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Attitudes and understanding of complementary and alternative medicine in cancer care:An exploratory study of patients’perspectives in Karachi,Pakistan

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Asian Pacific Journal of Tropical Medicine 2023年第9期16卷 400-408页

作者： Shahlla Imam Muneeba Aijaz wajiha iffat Shazia Qasim Jamshed Nahlah Elkudssiah Ismail Ganesh Sritheran Paneerselvam Khang Wen Goh Long Chiau Ming Halima Sadia Iqbal Azhar Department of Pharmacognosy Faculty of Pharmacy and Pharmaceutical SciencesUniversity of KarachiSindh 75270Pakistan Department of Pharmacognosy Institute of Pharmaceutical SciencesJinnah Sindh Medical UniversityKarachiSindh 75510Pakistan Department of Pharmaceutics Dow College of PharmacyDow University of Health SciencesKarachiSindh 75270Pakistan Clinical Pharmacy and Practice Faculty of PharmacyUnivesiti Sultan Zainal Abidin(UNISZA)Besut22200TerengganuMalaysia Malaysian Academy of Pharmacy Puchong 47160SelangorMalaysia Clinical Pharmacy and Pharmacy Practice Unit Faculty of PharmacyAIMST University08100 BedongKedahMalaysia School of Pharmacy Taylor’s UniversitySunway CityMalaysia Faculty of Data Science and Information Technology INTI International University71800 NilaiMalaysia School of Medical and Life Sciences Sunway University47500 Sunway CityMalaysia Department of Pharmacy Practice Faculty of PharmacyJinnah Women UniversityKarachiPakistan

Objective:To evaluate the prevalence and types of complementary and alternative medicine(CAM)modalities among patients with cancer in Karachi,***:This descriptive cross-sectional study was conducted from March 2021 to December *** hundred patients with cancer were invited to participate in the *** databases,namely,Google scholar,Publons,EMBASE,PubMed,Chinese National Knowledge Infrastructure Database,and ResearchGate was used for questionnaire *** self-administered survey included questions on demographic characteristics,education level,socio-economic conditions and information about CAM therapies,prevalence,effectiveness,and common CAM *** analysis was conducted using SPSS software version ***:Out of the 500 invited patients,433(86.6%)successfully completed and returned the *** contrast to patients who were with younger,highly educated,professionally active,higher income,and had advanced cancer,time since diagnosis,type of treatment,cancer types and family history are significantly associated with CAM *** results showed that 59.8%of the participants were acquainted with complementary and/or alternative medicine and considered safe owing to its natural *** prevalence of CAM usage among cancer patients was 40.9%and the most widely used CAM modality was herbal medicine(27.7%)and dietary supplements(28.8%).Patients used CAM as a complementary therapy to improve the morphological parameter(28.2%),strengthen the immune system(6.8%),and to decrease the side effects of conventional treatment(18.1%).Most of the respondents get the information regarding CAM therapy from the electronic media(43.2%)and the family members(48%)rather than healthcare ***:Participants used CAM modalities along with the conventional health care *** multicentre studies should be conducted to provide information regarding the usage of CAM therapies and their eventual benefi

关键词： Alternative medicine Cancer patients Complementary medicine Cross-sectional study

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 85-94页

作者： iffat Ara Rita Turcio Tasmia Islam Md.Sabbir Hossain Md.Kamrul Hasan Department of Biochemistry and Molecular Biology Tejgaon CollegeNational UniversityGazipur-1700Bangladesh Department of Pharmacy University of Naples Federico IIvia Domenico Montesano49-80131 Napoli NAItaly Department of Genetic Engineering and Biotechnology Jashore University of Science and TechnologyJashore-7408Bangladesh Department of Public Health North South UniversityDhaka-1229Bangladesh

Background:Licochalcone A(LCA)is a flavonoid derived from the roots of Glycyrrhiza uralensis *** DC and other related *** natural source has been extensively used in complementary medicine,especially traditional Chinese medicine,to treat various *** as a phenolic chalcone compound,LCA has gained significant attention in recent years due to its various pharmacological ***:The objective of this review article is to assess the anti-aging ralated pharmacological properties of ***:An exhaustive search of several scientific databases was conducted using various relevant keywords to write this review article on LCA,focusing on its therapeutic applications and anti-aging-related pharmacological *** inclusion and exclusion criteria were strictly followed to retrieve updated relevant ***:A collection of 292 papers were screened,and 131 were included in this review for an in-depth analysis of Licochalcone A,focusing on its anti-aging-related pharmacological activities and relevant mechanisms,and its toxicity and side ***,the potential of LCA as a pharmacological product is discussed,emphasizing its health benefits and potential as a pharmaceutical ***:These findings indicate that Licochalcone A is a promising natural therapeutic agent for anti-aging therapy and other ailments.

关键词： Licochalcone A Glycyrrhiza uralensis Chalcone Anti-aging Neuroprotective Antioxidant Skin protection Therapeutic agent

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Removal of lead and cadmium ions by single and binary systems using phytogenic magnetic nanoparticles functionalized by 3-marcaptopropanic acid

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Chinese Journal of Chemical Engineering 2019年第4期27卷 949-964页

作者： Imran Ali Changsheng Peng iffat Naz College of Environmental Science and Engineering Ocean University of China Qingdao 266100 China The Key Lab of Marine Environmental Science and Ecology Ministry of Education Ocean University of China Qingdao 266100 China School of Environmental and Chemical Engineering Zhaoqing University Zhaoqing 526061 China Department of Biology. Qassim University Buraidah 51452 Kingdom of Saudi Arabia (KSA)

The present research study is focused on green fabrication of superparamagnetic Phytogenic Magnetic Nanoparticles(PMNPs), and then its surface functionalization with 3-Mercaptopropionic acid(3-MPA). The resulting material(i.e. 3-MPA@PMNPs) characterized by FTIR, powder XRD, SEM, TEM, EDX, VSM, BET and TGA techniques and then further employed for the investigation of the adsorptive removal of lead(Pb^2+) and cadmium(Cd^2+) ions from aqueous solutions in single and binary systems. The material showed fastest adsorptive rate(98.23%) for Pb^2+ and(96.5%) Cd2+within the contact time of 60 min at pH 6.5 in the single system. The experimental data were fitted well to Langmuir isotherm, indicated monolayer adsorption of both metal ions onto 3-MPA@PMNPs and an estimated comparable adsorptive capacity of 68.41 mg·g^-1(Pb2+) and 79.8 mg·g^-1(Cd2+) at p H 6.5. However, kinetic data agreed well with pseudo-second-order model, and indicated that the removal mainly supported chemisorption and/or ion-exchange mechanism. Thermodynamic parameters such asΔGo,ΔHo, and ΔSo, were-3259.20, 119.35 and 20.73 for Pb^2+, and-1491.10, 45.441 and 7.87 for Cd^2+ at temperature 298.15 K, confirmed that adsorption was endothermic, spontaneous and favorable. The material demonstrated higher selectivity of Pb2+ and its removal efficiency was(98.20 ± 0.3)% in binary system experiments. The material persisted performance up-to seven(07) consecutive treatment cycles without losing their stability and offered comparable fastest magnetic separation(35 s) from aqueous solutions. Therefore, it is recommended that the prepared material can be employed to remove toxic heavy metal ions from water/wastewaters and this "green" method can easily be implemented at large scale in low economy countries.

关键词： Green recipe Phytogenic magnetic nanoparticles Physical characterization of nanoparticles Lead and cadmium ions removal

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Dynamics of Communal Land Degradation and Its Implications in the Arid Mountains of Pakistan:A Study of District Karak, Khyber Pakhtunkuwa

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Journal of Mountain Science 2014年第2期11卷 485-495页

作者： iffat TABASSUM Fazlur RAHMAN Fazlul HAQ Institute of Geography Urban & Regional Planning University of Peshawar

Similar to other areas of Pakistan, land resources in Khyber Pakhtunkhwa(KP) is kept under various ownership regimes for socio-economic and ecological benefits. For the last three to four decades, communal lands and resources are subjected to high rate of degradation and deterioration, which is leading to multifarious socio-economical and ecological implications. This paper intends to look into factors that are responsible for the degradation of communal land and the adaptability of the management mechanisms developed by the local inhabitants to conserve these resources. Moreover, this study also explores the sustainability of these adopted strategies in present circumstances. Data regarding socio-economic parameters of the inhabitants and their interactions with communal lands were collected through questionnaire cum interview method. As long-term climatic data for the area do not exist therefore focus group discussions were conducted to document the changing trend in rainfall regimes and temperature variations for the last about four decades. Results indicate that communal lands are highly vulnerable to degradation due to biophysical and anthropogenic factors. Local inhabitants have developed suitable measures to control the situation, however, accelerated socioeconomic transformations in the area have weakened the role of local institutions and that led to further degradation of these resources. Nevertheless, a number of locally formulated rules have been revived and implemented and it is hoped that these threatened resources would be conserved.

关键词： Communal lands Land degradation Climatic variability Adopted strategies Dry areas

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Variable mass and thermal properties in three-dimensional viscous flow: Application of Darcy law

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Journal of Central South University 2019年第5期26卷 1271-1282页

作者： iffat JABEEN Muhammad FAROOQ Nazir A. MIR Department of Mathematics Riphah International UniversityIslamabad 44000Pakistan Department of Mathematics COMSATS University IslamabadIslamabad 44000Pakistan

This article concentrates on the properties of three-dimensional magneto-hydrodynamic flow of a viscous fluid saturated with Darcy porous medium deformed by a nonlinear variable thickened *** of flow is disclosed in the neighborhood of stagnation *** of heat transport are characterized with Newtonian heating and variable thermal *** transport is carried out with first order chemical reaction and variable mass *** governing equations are transformed by implementation of appropriate *** convergent series solutions are computed via homotopic *** aspects of numerous parameters are discussed through graphical *** force coefficient,Sherwood and Nusselt numbers are illustrated through graphs corresponding to various pertinent *** discussion reveals that conjugate and constructive chemical reaction parameters enhance the temperature and concentration distributions,respectively.

关键词： Newtonian heating chemical reaction variable mass diffusivity Darcy law

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Forest cover dynamics in Palas Valley Kohistan, Hindu Kush-Himalayan Mountains, Pakistan

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Journal of Mountain Science 2021年第2期18卷 416-426页

作者： Noor ul HAQ Fazlur RAHMAN iffat TABASSUM MEHRAN Department of Geography University of PeshawarPeshawar 25120Pakistan Department of Urban and Regional Planning University of PeshawarPeshawar 25120Pakistan

Forest cover change in the mountainous region is driven by a variety of anthropogenic and natural *** Hindu Kush-Himalayan Mountains has experienced a considerable vegetation cover change due to intensive human activities,such as population growth,proximate causes,accessibility,unstable political situations,government policy failure and *** present study seeks to find out the impact of population growth and road network expansion on forest cover of Palas valley based on remotely sensed data and employing geospatial *** in forest cover were determined by classifying time-series satellite images of Landsat and Sentinel 2 *** images of October 1980,2000,2010 and 2017 were classified into six land cover classes and then the impact of population growth and accessibility on forest cover was ***,forest cover and land-use change detection map was prepared using classified images of 1980 and *** data were collected mainly from field visits(ground verification),census reports,Communication and Works Department,*** imageries were obtained from the United States Geological Survey’s websites and classified in ERDAS imagine 2014 and ESRI ArcGIS 10.2.1 using supervised classification-maximum likelihood *** of this study revealed that a substantial reduction in forest cover has taken place mainly in the proximity of human *** the average,during the study period,annually more than 460 hectares of forest area has been converted into other uses.

关键词： Forest cover changes Population growth Road networks Deforestation Palas Valley Pakistan

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Socio-Economic Drivers of Deforestation in Roghani Valley,Hindu-Raj Mountains,Northern Pakistan

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Journal of Mountain Science 2014年第1期11卷 167-179页

作者： Fazlur RAHMAN Fazlul HAQ iffat TABASSUM Ihsan ULLAH Institute of Geography Urban & Regional Planning University of Peshawar

Deforestation and associated ecological disturbances are the issues of global *** have investigated a number of driving forces which accelerate the rate of deforestation at local and regional *** include poverty,population growth,market demand and prices,political instability,agricultural expansion and changes in property right and ownership *** paper seeks to explore the impacts of population growth,changing tenure system and other socioeconomic factors on the forest cover of Roghani Valley,located in Hindu Raj Mountains,Northern *** present study is mainly based on information collected through participatory observation,selfadministered interviews and questionnaire *** Information System(GIS) database is also used for mapping and *** results reveal that in the past three to four decades the study area has been subjected to severe deforestation and about half of the forest area has been converted into barren ***,the area under natural forests decreased from 2099 to 1444 hectares in four *** large-scale deforestation is attributed to both proximate and under lying causes particularly traditional land tenure system and demographic ***,forest resources have been degraded and a number of plant species have disappeared from the forests of the study area while several others are in the process of disappearance.

关键词： Deforestation Natural Vegetation Cover Population Growth Traditional Tenure Systems Land Use and Land Cover Change Household Dynamics

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Alendronate and FTI-277 combination as a possible therapeutic approach for hepatocellular carcinoma:An in vitro study

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Hepatobiliary & Pancreatic Diseases International 2018年第3期17卷 241-250页

作者： Amber Ilyas Zehra Hashim iffat Saeed Channa Shamshad Zarina National Center for Proteomics University of Karachi

Background： An important product of mevalonate pathway is downstream synthesis of isoprenoid unitsthat has long been implicated in development and progression of tumor. It has been speculated thatinhibition of protein prenylation might be therapeutically beneficial. The objective of current study wasto evaluate antitumor potential of a novel therapeutic combination of mevalonate pathway inhibitors, FTI-277 and alendronate. We also examined differentially expressed proteins in response to treatment usingproteomics approach.

关键词： Chemotherapy Hepatocellular carcinoma Gene expression Proteomics Therapeutic

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Effect of Ascorbic Acid Supplementation on Liver Function Tests in Hepatitis C Patients

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Open Journal of Internal Medicine 2020年第3期10卷 263-279页

作者： iffat Nayila University of Lahore Lahore Pakistan

An isolated liver function test is of little role in selection of liver disease because many harmful liver diseases may be correlated with normal levels of LFT’s. The outline of enzyme abnormalities in the perspective of patient’s commonly observed symptoms and laboratory data might be helpful in directing the subsequent diagnosis of liver diseases. Liver Function Tests (LFTs) are most generally used screening blood tests for assessment of different liver diseases and these tests provide a lot of evidence for disease processes whether for the purpose of investigation of supposed liver disease or help in observing the progress of disease action or simply by blood investigation. The evaluation of different liver enzymes simply gives diagnostic information on basic level whether patient’s principal disorder is actually hepatitis or cholestasis in source. However, it is necessary in various cases to evaluate LFTs with knowledge of liver functioning enzyme fractions. The objective of this study was to explore the effects of ascorbic acid supplementation on serum liver function tests in Hepatitis C patients. A total of 100 hepatitis C patients were selected randomly. 50 were given ascorbic acid supplementation for one month along with anti HCV treatment. The other 50 HCV patients took their normal anti HCV treatment without intake of ascorbic acid supplementation, and serum ascorbic acid level and liver function test parameters were observed before and after intake of ascorbic acid in both groups. The liver function parameters determined were aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), serum total bilirubin, direct bilirubin, indirect bilirubin and serum protein (total protein, albumin, globulin and A/G ratio). These parameters along with serum ascorbic acid were measured before and 30 days after vitamin C supplementation. Various abnormally elevated LFTs were also improved more rapidly when compared to other group which w

关键词： Supplementation Ascorbic Acid Liver Function Tests Alanine Aminotransferase Aspartate Aminotransferase Significant Diagnoses Alkaline Phosphatase

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巴基斯坦高校创业教育探究--一项教师视角的案例研究

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现代大学教育 2015年第4期31卷 40-47页

作者： iffat Batool 徐小洲 Imran Haider Shamsi 孙杨李娜浙江大学教育学院南京大学教育研究院哈尔滨师范大学教育科学学院

作为一个发展中国家,巴基斯坦面临着贫穷、失业等诸多问题,关注高校创业教育并给予实践,鼓励和引导创业,将极大地促进就业率,为发展巴基斯坦国家经济做出巨大贡献。此研究以巴基斯坦两所高校的教师为研究对象,希望通过对巴基斯坦的旁遮... 详细信息

作为一个发展中国家,巴基斯坦面临着贫穷、失业等诸多问题,关注高校创业教育并给予实践,鼓励和引导创业,将极大地促进就业率,为发展巴基斯坦国家经济做出巨大贡献。此研究以巴基斯坦两所高校的教师为研究对象,希望通过对巴基斯坦的旁遮普大学和白沙瓦大学的创业教育调研来进一步认识巴基斯坦高校创业教育的现状。目前巴基斯坦高校创业教育存在着诸如体制不均衡、课程改革滞后等问题,提升巴基斯坦创业教育水平需要政府和高校的共同努力。

关键词：巴基斯坦高等院校创业教育教师

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