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Upregulation of epidermal growth factor receptor 4 in oral leukoplakia

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International Journal of Oral Science 2013年第1期5卷 14-20页

作者： Hiroshi Kobayashi Kenichi Kumagai Akito Gotoh Takanori Eguchi Hiroyuki yamada Yoshiki Hamada Satsuki Suzuki Ryuji Suzuki Department of Oral and Maxillofacial Surgery Tsurumi University Department of Rheumatology and Clinical Immunology Clinical Research Center for Rheumatology and AllergySagamihara National HospitalNational Hospital Organization Section of Biological Science Research Center for Odontology Nippon Dental University School of Dentistry

In the present study,we investigate the expression profile of the epidermal growth factor receptor family,which comprises EGFR/ ErbBl,HER2/ErbB2,HER3/ErbB3 and HER4/ErbB4 in oral leukoplakia(LP).The expression of four epidermal growth factor receptor (EGFR) family genes and their ligands were measured in LP tissues from 14 patients and compared with levels in 10 patients with oral lichen planus(OLP) and normal oral mucosa(NOM) from 14 healthy donors by real-time polymerase chain reaction(PCR) and *** mRNA coexpression of ErbBl,ErbB2,ErbB3and ErbB4 was detected in LP *** of the receptors,only ErbB4 mRNA and protein was more highly expressed in LP compared with NOM *** were strongly expressed by epithelial keratinocytes in LP lesions,as shown by *** the ligands,the mRNA of Neuregulin2 and 4 were more highly expressed in OLP compared with NOM ***,enhanced ErbB4 on the keratinocytes and synchronous modulation of EGFR family genes may contribute to the pathogenesis and carcinogenesis of LP.

关键词： epidermal growth factor receptor immunohistochemistry oral leukoplakia quantitative real-time polymerase chain reaction

Increased tumor necrosis factor receptor 1 expression in human colorectal adenomas

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World Journal of Gastroenterology 2012年第38期18卷 5360-5368页

作者： Kunihiro Hosono Eiji yamada Hiroki Endo Hirokazu Takahashi Masahiko Inamori Yoshitaka Hippo Hitoshi Nakagama Atsushi Nakajima Division of Gas-troenterology Yokohama City University School of Medicine Yokohama 2360004 Japan Division of Cancer Development System National Cancer Center Research Institute Tokyo 1040045 Japan

AIM: To determine the expression statuses of tumor necrosis factor (TNF)-α, its receptors (TNF-R) and downstream effector molecules in human colorectal adenomas. METHODS: We measured the serum concentrations of TNF-α and its receptors in 62 colorectal adenoma patients and 34 healthy controls. The protein expression of TNF-α, TNF-R1, TNF-R2 and downstream signals of the TNF receptors, such as c-Jun N-terminal kinase (JNK), nuclear factor-κ B and caspase-3, were also investigated in human colorectal adenomas and in normal colorectal mucosal tissues by immunohistochemistry. Immunofluorescence confocal microscopy was used to investigate the consistency of expression of TNF-R1 and phospho-JNK (p-JNK). RESULTS: The serum levels of soluble TNF-R1 (sTNF-R1) in adenoma patients were significantly higher than in the control group (3.67 ± 0.86 ng/mL vs 1.57 ± 0.72 ng/mL, P < 0.001). Receiver operating characteristic analysis revealed the high diagnostic sensitivity of TNF-R1 measurements (AUC was 0.928) for the diagnosis of adenoma, and the best cut-off level of TNF-R1 was 2.08 ng/mL, with a sensitivity of 93.4% and a specificity of 82.4%. There were no significant differences in the serum levels of TNF-α or sTNF-R2 between the two groups. Immunohistochemistry showed high levels of TNF-R1 and p-JNK expression in the epithelial cells of adenomas. Furthermore, a high incidence of co-localization of TNF-R1 and p-JNK was identified in adenoma tissue. CONCLUSION: TNF-R1 may be a promising biomarker of colorectal adenoma, and it may also play an important role in the very early stages of colorectal carcinogenesis.

关键词： Tumor necrosis factor-α Tumor necrosis factor receptor 1 c-Jun N-terminal kinase Colorectal adenoma Biomarker

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金鸡影展访谈录银河写手

环球银幕 2023年第12期 52-57页

作者： waka(采访/撰文) 周启龙(设计) 不详

从在FIRST青年电影展捧得评委会大奖和最佳编剧奖,到金鸡华语新片展继续“炸场”,《银河写手》这部描绘编剧生活的“圈内”喜剧已经不可阻挡地出圈,获得了更多普通观众的喜爱。与近两年类似题材的作品不同,《银河写手》更注重喜剧的节... 详细信息

从在FIRST青年电影展捧得评委会大奖和最佳编剧奖,到金鸡华语新片展继续“炸场”,《银河写手》这部描绘编剧生活的“圈内”喜剧已经不可阻挡地出圈,获得了更多普通观众的喜爱。与近两年类似题材的作品不同,《银河写手》更注重喜剧的节奏、生活的质感而非个人化的表达,影片的第一批观众们在享受被高密度的包袱掌控情绪的同时,也久违地在国产类型片中感受到“活人的温度”。

关键词：写手喜剧金鸡

Comparison of minimally invasive glaucoma surgery with trabecular micro-bypass stent and microhook ab interno trabeculotomy performed in conjunction with cataract surgery

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1082-1088页

作者： Naoto Tokuda Yasushi Kitaoka Ayaka Tsukamoto Yasuhiro Toyoda Yusuke yamada Kana Sase Hitoshi Takagi Department of Ophthalmology St Marianna University School of Medicine2-16-1 Sugao Miyamae-ku Kawasaki-shiKanagawa 216-8851Japan

AIM: To evaluate the effectuality and safety of cataract surgery combined with either ab interno trabeculotomy by the microhook(μLOT) or a single i Stent? trabecular bypass implantation(i Stent) in eyes with cataract and mild-tomoderate glaucoma. METHODS: This study enrolled subjects with mild-tomoderate open angle glaucoma with visually significant cataract who used two or more ophthalmic antiglaucoma agents between 60 and 90 y of age. Patients underwent cataract surgery cooperated with either implantation of an i Stent(i Stent-phaco) or excisional goniotomy with the μLOT(μLOT-phaco). Patients underwent μLOT-phaco in the eye with lower the mean deviation, according to the Humphrey field analyzer, while i Stent-phaco was carried out on the other eye. Intraocular pressure(IOP) pre-and post-surgery, alterations in anterior chamber flare(ACF), and corneal endothelial cell density(ECD) were ***: Twenty subjects were enrolled(mean age: 73.6±7.3 y). The mean medicated preoperative IOP was 16.7 mm Hg in the μLOT and 16.2 mm Hg in the i Stent eyes. The mean final IOP at 12 mo was 13.6 mm Hg in the μLOT eyes and 13.6 mm Hg in the i Stent eyes, representing a 17.8% and 17.2% reduction, respectively. The preoperative ACF in the μLOT eyes was 9.5 pc/ms and it returned to normal in 30 d postoperatively, with a value of 11.4 pc/ms. In the i Stent eyes, ACF was 9.6 pc/ms preoperatively and it returned to normal by 7 d postoperatively(11.2 pc/ms atday 7), demonstrating that postoperative inflammation was less in the i Stent eyes. The corneal ECD in both groups was not significantly ***: In this study, i Stent and μLOT are both effective through 12 mo of follow-up. Safety is more favorable in the i Stent eyes, based on early anterior chamber inflammation.

关键词： minimally invasive glaucoma surgery iStent ab interno trabeculotomy

PI-3 kinase pathway can mediate the effect of TGF-β1 in inducing the expression of SHARP-2 in LLC-PK1 cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第9期10卷 702-706页

作者： Zhang-fei SHOU Qin ZHOU Jie-ru CAI Jiang-hua CHEN Kazuya yamada Kaoru MIYAMOTO Kidney Disease Center the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Key Laboratory of Multi-organ Combined Transplantation Ministry of Health Hangzhou 310003 China Department of Biochemistry Faculty of Medical Sciences University of Fukui Eiheiji-cho Fukui 910-1193 Japan

We aim to investigate the effect of transforming growth factor （TGF）-β1 on the expression of enhancer of split- and hairy-related protein-2 （SHARP-2） messenger RNA （mRNA） and its signaling pathway. In this study, several cell lines including LLC-PK1 （a porcine kidney tubular epithelial cell line）, MDCK （Madin-Darby canine kidney） and CTLL-2 （cytotoxic T-lymphocyte line） were treated with recombinant human TGF-131, and a series of experiments were carried out, involving Northern blot analysis of total RNA from these cells. Further, several specific chemical inhibitors were applied before TGF-β1 treatment to probe the signaling pathway. The results showed that TGF-β1 can significadtly up-regulate SHARP-2 mRNA expression in the LLC-PK1 cell line. The peak level of induction was found 2 h after TGF-β1 stimulation. While one phospho- inositide 3-kinases （PI-3） kinase inhibitor, LY294002, completely blocked the effect of TGF-131 on SHARP-2 mRNA expression in LLC-PK1 cells at a low concentration, other inhibitors, including PD98059, staurosporine, AG490, wortmannin, okadaic acid and rapamycin, had no effect. The effect of LY294002 was dose-dependent. We conclude that, in LLC-PK1 cells at least, TGF-β1 can effectively induce the SHARP-2 mRNA expression and that the PI-3 kinase pathway can mediate this effect.

关键词： Transforming growth factor (TGF)-β1 Split- and hairy-related protein-2 (SHARP-2) Phosphoinositide 3-kinases (PI-3)kinase pathway LY294002

Delayed immune-related sclerosing cholangitis after discontinuation of pembrolizumab:A case report

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World Journal of Gastroenterology 2022年第28期28卷 3732-3738页

作者： Takeshi Tanaka Arata Sakai Masahiro Tsujimae Yasutaka yamada Takashi Kobayashi Atsuhiro Masuda Yuzo Kodama Division of Gastroenterology Department of Internal MedicineKobe University Graduate School of MedicineKobe 650-0017HyogoJapan

BACKGROUND Secondary sclerosing cholangitis,characterized by biliary obstruction,can be caused by drugs such as immune checkpoint inhibitors(ICIs).While there a few reports of sclerosing cholangitis after immune checkpoint inhibitor administration,no case has been reported after discontinuation of such *** SUMMARY A 68-year-old man who underwent chemotherapy for lung adenocarcinoma with bone metastasis presented with abdominal pain and fever 4 mo after the final administration of *** tomography revealed thickening of the gallbladder wall and dilatation of the common bile *** retrograde cholangiopancreatography revealed an irregularly narrowed intrahepatic bile *** of the bile duct demonstrated that CD8+T cells were predominant over CD4+T *** biopsy showed dominant infiltration of CD8+T in the portal tract,but onion-skin lesions were not *** patient was diagnosed with immune-related sclerosing cholangitis induced by *** of methylprednisolone and endoscopic nasobiliary drainage were performed,but the cholangiography and laboratory test findings did not *** further treatment was administered due to disease progression,and the patient was referred for palliative *** Immune-related sclerosing cholangitis may have a late onset,and such cases occurring after discontinuation of ICIs should be carefully managed.

关键词： Immune-related adverse events Sclerosing cholangitis Delayed immunerelated events Case report

Static Stability Analysis of a Single Planar Object Grasped by *** Hand

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Journal of Mechanics Engineering and Automation 2012年第10期2卷 606-627页

作者： Takayoshi yamada Manabu yamada Hidehiko Yamamoto Department of Human and Information Systems Faculty of Engineering Gifu University Gifu 501-1193 Japan Department of Mechanical Engineering Faculty of Engineering Nagoya Institute of Technology Nagoya 466-8555 Japan

In this study, the static stability of the grasp of a single planar object is analyzed using the potential energy method. In previous papers, we considered cases in which individual fingers were replaced by a multidimensional translational spring model, in which each finger is constructed with prismatic joints. Human hands and the most developed mechanical hands are constructed with revolute joints. In this paper, the effects of fingertip rotation and a revolute joint spring model are investigated. A grasp stiffness matrix is analytically derived by considering not only frictional rolling contact but also frictionless sliding contact. The difl＇erence between the frictional stiffness matrix and the frictionless one is analytically obtained. The effect of local curvature at contact points is analytically derived. The grasp displacement directions affected by the change in curvature and the contact condition are also obtained. The derived stiffness matrix of the revolute joint model is compared with that of the prismatic joint model, and then the stiffness relation is clarified. The gravity effect of the object is also considered. The effectiveness of our method is demonstrated through numerical examples. The stability is evaluated by the eigenvalues of the grasp stiffness matrix, and the grasp displacement direction is obtained by the corresponding eigenvectors. The effect of joint angle is also discussed.

关键词： Grasping multifingered hands static grasp stability revolute joint stiffness model.

Japanese Mythology From Ethnological Perspectives

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History Research 2013年第5期3卷 309-316页

作者： Hitoshi yamada Tohoku University Sendai Japan

Comparative studies of Japanese mythology have developed since the 1920s above all through eftbrts of Japanese ethnologists. They have paid attention to the possible ethno-cultural complexes that brought mythological motifs into the archipelago. In the present paper the theories set forth by Nobuhiro Matsumoto, Akihide Mishina, and Masao Oka are examined in terms of retrospect. The result shows that they shared the view that at least three different complexes, based in ancient Yamato, Izumo, and Kyushu respectively, contributed to the formation of Japanese mythology compiled in the 8th century CE （Common Era）. Their assumptions were synthesized by Taryo Obayashi in 1961, the hypothesis which has survived until today. In future we should cooperate with other disciplines and address the formation process of Japanese mythology.

关键词： Japanese mythology retrospect ethnology ethnogenesis diffusion

Comparative Study on Structural Redundancy of Cable-Stayed and Extradosed Bridges Through Safety Assessment of Their Stay Cables

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Engineering 2021年第1期7卷 111-123页

作者： Khawaja Ali Hiroshi Katsuchi Hitoshi yamada Department of Civil Engineering Yokohama National UniversityYokohama 240-8501Japan

This study provides new insights into the comparison of cable-stayed and extradosed bridges based on the safety assessment of their stay *** bridges are often regarded as identical structures owing to the use of inclined cables;however,the international standards for bridge design stipulate different safety factors for stay cables of both types of *** address this misconception,a comparative study was carried out on the safety factors of stay cables under fatigue and ultimate limit states by considering the effects of various untoward and damaging factors,such as overloading,cable loss,and *** primary goal of this study is to describe the structural disparities between both types of bridges and evaluate their structural redundancies by employing deterministic and nondeterministic *** achieve this goal,three-dimensional finite-element models of both bridges were developed based on the current design guidelines for stay cables in *** the balanced states of the bridge models were achieved,static analyses were performed for different safety factors of stay cables in a parametric ***,the first-order reliability method and Monte Carlo method were applied to determine the reliability index of stay *** analysis results show that cable-stayed and extradosed bridges exhibit different structural redundancies for different safety factors under the same loading ***,a significant increase in structural redundancy occurs with an incremental increase in the safety factors of stay cables.

关键词： Cable-stayed bridge Extradosed bridge Redundancy Stay cable Safety factor Reliability analysis