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Early-onset primary torsional dystonia in a 4-generation Chinese family with a mutation in the DYT1 gene

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Chinese Medical Journal 2005年第10期118卷 873-876页

作者： YEUNG wai Lan lam Ching Wan CHENG wai Tsoi SIN Ngai Chuen WONG Wing Kin WONG Chun Nei TSE Ka Ming FOK Tai Fai Departments of Paediatrics Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina Chemical Patholog Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina Department of Paediatrics and Adolescent Medicine Queen Mary HospitalUniversity of Hong Kong Nuclear Medicine&PET Division Scanning DepartmentSt.Teresa’s HospitalHong KongChina

Primary torsion dystonia(PTD)is a clinically and genetically heterogeneous movement *** least thirteen different types of dystonia can be distinguished on a genetic basis.~1 The DYT1 gene was first mapped by Ozelius et al in 1989.~2(Kramer et)al^3 linked the same locus to PTD in 12 Ashkenazi Jewish families in *** patients with early-onset generalized PTD were caused by the same three base pair(GAG)deletion in the DYT1 gene on chromosome 9q34.^(1,4,5)The product of the gene is a protein called torsinA.~5(Although the)function of this protein is as yet uncertain,it is widely distributed throughout the brain with high levels in the substantia nigra compacta dopamine neurones.

关键词： DYT1 gene dystonia positron emission tomography

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三维打印技术在皮肤组织修复上的应用

生物医学工程学杂志 2018年第5期35卷 805-810页

作者：林越威敖宁建暨南大学生命科学技术学院生物医学工程系广州510632 广东省教育厅生物材料重点实验室广州510632

三维打印是一种低成本、高效益的生产方法,有助于改善目前皮肤修复材料产业成本高昂、利润放缓的趋势,并开发出性能更优秀的产品。常用于皮肤修复材料制备中的三维打印技术有熔融沉积成型技术和三维生物打印技术:其中熔融沉积成型技术... 详细信息

三维打印是一种低成本、高效益的生产方法,有助于改善目前皮肤修复材料产业成本高昂、利润放缓的趋势,并开发出性能更优秀的产品。常用于皮肤修复材料制备中的三维打印技术有熔融沉积成型技术和三维生物打印技术:其中熔融沉积成型技术具有设备简单轻巧的优点,但材料选择不足;三维生物打印技术可供选择的材料较多,但设备笨重且昂贵。近年对两种技术的研究均集中于材料的开发和应用上。本文详细介绍了熔融沉积成型技术和三维生物打印技术的原理、在伤口敷料和组织工程皮肤生产上的研究进展,以及三维打印在皮肤组织修复上的未来发展,包括容貌修复和仿生组织工程皮肤的研究,并对三维打印技术应用在皮肤组织修复领域的发展进行了展望。

关键词：三维打印伤口敷料组织工程皮肤熔融沉积成型三维生物打印

Efficacy and safety of on demand tadalafil in the treatment of East and Southeast Asian men with erectile dysfunction:a randomized double-blind,parallel,placebo-controlled clinical study

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Asian Journal of Andrology 2006年第6期8卷 685-692页

作者： wai Chun Andrew yip Han-Sun Chiang Jesus Benjamin Mendoza Hui-Meng Tan Man-Kay Li Wei Christine Wang Vladimir Kopernicky Department of Surgery Kwong Wah HospitalHong KongChina College of Medicine Fu Jen Catholic UniversityTaipei 24205TaiwanChina Department of Urology National Kidney and Transplant InstituteQuezon City 1100the Philippines Department of Urology Subang Jaya Medical CentreSelangor Darul Ehsan 47500Malaysia Department of Urology National University Hospital119074Singapore Lilly Research Laboratories Eli Lilly and CompanyIndianapolisIndiana 46285USA Lilly Area Medical Center Vienna 1030Austria

Aim： To assess the efficacy and safety of tadalafil in comparison to a placebo, when taken on demand for 12 weeks by East/Southeast Asian men with erectile dysfunction （ED）, Methods： This multicenter, randomized, double-blind, parallel group, placebo-controlled study was conducted at 17 centers across East and Southeast Asia between August 2002 and February 2003. Men more than 18 years of age with mild to severe ED of various etiologies were randomized to receive a placebo or 20 mg of tadalafil taken as needed （maximum once daily）. Efficacy assessments included the International Index of Erectile Function, the Sexual Encounter Profile diary and Global Assessment Questions. Results： Tadalafil significantly improved erectile function as compared to the placebo （P 〈 0.001）. At the endpoint, the patients receiving 20 mg of tadalafil reported a greater mean per patient percentage of successful intercourse attempts （Sexual Encounter Profile question 3： 70.9% compared to 33.5% in the placebo） and a greater proportion of improved erections （Global Assessment Question： 86.2% compared to 30.1%）. Most （≥3%） treatment emergent adverse events were mild or moderate. The most common treatment emergent adverse events were headache, back pain, dizziness and dyspepsia. Conclusion： Tadalafil was an effective and well-tolerated treatment for ED in East and Southeast Asian men.

关键词： tadalafil phosphodiesterase type 5 inhibitor erectile dysfunction efficacy safety Asian

A decomposition analysis to examine the change in the number of recipients in the comprehensive social security assistance(CSSA)system

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China Population and Development Studies 2021年第1期4卷 284-297页

作者： Paul yip Milton Chan B.K.So K.P.Wat Kwok Fai lam Social Work and Social Administration The University of Hong KongHong Kong SARPeople’s Republic of China Center for Suicide Research and Prevention The University of Hong KongHong Kong SARPeople’s Republic of China Department of Mathematics Jilin UniversityChangChunPeople’s Republic of China Department of Statistics and Actuarial Science The University of Hong KongHong Kong SARPeople’s Republic of China

Social security is an important social and public policy measure to help address poverty in any contemporary *** Comprehensive Social Security Assistance(CSSA)system in Hong Kong provides a safety net for those aged children and adults below 65 years old who cannot support themselves *** is designed to bring their income up to a prescribed level to meet their basic *** rapid increase in social welfare expenditure in the last decade has become a concern to the Hong Kong SAR *** overall social welfare expenditure has accounted for nearly 15.6%of government expenditure in 2018,with the total amount increasing from$58 billion to$90 billion(an increase of 72.4%)for the period ***,the amount spent on CSSA only increased from$20.7 billion to$22.3 billion with an increase of 7.7%only for the same *** much slower magnitude of increase is related to the reduction in the number of CSSA recipients,which decreased from 237,501 to 185,528 over the period.A decomposition method was used to assess the changes in the number of people in the CSSA *** showed that the rate of arriving into the system has been decreasing due to a robust economy with a very low unemployment rate;whereas moving out of the system has also been decreasing in the past 5 *** phenomenon can be partly attributed to the widening of the income gap in the community in the *** the increase in population size,as long as employment conditions remain strong and the momentum of leaving the system can be maintained,the number of CSSA recipients will continue to ***,the results also suggested that a certain proportion of CSSA recipients will not be able to move out of the system and have been *** innovative methods to help them out of CSSA are *** view of the poor economic outlook arising from the COVID-19 pandemic,it is important for the Government to have effective measures to keep people in their *** the

关键词： Comprehensive Social Security Assistance(CSSA)system Social security Decomposition analysis

LINEAR AND HYPERBRANCHED POLYMERS WITH HIGH THERMAL STABILITY AND LUMINESCENCE EFFICIENCY

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作者：叶维廉(wai-Lim yip)

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Chinese Journal of Polymer Science 2001年第6期19卷 585-590页

作者： Jacky Wing yip lam Jing-dong Luo Han Peng Zhi-liang Xie Kai-tian Xue Yu-ping Dong Lin Cheng Cheng-feng Qiu Hoi Sing Kwok Ben-zhong Tang Departments of Chemistry and Electrical & Electronic Engineering Hong Kong University of Science & Technology Clear Water Bay, Kowloon, Hong Kong China Hong Kong Univ Sci & Technol Dept Chem Kowloon Hong Kong Peoples R China Hong Kong Univ Sci & Technol Dept Elect & Elect Engn Kowloon Hong Kong Peoples R China

New acetylene monomers, 6-{[(1-naphthylethynyl-4-phenyl)carbonyl]oxy}-1-phenyl-1-hexyne (1), 2,5-diethynyl-thiophene (3), and 4,4'-diethynylbiphenyl (6) were synthesized. Homopolymerization of 1 and copolycyclotrimerizations of 3 and 6 with 1-heptyne and 1-octyne have been achieved with WCl6- and TaCl5-Ph4Sn catalysts, respectively, giving soluble linear disubstituted polyacetylene (2) and hyperbranched polyarylenes (5 and 8) with high molecular weights (up to 1.2 x 10(5)) in high yields (up to 98%). The structures and properties of the polymers are characterized and evaluated by R NMR, TGA, UV, photoluminescence (PL), and electroluminescence (EL) analyses. All the polymers possess high thermal stability and emit strong blue light upon photoexcitation. The intensity of the emitted light is greater than that of poly(1-phenyl-1-octyne), a well-known highly luminescent disubstituted polyacetylene. Little aggregation-induced red shift in the PL was observed in the thin films of the polymers. By constructing a multi-layer EL device, high EL quantum yield (0.18%) has been achieved in 2, which are the best results for substituted polyacetylenes attainable so far.

关键词： disubstituted polyacetylene hyperbranched polyarylene light emission

Visible-light-driven photocatalytic bacterial disinfection in a partition system

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Visible-light-driven photocatalytic bacterial disinfection i...

A truncated hepatitis E virus ORF2 protein expressed in tobacco plastids is immunogenic in mice

中国矿物岩石地球化学学会第13届学术年会

作者： NG Tsz wai LEE Kwan Yin yip Ho Yin WONG Po-Keung School of Life Sciences The Chinese University of Hong Kong

＜正＞Photocatalysis has received increasing interest for water *** has been well-studied for the inactivation of various microorganisms,including bacteria,algae,viruses,fungi and ***,many different effective visible-light-driven（VLD） photocatalysts were reported to disinfect water-borne microbes with the production of reactive charged and oxidative *** these photocatalysts must be immobilized in practical *** of photocatalyst leads to higher cost and technical challenges for application.

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World Journal of Gastroenterology 2006年第2期12卷 306-312页

作者： Yuan-Xiang Zhou Maggie Yuk-Ting Lee James Ming-Him Ng Mee-Len Chye Wing-Kin yip Sze-Yong Zee Eric lam Department of Botany The University of Hong Kong PokfulamRoad Hong Kong China Biotech Center Rutgers University 59 Dudley RoadNew Brunswick NJ 08901-8520 United States

AIM： To cost-effectively express the 23-ku pE2, the most promising subunit vaccine encoded by the E2 fragment comprising of the 3＇-portion of hepatitis E virus （HEV） open reading frame 2 （ORF2） in plastids of tobacco （Nicotiana tabacum cv. SR1）, to investigate the transgene expression and pE2 accumulation in plastids, and to evaluate the antigenic effect of the plastid-derived pE2 in mice. METHODS： Plastid-targeting vector pRB94-E2 containing the E2 fragment driven by rice psbA promoter was constructed. Upon delivery into tobacco plastids, this construct could initiate homologous recombination in psaB-trnfM and trnG-psbC fragments in plastid genome, and result in transgene inserted between the two fragments. The pRB94-E2 was delivered with a biolistic particle bombardment method, and the plastid-transformed plants were obtained following the regeneration of the bombarded leaf tissues on a spectinomycin-supplemented medium. Transplastomic status of the regenerated plants was confirmed by PCR and Southern blot analysis, transgene expression was investigated by Northern blot analysis, and accumulation of pE2 was measured by ELISA. Furthermore, protein extracts were used to immunize mice, and the presence of the pE2-reactive antibodies in serum samples of the immunized mice was studied by ELISA. RESULTS： Transplastomic lines confirmed by PCR and Southern blot analysis could actively transcribe the E2 mRNA. The pE2 polypeptide was accumulated to a level as high as 13.27 μg/g fresh leaves. The pE2 could stimulate the immunized mice to generate pE2-specific antibodies. CONCLUSION： HEV-E2 fragment can be inserted into the plastid genome and the recombinant pE2 antigen derived is antigenic in mice. Hence, plastids may be a novel source for cost-effective production of HEV vaccines.

关键词： Hepatitis E virus E2 Plastid transformation Vaccine Tobacco

玻璃体腔注射Bevacizumab联合Ahmed青光眼阀植入治疗新生血管性青光眼

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中国实用眼科杂志 2011年第8期29卷 779-784页

作者：张海涛王保君胡俊喜徐英英 wai-Ching lam 新乡医学院第一附属医院眼科河南省新乡市453100 加拿大多伦多大学西部医院眼科

目的观察玻璃体腔注射Bevacizumab联合Ahmed青光眼阀植入治疗新生血管性青光眼（NVG）的术后疗效和并发症。方法回顾性临床病例对照研究。选择新乡医学院第一附属医院眼科在2007年至2008年2月间接受过玻璃体腔注射Bevacizumab0．05mL／1... 详细信息

目的观察玻璃体腔注射Bevacizumab联合Ahmed青光眼阀植入治疗新生血管性青光眼（NVG）的术后疗效和并发症。方法回顾性临床病例对照研究。选择新乡医学院第一附属医院眼科在2007年至2008年2月间接受过玻璃体腔注射Bevacizumab0．05mL／1．25mg和Ahmed青光眼阀植入术的NVG患者，术前及术后定期随访检查，记录抗青光眼药物数量、Snellen视力、Godmann压平式眼压计测量的IOP等项目。手术成功标准：术后IOP处于6～21mmHg范围内，不再使用或不需额外增加抗青光眼药物治疗，不需进一步抗青光眼手术治疗，术眼视力未丧失光感。结果纳入分析35例（35只眼），随访时间（24．6±14.2）月。Ahmed青光眼阀植入术后IOP比术前降低（P〈0．01），其中术前、术后6月、1年和3年分别为（44．9±4．8）mmHg、（1822±4．0）mmHg、（15．5±3．3）mmHg和（9．8±2．6）mmHg（1mmHg=0．133kPa）；抗青光眼药物数量术后较术前减少（P〈0．01），其中术前、术后6月、1年和3年分别为（3．3±0．5）种、（0．9±0．5）种、（0．8±0．9）种和（0．8±0．6）种。最后一次随访时，视力较术前保持稳定19例（54．3％），改善4例（11．4％），下降12例（34．3％），丧失光感3例（8．6％）。经3年随访，失败病例7例（20．0％o经Kaplan—Meier生存分析，术后1年、2年、3年累计生存率分别为82．9％、74．1％和71．0％。经Cox逐步回归分析，术前视力较差（〈20／400）与术后生存时间具有相关性（RR=3．571，P〈0．05）。术后并发症8例（22．9％），其中前房出血2例（5．7％），脉络膜渗液2例（5．7％），其余并发症较少见，未发生需要取出引流阀的并发症。结论玻璃体腔注射Bevacizumab联合Ahmed青光眼阀植入术安全有效，可作为新生血管性青光眼临床治疗方法之一。

关键词： Ahmed青光眼阀新生血管性青光眼 Bevacizumab 玻璃体注射