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Science china(Technological Sciences) 2023年第11期66卷 3287-3297页

作者： SHEN GengZhe HUANG WeiQing LI HaiFeng WANG FengMing SU DaoJian LI BaiJun ZHANG BoLun LIANG Ping ZHANG chi XIN Yue HE Xin School of Applied Physics and Materials Wuyi UniversityJiangmen 529020China School of Materials and Energy Guangdong University of TechnologyGuangzhou 510006China

A capacitive tactile sensor(CTS)has been developed by assembling a double-sided patterned dielectric layer and novel *** patterned aluminium foil-supported electrode comprises zinc-aluminium layered double hydroxides(Zn AlLDH),MXene,and Ag NWs via electrostatic *** flexible device enables greater structural deformation,thereby enhancing sensitivity to a wide range of *** sensitivity of the CTS can be customized to meet specific requirements by matching the microstructured electrodes with the patterned dielectric *** optimized sensor exhibits a sensitivity of 2.752 kPa^(–1)within 30 kPa,a response time of approximately 100 ms,and a wide detection range of 0–300 *** strong physical interaction among the electrode materials ensures a reliable conductive network,ensuring the long-term stability of the sensor,even after 7500 loading and unloading ***,the fabricated CTS device presents a promising prospect for the integration into wearable electronics,with the ability to effectively respond to both human activities and external physical stimuli.

关键词： capacitive tactile sensor adjustable sensitivity long-term durability human activity monitoring

Extensive retroperitoneal and right thigh abscess in a patient with ruptured retrocecal appendicitis:An extremely fulminant form of a common disease

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World Journal of Gastroenterology 2006年第3期12卷 496-499页

作者： chi-Hsun Hsieh Yu-Chun Wang Horng-Ren Yang Ping-Kuei Chung Long-Bin Jeng Ray-Jade Chen Department of Traumaand Emergency Surgery China Medical University HospitalTaichung Taiwan China

As a disease commonly encountered in daily practice, acute appendicitis is usually diagnosed and managed easily with a low mortality and morbidity rate. However, acute appendicitis may occasionally become extraordinarily complicated and life threatening. A 56-year-old man, healthy prior to this admission, was brought to the hospital due to spiking high fever, poor appetite, dysuria, progressive right flank and painful swelling of the thigh for 3 d. Significant inflammatory change of soft tissue was noted, involving the entire right trunk from the subcostal margin to the knee joint. Painful disability of the right lower extremity and apparent signs of peritonitis at the right lower abdomen were disclosed. Laboratory results revealed leukocytosis and an elevated C-reactive protein level. Abdominal CT revealed several communicated gas-containing abscesses at the right retroperitoneal region with mass effect, pushing the duodenum and the pancreatic head upward, compressing and encasing inferior vena cava, destroying psoas muscle and dissecting downward into the right thigh. Laparotomy and right thigh exploration were performed immediately and about 500 mL of frank pus was drained. A ruptured retrocecal appendix was the cause of the abscess. The patient fully recovered at the end of the third post-operation week. This case reminds us that acute appendicitis should be treated carefully on an emergency basis to avoid serious complications. CT scan is the diagnostic tool of choice, with rapid evaluation followed by adequate drainage as the key to the survival of the patient.

关键词： Acute appendicitis Retrocecal appendicitis Complication Retroperitoneal abscess Thigh abscess

Association of emergency room visits for respiratory diseases with sources of ambient PM2.5

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Journal of Environmental Sciences 2019年第12期31卷 154-163页

作者： Rui chi Hongyu Li Qian Wang Qiangrong Zhai Daidai Wang Meng Wu Qichen Liu Shaowei Wu Qingbian Ma Furong Deng Xinbiao Guo Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100191China Emergency Department Peking University Third HospitalBeijing 100191China chinese Academy fo r Environmental Planning Beijing 100012China Beijing Center for Disease Control and Prevention Beijing 100013China

Previous studies have reported associations of short-term exposure to different sources of ambient fine particulate matter(PM2.5)and increased mortality or hospitalizations for respiratory *** studies,however,have focused on the short-term effects of source-specific PM2.5 on emergency room visits(ERVs)of respiratory *** apportionment for PM2.5 was performed with Positive Matrix Factorization(PMF)and generalized additive model was applied to estimate associations between source-specific PM2.5 and respiratory disease *** association of PM2.5 and total respiratory ERVs was found on lag4(RR=1.011,95%CI:1.002,1.020)per interquartile range(76μg/m3)*** found PM2.5 to be significantly associated with asthma,bronchitis and chronic obstructive pulmonary disease(COPD)ERVs,with the strongest effects on lag5(RR=1.072,95%CI:1.024,1.119),lag4(RR=1.104,95%CI:1.032,1.176)and lag3(RR=1.091,95%CI:1.047,1.135),*** estimated effects of PM2.5 changed little after adjusting for different air *** primary PM2.5 sources were identified using PMF analysis,including dust/soil(6.7%),industry emission(4.5%),secondary aerosols(30.3%),metal processing(3.2%),coal combustion(37.5%)and traffic-related source(17.8%).Some of the sources were identified to have effects on ERVs of total respiratory diseases(dust/soil,secondary aerosols,metal processing,coal combustion and traffic-related source),bronchitis ERVs(dust/soil)and COPD ERVs(traffic-related source,industry emission and secondary aerosols).Different sources of PM2.5 contribute to increased risk of respiratory ERVs to different extents,which may provide potential implications for the decision making of air quality related policies,rational emission control and public health welfare.

关键词： Emergency room visits Respiratory diseases PM2.5 Source apportionment

基于“指节”驱动刚柔耦合式变弯度机翼后缘结构的设计方法

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航空科学技术 2024年第5期35卷 82-92页

作者：葛文杰朱楠楠丁世聪张驰王成民蒋友西北工业大学陕西西安710072

利用刚性机构驱动的变形翼,蒙皮易出现不光滑变形的现象,而用柔顺机构设计的变形翼,虽蒙皮曲线光滑,飞机的稳定性和机动性增强,但难以满足变形与承载双重优化。为此,基于“指节”驱动式仿生刚柔耦合的设计思想,本文设计了一种瓦特I型六... 详细信息

利用刚性机构驱动的变形翼,蒙皮易出现不光滑变形的现象,而用柔顺机构设计的变形翼,虽蒙皮曲线光滑,飞机的稳定性和机动性增强,但难以满足变形与承载双重优化。为此,基于“指节”驱动式仿生刚柔耦合的设计思想,本文设计了一种瓦特I型六杆驱动的变弯度机翼后缘三“指节”刚性机构,并建立了可承受气动载荷和光滑变形的柔顺机构拓扑优化方法。先设计了一种由单电机驱动的瓦特I型六杆操控机构,再改进了“指节”式驱动下变形翼后缘的变密度拓扑优化方法,后求解并给出了一种具有三“指节”式杆驱动特点的变弯度后缘柔顺驱动机构,最后对优化模型进行了刚柔体动力学、空气动力学以及流固耦合仿真,并搭建了试验平台和样机模型,对柔性变形翼的可行性及其设计方法有效性进行论证,结果表明该机翼可以光滑、连续地大变形,同时又具有较强的承载能力。

关键词：刚柔耦合柔顺机构拓扑优化变形翼流固耦合

Development of test scenarios and bicyclist surrogate for the evaluation of bicyclist automatic emergency braking systems

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Journal of Intelligent and Connected Vehicles 2018年第1期1卷 15-27页

作者： Qiang Yi Stanley chien Lingxi Li Wensen Niu Yaobin Chen David Good chi-chih Chen Rini Sherony Department of Electrical and Computer Engineering Indiana University-Purdue UniversityIndianapolisIndianaUSA School of Public and Environmental Affairs Indiana UniversityBloomingtonIndianaUSA Department of Electrical and Computer Engineering Ohio State UniversityColumbusOhioUSA Toyota Collaborative Safety Research Center Ann ArborMichiganUSA

Purpose–To support the standardized evaluation of bicyclist automatic emergency braking(AEB)systems,test scenarios,test procedures and test system hardware and software tools have been investigated and developed by the Transportation Active Safety Institute(TASI)at Indiana University-Purdue University *** paper aims to focus on the development of test scenarios and bicyclist surrogate for evaluating vehicle–bicyclist AEB ***/methodology/approach–The harmonized general estimates system(GES)/FARS 2010-2011 crash data and TASI 110-car naturalistic driving data(NDD)are used to determine the crash geometries and environmental factors of crash scenarios including lighting conditions,vehicle speeds,bicyclist speeds,etc.A surrogate bicyclist including a bicycle rider and a bicycle surrogate is designed to match the visual and radar characteristics of bicyclists in the USA.A bicycle target is designed with both leg pedaling and wheel rotation to produce proper micro-Doppler features and generate realistic motion for camera-based AEB ***–Based on the analysis of the harmonized GES/FARS crash data,five crash scenarios are recommended for performance testing of bicyclist AEB *** with TASI 110-car naturalistic driving data,the crash environmental factors including lighting conditions,obscuring objects,vehicle speed and bicyclist speed are *** surrogate bicyclist was designed to represent the visual and radar characteristics of the real bicyclists in the *** height of the bicycle rider mannequin is 173 cm,representing the weighted height of 50th percentile US male and female *** size and shape of the surrogate bicycle were determined as 26-inch wheel and mountain/road bicycle frame,*** leg pedaling motion and wheel rotation are suggested to produce proper micro-Doppler features and support the camera-based AEB ***/value–The results have demonstrated that the developed scenarios,

关键词： Bicyclist Surrogate bicyclist Automatic emergency braking(AEB) Crash scenarios Crash testing Naturalistic driving Radar cross section(RCS) Micro-Doppler

天然产物库中体外颉颃A型塞内卡病毒化合物的筛选及作用途径研究

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中国畜牧兽医 2024年第7期51卷 3155-3165页

作者：王西彤沙洲迟田英崔进郑辉陈峰曹振山张慧戈胜强魏荣尼博黄保续东北农业大学动物医学学院哈尔滨150006 中国动物卫生与流行病学中心青岛266033 青岛市现代生物工程及动物疫病研究重点实验室青岛266032 农业农村部动物生物安全风险预警及防控重点实验室(南方) 青岛266032 山东省动物疫病预防与控制中心济南250100 青岛市动物生物安全重点实验室青岛266032

【目的】寻找对A型塞内卡病毒(SVA)具有抑制活性的天然产物,并深入研究其颉颃途径。【方法】将天然产物浓度统一稀释至10μmol/L,与荧光素酶重组塞内卡病毒(rSVA-NLuc)相结合,在天然产物小分子库中筛选出具有荧光素酶抑制活性的化合物,... 详细信息

【目的】寻找对A型塞内卡病毒(SVA)具有抑制活性的天然产物,并深入研究其颉颃途径。【方法】将天然产物浓度统一稀释至10μmol/L,与荧光素酶重组塞内卡病毒(rSVA-NLuc)相结合,在天然产物小分子库中筛选出具有荧光素酶抑制活性的化合物,采用实时荧光定量RT-PCR方法验证其活性,通过乳酸脱氢酶(LDH)法进行细胞毒性试验确定最大无毒浓度,结合病毒滴度测定、实时荧光定量RT-PCR、Western blotting、间接免疫荧光试验(IFA)等技术,在病毒感染周期的不同阶段,对其颉颃SVA的效果及途径进行研究。【结果】通过初筛,从136种天然产物中筛选出莫能霉素钠盐、孕酮、叶下珠次素、4-羟基德里辛和2-甲基雌酮5种能体外颉颃SVA的化合物。进一步通过实时荧光定量RT-PCR复核验证和细胞毒性检测,筛选出一种能体外颉颃SVA的天然产物——孕酮。与空白对照组相比,其在体外可导致SVA mRNA表达水平极显著下降(P<0.01),最大无毒浓度达50μmol/L。进一步研究表明,孕酮能在感染后8、12、24、36 h持续抑制SVA增殖,与对照组相比,在感染后24和36 h病毒滴度显著下降(P<0.05)。与对照组相比,不同浓度(10、20和50μmol/L)孕酮在吸附阶段导致SVA吸附水平极显著下降(P<0.01);在复制阶段使SVA VP3水平显著下降且使病毒滴度极显著下降(P<0.01);在释放阶段使释放胞外的病毒比例极显著下降(P<0.01);但对其他途径无显著影响。说明孕酮能在体外抑制SVA吸附、复制和释放,但对其入胞、组装途径无明显作用。【结论】本研究从天然产物小分子库中筛选出一种具有低细胞毒性且对SVA具有较强颉颃作用的天然产物——孕酮。该产物对SVA吸附、复制和释放阶段具有抑制作用,从而颉颃SVA的感染。本研究为促进抗SVA药物的开发和研究SVA的感染偏好性提供了科学参考。

关键词：孕酮 A型塞内卡病毒(SVA) 天然产物颉颃途径

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揉拨法调节DHPR/RyR通路对肌筋膜疼痛综合征大鼠的改善作用研究

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广州中医药大学学报 2024年第5期41卷 1270-1276页

作者：向超何生华赵欣万骐马炽胡艳平武汉市中医医院推拿科湖北武汉430014 湖北中医药大学针灸骨伤学院湖北武汉430000

【目的】探讨揉拨法对肌筋膜疼痛综合征(MPS)大鼠的治疗作用及机制。【方法】从60只大鼠中随机抽取12只作为正常组,其余大鼠采用钝性打击结合离心运动法构建MPS模型。再将48只造模成功的大鼠随机分为模型组、揉拨法组、揉拨法+丹曲林[... 详细信息

【目的】探讨揉拨法对肌筋膜疼痛综合征(MPS)大鼠的治疗作用及机制。【方法】从60只大鼠中随机抽取12只作为正常组,其余大鼠采用钝性打击结合离心运动法构建MPS模型。再将48只造模成功的大鼠随机分为模型组、揉拨法组、揉拨法+丹曲林[利若丁受体(Ry R)抑制剂]组、揉拨法+生理盐水组,每组12只。采用von-Frey法测定机械性痛阈值;检测软组织张力、肌电图;透射电镜观察激痛点组织超微结构;比色法检测激痛点组织内钙离子(Ca^(2+))含量;Western Blot法检测激痛点组织二氢吡啶受体(DHPR)α1、Ry R、乙酰胆碱酯酶(ACh E)蛋白表达。【结果】与正常组比较,模型组大鼠机械性痛阈值、激痛点软组织张力以及激痛点组织DHPRα1、Ry R、ACh E蛋白表达降低,Ca^(2+)含量增加(均P<0.05),肌电图出现振幅较高的峰电位、变化明显,激痛点组织超微结构受损;与模型组比较,揉拨法组、揉拨法+生理盐水组大鼠机械性痛阈值、激痛点软组织张力以及激痛点组织DHPRα1、Ry R、ACh E蛋白表达升高,Ca^(2+)含量减少(均P<0.05),肌电图恢复平稳,激痛点组织超微结构损伤减轻;与揉拨法组比较,揉拨法+丹曲林组大鼠机械性痛阈值、激痛点软组织张力以及激痛点组织DHPRα1、Ry R、ACh E蛋白表达降低,Ca^(2+)含量增加(均P<0.05),肌电图出现电活动变化,激痛点组织超微结构损伤加重。【结论】揉拨法可能通过激活DHPR/Ry R信号通路改善大鼠MPS。

关键词：揉拨法肌筋膜疼痛综合征(MPS) 激痛点 DHPR/RyR通路大鼠

Timing and characteristics of nuclear events during conjugation and genomic exclusion in Paramecium multimicronucleatum

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Marine Life Science & Technology 2022年第3期4卷 317-328页

作者： Xue Zhang Xiaoteng Lu Yong chi Yaohan Jiang Chundi Wang Saleh AAl‑Farraj Adriana Vallesi Feng Gao Institute of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China Key Laboratory of Mariculture(OUC) Ministry of EducationQingdao 266003China Department of Biology Shenzhen MSU-BIT UniversityShenzhen 518172China Laboratory of Marine Protozoan Biodiversity and Evolution Shandong UniversityWeihai 264209China Zoology Department College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Laboratory of Eukaryotic Microbiology and Animal Biology University of Camerino62032 CamerinoItaly Laboratory for Marine Biology and Biotechnology Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

Ciliated protists are ideal material for studying the origin and evolution of sex,because of their nuclear dimorphism(containing both germline micronucleus and somatic macronucleus in the same cytoplasm),special sexual processes(conjugation and autogamy),and high diversity of mating-type ***,the study of sexual process is limited to only a few species,due to the difficulties in inducing or observing *** the present study,we investigate the conjugation process in Paramecium multimicronucleatum:(1)of the three prezygotic divisions,all micronuclei undergo the first two divisions(meiosis I,II),while a variable number of nuclei undergo the third division(mitosis);(2)the synkaryon divides three times after fertilization,giving rise to eight products that differentiate into four macronuclear anlagen and four micronuclei;(3)cells restore the vegetative stage after two successive cell fissions during which the macronuclear anlagen are distributed into daughter cells without division,while micronuclei divide mitotically;(4)the parental macronucleus begins to fragment following the first meiotic division and finally degenerates completely;(5)the entire process takes about 110 h,of which about 85 h are required for macronuclear *** addition,we describe for the first time the process of genomic exclusion occurring between amicronucleate and micronucleate cells of ***,during which the micronucleate cell contributes a pronucleus to the amicronucleate cell,resulting in both exconjugants being *** results provide new insights into the diversity of sexual processes and lay an important cytological basis for future in-depth studies of mating systems in ciliates.

关键词： Amicronucleate cells Nuclear development Ciliate Life cycle Sexual reproduction

Evaluation of the sustainable development level of countries along the Belt and Road and its impact factors:Empirical analysis based on the Super-efficiency slacks-based measure and Tobit measure models

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chinese Journal of Population,Resources and Environment 2021年第2期19卷 162-170页

作者： Tianhang Huang Xiaoyu Zhao chi-Han Ai Shaofeng Chen Yi Wang Xiaoyue Hu School of Public Policy and Management University of Chinese Academy of SciencesBeijing100190China Tamkang University Lanyang Campus New Taipei City251301China Institutes of Science and Development Chinese Academy of SciencesSchool of Public Policy and ManagementUniversity of Chinese Academy of SciencesBeijing100190China School of Sociology and Population Studies Renmin University of ChinaBeijing102249China

Sustainable development is an important component of the Belt and Road Initiative(BRI)and is of great significance for evaluating the levels of sustainable development of countries along this route(henceforth,BRI countries).Therefore,this study aims to identify the factors that influence the levels of sustainable development of BRI countries in a reasonable and objective ***,this study employs the super efficiency slacks-based measure(Super-SBM)model,which considers unexpected outputs to measure the level of sustainable development of BRI *** dynamic change and composition of the sustainable development level of these countries are calculated using the global Malmquist-Luenberger ***,the Tobit model is used to identify the factors influencing the level of sustainable development of BRI countries in general and in various *** empirical results suggest the following points.(a)The overall level of sustainable development of BRI countries is low,whereas those of high-income and middle-and high-income countries are relatively high.(b)The overall sustainable development levels of BRI countries declined to a certain extent in 2008 owing to the effect of the financial crisis,.However,the sustainable development level of other countries,barring low-income countries,has gradually increased since 2011.(c)Since 2008,technological progress has replaced technical efficiency as the main driving force behind the improvement of the sustainable development level of BRI countries.(d)A U-shaped relationship is observed between the economic and sustainable development levels of these countries.(e)The level of science and technology and the proportion of renewable energy consumption can promote the sustainable development of these ***,a negative correlation exists between the level of opening to the outside world and that of sustainable development of countries that mainly export resource-based products and are dominated by

关键词： Belt and Road Initiative Sustainable development level Super-efficiency slacks-based measure model Global Malmquist-Luenberger Index Tobit model

Occurrence and Diversity of Pichia spp. in Marine Environments

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Journal of Ocean University of china 2008年第3期7卷 281-286页

作者： LI Jing chi Zhenming WANG Xianghong WANG Lin SHENG Jun GONG Fang Unesco chinese Center of Marine Biotechnology Ocean University of China Qingdao 266003 P. R. China

A total of 328 yeast strains from seawater, sediments, mud of salterns, the guts of marine fish and marine algae were obtained. The results of routine identification and molecular methods show that five yeast strains obtained in this study belonged to Pichia spp., including Pichia guilliermondii 1 uv-small, Pichia ohmeri YF04d, Pichia fermentans YF12b, Pichia burtonii YF11A and Pichia anomala YF07b. Further studies revealed that Pichia anomala YF07b could produce killer toxin against pathogenic yeasts in crabs while Pichia guilliermondii luv-small could produce high activity of extracellular inulinase. It is advisable to test if Pichia ohmeri YF04d obtained in this study is related to central-venous-catheter-associated infection.

关键词： Marine yeasts Pichia killer toxin inulinase