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Application of a wire-guided side-viewing duodenoscope in total esophagectomy with colonic interposition

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World Journal of Gastroenterology 2011年第13期17卷 1787-1790页

作者： Chin-Yuan Yii Jen-Wei Chou Yen-Chun Peng wai-keung chow Division of Gastroenterology and Hepatology Department of Internal Medi- cine China Medical University Hospital Taichung 40447 Taiwan China Division of Gastroenterology and Hepatology Department of Internal Medicine Taichung Veterans General Hospital Taichung 40447 Taiwan China

Therapeutic endoscopic retrograde cholangiopancreatography (ERCP) is the mainstay treatment for bile duct disease. The procedure is difficult per se, especially when a side-viewing duodenoscope is used, and when the patient has altered anatomical features, such as colonic interposition. Currently, there is no consensus on the standard approach for therapeutic ERCP in patients with total esophagectomy and colonic interposition. We describe a novel treatment design that involves the use of a side-viewing duodenoscope to perform therapeutic ERCP in patients with total esophagectomy and colonic interposition. A gastroscope was initially introduced into the interposed colon and a radio-opaque standard guidewire was advanced to a distance beyond the papilla of Vater, before the gastroscope was withdrawn. A sideviewing duodenoscope was then introduced along the guidewire under fluoroscopic guidance. After cannulation into the papilla of Vater, endoscopic retrograde chol-angiography (ERC) revealed a filling defect (maximum diameter: 15 cm) at the distal portion of the common bile duct (CBD). This defect was determined to be a stone, which was successfully retrieved by a Dormia basket after complete sphincterotomy. With this treatment design, it is possible to perform therapeutic ERCP in patients with colonic interposition, thereby precluding the need for percutaneous drainage or surgery.

关键词： Wire-guided Duodenoscope Endoscopic retrograde cholangiopancreatography Esophagectomy Interposition of colon

Prevalence and risk factors for impaired renal function among Asian patients with nonalcoholic fatty liver disease

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 241-248页

作者： Chao Sun George Boon-Bee Goh Wan-Cheng chow Wah-Kheong Chan Grace Lai-Hung Wong wai-Kay Seto Yi-Hsiang Huang Han-Chieh Lin I-Cheng Lee Hye Won Lee Seung Up Kim Vincent wai-Sun Wong Jian-Gao Fan Center for Fatty Liver Disease Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghai 200092China Department of Gastroenterology&Hepatology Singapore General HospitalSingaporeSingapore Gastroenterology and Hepatology Unit Department of MedicineFaculty of MedicineUniversity of MalayaKuala LumpurMalaysia Department of Medicine and Therapeutics and State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina Institute of Clinical Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Division of Gastroenterology and Hepatology Taipei Veterans General HospitalTaipeiTaiwanChina Faculty of Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Department of Internal Medicine Yonsei University College of MedicineSeoulKorea

Background:Nonalcoholic fatty liver disease(NAFLD)is associated with impaired renal function,and both diseases often occur alongside other metabolic ***,the prevalence and risk factors for impaired renal function in patients with NAFLD remain *** objective of this study was to identify the prevalence and risk factors for renal impairment in NAFLD ***:All adults aged 18-70 years with ultrasound-diagnosed NAFLD and transient elastography examination from eight Asian centers were enrolled in this prospective *** fibrosis and cirrhosis were assessed by FibroScan-aspartate aminotransferase(FAST),Agile 3+and Agile 4 *** renal function and chronic kidney disease(CKD)were defined by an estimated glomerular filtration rate(eGFR)with value of<90 mL/min/1.73 m^(2) and<60 mL/min/1.73 m^(2),respectively,as estimated by the CKD-Epidemiology Collaboration(CKD-EPI)***:Among 529 included NAFLD patients,the prevalence rates of impaired renal function and CKD were 37.4%and 4.9%,*** multivariate analysis,a moderate-high risk of advanced liver fibrosis and cirrhosis according to Agile 3+and Agile 4 scores were independent risk factors for CKD(P<0.05).Furthermore,increased fasting plasma glucose(FPG)and blood pressure were significantly associated with impaired renal function after controlling for the other components of metabolic syndrome(P<0.05).Compared with patients with normoglycemia,those with prediabetes[FPG≥5.6 mmol/L or hemoglobin A1c(HbA1c)≥5.7%]were more likely to have impaired renal function(P<0.05).Conclusions:Agile 3+and Agile 4 are reliable for identifying NAFLD patients with high risk of *** glycemic control in the prediabetic stage might have a potential renoprotective role in these patients.

关键词： Nonalcoholic fatty liver disease Impaired renal function Agile 3+ Agile 4 Metabolic syndrome

Sungai Lembing’s green tourism: Pioneering the future of resourcebased urban renewal

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The Innovation 2024年第3期5卷 19-20页

作者： Haoxuan Yu Ginura Gunaratna Izni Zahidi chow Ming Fai Department of Civil Engineering School of EngineeringMonash University MalaysiaBandar SunwaySelangor 47500Malaysia

HOW DID SUNGAI LEMBING PAVE ITS PATH TO A GREEN EVOLUTION?Sungai Lembing,a resource-based town situated in Pahang,Malaysia,has historically positioned itself as a pivotal hub in the global tin mining ***,Sungai Lembing’s history dates back to the Paleozoic and Mesozoic *** eras were marked by the closure of the Tethyan Ocean and the convergence of continental landmasses from the eastern part of the Gondwana *** complex geological background resulted in a wide variety of mineral resources.

关键词： situated eastern Pioneer

Drosophila adhesion GPCR Remoulade regulates axon growth, branching, and guidance by modulating Rac1 GTPase

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Journal of Genetics and Genomics 2024年第4期51卷 458-461页

作者： Xi Yang Changkun Pan Meitong Ye Jinshuo Liang Haoyang Cheng Qing Liang Shu Huang Jianshu Wang Hoi Yee chow Haihuai He Cancer Center and State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuan 610041China National Clinical Research Center for Geriatrics and State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuan 610041China Department of Neurosurgery Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan 610041China

The assembly of neurons into complex circuits relies upon appropriate axonal navigation to distant *** considerable progress has been made toward understanding the regulation of the guidance and branching of axon extension,the molecular and cellular mechanisms underlying the coordination of the motility of the axon tip,axon growth,and branching remain largely unknown(Sudhof,2017).The Drosophila mushroom body(MB),the major site for associative learning and memory,is a powerful model system to investigate complex axon *** MB is a bilaterally symmetric central brain structure,mainly composed of Kenyon cells,MB output neurons,and dopaminergic neurons(Li et al.,2020).Among the seven neuronal subtypes of~2000 Kenyon cells,Y,a/β,and a/β'subtypes extend axons in a fascicle and bifurcate to produce two sister branches,one projecting into the dorsal lobe and the other into the medial lobe.

关键词： branching medial axon

Synthesis,Structures,and Chiroptical Properties of NBN-Doped Helicenes with Boron Atoms in the Inner Rims

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Precision Chemistry 2024年第1期2卷 28-39页

作者： Weiwen Zhuang Yujian Liu Ziqi Deng Yu Guo Philip C.Y.chow David Lee Phillips Wei Jiang Zhaohui Wang Junzhi Liu State Key Laboratory of Synthetic Chemistry HKU-CAS Joint Laboratory on New Materials and Department of ChemistryThe University of Hong KongPokfulamHong KongChina Key Laboratory of Organic Optoelectronics and Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084China Department of Mechanical Engineering The University of Hong KongPokfulamHong KongChina

The precise synthesis of helicenes with topologically defined length and specific heteroatomic perturbation in the screw-like conjugated skeletons plays an emerging role in the manipulation of chiral ***,selective,and programmable routes to helicenes or heterohelicenes are highly desirable yet challenging for structure-chiroptical property relationship ***,we report the synthesis and characterization of NBN-doped helicenes with boron atoms in the inner rims,enabled by the highly regioselective one-pot borylation of rationally designed precursors with,namely,fold-in or pan-out *** incorporation of nonbonded boron and nitrogen atoms resulted in narrow-band emission and improved optical properties for the single-stranded carbon *** addition,numbers and arrangement modes of fused six-membered rings have distinct effects on configurational stability and chiroptical properties,revealing that BN-[6]H with strong circular dichroism is a promising candidate for chiral *** combination of experimental and theoretical studies on these helical structures might provide insights into the design of helically chiral small-molecule-based sensors or emitters.

关键词： Nitrogen-boron Helicenes Borylation Chiroptical properties Narrow-band emission

变废为宝:“蓝色循环”海洋塑料废物管理新策略

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Science Bulletin 2024年第8期69卷 993-996页

作者：余灏轩 Izni Zahidi chow Ming Fai 梁东方 DagØivind Madsen Department of Civil Engineering School of EngineeringMonash University MalaysiaBandar Sunway 47500Malaysia Monash Climate-Resilient Infrastructure Research Hub(M-CRInfra) School of EngineeringMonash University MalaysiaBandar Sunway 47500Malaysia Department of Engineering University of CambridgeCambridge CB21PZUK Davis School of Business Colorado Mesa UniversityGrand Junction 81501-3122USA

The"Blue Circle"vision,initiated by Zhejiang Province in China,represents a groundbreaking advancement in addressing marine plastic *** more than just an innovative concept,it embodies a future-forward approach to managing marine plastic waste,revealing the untapped potential in what was previously considered mere *** initiative,marrying scientific innovation with advanced technology,has been rightfully acknowledged with the prestigious2023 United Nations"Champions of the Earth"award,recognizing its innovative strategy in environmental stewardship(https://***/a/202310/31/***).

关键词： breaking debris initiated

ChatGPT智能处理器使用我们的语言吗?

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哲学分析 2024年第4期15卷 3-16,196页

作者：周柏乔香港公开大学中国香港

有人说ChatGPT智能处理器只会吐出话语,不(会)说话。尽管它的话有意思,而且可以被理解,但理解它的话真的在于挖掘它的“心思”或“心意”吗?假定与其对话的自然人都认为ChatGPT没有“心思”或“心意”,却发现对话有意思,起码有助于一般... 详细信息

有人说ChatGPT智能处理器只会吐出话语,不(会)说话。尽管它的话有意思,而且可以被理解,但理解它的话真的在于挖掘它的“心思”或“心意”吗?假定与其对话的自然人都认为ChatGPT没有“心思”或“心意”,却发现对话有意思,起码有助于一般人通过ChatGPT的话语进一步认识自己的“心思”或“心意”,这是否意味着ChatGPT是个语言使用者,和人类的语言使用者一样,可通过与人们的对话帮助自然人认识自己的想法?如果是这样,就会出现矛盾:它不(会)说话却成为语言使用者。借用蒯因的翻译理论、戴维森的诠释理论以及维特根斯坦的后期论述,可以说明自然人有哪些语言本领,AI工程当予以实现,ChatGPT智能处理器方可媲美自然人的语言使用能力。

关键词： ChatGPT 蒯因戴维森维特根斯坦

Soft,body conformable electronics for thermoregulation enabled by kirigami

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Bio-Design and Manufacturing 2024年第4期7卷 453-462页

作者： Lung chow Guangyao Zhao Pengcheng Wu Xingcan Huang Jiyu Li Jian Li Wanying Wang Guihuan Guo Zhiyuan Li Jiachen Wang Jingkun Zhou Yawen Yang Yuyu Gao Binbin Zhang Qiang Zhang Dengfeng Li Ya Huang Kuanming Yao Jian Lu Xinge Yu Department of Biomedical Engineering City University of Hong KongHong Kong 999077China Hong Kong Centre for Cerebro-Cardiovascular Health Engineering Hong Kong 999077China Department of Biomedical Sciences City University of Hong KongHong Kong 999077China Department of Mechanical Engineering City University of Hong KongHong Kong 999077China

The application of thermoelectric devices(TEDs)for personalized thermoregulation is attractive for saving energy while balancing the quality of *** that directly attach to human skin remarkably minimized the energy wasted for cooling the entire ***,facing the extreme dynamic geometry change and strain of human skin,conventional TEDs cannot align with the contour of our bodies for the best thermoregulation ***,we designed a kirigami-based wearable TED with excellent water vapor permeability,flexibility,and *** analysis and experimental results reveal that our product can withstand various types of large mechanical deformation without circuit *** stated outcome and proposed facile approach not only reinforce the development of wearable TEDs but also offer an innovative opportunity for different electronics that require high conformability.

关键词： Thermoregulation Thermoelectric Kirigami Body conformable Wearable

香港地区中学文凭考试诊断反馈系统的开发及改进

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中国考试 2024年第2期 40-46页

作者：禤美瑶萧伟乐周钜宽杨汉基席小明香港考试及评核局中国香港999077

为进一步推动“评核促进学习”,香港地区考试及评核局以历年香港地区中学文凭考试(HKDSE)的评核数据为基础开发了HKDSE诊断反馈系统。目前,该系统结合HKDSE 6个科目选择题的试题库,对学生学习表现数据加以分析并建立统计模型,为教师与... 详细信息

为进一步推动“评核促进学习”,香港地区考试及评核局以历年香港地区中学文凭考试(HKDSE)的评核数据为基础开发了HKDSE诊断反馈系统。目前,该系统结合HKDSE 6个科目选择题的试题库,对学生学习表现数据加以分析并建立统计模型,为教师与学生提供诊断性反馈报告,突出学生在不同能力或范畴的不足与强项。来自14所学校的约2200名学生及教师试用了该系统,通过问卷调查和访谈法,收集意见建议,以改进系统设计。系统改良版在“数据主导评核提升计划”中正式推出,辅之以学科教师培训,以帮助学校提升评核质量。

关键词：香港地区中学文凭考试诊断反馈评核促进学习个性化学习