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Hepatitis B virus as a risk factor for hepatocellular carcinoma:There is still much work to do

肝脏研究（英文） 2024年第2期8卷 83-90页

作者： walaa abdelhamed Mohamed El-Kassas Endemic Medicine Department Sohag UniversitySohagEgypt Endemic Medicine Department Faculty of MedicineHelwan UniversityCairoEgypt Liver Disease Research Center College of MedicineKing Saud UniversityRiyadhSaudi Arabia

Hepatitis B virus(HBV)infection is a significant health problem that can result in progression to liver cirrhosis,decompensation,and the development of hepatocellular carcinoma(HCC).On a country level,the prevalence of chronic HBV infection varies between 0.1％and 35.0％,depending on the locality and the population being ***-third of all liver cancer fatalities worldwide are attributable to *** adoption of standard birth-dose immunization exerted the most significant impact on the decline of HBV *** incidence ranges from 0.01％to 1.40％in noncirrhotic patients and from 0.9％to 5.4％annually,in the settings of liver *** antiviral therapy significantly reduces the risk of developing HBV-related HCC,studies have demonstrated that the risk persists,and that HCC screening is still *** review discusses the complex relationship between HBV infection and HCC,recent epidemiological data,different aspects of clinical disease characteristics,and the impact of antiviral therapy in this context.

关键词： Hepatitis B virus (HBV) Hepatocellular carcinoma (HCC) HBV vaccine Carcinogenesis Antiviral therapy

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Hepatocellular carcinoma recurrence:Predictors and management

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Liver Research 2023年第4期7卷 321-332页

作者： walaa abdelhamed Mohamed El-Kassas Endemic Medicine Department Sohag UniversitySohagEgypt Endemic Medicine Department Faculty of MedicineHelwan UniversityCairoEgypt

Hepatocellular carcinoma(HCC),the sixth most common cancer globally,is associated with high mortality rates and more than 830,000 annual *** advances in the available management options including surgical resection and local ablative therapies,recurrence rates after the initial treatment exceed 50%,even among patients who have undergone curative-intent ***,postsurgical HCC recurrence occurs in about 70%of cases five years *** management of recurrent HCC remains *** review discusses different predictors for HCC recurrence after each treatment modality and different approaches available to stratify these *** specific guidelines for managing HCC recurrence and strict surveillance protocols for such recurrence after initial HCC management are needed.

关键词： Hepatocellular carcinoma(HCC) Recurrence Ablation Liver resection Liver transplantation

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Fibrolamellar hepatocellular carcinoma:A rare but unpleasant event

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World Journal of Gastrointestinal Oncology 2022年第6期14卷 1103-1114页

作者： walaa abdelhamed Mohamed El-Kassas Department of Endemic Medicine Sohag UniversitySohag 14322Egypt Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt

Fibrolamellar carcinoma(FLC)is a rare variant of hepatocellular carcinoma(HCC),comprising 1%–9%of all *** is a poorly understood malignancy,which seems to be more prevalent in young patients with no underlying liver *** term“fibrolamellar”is derived from thick fibrous collagen bands surrounding the tumor *** HCC,cirrhosis and viral hepatitis infection are not predisposing to FLC,and it is not associated with elevations in serum *** patients often present with vague abdominal pain,nausea,malaise,and weight *** cases present are at an advanced stage at the time of initial ***,curative treatment options can still be offered to up to 70%of ***(resection/liver transplantation)is the mainstay of treatment and the only potentially curative *** have been less chemoresponsive than the conventional HCC,however,in advanced cases,multimodality treatments can be *** advances in molecular studies of FLC have found a unique DNAJB1–PRKACA fusion transcript in most of the cases *** review aims to describe clinical characteristics,diagnostic methods,and therapeutic modalities for this rare tumor to raise awareness among clinicians and surgeons.

关键词： Fibrolamellar carcinoma Hepatocellular carcinoma Hepatitis Cirrhosis Viral hepatitis infection

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