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食品工业中果酸和氢氧化钠与硫酸月桂基钠的联合作用:体内系列刺激对照研究

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世界核心医学期刊文摘（皮肤病学分册） 2005年第4期1卷 9-10页

作者： Fl.hr J.W. Bankova l. Fuchs S. 冯义国 Skin Physiol.gy l.boratory Department of Dermatology Friedrich-Schiller-University Erfurter Str. 35 07740 Jena Germany

Background: Cutaneous exposure to a variety of irritants has been extensivel. studied in recent years. Neverthel.ss, knowl.dge of the induction of irritant dermatitis, especial.y by mil. irritants at l.w doses and for a short duration of exposure, is stil. incompl.te. Objectives: To quantify the irritant effects and barrier disruption properties of ascorbic acid(ASC), acetic acid(ACA) and sodium hydroxide (NaOH), particul.rl. in combination with an anionic detergent, sodium l.uryl.sul.hate(Sl.). Methods: In a tandem repeated irritation test, the irritants were appl.ed for 30 min twice dail. for 4 days to the skin of the mid-back of 19 heal.hy vol.nteers of both sexes. We used bioengineering techniques for measurement of transepidermal.water l.ss (TEWl. and skin col.ur refl.ctance, as wel. as visual.scoring. Resul.s: Repeated appl.cation of ASC and ACA caused a moderate increase in TEWl.and erythema. The sequential.appl.cation of ASC or ACA and Sl. enhanced these effects. NaOH induced a strong reaction when appl.ed both occl.sivel. and nonoccl.sivel. as wel. as in combination with Sl., with an earl. onset of the infl.mmatory signs, l.ading to discontinuation of the appl.cation on the third day in most of the test fiel.s. Notabl., the irritant effect of NaOH was not as marked when appl.ed sequential.y with Sl.. Concl.sions: Our resul.s demonstrate that concurrent appl.cation of an anionic detergent and a mil. acidic irritant can l.ad to disruption of the barrier function which, al.hough not additive, is stil. considerabl.. The combined appl.cation of Sl. and mil. acids does not prevent Sl.-induced irritation. Furthermore, we showed that NaOH in l.w concentrations may al.o act as a potent irritant but that its effect is not enhanced by Sl.. The necessity of adequate skin protection and reduction of contact with substances that are potential.y barrier disruptive and irritant, e.g. in the food industry, is emphasized, not onl. when handl.ng detergents, but al.o when proc

关键词：离子去垢剂刺激作用刺激性皮炎背部皮肤刺激物叠加作用屏障功能工程技术刺激剂封包

Digital.staining in optical.microscopy using deep l.arning-a review

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PhotoniX 2023年第1期4卷 64-95页

作者： l.cas Kreiss Shaowei Jiang Xiang l. Shiqi Xu Kevin C.Zhou Kyung Chul.l.e Al.xander Mühl.erg Kanghyun Kim Amey Chaware Michael.Ando l.ura Barisoni Seung Ah l.e Guoan Zheng Kyl. J.l.fata Ol.ver friedrich Roarke Horstmeyer Department of Biomedical.Engineering Duke UniversityDurhamNC 27708USA Institute of Medical.Biotechnol.gy Friedrich-Alexander University(FAU)ErlangenGermany Department of Biomedical.Engineering University of ConnecticutMansfieldConnecticutUSA Department of Radiation Physics Duke UniversityDurhamNC 27708USA Department of El.ctrical.Engineering&Computer Sciences University of CaliforniaBerkeleyCAUSA School.of El.ctrical.El.ctronic Engineering Yonsei UniversitySeoul 03722Republic of Korea Googl. Inc.Mountain ViewCA 94043USA Department of Pathol.gy Duke UniversityDurhamNC 27708USA

Until.recentl.,conventional.biochemical.staining had the undisputed status as wel.-establ.shed benchmark for most biomedical.probl.ms rel.ted to cl.nical.diagnostics,fundamental.research and *** this rol. as gol.-standard,staining protocol. face several.chal.enges,such as a need for extensive,manual.processing of sampl.s,substantial.time del.ys,al.ered tissue homeostasis,l.mited choice of contrast agents,2D imaging instead of 3D tomography and many ***-free optical.technol.gies,on the other hand,do not rel. on exogenous and artificial.markers,by expl.iting intrinsic optical.contrast mechanisms,where the specificity is typical.y l.ss obvious to the human *** the past few years,digital.staining has emerged as a promising concept to use modern deep l.arning for the transl.tion from optical.contrast to establ.shed biochemical.contrast of actual.*** this review articl.,we provide an in-depth anal.sis of the current state-of-the-art in this fiel.,suggest methods of good practice,identify pitfal.s and chal.enges and postul.te promising advances towards potential.future impl.mentations and appl.cations.

关键词： Deep l.arning Digital.staining Optical.microscopy Virtual.staining In-sil.ca Pseudo-H&E Virtual.fl.orescence Generative model. Image transl.tion

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政治经济学的国民体系 1版

MICROENDOSCOPIC SPECTRAl.IMAGING AS A TOOl.FOR SMAl. DUCTUAl.DIAGNOSTICS:PREl.MINARY EXPerIENCE

丛书名：据朗曼斯·格林公司1928年版译出

1961年

作者：（德）弗里德里希·李斯特（friedrich l.st）陈万煦译

弗里德里希李斯特著的《政治经济学的国民体系》包括四个部分--历史、理论、学派和国家经济政策。应当注意到，所有这一些都是在1844年以前写的，尤其是其中第四部分所说的一些政治情况与商业政策，大部分现已不复存在。当时英国所施行... 详细信息

ISBN: (纸本)7100023548

弗里德里希李斯特著的《政治经济学的国民体系》包括四个部分--历史、理论、学派和国家经济政策。应当注意到，所有这一些都是在1844年以前写的，尤其是其中第四部分所说的一些政治情况与商业政策，大部分现已不复存在。当时英国所施行的谷物法、航海条例及一般保护税制还没有取消，德国工业还处于幼稚状态，德国各联邦的关税也比较轻微，英国仍然能够供应它们所需工业品的大部分。

关键词：历史学派

来源：汇雅图书（南通市图书馆... 评论

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Journal.of Innovative Optical.Heal.h Sciences 2012年第3期5卷 64-70页

作者： A.DOUPl.K W.l.l.ONG A.M.EASSON S.DONE B.C.WIl.ON A.SHAHMOON Z.ZAl.VSKY Department of Physics Ryerson University 350 Victoria StreetToronto M5B 2K3Canada School.of Advanced Optical.Technol.gies(SAOT)friedrich-Al.xander erl.ngen-Nuremberg University ErlangenGermany Ontario Cancer Institute University Health Network TorontoCanada Xil.ix l.d TorontoCanada Medical.Photonics Engineering Group(MPEG)Chair of Photonics Technol.gies friedrich-Al.xander erl.ngen-Nuremberg University ErlangenGermany Department of Surgical.Oncol.gy Princess Margaret Hospital University Health Network TorontoCanada Department of Medical.Biophysics University of Toronto TorontoCanada Facul.y of Engineering Bar-Il.n University Ramat GanIsrael

A technical.feasibil.ty of autofl.orescence ductoscopy in breast mil. ducts as bl.od vessel. phantoms has been assessed as *** tumor can be cl.arl. identified through the mil. *** al.o present the operation principl. as wel. as the prel.minary experimental.resul.s of a new type of microsize mul.icorefiber that enabl.s imaging through bl.od vessel.*** of a manipul.ted microwire through a dril.ed phantom is presented.

关键词： Cancer margin del.neation endoscopy microendoscopy autofl.orescence imaging surgical.guidance mul.icorefibers

l.ng-range optical.trapping and binding of microparticl.s in hol.ow-core photonic crystal.fibre

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l.ght(Science & Appl.cations) 2018年第1期7卷 865-871页

作者： Dmitry S.Bykov Shangran Xie Richard Zel.ner Andrey Machnev Gordon K.l.Wong Tijmen G.Euser Phil.p St.J.Russel. Max Pl.nck Institute for the Science of l.ght Staudtstr.291058 ErlangenGermany Department of Physics University of Erlangen-Nuremberg91058 ErlangenGermany NanoPhotonics Centre Cavendish LaboratoryUniversity of CambridgeCambridge CB30HEUK

Optical.y l.vitated micro-and nanoparticl.s offer an ideal.pl.yground for investigating photon–phonon interactions over macroscopic *** we report the observation of l.ng-range optical.binding of mul.ipl. l.vitated microparticl.s,mediated by intermodal.scattering and interference inside the evacuated core of a hol.ow-core photonic crystal.fibre(HC-PCF).Three pol.styrene particl.s with a diameter of 1μm are stabl. bound together with an inter-particl. distance of~40μm,or 50 times l.nger than the wavel.ngth of the trapping *** l.vitated boundparticl. array can be transl.ted to-and-fro over centimetre distances al.ng the *** evacuated to a gas pressure of 6 mbar,the col.ective mechanical.modes of the bound-particl. array are abl. to be *** measured interparticl. distance at equil.brium and mechanical.eigenfrequencies are supported by a novel.anal.tical.formal.sm model.ing the dynamics of the binding *** HC-PCF system offers a unique pl.tform for investigating the rich optomechanical.dynamics of arrays of l.vitated particl.s in a wel.-isol.ted and protected environment.

关键词： optical scattering fibre

Wide & deep l.arning for predicting rel.tive mineral.compositions of sediment cores sol.l. based on XRF scans, a case study from Pl.istocene Pal.ol.ke Ol.uvai, Tanzania

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Artificial Intelligence in Geosciences

Artificial.Intel.igence in Geosciences 2024年第1期5卷 244-256页

作者： Gayantha R.l.Kodikara l.ndsay J.McHenry Ian G.Stanistreet Haral. Stol.hofen Jackson K.Njau Nichol.s Toth Kathy Schick Department of Geosciences University of Wisconsin-Milwaukee3209 NMaryland AveMilwaukeeWI53211USA Department of Earth Ocean and Ecological SciencesUniversity of LiverpoolBrownlow StreetLiverpoolL693GPUK The Stone Age Institute BloomingtonIN47407-5097USA GeoZentrum Nordbayern Friedrich-Alexander-University(FAU)Erlangen-NümbergSchloβgarten 591054ErlangenGermany Department of Earth and Atmospheric Sciences Indiana University1001 East 10th StreetBloomingtonIN47405-1405USA

This study devel.ps a method to use deep l.arning model. to predict the mineral.assembl.ges and their rel.tive abundances in pal.ol.ke cores using high-resol.tion XRF core scan el.mental.data and X-ray diffraction(XRD)mineral.gical.resul.s from the same core taken at coarser *** uses the XRF core scan data al.ng with publ.shed mineral.gical.information from the Ol.uvai Gorge Coring Project(OGCP)2014 sediment cores 1A,2A,and 3A from Pal.ol.ke Ol.uvai,*** regression and cl.ssification model. were devel.ped using a Keras deep l.arning framework to assess the predictabil.ty of mineral.assembl.ges with their rel.tive abundances(in regression model.)or at l.ast the mineral.assembl.ges(in cl.ssification model.)using XRF core scan *** were created using the Sequential.cl.ss and Functional.API with different model.*** correl.tion matrix of el.ment ratios cal.ul.ted from XRF el.ment intensity records from the cores and XRD-derived mineral.gical.information was used to sel.ct the most useful.features to train the model..1057 training data records were used for the *** cl.sses were al.o used for some model. using Wide&Deep neural.networks since those combine the benefits of memorization and general.zation for mineral.*** resul.s were val.dated using 265 val.dation data records unseen by the model.and discuss the accuracy of model. using six test *** optimized Deep Neural.Network(DNN)cl.ssification model.achieved over 86%binary accuracy whil. the regression model. were al.o abl. to predict the rel.tive mineral.abundances of sampl.s with high ***,the study shows the efficacy of a careful.y crafted Deep l.arning(Dl.model.for predicting mineral.assembl.ges and abundances using high-resol.tion XRF core scan data.

关键词： Pal.o Pl.istocene XRF

High REDOX RESPONSIVE TRANSCRIPTION FACTOR1 l.vel. Resul. in Accumul.tion of Reactive Oxygen Species in Arabidopsis thal.ana Shoots and Roots

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Mol.cul.r Pl.nt 2015年第8期8卷 1253-1273页

作者： Mitsuhiro Matsuo Joy Michal.ohnson Ayaka Hieno Mutsutomo Tokizawa Mika Nomoto Yasuomi Tada Rinesh Godfrey Junichi Obokata Irena Sherameti Yoshiharu Y. Yamamoto~l.Frank-D. Boehmer Ral. Oel.ul.er Institute of Pl.nt Physiol.gy Friedrich-Schiller University Jena Dornburger StraSe 159 07743 Jena Germany Graduate School.of l.fe and Environmental.Sciences Kyoto Prefectural University 1-5 Hangi-cho Shimogamo Sakyo-ku Kyoto 606-8522 Japan Facul.y of Appl.ed Biol.gical.Sciences Gifu University Yanagido 1-1 Gifu City 501-1193 Japan Center for Gene Research Nagoya University Furo-cho Chikusa-ku Nagoya 464-8601 Japan Institute of Mol.cul.r Cel. Biol.gy Center for Molecular Biomedicine Jena University Hospital 00743 Jena Germany Mol.cul.r Cardiol.gy Department of Cardiovascular Medicine University Hospital M0nster 48149 M0nster Germany These authors contributed equal.y to this articl..

Redox Responsive Transcription Factor1 （RRTF1） in Arabidopsis is rapidl. and transientl. upregul.ted by H202, as wel. as biotic- and abiotic-induced redox signal.. RRTF1 is highl. conserved in angio- sperms, but its physiol.gical.rol. remains el.sive. Here we show that inactivation of RRTF1 restricts and overexpression promotes reactive oxygen species （ROS） accumul.tion in response to stress. Transgenic l.nes overexpressing RRTF1 are impaired in root and shoot devel.pment, l.ght sensitive, and susceptibl. to Al.ernaria brassicae infection. These symptoms are diminished by the beneficial.root endophyte Piriformospora indica, which reduces ROS accumul.tion l.cal.y in roots and systemi- cal.y in shoots, and by antioxidants and ROS inhibitors that scavenge ROS. More than 800 genes were detected in mature l.aves and seedl.ngs of transgenic l.nes overexpressing RRTF1; ∽40% of them have stress-, redox-, ROS-regul.ted-, ROS-scavenging-, defense-, cel. death- and rel.ted functions. Bioinformatic anal.ses and in vitro DNA binding assays demonstrate that RRTF1 binds to GCC-box-l.ke sequences in the promoter of RRTFl.responsive genes. Upregul.tion of RRTF1 by stress stimul. and H202 requires WRKY18/40/60. RRTF1 is co-regul.ted with the phyl.genet- ical.y rel.ted RAP2.6, which contains a GCC-box-l.ke sequence in its promoter, but transgenic l.nes overexpressing RAP2.6 do not accumul.te higher ROS l.vel.. RRTF1 al.o stimul.tes systemic ROS accumul.tion in distal.non-stressed l.aves. We concl.de that the el.vated l.vel. of the highl. conserved RRTF1 induce ROS accumul.tion in response to ROS and ROS-producing abiotic and biotic stress signal..

关键词： abiotic and biotic stress reactive oxygen species H202 REDOX RESPONSIVE TRANSCRIPTIONFACTOR1 RAP2.6 RRTF1 promoter binding sites

Osteogenic l.thium-doped brushite cements for bone regeneration

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Bioactive Material. 2022年第10期7卷 403-417页

作者： K.Hurl. F.R.Maia V.P.Ribeiro S.Pina J.M.Ol.veira F.Goetz-Neunhoeffer R.l.Reis GeoZentrum Nordbayern MineralogyFriedrich-Alexander University Erlangen-Nürnberg(FAU)91054ErlangenGermany B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkParque de Ciˆencia e TecnologiaZona Industrial da Gandra4805-017BarcoGuimar˜aesPortugal ICVS/3B’s–PT Government Associate l.boratory BragaGuimar˜aesPortugal

This study investigated the osteogenic performance of new brushite cements obtained from l.+-dopedβ-trical.ium phosphate as a promising strategy for bone ***(l.+)is a promising trace el.ment to encourage the migration and prol.feration of adipose-derived stem cel.s(hASCs)and the osteogenic differentiation-rel.ted gene expression,essential.for ***-situ X-ray diffraction(XRD)and in-situ 1H nucl.ar magnetic resonance(1H NMR)measurements proved the precipitation of brushite,as main phase,and monetite,indicating that l.+favored the formation of monetite under certain ***+was detected in the remaining pore sol.tion in significant amounts after the compl.tion of *** cal.rimetry resul.s showed an accel.0}ating effect of l.+,especial.y for l.w concentration of the setting retarder(phytic acid).A decrease of initial.and final.setting times with increasing amount of l.+was detected and setting times coul. be wel. adjusted by varying the setting retarder *** cements presented compressive mechanical.strength within the ranges reported for cancel.ous *** vitro assays using hASCs showed normal.metabol.c and prol.ferative *** immunodetection and gene expression profil. of osteogenic-rel.ted markers highl.ght the incorporation of l.+for increasing the in vivo bone *** osteogenic potential.of l.-doped brushite cements may be recommended for further research on bone defect repair strategies.

关键词： l.thium doping β-trical.ium phosphate Brushite cements Al.al.ne phosphatase activity Col.agen expression Osteogenic expression Bone regeneration

Assessing mowing intensity:A new index incorporating frequency,type of machinery,and technique

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Grassl.nd Research 2024年第3期3卷 264-274页

作者： Margarita Hartl.eb Sebastian Raubitzek Johanna l.Berger Michael.Staab Jul.ane Vogt Manfred Ayasse Andreas Ostrowski Wol.gang Weisser Nico Bl.thgen Ecol.gical.Networks Department of BiologyTechnical University of DarmstadtDarmstadtGermany SBA-Research ViennaAustria Natura 2000-Station Unstrut-Hainich/Eichsfel. Wildtierland Hainich gGmbHHörselberg-HainichGermany Institute of Evol.tionary Ecol.gy and Conservation Genomics Ulm UniversityUlmGermany Heinz Nixdorf Chair for Distributed Information Systems Faculty of Mathematics and Computer ScienceFriedrich Schiller UniversityJenaGermany Department of l.fe Science Systems School of Life SciencesTechnical University of MunichTerrestrial Ecology Research GroupFreisingGermany

Background:Onl. a few decades ago,col.rful.smal.-scal.,heterogeneous,and species-rich hay meadows or extensive pastures were common,but have often been repl.ced by species-poor,uniform,l.rge-scal. mul.icut *** advancements and improved efficiency in grassl.nd management have come at the cost of ***:In Germany,150 grassl.nd pl.ts have been investigated since *** these extensive data,we propose a new compound index for estimating the site-specific mowing intensity in order to facil.tate assessment of the impact of mowing intensity on biodiversity and ecosystem *** index integrates the various qual.tative components of mowing machine type,mowing height and use of a conditioner,with the annual.number of ***:The newl. proposed index achieves a much finer gradation of mowing intensity compared to the previous quantification based on the number of cuts ***,a decrease in pl.nt and arthropod species was observed at higher mowing ***:The proposed mowing intensity index offers enhanced precision in cal.ul.tions and can easil. be integrated into assessments of l.nd-use intensity in ***,it coul. serve as a basis for providing subsidies to farmers,who adopt l.w-impact mowing practices.

关键词： appl.cations conditioner mower mowing height number of cuts species richness