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Over-the-scope-grasper: A new tool for pancreatic necrosectomy and beyond-first multicenter experience

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World Journal of Gastrointestinal Surgery 2022年第8期14卷 799-808页

作者： markus Brand Jeannine Bachmann Christoph Schlag Ulrich Huegle Imdadur Rahman Edris Wedi Benjamin walter Oliver moschler Lukas Sturm Alexander meining Department of Internal medicine II University of WürzburgWürzburg 97080Germany Department of Surgery Klinikum rechts der IsarUniversity of MünchenMünchen 81675Germany Department of Gastroenterology and Hepatology University of ZürichZürich 8091Switzerland Department of Gastroenterology and Hepatology Klinikum Koln-HolweideKoln 50968Germany Department of Gastroenterology University Hospital SouthamptonSouthampton SO166YDUnited Kingdom Department of Gastroenterology Gastrointestinal Oncology and Interventionell EndoscopySana Klinikum OffenbachOffenbach 63069Germany Department of Internal medicine I University of UlmUlm 89070Germany Department of Gastroenterology Marienhospital OsnabrückOsnabrück 49074Germany Department of Internal medicine II University of FreiburgFreiburg 79106Germany

BACKGROUND Endoscopic treatment of pancreatic necrosis can be challenging and timeconsuming because sticky necrotic debris is sometimes difficult to remove. The over-the-scope-grasper, a new tool that has recently become available for this purpose, might also be useful for other indications. However, clinical data on the efficacy and safety of this new device are *** To evaluate the technical success and safety of the device in a multicenter *** The over-the-scope-grasper was used in nine selected endoscopic centers between November 2020and October 2021 for appropriate indications. Overall, 56 procedures were included in the *** retrospectively evaluated procedural parameters of all endoscopic interventions using a predefined questionnaire, with special respect to technical success, indications, duration of intervention, type of sedation, and complications. In the case of pancreatic necrosectomy, the access route, stent type, number of necrosis pieces removed, and clinical handling were also *** A total of 56 procedures were performed, with an overall technical success rate of 98%. most of the procedures were endoscopic pancreatic necrosectomies(33 transgastric, 4 transduodenal). In 70%of the procedures, access to the necrotic cavity was established with a lumen apposing metal *** technical success of pancreatic necrosectomy was 97%, with a mean of 8 pieces(range, 2-25pieces) of necrosis removed in a mean procedure time of 59 min(range, 15-120 min). In addition,the device has been used to remove blood clots(n = 6), to clear insufficiency cavities before endoluminal vacuum therapy(n = 5), and to remove foreign bodies from the upper gastrointestinal tract(n = 8). In these cases, the technical success rate was 100%. No moderate or severe/fatal complications were reported in any of the 56 *** These first multicenter data demonstrate that the over-the-scope-grasper is a promising device for endoscopic pancreat

关键词： Over-the-scope-grasper Endoscopic pancreatic necrosectomy Grasper Direct endoscopic necrosectomy Pancreatic necrosis Endoscopic tool

银纳米对不同骨科生物材料上金黄色葡萄球菌生物膜的影响

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华西医学 2023年第7期38卷 1047-1052页

作者：严新安 walter m Chirume 方跃四川大学华西医院骨科成都610041 四川大学华西医院创伤医学中心成都610041

目的观察银纳米颗粒(silver nanoparticle,AgNP)的抑制细菌生物膜特性,并研究其在常用的3种骨科生物材料上的抑制生物膜作用。方法通过微孔板内药敏试验培养确定AgNP的最低抑制浮游菌浓度(minimal inhibitory concentration,mIC)和最低... 详细信息

目的观察银纳米颗粒(silver nanoparticle,AgNP)的抑制细菌生物膜特性,并研究其在常用的3种骨科生物材料上的抑制生物膜作用。方法通过微孔板内药敏试验培养确定AgNP的最低抑制浮游菌浓度(minimal inhibitory concentration,mIC)和最低抑制生物膜浓度(minimal biofilm inhibitory concentration,mBIC)。在钛合金、氧化钛和不锈钢3种骨科生物材料上培养金黄色葡萄球菌(ATCC 25923)生物膜,使用32、16、8、4、2、0μg/mL AgNP干预生物膜,确定AgNP在3种材料上的mBIC。分析扫描电子显微镜结果,并通过测定光密度值观察AgNP对生物膜形成的影响。结果微孔板内AgNP的mIC和mBIC均为16μg/mL。在对内植物的生物膜抑制实验中,AgNP在氧化钛中mBIC为16μg/mL,在钛合金和不锈钢中mBIC为32μg/mL。3种材料中,氧化钛上光密度值最低,钛合金上光密度值最高。结论AgNP具有强大的抗细菌生物膜特性,能够在体外阻止金黄色葡萄球菌生物膜形成。钛合金上生物膜形成最多,而氧化钛上最少,不锈钢则介于两者之间。

关键词：银纳米金黄色葡萄球菌生物膜内植物骨髓炎

Allicin neuroprotective effect during oxidative/inflammatory injury involves AT1-Hsp70-iNOS counterbalance axis

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BIOCELL 2020年第4期44卷 671-681页

作者： LUCIANA mAZZEI mARÍA BELÉN RUIZ-ROSO NATALIA DE LAS HERAS SANDRA BALLESTEROS CAROLINA TORRESPALAZZOLO LEÓN FERDER ALEJANDRA BEATRIZ CAmARGO walter mANUCHA Instituto de medicina y Biología Experimental de Cuyo(ImBECU) Consejo Nacional de Investigaciones Científicas y Tecnológicas(CONICET)Mendoza5500Argentina Área de Farmacología Departamento de PatologíaFacultad de Ciencias MédicasUniversidad Nacional de Cuyo Centro UniversitarioMendoza5500Argentina Departamento de Fisiología Facultad de MedicinaUniversidad ComplutenseMadrid34523España IBAm Universidad Nacional de CuyoCONICETFacultad de Ciencias AgrariasMendozaM5528AHBArgentina Department of Pediatrics Nephrology DivisionMiller School of MedicineUniversity of MiamiMiami33012USA

The ancestral cultures have described many therapeutic properties of garlic,therefore,it is of central interest to elucidate the molecular basis explaining this millenary empirical ***,it has been demonstrated a neuroprotective effect of allicin–a phytochemical present in garlic-linked to oxidative-inflammatory *** improved neuronal injury by heat shock protein 70(Hsp70)and inducible nitric oxide synthase(iNOS)***,allicin exerts renal protection involving a possible angiotensin type 1 receptor(AT1)*** connection,AT1 overexpression has been recognized as a central deleterious factor in many brain ***,there are no studies that evaluate AT1-Hsp70-iNOS interaction as a mechanism linked to ***,our central aim is to evaluate if the allicin protective effect is associated with an AT1-Hsp70-iNOS counterbalance *** this study,a murine microglial cell line(BV-2)was injured with lipopolysaccharides and treated or not with ***,it was evaluated cell viability,proinflammatory cytokine levels,cellular oxidative stress,iNOS,Hsp70,and AT1 protein expression(cellular and mitochondrial fractions),nitrite levels,and protein-protein *** results demonstrated that allicin could prevent neuronal injury due to a reduction in oxidative stress and inflammatory status mediated by an AT1-Hsp70-iNOS counterbalance axis linked to direct protein-protein interaction.

关键词： Allicin neuroinflammation BV-2 cells AT1 receptors iNOS Hsp70

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武汉体育学院学报 2013年第9期47卷 91-96页

作者：段艳平韦晓娜 BREHm walter 武汉体育学院运动心理学教研室湖北武汉430079 香港浸会大学社会科学学院体育学系潮州市职业技术学校广东潮州521000 拜罗伊特大学体育科学学院德国拜罗伊特95440

基于锻炼心理学领域中的"从无活动到保持活动的四步骤模型"(Four Steps from Inactivity to Ac tivity;FIT模型),以1 206名成年人为研究对象,通过横断性研究考查了6个身体活动变化阶段与10个社会心理学相关变量之间的关系。研究结果表明... 详细信息

基于锻炼心理学领域中的"从无活动到保持活动的四步骤模型"(Four Steps from Inactivity to Ac tivity;FIT模型),以1 206名成年人为研究对象,通过横断性研究考查了6个身体活动变化阶段与10个社会心理学相关变量之间的关系。研究结果表明,被试在身体活动阶段上的分布为:前考虑期147(12.2%),考虑期273(22.6%),准备期148(12.3%),探索期144(11.9%),波动期201(16.7%)和保持期293(24.3%)。有关社会心理学相关变量在相邻阶段间的配对比较,37项假设关系中的22项得到了支持,假设符合率为59.5%。进一步回归分析表明,性别、受教育程度、主观障碍、自我效能、情感态度和社会支持共同解释了阶段方差变异的32.6%。该研究初步验证了FIT模型所涉及的重要社会心理学相关因素与身体活动变化阶段之间的相关关系,基本支持了FIT模型的理论建构。

关键词：身体活动变化阶段成年人 FIT模型社会心理变量

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两种基于mEmS谐振器的原子力显微镜探针

电子显微学报 2014年第2期33卷 137-141页

作者：熊壮 mairiaux E walter B Faucher m Buchaillot L Legrand B 中国工程物理研究院电子工程研究所四川绵阳621900 Institut d’Electronique de Microélectronique et de Nanotechnologie-IEMN CNRS UMR8520NAM6 groupFrance

目前商用原子力显微镜(AFm)大多使用的微悬臂式探针,力灵敏度可达到pN级别。然而受到工艺水平及检测方法限制,微悬臂谐振频率难以超过3.5 mHz,且Q值较低,制约了AFm的成像速度以及在液体中的成像效果。另外,光杠杆的检测方法无法与探针... 详细信息

目前商用原子力显微镜(AFm)大多使用的微悬臂式探针,力灵敏度可达到pN级别。然而受到工艺水平及检测方法限制,微悬臂谐振频率难以超过3.5 mHz,且Q值较低,制约了AFm的成像速度以及在液体中的成像效果。另外,光杠杆的检测方法无法与探针本身进行片上集成,较小的悬臂也给激光束的聚焦带来困难。基于以上考虑,本文提出两种基于mEmS谐振器的探针,振频率可达11 mHz,Q值为4 000,并集成了执行与传感功能以及批量加工纳米针尖的工艺。目前两种探针都已经实现对树脂图案的成像功能,力灵敏度最高可达5pN/√Hz。

关键词：原子力显微镜 mEmS谐振器静电执行与检测热执行压阻检测

Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study

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World Journal of Radiology 2017年第6期9卷 287-294页

作者： Tamar m van Veenendaal Dominique m IJff Albert P Aldenkamp Richard H C Lazeron Paul A m Hofman Anton J A de Louw walter H Backes Jacobus F A Jansen School for mental Health and Neuroscience Maastricht University Departments of Radiology and Nuclear medicine Maastricht University Medical Center Departments of Neurology and Neuropsychology Epilepsy Center Kempenhaeghe Department of Neurology Gent University Hospital Department of Neurology Maastricht University Medical Center Faculty of Electrical Engineering University of Technology Eindhoven

AIm To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) *** The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A "low risk" category(lamotrigine or levetiracetam, n=16), an "intermediate risk" category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a "high risk" category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P m the low category compared with the high risk category(P 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects.

关键词： Antiepileptic drugs Cognitive side effects Brain networks Resting state Functional magnetic resonance imaging Graph analysis

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炼胶车间下辅机设备的选用

橡塑技术与装备 2001年第12期27卷 15-17页

作者： walter m.Haeder 艾卫民

1 简介橡胶工业所用的胶料几乎都是由密炼机分批制备的.这种方法使得橡胶工业的炼胶生产线极具灵活性.新型的密炼机可以加工目前供应的各种形式的橡胶,如胶包、胶条、颗粒胶等,而连续混炼系统,如双螺杆挤出机在这方面则没有如此强的适应性.

关键词：挤出机机头胶料辊筒机头密炼机炼胶设备下辅机双螺杆挤出机轮胎工业橡胶工业销钉式挤出机造粒机头炼胶车间

Two-photon absorption and stimulated emission in poly-crystalline Zinc Selenide with femtosecond laser excitation

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Opto-Electronic Advances 2022年第1期5卷 1-12页

作者： Qianliang Li walter Perrie Zhaoqing Li Stuart P Edwardson Geoff Dearden Laser Engineering Group School of EngineeringUniversity of LiverpoolLiverpoolL693GQUnited Kingdom Laser Processing Research Centre School of MechanicalAerospace and Civil EngineeringUniversity of ManchesterManchester M139PLUnited Kingdom

The optical nonlinearity in polycrystalline zinc selenide(ZnSe),excited with 775 nm,1 kHz femtosecond laser pulses was investigated via the nonlinear transmission with material thickness and the Z scan *** measured two photon absorption coefficientβwas intensity dependent,inferring that reverse saturated absorption(RSA)is also relevant dur-ing high intensity excitation in *** low peak intensity Im^(-2),we findβ=3.5 cm GW^(-1) at 775 *** spec-tral properties of the broad blueish two-photon induced fluorescence(460 nm-500 nm)was studied,displaying self-ab-sorption near the band edge while the upper state lifetime was measured to be τ_(e)~3.3 *** emission was ob-served when pumping a 0.5 mm thick polycrystalline ZnSe sample within an optical cavity,confirmed by significant line narrowing fromΔλ=11 nm(cavity blocked)toΔλ=2.8 nm at peak wavelength λ_(p)=475 nm while the upper state life-time also *** results suggest that with more optimum pumping conditions and crystal cooling,polycrystal-line ZnSe might reach lasing threshold via two-photon pumping atλ=775 nm.

关键词： ZnSe femtosecond laser nonlinear absorption stimulated emission fluorescence

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甘薯粉的蛋白质营养价值

国外农学-杂粮作物 1986年第1期 44-46页

作者： W.m.walter 马代夫

甘薯蛋白质生物学价值相当高,Adolph等(1939)报道,人类可以只依靠甘薯氮素来维持氮素平衡。从甘薯中提取的蛋白质,其蛋白质效能比(PER)与酪蛋白的相等(walter,

关键词：蛋白质宝石烘箱干燥滚桶甘薯粉效能比非蛋白氮营养价值营养质量