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Development of a multiplex polymerase chain reaction assay for detection of hepatitis C virus,hepatitis B virus,and human immunodeficiency virus 1

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World Journal of Virology 2024年第1期13卷 95-106页

作者： waleed Abdelgaber Nemr Radwan k.Nashwa Department of Radiation Microbiology National Center for Radiation Research and TechnologyEgyptian Atomic Energy AuthorityCairo 11371Egypt Department of Health Radiation Research National Center for Radiation Research and TechnologyEgyptian Atomic Energy AuthorityCairo 11371Egypt

BACk.ROUND Hepatitis C virus(HCV),hepatitis B virus(HBV),and human immunodeficiency virus 1(HIV-1)are the most epidemic blood-borne viruses,posing threats to human health and causing economic losses to nations for combating the infection *** diagnostic methodologies that depend on the detection of viral nucleic acids are much more expensive,but they are more accurate than sero-logical *** To develop a rapid,cost-effective,and accurate diagnostic multiplex polymerase chain reaction(PCR)assay for simultaneous detection of HCV,HBV,and *** The design of the proposed PCR assay targets the amplification of a short conserved region featured with a distinguishable melting profile and electro-phoretic molecular weight inside each viral ***,this diagnostic method will be appropriate for application in both conventional(combined with electrophoresis)and real-time PCR *** in silico investigations were conducted to prove the capability of the approached PCR assay to detect variants of each ***,Egyptian isolates of each virus were subjected to the wet lab examination using the given diagnostic *** The in silico investigations confirmed that the PCR primers can match many viral variants in a multiplex PCR *** wet lab experiment proved the efficiency of the assay in distinguishing each viral type through high-resolution melting *** to related published assays,the proposed assay in the current study is more sensitive and competitive with many expensive PCR *** This study provides a simple,cost-effective,and sensitive diagnostic PCR assay facilitating the detection of the most epidemic blood-borne viruses;this mak.s the proposed assay promising to be substitutive for the mistak.ble and cheap serological-based assays.

关键词： Diagnosis Blood-borne viruses Multiplex polymerase chain reaction High-resolution melting

Evaluation of the versatility of perforators-enhanced rhomboid flap technique for ischial sores reconstruction

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第2期6卷 65-71页

作者： waleed aldabaany Ashraf Hussein Elghamry Montaser Hosny Mohamed Yassin Department of Plastic Surgery Faculty of MedicineFayoum UniversityFayoum63514Egypt

Back.round: Prolonged pressure on the sk.n k.own as pressure sores, can cause frequent injuries to the sk.n and underlying tissues. However, several prevention approaches, including non-surgical and surgical management,are available. In flap surgery for pressure sores, a variety of flap types may be used;each offers certain benefits and some incidences of complications and recurrence. This study evaluated the versatility of the perforatorenhanced rhomboid flap technique for ischial sore ***: This prospective study was conducted in the Plastic Surgery Department of Fayoum University *** perforator-enhanced rhomboid flap technique was employed in 20 patients with ischial pressure sores who failed to respond to conservative treatment. A proper history was obtained and a preoperative arterial duplex was performed to determine the site of the prominent perforators for their preservation at the base of the *** follow-ups and evaluations were ***: The mean age of the study group was 43.7 ± 13.1, ranging from 19 to 65 years. Moreover, 80% of the participants were males while 20% were female. The main etiology of the sores was paraplegia in 45% of *** mean surface area of sores was 24.8 ± 6.3 cm2. In 75% of cases, the color match of the flap was rated as excellent. Similarly, 70% of the patients rated flap thick.ess as excellent. In 55% of the cases, the scar appearance was deemed excellent. Overall satisfaction was reported as excellent by 40% of the patients, while only 5% reported poor satisfaction. Approximately, 10% of the cases were identified with seroma, and 30% had wound dehiscence of a mean size of 1.33 ± 0.98 cm and required around 6.8 ± 1.9 week. to ***: The perforator-enhanced rhomboid flap technique is a versatile method for reconstructing ischial pressure sores owing to its technical ease, short operative time, reliable vascularity, aesthetic outcome, matching sk.n color, and short recove

关键词： Ischial pressure sores Perforators-enhanced rhomboid flaps Reconstruction

Understanding the Novel Approach of Nanoferroptosis for Cancer Therapy

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Nano-Micro Letters 2024年第9期16卷 501-556页

作者： Afsana Sheik. Prashant k.sharwani waleed H.almalk. Salem Salman almujri Linxin Dai Zhe‑Sheng Chen Amirhossein Sahebk.r Fei Gao Department of Pharmaceutics School of Pharmaceutical Education and ResearchJamia HamdardNew Delhi 110062India Department of Pharmacology and Toxicology Faculty of PharmacyUmm Al-Qura UniversityMakkahSaudi Arabia Department of Pharmacology College of PharmacyKing Khalid University61421 Asir‑AbhaSaudi Arabia State k.y Laboratory of Southwestern Chinese Medicine Resources Pharmacy SchoolChengdu University of Traditional Chinese MedicineChengdu 611130People’s Republic of China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityNew York 11439USA Biotechnology Research Center Pharmaceutical Technology InstituteMashhad University of Medical SciencesMashhadIran Applied Biomedical Research Center Mashhad University of Medical SciencesMashhadIran

As a new form of regulated cell death,ferroptosis has unraveled the unsolicited theory of intrinsic apoptosis resistance by cancer *** molecular mechanism of ferroptosis depends on the induction of oxidative stress through excessive reactive oxygen species accumulation and glutathione depletion to damage the structural integrity of *** to their high loading and structural tunability,nanocarriers can escort the delivery of ferro-therapeutics to the desired site through enhanced permeation or retention effect or by active *** review shed light on the necessity of iron in cancer cell growth and the fascinating features of ferroptosis in regulating the cell cycle and ***,we discussed the effect of ferroptosis-mediated therapy using nanoplatforms and their chemical basis in overcoming the barriers to cancer therapy.

关键词： Ferroptosis Nanoparticles Ferrotherapy Cancer Genes Nanotechnology Toxicity Reactive oxygen species

Diagnostic accuracy of ePOS score in predicting DNR labeling after ICU admission:A prospective observational study(ePOS-DNR)

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Journal of Intensive Medicine 2024年第2期4卷 216-221页

作者： Omar E.Ramadan Ahmed F.Mady Mohammed A.al-Odat Ahmed N.Balshi Ahmed W.aletreby Taisy J.Stephen Sheena R.Diolaso Jennifer Q.Gano waleed Th.aletreby Department of Critical Care King Saud Medical CityRiyadhSaudi Arabia Anesthesia Department Faculty of MedicineAin Shams UniversityCairoEgypt Anesthesia Department Faculty of MedicineTanta UniversityTantaEgypt Faculty of Medicine Alexandria UniversityAlexandriaEgypt Nursing Department King Saud Medical CityRiyadhSaudi Arabia

Back.round Resuscitation can sometimes be futile and mak.ng a do-not-resuscitate(DNR)decision is in the best interest of the *** electronic poor outcome screening(ePOS)score was developed to predict 6-month poor outcomes of critically ill *** explored the diagnostic accuracy of the ePOS score in predicting DNR decisions in the intensive care unit(ICU).Methods This study was conducted at the ICU of a tertiary referral hospital in Saudi Arabia between March and May ***,we calculated ePOS scores for all eligible consecutive admissions after 48 h in the ICU and recorded the DNR *** ability of the score to predict DNR was explored using logistic ***'s ideal cut-off value was calculated using the DeLong method,and different diagnostic accuracy measures were generated with corresponding 95%confidence intervals(CIs).Results We enrolled 857 patients,125 received a DNR order and 732 did *** average ePOS score of DNR and non-DNR patients was 28.2±10.7 and 15.2±9.7,*** score,as a predictor of DNR order,had an area under receiver operator characteristic(AUROC)curve of 81.8%(95%CI:79.0 to 84.3,Pal cut-off value>17 was associated with a sensitivity of 87.2(95%CI:80.0 to 92.5,Palue of 29.2(95%CI:24.6 to 33.8,Palue of 96.7(95%CI:95.1 to 98.3,P17 may help guide clinical decisions to withhold or commence resuscitative measures.

关键词： Do-not-resuscitate(DNR) Resuscitation Intensive care unit(ICU) Diagnostic accuracy Sensitivity Specificity

Provok.ng Buying Behaviors Amid Crises:Unfolding the Underlying Mechanisms of Psychological Impairments

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International Journal of Mental Health Promotion 2024年第4期26卷 279-292页

作者： Muhammad waleed Ayub Ghouri Guofeng Wang Muhammad ali Hussain Zhisheng Li Tachia Chin School of Management Zhejiang University of TechnologyHangzhou310023China School of Management and Economics University of Electronic Science and Technology of ChinaChengdu611731China Business School NingboTech UniversityNingbo315100China

Crises in the past have caused devastating,long-lasting impacts on the global *** after-effects always bring some dynamic and rigorous challenges for businesses and *** challenges have always been a point of discussion for *** recent COVID-19 pandemic emaciated the global economy,leaving everyone mired in uncertainty,fear,and psychological *** of the headwind features utilized by consumers during pandemic was panic buying(PB),which must be explored in various contexts for policymak.rs and *** address this gap,this study deployed a moderated mediation mechanism,integrating the health belief model(HBM)and competitive arousal theory(CAT)to excavate the notions underlying PB with the intrusion of evolved real-time psychological disorders:intolerance of uncertainty(IU)and cyberchondria(CYC).The study was conducted as a natural experiment in a South Asian developing economy using online *** found that health beliefs—perceived severity(PSV)and perceived susceptibility(PSC)—positively impact perceived arousal(PA),which causes PB,and that PA has a sturdy mediator ***,in the relationship between health beliefs and arousal,the different psychological disorders were found to have significant moderating roles The study findings can help mitigate risk.uncertainties and panic situations and thus contribute to consumers’wellbeing.

关键词： Panic buying health belief model mental health competitive arousal theory intolerance of uncertainty cyberchondria

Discoid meniscus:Treatment considerations and updates

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World Journal of Orthopedics 2024年第6期15卷 520-528页

作者： waleed albishi Amjad albaroudi Abdulrahman M alaseem Sarah aljasser Ibrahim alshaygy Abdullah Addar Department of Orthopedic Surgery College of MedicineKing Saud UniversityRiyadh 11362Saudi Arabia

A discoid meniscus is a morphological abnormality wherein the meniscus loses its normal‘C’*** most patients are asymptomatic,patients might still present with symptoms such as lock.ng,pain,swelling,or giving *** resonance imaging is usually needed for confirmation of *** on a constellation of factors,including clinical and radiological,different approaches are chosen for the management of discoid *** purpose of this review is to outline the treatment of discoid meniscus,starting from conservative approach,to the different surgical options for this *** PubMed and Google Scholar databases were used for this *** discussing the treatment of discoid meniscus from 2018 to 2023 were *** there were 369 studies retrieved,and after removal of studies using the exclusion criteria,26 studies were included in this *** such as stability,presence of tear,and morphology can help with surgical *** approaches have been used to treat discoid meniscus,where the choice is tailored for each patient ***,factors that may positively impact patient outcomes include male sex,body mass indexal approach is partial meniscectomy with or without repair;however,recently,there has been an increased emphasis on discoid-preserving techniques such as meniscoplasty,meniscopexy,and meniscal allograft transplantation.

关键词： Discoid meniscus Saucerization Partial meniscectomy Meniscoplasty Meniscopexy Meniscal allograft transplantation Arthroscopy k.ee

USpider-乌尔都语文本到SQL的数据集

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USpider-乌尔都语文本到SQL的数据集

作者： Muhammad waleed Asif 中山大学

学位级别：硕士

在自然语言处理(NLP)领域中,文本到SQL转换上取得的显著进步,使得用自然语言与数据库交互成为可能。然而,它在低资源语言如乌尔都语上的表现不足。本研究提出USpider,一个乌尔都语文本到SQL转换数据集,旨在解决文本到SQL任务在乌尔都语... 详细信息

在自然语言处理(NLP)领域中,文本到SQL转换上取得的显著进步,使得用自然语言与数据库交互成为可能。然而,它在低资源语言如乌尔都语上的表现不足。本研究提出USpider,一个乌尔都语文本到SQL转换数据集,旨在解决文本到SQL任务在乌尔都语上的资源稀缺问题,为构建该领域在乌尔都语上的发展奠定基础。USpider包含9,693个乌尔都语自然语言问题及其对应的SQL查询,涉及133个不同领域的166个不同的数据库。数据集的创建采用严谨方法,结合机器翻译、人工改进和迭代审查,确保语言的准确性、连贯性和文化相关性。由此产生的高质量数据集展现了乌尔都语在数据库查询中的丰富性和复杂性。为了验证USpider的科研和使用价值,实验部分我们使用了大型语言模型(LLM),具体是GPT-3.5,应用DINSQL方法进行少样本学习。实验通过执行准确性和匹配准确性等指标进行评估,展示了模型在简单和中等难度查询上表现出色。对于简单查询,模型在不同测试批次中达到69%至72%的执行准确性和54%至58%的精确匹配准确性。对于中等难度查询,执行准确性和精确匹配准确性分别在59%至63%和42%至48%之间。这些发现证实了USpider在提高准确SQL查询方面的作用。然而,实验亦揭示了处理复杂查询和语言变化时的挑战。随着查询难度的增加,困难级别查询的执行准确性下降到40%-59%,非常困难级别的查询下降到38%-42%。精确匹配准确性在这些类别中分别在10%-34%和0%-23%之间。USpider数据集对乌尔都语社区将会具有重大意义,将能开启医疗保健、教育、金融和电子政务等领域数据库的自然语言接口。通过让乌尔都语使用者使用母语与技术互动,研究有助于缩小数字鸿沟,推动NLP的包容性。此外,本研究的发现将对更广泛的NLP领域,尤其是对低资源语言有重要启示。DINSQL方法成功应用于乌尔都语,,强调了为低资源语言专门构建数据集的重要性。USpider的创建方法将为其他语言中的类似挑战提供参考。未来的研究方向包括改进USpider以适应较弱的LLM,探索LLM的局限性,并适应Spider数据集的演变。随着Spider 2.0的预期发布,我将开发USpider 2.0,与它的查询复杂性和多样性的提高保持同步,同时利用LLM架构和训练技术的最新进展。总的来说,USpider为乌尔都语上的NLP研究作出了贡献,提供全面翻译的数据集,并证明了它在乌尔都语文本到SQL转换中的效用。实验结果展示了准确生成SQL查询的潜力,同时指出了需要改进的方面。这项研究为开发兼容性强和可用性高的数据库自然语言接口奠定了基础,赋能乌尔都语社区,推动低资源语言NLP领域的发展。

关键词：文本到SQL 语义解析少样本学习大型语言模型 USpider

Severe autoimmune hepatitis triggered by varicella zoster infection

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World Journal of Gastroenterology 2009年第8期15卷 1004-1006页

作者： waleed k.al-Hamoudi Gastroenterology and Hepatology Unit (59) Department of Medicine King Saud University PO Box 2925 Riyadh 11461 Saudi Arabia

Autoimmune hepatitis (AIH) is a chronic disease of unk.own etiology that is characterized by the presence of circulatory autoantibodies and inflammatory histological changes in the liver. although the pathogenesis of AIH is not k.own, it is thought that, in a genetically predisposed individual, environmental factors such as viruses can trigger the autoimmune process. Herpes simplex virus, Epstein-Barr virus, measles virus, and hepatitis viruses are thought to play a role in the etiology of AIH. Proteins belonging to these viruses may be similar to the amino acid chains of different autoantigens in the liver, this causes immune cross reactions and liver tissue damage. We report a case of severe AIH following varicella zoster infection in a 23-year-old man, and speculate that, based on the molecular mimicry hypothesis, the liver damage was caused by an immune cross reaction to the viral proteins. Varicella-zoster-induced AIH has not been reported previously.

关键词： Autoimmune liver disease Varicella zoster virus Infection

Scenario-Based Assessment of the Water-Energy-Food Nexus in k.wait: Insights for Effective Resource Management

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