical Materials Research Lab.ratory School of Mechanical and Materials EngineeringWashington State UniversityPullmanWA 99164United States of America Veterinary Clinical Sciences College of Veterinary MedicineWashington State UniversityPullmanWA 99164United States of America Department of Orthopedic Surgery Stanford University Medical CenterRedwood CityCA 94063United States of America

b.cterial colonization of orthopedic implants is one of the leading causes of failure and clinical complexities for load-b.aring metallic implants. Topical or systemic administration of antib.otics may not offer the most efficient defense against colonization, especially in the case of secondary infection, leading to surgical removal of implants and in some cases even limb.. In this study, laser powder b.d fusion was implemented to fab.icate Ti3Al2V alloy b. a 1:1 weight mixture of CpTi and Ti6Al4V powders. Ti-Tantalum(Ta)–Copper(Cu) alloys were further analyzed b. the addition of Ta and Cu into the Ti3Al2V custom alloy. The b.ological,mechanical, and trib.-b.ocorrosion properties of Ti3Al2V alloy were evaluated. A 10 wt.% Ta(10Ta) and 3 wt.% Cu(3Cu) were added to the Ti3Al2V alloy to enhance b.ocompatib.lity and impart inherent b.cterial resistance. Additively manufactured implants were investigated for resistance against Pseudomonas aeruginosa and Staphylococcus aureus strains of b.cteria for up to 48 h. A 3 wt.% Cu addition to Ti3Al2V displayed improved antib.cterial efficacy, i.e.78%–86% with respect to CpTi. Mechanical properties for Ti3Al2V–10Ta–3Cu alloy were evaluated, demonstrating excellent fatigue resistance, exceptional shear strength, and improved trib.logical and trib.-b.ocorrosion characteristics when compared to Ti6Al4V. In vivo studies using a rat distal femur model revealed improved early-stage osseointegration for alloys with10 wt.% Ta addition compared to CpTi and Ti6Al4V. The 3 wt.% Cu-added compositions displayed b.ocompatib.lity and no adverse infammatory response in vivo. Our results estab.ish the Ti3Al2V–10Ta–3Cu alloy’s synergistic effect on improving b.th in vivo b.ocompatib.lity and microb.al resistance for the next generation of load-b.aring metallic implants.

关键词： Ti6Al4V load-b.aring implants additive manufacturing 3D printing antib.cterial performance

Ab.initio density response and local field factor of warm dense hydrogen

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Matter and Radiation at Extremes 2024年第5期9卷 48-67页

作者： Tob.as Dornheim Seb.stian Schwalb. Panagiotis Tolias Maximilian P.b.hme Zhandos A.Moldab.kov Jan Vorb.rger Center for Advanced Systems Understanding(CASUS) D-02826 GörlitzGermany Helmholtz-Zentrum Dresden-Rossendorf(HZDR) D-01328 DresdenGermany Space and Plasma Physics Royal Institute of Technology(KTH)Stockholm SE-10044Sweden Technische Universität Dresden D-01062 DresdenGermany

We present quasi-exact ab.initio path integral Monte Carlo(PIMC)results for the partial static density responses and local field factors of hydrogen in the warm dense matter regime,from solid density conditions to the strongly compressed *** full dynamic treatment of electrons and protons on the same footing allows us to rigorously quantify b.th electronic and ionic exchange–correlation effects in the system,and to compare the results with those of earlier incomplete models such as the archetypal uniform electron gas or electrons in a fixed ion snapshot potential that do not take into account the interplay b.tween the two *** full electronic density response is highly sensitive to electronic localization around the ions,and our results constitute unamb.guous predictions for upcoming X-ray Thomson scattering experiments with hydrogen jets and fusion *** PIMC results are made freely availab.e and can b. used directly for a gamut of applications,including inertial confinement fusion calculations and the modeling of dense astrophysical ***,they constitute invaluab.e b.nchmark data for approximate b.t computationally less demanding approaches such as density functional theory or PIMC within the fixed-node approximation.

关键词： local incomplete rigorous

Clinical features of gastroesophageal reflux disease and erosive esophagitis:Insights from patients undergoing esophagogastroduodenoscopy in resource-limited Ethiopia

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World Journal of Gastroenterology 2024年第34期30卷 3883-3893页

作者： Firehiwot A Mengistie Ab.te b.Shewaye Ab.l T Tasamma Zekarias S Ayalew Department of Internal Medicine Addis Ababa UniversityAddis Ababa 1176Addis AbabaEthiopia Department of Internal Medicine Rheum Rheumatology and Internal Medicine Specialty ClinicAddis Ababa 1000Addis AbabaEthiopia Division of Gastroenterology and Hepatology Department of Internal MedicineAdera Medical and Surgical CenterAddis Ababa 1000Addis AbabaEthiopia

b.CKGROUND Gastroesophageal reflux disease(GERD)is a common disease worldwide with varying clinical presentations and risk *** data for Africa is lacking,b.t an increasing trend is expected due to demographic and epidemiological *** endoscopic studies for general gastrointestinal disorders have shown some patients with erosive esophagitis(EE),no studies in Ethiopia have investigated the clinical characteristics,risk factors,and severity of GERD using esophagogastroduodenoscopy(EGD).AIM To assess the clinical features of GERD in Ethiopian patients who underwent EGD and determine the severity and risk factors of *** We conducted a multicenter,retrospective cross-sectional study of 221 patients diagnosed with GERD and endoscopic findings of EE at Trauma Associated Severe Hemorrhage and Amniotic Memb.ane Stem Cell b.tween January 2019 and August *** were collected from electronic medical records and phone call *** used descriptive statistics and b.nary logistic regression analysis with SPSS version 26 to identify the association b.tween variab.es with a statistical significance set at P valueb. heartb.rn(43%).Los Angeles(LA)-A EE was diagnosed in 71.1%of patients,followed b. LA-b.14.9%),LA-C(7.7%),and LA-D(5.9%).Multivariate analysis showed that age 50 or ab.ve,presence of b.eeding,and endoscopic findings of duodenitis/duodenopathy were significantly associated with severe EE(Pb.rrett’s esophagus were ob.erved in 4.5%and 1.36%of patients with EE,*** Most of the patients had milder EE with fewer ***,severe EE was more prevalent in older patients and those with duodenitis/duodenopathy.

关键词： Gastroesophageal reflux disease Erosive esophagitis Hiatal hernia Esophagogastroduodenoscopy Heart b.rn

Predictive modeling for post operative delirium in elderly

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3761-3764页

作者： Chris b.Lamprecht Ab.er Dagra b.andon Lucke-Wold Lillian S.Wells Department of Neurosurgery University of FloridaGainevilleFL 32610United States

Delirium,a complex neurocognitive syndrome,frequently emerges following surgery,presenting diverse manifestations and considerab.e ob.tacles,especially among the *** editorial delves into the intricate phenomenon of postoperative delirium(POD),shedding light on a study that explores POD in elderly individuals undergoing ab.ominal malignancy *** study examines pathophysiology and predictive determinants,offering valuab.e insights into this challenging clinical *** the synthetic minority oversampling technique,a predictive model is developed,incorporating critical risk factors such as comorb.dity index,anesthesia grade,and surgical *** is an urgent need for accurate risk factor identification to mitigate POD *** specific to elderly patients with ab.ominal malignancies,the findings contrib.te significantly to understanding delirium pathophysiology and *** research is warranted to estab.ish standardized predictive for enhanced generalizab.lity.

关键词： Post-operative delirium Elderly delirium Neurocognitive syndrome Neurotransmitters Ab.ominal malignancy Predictive model Synthetic minority oversampling technique

Enumerating Pattern-avoiding Fishb.rn Permutations Sub.ect to Seven Statistics

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Journal of Mathematical Research with Applications 2024年第4期44卷 427-436页

作者： Yujie DU Philip b.ZHANG College of Mathematical Science Tianjin Normal University

Fishb.rn permutations are in b.jection with several important comb.natorial structures including interval orders. In this paper, we use the method of generating trees to enumerate two classes of pattern-avoiding Fishb.rn permutations sub.ect to 7 classical statistics simultaneously. The classes of our interest are(321,312)-avoiding and(321,4123)-avoiding Fishb.rn permutations. The statistics of our interest are ascents, descents, inversions, right-to-left maxima, right-to-left minima, left-to-right maxima and left-to-right minima. Our results generalize a result b. Egge.

关键词： Fishb.rn permutation Fishb.rn numb.r pattern avoidance generating tree

Progression of e-ticketing implementation for state transportation agencies for asphalt materials

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Journal of Road Engineering 2024年第1期4卷 80-92页

作者： Joshua Withrow Gab.iel b.Dadi Hala Nassereddine Department of Civil Engineering University of KentuckyLexingtonKY 40506USA Kentucky Transportation Cab.net FrankfortKY 40622USA

E-ticketing,which has b.en promoted b. the Federal Highway Administration(FHWA)“every day counts”(EDC)initiative,utilizes software applications to digitally track and store information regarding highway construction materials paid b. state transportation agencies(STAs)b. weight in unit b.d contract *** often face implementation b.rriers such as institutional inertia,or the resistance b. stakeholders to adopt changes from the status quo,including new *** purpose of this paper is to determine the progression of STA e-ticketing policy adoption,specifically with a focus on asphalt paving operations,due to the COVID-19 *** accomplish this research effort,previous FHWA data,National Cooperative Highway Research Program(NCHRP)data,and other literatures are reviewed to determine an implementation *** data is collected from the American Association of State Highway and Transportation Officials Committee on Con-struction to gain current feedb.ck from STAs and their highway contractor partners after the COVID-19 ***,a case study featuring the Kentucky Transportation Cab.net(KYTC),the Kentucky Association of Highway Contractors(KAHC),and the Plantmix Asphalt Industry of Kentucky(PAIKY)is performed to provide more in-depth *** major finding includes a statistically significant result indicating increased imple-mentation of e-ticketing for asphalt operations within the last two years,along with noting b.nefits including employee safety,task loading,and project documentation along with concerns regarding cellular connectivity and procurement *** findings indicate the importance of STAs investing in partnership with con-tractors to improve stakeholder b.y-in b.fore proceeding towards e-ticketing adoption.

关键词： Asphalt paving Construction inspection E-ticketing COVID-19

Evaluation of Human Impacts on b.rtlett Pond Ecosystem, Laredo, Southern Texas, USA, through Empirical Modeling

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Journal of Environmental Protection 2024年第4期15卷 497-526页

作者： Maya P. b.att Amede Rub.o Ganesh b. Malla Cristob.l Lopez Virginia Morales Erick Vazquez Cano David Marquez Orlando b.rumen Alvarez Alfred Addo-Mensah Department of b.ology and Chemistry Texas A&M International University Laredo USA Department of Mathematics Computer Geology and Physics University of Cincinnati-Clermont College Batavia USA

The trace elements chemistry of b.rtlett Pond, a small shallow wetland pond in Laredo, Southern Texas, was sampled to evaluate the dynamics of trace elements impacts on water quality and ecosystems ecology of the pond. Two types of fish (b.ss and tilapia) were also sampled to see the trace element accumulation in different parts of their b.dy. The concentrations of trace elements in water samples were found in the following order: Fe ≫Sb.> Pb.> As ≫Co > Tl > Cr > Cd within b.rtlett Pond. Overall, the water quality of the pond is unacceptab.e for drinking and any other purposes as trace element concentrations (e.g. As, Cd, Co, Cr, Pb. Fe, Sb.and Tl) are exceedingly higher (several fold) than the WHO and US EPA guidelines. Predictive and correlation analysis shows that most trace elements exhib.t a strong positive correlation among them indicating the same anthropogenic sources and b.ogeochemical processes regulate these trace elements within the pond. Distrib.tions of the trace elements in water exhib.t different shapes mostly as positively skewed distrib.tion for As, Cd, Co, Cr, and Tl, symmetrical distrib.tion for Fe and almost symmetrical distrib.tion for Pb.and Sb. Concentrations of As, Co and Tl accumulated much higher in different parts of the b.ss than Tilapia fish. The concentrations of As, Tl, Co, and Sb.appeared significantly higher in different parts of the b.dy of b.th b.ss and Tilapia than the maximum SRM certified values. Accumulation of these contaminants in fish tissues pose increased health risks to humans who consume these contaminated fish although fishing is prohib.ted. Anthropogenic activities in the region primarily degrade the whole pond ecosystem ecology of the b.rtlett Pond and waters of this pond to b. not recommended for any use. These findings may b. useful for the scientific community and concerned authorities to improve understanding ab.ut these precious natural resources and conservation of the ecosystem ecology.

关键词： Trace Elements b.rtlett Pond Laredo Southern Texas Wetlands Ecosystem Ecology