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World Journal of Emergency Medicine 2021年第2期12卷 143-150页

作者： Rex Pui Kin lam Eric Ho Yin Lau wai lam yip Joe Kai Shing Leung Matthew Sik Hon Tsui Emergency Medicine Unit Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina Accident and Emergency Department Pamela Youde Nethersole Eastern HospitalHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina

Dear editor,Traditional Chinese medicine (TCM) is popular in many countries,especially in the Chinese population.^([1,2]) In Hong Kong,it has been estimated that around 15%of the population consumed Chinese medicine products/herbs in the preceding *** reasons for consumption include regulating bodily functions,curing disease,and building up health.

关键词： has editor curing

Utilization of the Accident & Emergency Departments by Chinese elderly in Hong Kong

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World Journal of Emergency Medicine 2015年第4期6卷 283-288页

作者： wai lam yip Kit Ling Fan Chun Tat Lui Ling Pong Leung Fu Ng Kwok Leung Tsui Accident & Emergency Department Queen Mary Hospital Emergency Medicine Unit The University of Hong Kong Accident & Emergency Department Tuen Mun Hospital Accident & Emergency Department Caritas Medical Centre

BACKGROUND: The epidemiological data on elderly patients attending Accident and Emergency Departments(AEDs) in Hong Kong is lacking. The study aimed to examine the epidemiology of geriatric patient visits to AEDs in Hong Kong, including demographic data and predictors of life-saving interventions(LSI) and ***: A retrospective cross-sectional study of geriatric patients older than 64 years old attending three AEDs during the year 2012, with a sample of 1 200 patient visits recruited. The data were retrieved from the medical records of the respective hospitals. Descriptive characteristics of the visits were provided. Multivariate logistic regression was performed to evaluate the predictors of LSI and hospital ***: The mean age of the patients was 79.1 years. Totally 49.7% of the patients were male. "Diseases of the respiratory system" was the commonest diagnosis in AEDs as well as that required admission. The admission rate was 56.8%. Logistic regression demonstrated that dependent activity of daily living(ADL), arrival by ambulance, and the higher number of co-morbidities were predictors of LSI, while advanced age, dependent ADL, institutionalized patients, arrival by ambulance, and higher number of co-morbidities were predictors of hospital ***: Ageing population is creating an imminent burden on the emergency service in Hong Kong. Previously unavailable epidemiological information about geriatric attendance to AEDs was described. This forms the basis for development of future studies concerning the medical services on this specific group of patients.

关键词： Elderly Geriatric Emergency department Epidemiology

Theoretical study of substituent effect on the charge mobility of 2,5-bis(trialkylsilylethynyl)-1,1,3,4-tetraphenylsiloles

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Science China Chemistry 2010年第11期53卷 2311-2317页

作者： lam Jacky Wing yip Department of Chemistry The Hong Kong University of Science & Technology

The theoretical calculation of the charge mobility of 2,5-bis(trialkylsilylethynyl)-1,1,3,4-tetraphenylsiloles is presented.B3LYP/6-31* calculations demonstrated that these silole molecules possessed large coupling matrix elements and reorganization energies for electron and hole transfers and high electron *** bulkiness of the trialkyl substituents influenced the charge mobility of the silole molecules,with the smaller trimethyl group imparting higher charge mobility than triethyl and triisopropyl substituents.

关键词： silole theoretical calculation substitution effect electronic structure charge mobility

Microcurvature landscapes induce neural stem cell polarity and enhance neural differentiation

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Bio-Design and Manufacturing 2023年第5期6卷 522-535页

作者： Ho-Yin Yuen wai-Sze yip Suet To Xin Zhao Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARChina State Key Laboratory of Ultra-Precision Machining Technology Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARChina

Tissue curvature has long been recognized as an important anatomical parameter that affects intracellular behaviors,and there is emerging interest in applying cell-scale curvature as a designer property to drive cell fates for tissue engineering *** neural cells are known to undergo dramatic and terminal morphological changes during development and curvature-limiting behaviors have been demonstrated in neurite outgrowth studies,there are still crucial gaps in understanding neural cell behaviors,particularly in the context of a three-dimensional(3D)curvature landscape similar to an actual tissue engineering *** this study,we fabricated two substrates of microcurvature(curvature-substrates)that present a smooth and repeating landscape with focuses of either a concave or a convex *** these curvature-substrates,we studied the properties of morphological differentiation in N2a neuroblastoma *** contrast to other studies where two-dimensional(2D)curvature was demonstrated to limit neurite outgrowth,we found that both the concave and convex substrates acted as continuous and uniform mechanical protrusions that significantly enhanced neural polarity and differentiation with few morphological changes in the main cell *** enhanced differentiation was manifested in various properties,including increased neurite length,increased nuclear displacement,and upregulation of various neural *** demonstrating how the micron-scale curvature landscape induces neuronal polarity,we provide further insights into the design of biomaterials utilizing the influence of surface curvature in neural tissue engineering.

关键词： Curvature Neural differentiation Neurite outgrowth Mechanotransduction

APACHE system is better than Ranson system in the prediction of severity of acute pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2006年第2期5卷 294-299页

作者： Yuk Pang Yeung Billy Yeung Kit lam Andrew wai Chun yip Department ot Surgery Kwong Wah Hospital 25 Waterloo Road Kowloon Hong Kong China

BACKGROUND: It has been suggested that addition of obesity score to the APACHE-Ⅱ system can lead to more accurate prediction of severity of acute pancreatitis. However there is scanty information on the usefulness of the combined APACHE-O scoring system in Asian patients. This study aimed to compare the accuracy of Ranson, APACHE-Ⅱ and APACHE-O systems in assessing severity of acute pancreatitis in a local Chinese population. METHODS: One hundred and one consecutive patients with acute pancreatitis were prospectively studied. Body mass index (BMI) was measured on admission. Ranson score, APACHE-Ⅱ and APACHE-O scores were recorded on admission and at 48 hours. By adopting the cut-off levels and definitions advocated in the Atlanta consensus for severe disease, the diagnostic accuracy of the three scoring systems was compared by the area under the curve (AUC) under the receiver operator characteristic curve. RESULTS: Of the 101 patients, 12 (11.9%) patients suffered from severe pancreatitis. Obesity was uncommon and only two patients (2.0%) had BMI >30. Eighty-two (81.2%) patients were normal weight (BMI≤25) whereas 17 (16.8%) were overweight ( BMI 25-30 ). Overweight or obesity (BMI >25) was not associated with severe pancreatitis (P= 0.40). The AUC for admission scores of Ranson, APACHE-Ⅱ, and APACHE-O systems was 0. 549, 0. 904 and 0. 904, respectively. The AUC for 48-hour scores of Ranson, APACHE-Ⅱ and APACHE-O systems was 0.808, 0.955 and 0.951, respectively. CONCLUSIONS: The APACHE-Ⅱ scoring system is more accurate than the Ranson scoring system of the prediction of severity in acute pancreatitis. Addition of obesity score does not significantly improve the predictive accuracy of the APACHE-Ⅱ system in our local population with a low prevalence of obesity.

关键词： acute pancreatitis APACHE-Ⅱ score APACHE-O score disease severity Ranson score

Crystalline Behavior and Structure of a Liquid Crystal Com- pound, 5-{[4＇-（（（Pentyl）oxy）-4-biphenylyl）carbonyl]oxy}- 1 -pentyne

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Chinese Journal of Chemistry 2011年第4期29卷 631-638页

作者：刘雷静李杲周恩乐 lam,Jacky Wing yip 唐本忠 State Key Laboratory of Supramolecular Structure and Materials Jilin University Changchun Jilin 130012 China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Graduate School of Chinese Academy of Sciences Changchun Jilin 130022 China Department of Chemistry Hong Kong University of Science & Technology Clear Water Bay Kowloon Hong Kong China

Single crystals of two liquid crystal compounds, 5-{[4＇-（（（pentyl）oxy）-4-biphenylyl）carbonyl]oxy}-1-pentyne （A3EO5） and 5-{[（4＇-nonyloxy-4-biphenylyl）carbonyl]oxy}-1-pentyne （A3EO9）, have been prepared by solution growth technique. The morphologies and structures of A3EO5 and A3EO9 crystals were investigated by wide angle X-ray diffraction （WXRD）, atom force microscope （AFM） and transmission electron microscope （TEM）. In contrast to the same series of compounds which have a longer alkyl tail, 5-{[（4＇-heptoxy-4-biphenylyl）carbonyl]oxy}-1-pentyne （A3EO7）, 5-{[（4＇-heptoxy-4-biphenylyl）oxy]carbonyl}-1-pentyne （A3E＇O7） and A3EO9, A3EO5 shows strikingly different crystalline behavior. The former three compounds have only one crystal form, whereas A3EO5 exhibits polymorphism. Specifically, A3EO5 crystals grown from toluene solution show two crys- tal forms. The first one is crystal I which adopts a monoclinic P112/m space group with unit cell parameters of a= 5.79A, b=8.34A, c=43.92/k, y=96°, and the other one is crystal II which adopts a monoclinic P112 space group with unit cell parameters of a=5.55A, b=7.38A, c=31.75 ]k, y=94°. When using dioxane as the solvent to grow A3EO5 crystal, we can selectively obtain crystal Ⅰ. A3EO5 melt-grown crystals also have two crystal forms which derive from crystal I and crystal Ⅱ, respectively. The different crystalline behavior of the compounds should correlate with their different electron dipole moment resulting from the different length of alkyl tail.

关键词： crystal growth crystal morphology crystal structure electron diffraction single crystal

Economic Growth, Energy Use, and Greenhouse Gases Emission in Macao SAR, China

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Chinese Journal of Urban and Environmental Studies 2022年第1期10卷 23-43页

作者： wai Ming TO King Hang lam School of Business Macao Polytechnic Institute Department of Electrical and Electronic Engineering The University of Hong Kong

A city’s economic structure and energy mix would change when the city is developed to accommodate more residents, visitors, and activities. This paper reviews Macao’s economic growth, energy use, and greenhouse gases(GHG) emission from 1985 to 2020. Specifically, Macao’s gross domestic product(GDP), energy use, and GHG emission have surged after the gaming industry was liberalized in *** official data show that Macao’s GDP was MOP 11 billion in 1985, increased by four-fold to MOP54 billion in 2000, and then surged rapidly to MOP 445 billion in 2019. Additionally, Macao’s total energy use increased from 8,840 TJ in 1985 to 48,330 TJ in 2019 while Macao’s GHG emission increased from 0.70 Mt of CO2-equivalent in 1985 to 6.13 Mt of CO2-equivalent in 2019. Macao’s GHG emission from all local sources per capita and GDP per capita exhibit an inverted U-shaped relationship, showing an environmental Kuznets curve. Due to the negative impact of COVID-19pandemic, Macao’s GDP dropped by 56% to MOP 194 billion while its total energy use and GHG emission dropped by 33% and 17% to 32,198 TJ and 5.06 Mt of CO2-equivalent, respectively, in 2020.

关键词： Economic growth energy use greenhouse gases environmental Kuznets curve COVID-19

Synthesis of an AIE-active fluorogen and its application in cell imaging

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Science China Chemistry 2009年第1期52卷 15-19页

作者： lam Jacky Wing yip FAISAL Mahtab NG Ka Ming LUO Kathy Qian Department of Chemistry The Hong Kong University of Science & Technology (HKUST) Clear Water Bay Department of Chemical and Biomolecular Engineering HKUST Clear Water Bay Bioengineering Graduate Program HKUST Clear Water Bay

A fluorogen named 1-decyl-1-methyl-2,5-bis{4-[(N,N-diethylamino)methyl]phenyl}-3,4-diphenylsilole (3) was synthesized. It emitted weakly as isolated molecule but strongly as supramolecular aggregate, showing a characteristic behavior of aggregation-induced emission (AIE). The molecules of 3 formed highly emissive nanoparticles in aqueous media, which quickly and selectively marked cytoplasm of HeLa cells and posed no toxicity to the living cells. The fluorogen is thus a promising candidate mate-rial for cell imaging as a sensitive, selective and cytocompatible biosensor.

关键词： aggregation-induced emission biosensor cell imaging

Virtual reality based multiple life skill training for intellectual disability:A multicenter randomized controlled trial

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Engineered Regeneration 2022年第2期3卷 121-130页

作者： James Chung-wai Cheung Ming Ni Andy Yiu-Chau Tam Tim Tin-Chun Chan Alyssa Ka-Yan Cheung Ocean Yu-Hong Tsang Chi-Bun yip Wing-Kai lam Duo wai-Chi Wong Department of Biomedical Engineering Faculty of EngineeringThe Hong Kong Polytechnic UniversityHong Kong 999077China Research Institute for Smart Ageing The Hong Kong Polytechnic UniversityHong Kong 999077China Jockey Club Smart Ageing Hub Department of Biomedical EngineeringFaculty of EngineeringThe Hong Kong Polytechnic UniversityHong Kong 999077China Department of Orthopaedics Pudong New Area People’s Hospital Affiliated to Shanghai Jiaotong UniversityShanghai 201299China Social Service Department Yan Chai HospitalHong Kong 999077China C2 Innovations and Research Limited Hong Kong 999077China Department of Kinesiology Shenyang Sport UniversityShenyang 110102China Sports Information and External Affairs Centre Hong Kong Sports InstituteHong Kong 999077China

Life skill-based training is essential for intellectual disabled individuals to regain autonomy and social *** reality(VR)could deliver a nascent application that is more engaging and *** objective of this study was to evaluate the training effects of the VR-based multiple life skill training program on life skill perfor-mance,self-efficacy,memory,cognitive and behavioral functions via a multicenter randomized controlled trial.A total of 145 intellectual disabled participants were recruited for a randomized controlled trial with three in-tervention arms:VR(n=42);traditional(n=53);and control(n=50).The life skill tasks for the interventions included 1)grocery shopping,2)cooking,and 3)kitchen *** measures were performance scores for the three tasks,self-efficacy scale,digit span score,and Frontal Assessment Battery score,graded by blinded ***-after effects of each group were evaluated using separated Wilcoxon Signed-rank *** sig-nificantly improved cooking,cleaning performance,and memory span,while traditional training significantly improved shopping,cooking,and cleaning *** generalized estimating equation evaluated effects between groups adjusted for age,gender and intelligence quotient(IQ).VR had significantly larger improvement effects in cooking and cleaning than the control group and memory span compared to traditional training and controls *** appeared to be a significant confounder on the training *** work may consider developing artificial intelligence to customize programs depending on IQ level.

关键词： Mental retardation Intellectual development X-reality Immersive rehabilitation Metaverse

Insight into evolution of invasive patterns on fingering phenomenon during immiscible two-phase flow through pore structure

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Petroleum Science 2024年第5期21卷 3307-3325页

作者： Yu Li Hui-Qing Liu Chao Peng Peng Jiao wai lam Loh Qing Wang State Key Laboratory of Petroleum Resources and Engineering China University of PetroleumBeijing102249China Department of Mechanical Engineering National University of Singapore117575Singapore Oil and gas production Business Department Kunlun Shuzhi Technology Co.LTDBeijing100040China

Understanding fingering, as a challenge to stable displacement during the immiscible flow, has become a crucial phenomenon for geological carbon sequestration, enhanced oil recovery, and groundwater protection. Typically governed by gravity, viscous and capillary forces, these factors lead invasive fluids to occupy pore space irregularly and incompletely. Previous studies have demonstrated capillary numbers,describing the viscous and capillary forces, to quantificationally induce evolution of invasion *** the evolution mechanisms of invasive patterns have not been deeply elucidated under the constant capillary number and three variable parameters including velocity, viscosity, and interfacial *** research employs two horizontal visualization systems and a two-phase laminar flow simulation to investigate the tendency of invasive pattern transition by various parameters at the pore scale. We showed that increasing invasive viscosity or reducing interfacial tension in a homogeneous pore space significantly enhanced sweep efficiency, under constant capillary number. Additionally, in the fingering crossover pattern, the region near the inlet was prone to capillary fingering with multi-directional invasion, while the viscous fingering with unidirectional invasion was more susceptible occurred in the region near the outlet. Furthermore, increasing invasive viscosity or decreasing invasive velocity and interfacial tension promoted the extension of viscous fingering from the outlet to the inlet, presenting that the subsequent invasive fluid flows toward the outlet. In the case of invasive trunk along a unidirectional path, the invasive flow increased exponentially closer to the outlet, resulting in a significant decrease in the width of the invasive interface. Our work holds promising applications for optimizing invasive patterns in heterogeneous porous media.

关键词： Immiscible two-phase flow Fingering phenomenon Invasive pattern Capillary number Parameters optimization