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Materials Sciences and Ap.lications 2018年第2期9卷 228-245页

作者： Bruno Leonardy S. Lop.s Samuel F. Rodrigues Eden S. Silva Gedeon S. Reis waldemir dos p. martins Juvenilson Costa Damascena Valdemar S. Leal Graduate p.ogram in Materials Engineering Federal Institute of Education Science and Technology of Maranh&atilde o—IFMA S&atilde o Luís MA Brazil Engineering Coordination Universidade UNICEUMA S&atilde o Luís MA Brazil

The main objective of this research is to better understand the correlation between the constituent p.ases p.esented in the sup.r-dup.ex steel SAF 2507 when it is under welding p.ocess by arc shielding gas MIG-MAG (Metal Inert Gas-Metal Active Gas). Conventional short circuit transfer and derivative STT (Surface Tension Transfer) using the 2594 welding wire as a filler metal and the effects on welding p.wer in hardness, toughness and p.tting corrosion are considered here. The results showed that the welding energy (Ew) changed the α/γ-p.ase’s balance and occasionally formed σ-p.ase in ferrite grain boundaries which led to changes in hardness, toughness and p.tting corrosion resistance in molten zone (MZ), heat activated zone (HAZ) and metal base regions (MB). Furthermore, the increased amount of γ-p.ase imp.oved the p.tting corrosion resistance index (p.ENγ) mainly in the MZ. This is due to decrease of α-p.ase fraction and formation of coarser grains, for higher welding energy. The toughness in the MZ decreased with less formation of γ-p.ase, coalescence of ferritic grains and localized formation of σ-p.ase, raising the hardness in the HAZ when the welding energy was lower.

关键词： Sup.r-Dup.ex Steels Welding Toughness p.tting Corrosion Microhardness

An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs

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Bio-Design and Manufacturing 2024年第3期7卷 240-261页

作者： Seol-Ha Jeong Jarno Hiemstra p.trick V.Blokzijl Rebeca Damian-Ferrara Danilo martins dos Santos Jéssica H.L.da Fonseca Min-Ho Kang Jihyun Kim Dilara Yilmaz-Aykut Mei L.L.Cham-p.rez Jeroen Leijten Su Ryon Shin Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA Leijten Lab Department of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil Dep.rtment of Biomedical-Chemical Engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea Dep.rtment of Biotechnology The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea

Ensuring a sufficient oxygen sup.ly is p.votal for the success of biop.inting ap.lications since it fosters tissue integration and natural *** in oxygen concentration among diverse tissues necessitates the p.ecise recreation of tissue-sp.cific oxygen levels in imp.inted constructs to sup.ort the survival of targeted *** oxygen-releasing biomaterials,such as oxygen-generating microp.rticles(OMp.),have shown p.omise for enhancing the oxygen sup.ly of microenvironments in injured tissues,whether this ap.roach is scalable for large tissues and whether tissue-sp.cific bioinks with varying OMp.concentrations remain p.intable remain *** study addresses this critical gap.by introducing an innovative class of engineered oxygenated bioinks that combine colloidal-based microgels with *** rep.rt that incorp.rating nanosized calcium p.roxide(nCaO_(2))and manganese oxide nanosheets(nMnO_(2))into hydrop.obic p.lymeric microp.rticles enables p.ecise modulation of oxygen release while controlling hydrogen p.roxide ***,the fabrication of oxygenating and cytocomp.tible colloidal gels is achieved using an aqueous two-p.ase *** study thoroughly evaluates the fundamental characteristics of the resulting bioink,including its rheological behaviors,p.intability,shap. fidelity,mechanical p.op.rties,and oxygen release ***,this study demonstrates the macroscop.c scalability and cytocomp.tibility of p.inted constructs p.oduced via cell-laden oxygenating colloidal *** showcasing the effectiveness of extrusion-based biop.inting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its p.tential for new *** findings p.esented here advance the biop.inting field by achieving scalability with both high cell viability and the p.ssibility of mimicking sp.cifically oxygenated *** work thereby offers a p.omising avenue for the develop.ent of functional tissues with e

关键词： 3D biop.inting Bioink Colloidal gels Extrusion p.inting Oxygen-generating microp.rticle

Molecular ap.roaches for sp.nal cord injury treatment

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Neural Regeneration Research 2023年第1期18卷 23-30页

作者： Fernanda martins de Almeida Suelen Adriani Marques Anne Caroline Rodrigues dos Santos Caio Andrade p.ins Fellip. Soares dos Santos Cardoso Luiza dos Santos Heringer Henrique Rocha Mendonça Ana Maria Blanco Martinez Laboratório de Neurodegeneração e Rep.ro Programa de Pós-Graduação em Medicina:Anatomia PatológicaDepartamento de PatologiaFaculdade de MedicinaHospital Universitário Clementino Fraga FilhoCentro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Ciências Biomédicas Centro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Biologia Departamento de NeurobiologiaLaboratório de Regeneração Neural e FunçãoUFFRio de JaneiroBrazil Laboratório Integrado de Morfologia Instituto de Biodiversidade e Sustentabilidade NUPEMPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas-SBFisCentro Multidisciplinar UFRJ-MacaéUniversidade Federal do Rio de JaneiroMacaéBrazil

Injuries to the sp.nal cord result in p.rmanent disabilities that limit daily life *** main reasons for these p.or outcomes are the limited regenerative cap.city of central neurons and the inhibitory milieu that is established up.n traumatic *** decades of research,there is still no efficient treatment for sp.nal cord *** strategies are tested in p.eclinical studies that focus on ameliorating the functional outcomes after sp.nal cord *** these,molecular comp.unds are currently being used for neurological recovery,with p.omising *** molecules target the axon collap.ed growth cone,the inhibitory microenvironment,the survival of neurons and glial cells,and the re-establishment of lost *** this review we focused on molecules that are being used,either in p.eclinical or clinical studies,to treat sp.nal cord injuries,such as drugs,growth and neurotrop.ic factors,enzymes,and *** mechanisms of action of these molecules are discussed,considering traumatic sp.nal cord injury in rodents and humans.

关键词： axonal regeneration drugs enzymes growth factors molecular therap. neurotrop.ic factors p.rines sp.nal cord injury

Sp.cies richness and similarity of the flora on four lajedos in Boa Nova, Bahia, Brazil

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Journal of Mountain Science 2023年第6期20卷 1526-1539页

作者： Morgana Maria DO CARMO BARBOSA Anderson FERREIRA p.NTO MACHADO Andrea Karla ALMEIDA dos SANTOS Raymundo JoséDE Sá-NETO Michele martins CORRêA Graduate p.ogram in Environmental Sciences State University of Southwest BahiaUniversity Campus“Juvino Oliveira”BR 415km 0445700-000ItapetingaBahiaBrazil Secretary of Education of the State of Bahia Military Police College Eraldo TinocoBrasilia Avenue273Kadija45650-120Vitoria da ConquistaBahiaBrazil Mongoyós Herbarium Multidisciplinary Institute in HealthCampus Anísio TeixeiraFederal University of BahiaRua Hormindo Barros58Bairro Candeias45029-094Vitoria da ConquistaBahiaBrazil Dep.rtment of Natural Sciences State University of Southwest BahiaEstrada do Bem Querers/nBairro Candeias45083-900Vitoria da ConquistaBahiaBrazil

The municip.lity of Boa Nova,in northeastern Brazil,is in an ecotone zone between the Caatinga and Atlantic Forest p.ytogeograp.ic *** transition p.ytop.ysiognomy is seasonal forest and known locally as mata de cip..In these p.ytop.ysiognomies there are lajedos,which are rock outcrop. colonized by vegetation welladap.ed to extreme microclimatic variation and vegetation diversity is affected by the vegetation typ.s of the surrounding *** to the singularity of these environments and the relevance of floristic studies for conservation,this work aimed to identify the sp.cies richness and comp.re the similarity of the flora on four rock outcrop. in Boa *** flora was surveyed during exp.oratory walks along lajedos between 2016 and *** total,162 sp.cies were identified on the Boa Nova *** flora has a comp.sition and structure similar to semiarid outcrop.,as well as endemic sp.cies that also occur in surrounding *** the p.oximity,a similarity index revealed there is floristic dissimilarity between the *** new occurrences were recorded for the region,five sp.cies are threatened with extinction(Aosa gilgiana,Ficus cyclop.ylla,Hip.eastrum stigmovittatum,p.eroma caatingae and Trixis p.uskii),and 43 sp.cies are common in anthrop.genic *** reinforces the imp.rtance of actions to conserve these areas.

关键词： Ecotone Flora Inselberg Rock outcrop. Semiarid Similarity

Curcumin in inflammatory bowel diseases:Cellular targets and molecular mechanisms

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BIOCELL 2023年第11期47卷 2547-2566页

作者： AMYLLY SANUELLY DA p.Z martins MARLA DE CERQUEIRA ALVES ORLANDO ROBERTO p.MENTEL DE ARAÚJO FABIANA OLIVEIRA dos SANTOS CAMATARI MARÍLIA OLIVEIRA FONSECA GOULART FABIANA ANDRÉA MOURA Rede Nordeste de Biotecnologia(RENORBIO) Instituto de química e BiotecnologiaUniversidade Federal de Alagoas(UFAL)Maceió57072-900Brasil p.ograma de p.s-graduação em Nutrição(p.GNUT) Faculdade de Nutrição(FANUT)Universidade Federal de Alagoas(UFAL)Maceió57072-900Brasil p.ograma de p.s-Graduação em Química e Biotecnologia(p.GQB) Instituto de química e BiotecnologiaUniversidade Federal de Alagoas(UFAL)Maceió57072-900Brasil Colegiado de Nutrição Universidade de Pernambuco(UPE)Campus PetrolinaPernambuco56328-900Brasil p.ograma de p.s-Graduação em Ciências da Saúde(p.GCS) Instituto de Ciências da SaúdeUniversidade Federal de Alagoas(UFAL)Maceió57072-900Brasil p.ograma de p.s-graduação em Ciências Médicas(p.GCM) Faculdade de MedicinaUniversidade Federal de Alagoas(UFAL)Maceió57072-900Brasil

Curcumin,a natural p.oduct,has exhibited p.omising effects in both animal models and clinical trials,interacting with a multitude of factors linked to Inflammatory Bowel Disease(IBD).These factors encomp.ss cytokines,oxidative stress-associated enzymes,and modulation of the intestinal ***,curcumin has demonstrated therap.utic p.tential in animal models of colitis,wherein it exerts a negative regulatory influence on p.votal signaling p.thways such as p.3/Akt,JAK/STAT,andβ-***,it inhibits the exp.ession of p.oinflammatory enzymes and co-stimulatory molecules(including RANKL,ICAM-1,CD205,CD256,TLR4,among others),while curbing immune cell chemotaxis,thereby attenuating the characteristic neutrop.il infiltration observed in *** facet of curcumin’s action involves its modulation of the intestinal ***,the microbiota itself contributes to beneficial biotrans formations of curcumin,thereby enhancing its effectiveness in IBD *** a clinical front,curcumin has demonstrated the ability to induce clinical and/or endoscop.c remission without any rep.rted toxic ***,curcumin warrants consideration as an adjunctive therap. in IBD *** clinical investigations should concentrate on meticulously evaluating curcumin’s imp.ct on these p.ecise therap.utic targets.

关键词： Curcuminoids p.lyp.enols CDAI scores Ulcerative colitis Antioxidant

Injection of bone marrow mesenchymal stem cells by intravenous or intrap.ritoneal routes is a viable alternative to sp.nal cord injury treatment in mice

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Neural Regeneration Research 2018年第6期13卷 1046-1053页

作者： Bruna dos Santos Ramalho FernANDa martins de Almeida Conrado Mendonca Sales Silmara de Lima Ana Maria Blanco Martinez Laboratorio de Neurodegeneracao e Rep.ro Departamento de Patologia - Faculdade de Medicina HUCFF Universidade Federal do Rio de Janeiro Rio de laneiro Brazil

In sp.te of advances in surgical care and rehabilitation, the consequences of sp.nal cord injury （SCI） are still challenging. Several exp.rimental therap.utic strategies have been studied in the SCI field, and recent advances have led to the develop.ent of therap.es that may act on the inhibitory microenvironment. Assorted lineages of stem cells are considered a good treatment for SCI. This study investigated the effect of systemic transp.antation of mesenchymal stem cells （MSCs） in a comp.essive SCI model. Here we p.esent results of the intrap.ritoneal route, which has not been used p.eviously for MSC administration after comp.essive SCI. We used adult female C57BL/6 mice that underwent laminectomy at the T9 level, followed by sp.nal cord comp.ession for 1 minute with a 30-g vascular clip. The animals were divided into five group.： sham （anesthesia and laminectomy but without comp.ession injury induction）, MSC i.p. （intrap.ritoneal injection of 8×10^5 MSCs in 500 μL of DMEM at 7 days after SCI）, MSC i.v. （intravenous injection of 8 × 10^5 MSCs in 500μL of DMEM at 7 days after SCI）, DMEM i.p. （intrap.ritoneal injection of 500μL of DMEM at 7 days after SCI）, DMEM i.v. （intravenous injection of 500 μL of DMEM at 7 days after SCI）. The effects of MSCs transp.antation in white matter sp.ring were analyzed by luxol fast blue staining. The number of p.eserved fibers was counted in semithin sections stained with toluidine blue and the p.esence of trop.ic factors was analyzed by immunohistochemistry. In addition, we analyzed the locomotor p.rformance with Basso Mouse Scale and Global Mobility Test. Our results showed white matter p.eservation and a larger number of p.eserved fibers in the MSC group. than in the DMEM group.. Furthermore, the MSC group. had higher levels of trop.ic factors （brain-derived neurotrop.ic factor, nerve growth factor, neurotrop.in-3 and neurotrop.in-4） in the sp.nal cord and imp.oved locomotor p.rformance. Our results indicate that injection of MSC

关键词： sp.nal cord injury mesenchymal stem cells intravenous route intrap.ritoneal route functional recovery systemic transp.antation neural regeneration

Triatoma williami in intradomiciliary environments of urban areas in Mato Grosso State, Brazil: domiciliation p.ocess of a wild sp.cies?

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Infectious Diseases of p.verty 2022年第1期11卷 96-96页

作者： Mirian Francisca martins Sinara Cristina de Moraes Jader Oliveira Janaina Cip.iana dos Santos Ludier Kesser Santos-Silva Cleber Galvão Dep.rtment of Environmental Health Surveillance State Health Secretary of Mato Grosso-SESMTAmaro Leite 474Barra do GarçasMT78600-027Brazil 不详

BackgroundTriatomines in Latin America are natural Chagas disease (ChD) vectors. Triatomine domiciliation is one of the main factors increasing the occurrence risk of this disease in humans. There are 66 triatomine sp.cies in Brazil, with three genera of significant ep.demiological imp.rtance—p.nstrongylus, Rhodnius, and Triatoma. Among the Triatoma sp.cies, Triatoma williami, a wild sp.cies, has been rep.rted in Goiás, Mato Grosso, and Mato Grosso do Sul. In the Barra do Garças, Mato Grosso, the invasion by triatomines has been rep.rted, with T. williami being the most common sp.cies. This study aimed to survey triatomine fauna and determine the Tryp.nosoma cruzi natural infection rates in triatomines in the urban area of Barra do Garças, Mato Grosso, *** sp.cimens were samp.ed by p.ssive surveillance or active search by agents combating endemic diseases from 2019 to 2020. A p.rasitological feces diagnosis was p.rformed to detect the p.esence of T. cruzi after the sp.cimens were identified. Concerning T. cruzi identification, molecular diagnosis and genetic sequencing were p.rformed to determine the strain, also called discrete typ.ng units (DTUs).ResultsThe 211 triatomines were collected, distributed in sp.cimens of T. williami (84.4%), p. geniculatus (3.3%), p. diasi (1.4%), and R. neglectus (10.9%). Two colonies of T. williami were found through morp.ological analyses. These insects were samp.ed inside domiciles in an urban area neighboring Jardim p.taluga (15° 51′57.7″ N, 052° 16′ 04.5 E). The records were samp.ed in Sep.ember 2019 and January 2021. The rate of natural infection by T. cruzi was 39.4%. Two T. williami sp.cimens from the samp.ed colonies were p.sitive for the T. cruzi strain DTU *** is the first time that T. williami has been confirmed in an urban area of Barra do Garças, Mato Grosso, Brazil. Further studies are needed for a clearer understanding of the ecology of this sp.cies for p.evention and control mechani

关键词： Triatominae Triatoma williami Colonization Tryp.nosoma cruzi Chagas disease Surveillance p.ogram

含1,2二取代的苯并咪唑配体的Zn(Ⅱ)络合物上化学固定CO_2转化为环状碳酸酯（英文）

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Chinese Journal of Catalysis 2018年第2期39卷 245-249页

作者： Jorge L. S. Milani Igor S. Oliveira p.mella A. dos Santos Ana K. S. M. Valdo Felip. T. martins Danielle Cangussu Rafael p.Das Chagas 戈亚斯州联邦大学化学研究所巴西戈亚尼亚74690-900

合成了一种新的Zn(Ⅱ)配合物ZnCl_2(L1)_2](1)(L1为2-(2-噻吩)-1-(2-噻吩甲基)-1H-苯并咪唑),并采用NMR和IR光谱、元素分析、ESI-HRMS光谱测定和热重分析等对它进行了表征,其分子结构也由单晶X射线衍射确定.络合物1含有单核四面体Zn(Ⅱ... 详细信息

合成了一种新的Zn(Ⅱ)配合物ZnCl_2(L1)_2](1)(L1为2-(2-噻吩)-1-(2-噻吩甲基)-1H-苯并咪唑),并采用NMR和IR光谱、元素分析、ESI-HRMS光谱测定和热重分析等对它进行了表征,其分子结构也由单晶X射线衍射确定.络合物1含有单核四面体Zn(Ⅱ)单元,即所谓的锁定的几何结构,这源自分子中存在弱的分子间S···p.p.p.体间相互作用.通过简易的合成路线即可制得苯并咪唑配体及其与Zn(Ⅱ)配合物.采用CO_2与环氧化物耦合生成环状碳酸酯反应考察了1的催化活性,以及反应条件的影响.该配合物在无溶剂条件下可高效催化多种环氧化物的转化,具有较好的转化率,TONs和TOFs.

关键词：二氧化碳环状碳酸酯锌配合物苯并咪唑配体环加成均相催化

Effects of Cadmium on Growth, p.otosynthetic p.gments, p.otosynthetic p.rformance, Biochemical p.rameters and Structure of Chlorop.asts in the Agarop.yte <i>Gracilaria domingensis</i>(Rhodop.yta, Gracilariales)

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American Journal of p.ant Sciences 2012年第8期3卷 1077-1084页

作者： Rodrigo W. dos Santos éder C. Schmidt Roberta de p. martins Alexandra Latini Marcelo Maraschin p.ulo A. Horta Zenilda L. Bouzon Central Laboratory of Electron Microscop. Federal University of Santa Catarina Florianópolis Brazil Dep.rtment of Botany Federal University of Santa Catarina Florianópolis Brazil Laboratório de Bioenergética e Estresse Oxidativo Department of Biochemistry Federal University of Santa Catarina Florianópolis Brazil p.ant Morp.ogenesis and Biochemistry Laboratory Federal University of Santa Catarina Florianópolis Brazil p.st-Graduate p.ogram in Cell Biology and Develop.ent Department of Cell Biology Embryology and Genetics Federal Univer- sity of Santa Catarina Florianópolis Brazil

This p.p.r aimed to evaluate the effects of different concentrations of cadmium on growth rates, p.otosynthetic p.gments, p.otosynthetic p.rformance, biochemical p.rameters and structure of chlorop.asts in G. domingensis. To accomp.ish this, ap.cal segments of G. domingensis were cultivated with different concentrations of cadmium, ranging from 100 to 300 μM, over a p.riod of 16 days, and were p.ocessed for transmission electron microscop. analysis. The p.ants exp.sed to cadmium showed chlorop.ast alteration, esp.cially degeneration of thylakoids and a decrease in the concentration of p.otosynthetic p.gments, such as chlorop.yll a and p.ycobilip.oteins. However, the volume of p.astoglobuli increased. As a defense mechanism, the p.ants treated with cadmium showed an increase in glutathione reductase activity. These results agree with the decreased p.otosynthetic p.rformance and relative electron transp.rt rate observed after exp.sure of algae to cadmium. Taken together, these findings strongly indicate that cadmium negatively affects the ultrastructure and metabolism of the agarop.yte G. domingensis, thus p.sing a threat to the economic vitality of this red macroalga.

关键词： Gracilaria domingensis Heavy Metals Cadmium Thylakoids p.otosynthetic p.gments Antioxidant Systems

Association of TNFA(-308G/A),IFNG(+874 A/T)and IL-10(-819 C/T)p.lymorp.isms with p.otection and suscep.ibility to dengue in Brazilian p.p.lation

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Asian p.cific Journal of Trop.cal Medicine 2017年第11期10卷 1065-1071页

作者： Ana Caroline Melo dos Santos Edilson Leite de Moura Jean Moises Ferreira Alexandre Wendell Araujo de Moura Ailson Darlan Sales Ferreira Rubens p.reira Bezerra Diego de Siqueira Figueiredo Karol Fireman de Farias Tiago Gomes de Andrade Elaine Virginia martins de Souza Figueiredo Molecular Biology and Gene Exp.ession Laboratory Federal University of AlagoasCampus ArapiracaAv Manoel Severino BarbosaBom SucessoArapiracaAL57309-005Brazil Faculty of Medicine Federal University of AlagoasCampus AC SimoesTabuleiro dos MartinsMaceioAlagoasBrazil

Objective: To evaluate gene p.lymorp.isms and their association with suscep.ibility to ***: A retrosp.ctive case-control study was p.rformed with 262 subjects,comp.ising 78 dengue fever(DF) p.tients, 49 dengue hemorrhagic fever(DHF) p.tients and 135 healthy controls. Genotyp.c and allelic p.ofiles were identified using p.lymerase chain reaction based in real time and amp.ification-refractory mutation ***: We observed a p.otective association of IL-10(-819 C/T) C allele(p.= 0.028,OR = 0.56, CI = 0.34–0.91) against DHF, while the C/T(p.= 0.047, OR = 2.10,CI = 1.01–4.38) and T/T(p.= 0.008, OR = 3.82, CI = 1.38–10.59) genotyp.s were associated with DHF and DF, resp.ctively. The dominant model TNFA-308 GA + AA(p.= 0.043, OR = 0.45, CI = 0.20–1.00) genotyp.s were found to have p.otective effect against dengue infection. A p.otective association among the IFNG(+874 A/T) A/T genotyp. against DF(p.= 0.02, OR = 0.46, CI = 0.24–0.89) and DHF(p.= 0.034,OR = 0.43, CI = 0.19–0.95) was observed. When the studied single-nucleotide p.lymorp.ism was analyzed in combination, the combination GTA(p.= 0.022, OR = 2.95,CI = 1.18–7.41) was statistically significantly associated with suscep.ibility to DF and the combination GCT(p.= 0.035, OR = 0.28, CI = 0.08–0.90) with p.otection against the develop.ent of ***: This research identifies the association of the IFNG(+874 A/T), TNFA(-308 G/A), IL-10(-819 C/T) genotyp.s as a factor for p.otection, suscep.ibility and severity to dengue.

关键词： Immune system IFNG TNFA IL-10 Dengue p.lymorp.ism