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Heterogeneous cu_(x)O Nano‑Skeletons from Waste Electronics for Enhanced Glucose Detection

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Nano-Micro Letters 2024年第11期16卷 554-568页

作者： Yexin Pan Ruohan Yu Yalong Jiang Haosong Zhong Qiaoyaxiao Yuan connie Kong wai Lee Rongliang Yang Siyu chen Yi chen Wing Yan Poon Mitch Guijun Li center on Smart Manufacturing Division of Integrative Systems and DesignThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SAR 999077People’s Republic of China The Sanya Science and Education Innovation Park of Wuhan University of Technology Sanya 572000People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China

Electronic waste(e-waste)and diabetes are global challenges to modern ***,solving these two challenges together has been challenging until ***,we propose a laser-induced transfer method to fabricate portable glucose sensors by recycling copper from *** bring up a laser-induced full-automatic fabrication method for synthesizing continuous heterogeneous cu_(x)O(h-cu_(x)O)nano-skeletons electrode for glucose sensing,offering rapid(clean,air-compatible,and continuous fabrication,applicable to a wide range of cu-containing *** this approach,h-cu_(x)O nanoskeletons,with an inner core predominantly composed of cu_(2)O with lower oxygen content,juxtaposed with an outer layer rich in amorphous cu_(x)O(a-cu_(x)O)with higher oxygen content,are derived from discarded printed circuit *** employed in glucose detection,the h-cu_(x)O nano-skeletons undergo a structural evolution process,transitioning into rigid cu_(2)O@cuO nano-skeletons prompted by electrochemical *** transformation yields exceptional glucose-sensing performance(sensitivity:9.893 mA mM^(-1) cm^(-2);detection limit:0.34μM),outperforming most previously reported glucose *** functional theory analysis elucidates that the heterogeneous structure facilitates gluconolactone *** glucose detection device has also been downsized to optimize its scalability and portability for convenient integration into people’s everyday lives.

关键词： copper oxide Electron 3D tomography E-waste Glucose detection Electrochemical activation

comparing 11 early warning scores and three shock indices in early sepsis prediction in the emergency department

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World Journal of Emergency Medicine 2024年第4期15卷 273-282页

作者： Rex Pui Kin Lam Zonglin Dai Eric Ho Yin Lau carrie Yuen Ting Ip Ho ching chan Lingyun Zhao Tat chiTsang Matthew Sik hon Tsui Timothy Hudson Rainer Department of Emergency Medicine School of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina

BAcKGROUND:This study aimed to evaluate the discriminatory performance of 11 vital sign-based early warning scores(EWSs)and three shock indices in early sepsis prediction in the emergency department(ED).METHODS:We performed a retrospective study on consecutive adult patients with an infection over 3 months in a public ED in hong *** primary outcome was sepsis(Sepsis-3 definition)within 48 h of ED *** c-statistics and the DeLong test,we compared 11 EWSs,including the National Early Warning Score 2(NEWS2),Modified Early Warning Score,and Worthing Physiological Scoring System(WPS),etc.,and three shock indices(the shock index[SI],modified shock index[MSI],and diastolic shock index[DSI]),with Systemic Inflammatory Response Syndrome(SIRS)and quick Sequential Organ Failure Assessment(qSOFA)in predicting the primary outcome,intensive care unit admission,and mortality at different time ***:We analyzed 601 patients,of whom 166(27.6%)developed ***2 had the highest point estimate(area under the receiver operating characteristic curve[AUROc]0.75,95%cI 0.70-0.79)and was significantly better than SIRS,qSOFA,other EWSs and shock indices,except WPS,at predicting the primary ***,the pooled sensitivity and specificity of NEWS2≥5 for the prediction of sepsis were 0.45(95%cI 0.37-0.52)and 0.88(95%cI 0.85-0.91),*** discriminatory performance of all EWSs and shock indices declined when used to predict mortality at a more remote time ***:NEWS2 compared favorably with other EWSs and shock indices in early sepsis prediction but its low sensitivity at the usual cut-off point requires further modification for sepsis screening.

关键词： Sepsis Emergency department clinical prediction rule Early warning score Shock index

Impact of Planted Mangrove Species on Biomass carbon and Other Structural Attributes in Ayeyarwady Region

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Open Journal of Forestry 2024年第1期14卷 98-116页

作者： Aung Wunna Tun wai Nyein Aye School of Ecology and Nature conservation Beijing Forestry University Beijing China School of Forestry Beijing Forestry University Beijing China

This study examines the impact of different mangrove species on the structure and carbon storage potential of mangrove stands in Myanmar. We focused on three species: Avicennia officinalis, Avicennia marina and Bruguiera sexangula. These species were selected for their fast growth, ability to protect against cyclones, and effectiveness in coastal defense during mangrove restoration. To collect data on tree structure and carbon storage, we conducted field surveys measuring parameters such as diameter at breast height (DBH), tree height and crown diameter for each tree. Non-destructive methods were used for data collection. Using ANOVA and post-hoc multiple comparison tests, we assessed differences in structure and carbon stock among the three species. Regression analysis was also performed to understand the relationship between carbon stock and structural attributes. In terms of stand densities, we observed variations among species, with pioneer stage plantations exhibiting higher densities compared to mature stands. Seedlings showed sufficient regeneration, supporting the sustainability of the forest. Biomass accumulation varied across species, with A. officinalis having the highest average biomass. Aboveground biomass showed a strong correlation with basal area. A. officinalis had the highest total biomass carbon accumulation at 55.29 ± 20.91 Mg c ha-1, with 77.43% aboveground carbon and 22.57% belowground carbon. A. marina stored 41.09 ± 11.03 Mg c ha-1, with a similar distribution of 76.05% aboveground and 23.95% belowground carbon, while B. sexangula stored 23.23 ± 3.12 Mg c ha-1, with 70.70% aboveground carbon and 29.30% belowground carbon. The amount of aboveground carbon was a significant portion of the overall carbon storage and correlated with tree density, diameter, basal area and height. Our findings highlight the importance of selecting suitable species and considering structural attributes for mangrove restoration and ca

关键词： Species Selection Biomass carbon Storage Ayeyarwady Region Myanmar

Prevalence and risk factors for impaired renal function among Asian patients with nonalcoholic fatty liver disease

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 241-248页

作者： chao Sun George Boon-Bee Goh Wan-cheng chow Wah-Kheong chan Grace Lai-Hung Wong wai-Kay Seto Yi-Hsiang Huang Han-chieh Lin I-cheng Lee Hye Won Lee Seung Up Kim Vincent wai-Sun Wong Jian-Gao Fan center for Fatty Liver Disease Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghai 200092China Department of Gastroenterology&Hepatology Singapore General HospitalSingaporeSingapore Gastroenterology and Hepatology Unit Department of MedicineFaculty of MedicineUniversity of MalayaKuala LumpurMalaysia Department of Medicine and Therapeutics and State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina Institute of clinical Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Division of Gastroenterology and Hepatology Taipei Veterans General HospitalTaipeiTaiwanChina Faculty of Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Department of Internal Medicine Yonsei University College of MedicineSeoulKorea

Background:Nonalcoholic fatty liver disease(NAFLD)is associated with impaired renal function,and both diseases often occur alongside other metabolic ***,the prevalence and risk factors for impaired renal function in patients with NAFLD remain *** objective of this study was to identify the prevalence and risk factors for renal impairment in NAFLD ***:All adults aged 18-70 years with ultrasound-diagnosed NAFLD and transient elastography examination from eight Asian centers were enrolled in this prospective *** fibrosis and cirrhosis were assessed by FibroScan-aspartate aminotransferase(FAST),Agile 3+and Agile 4 *** renal function and chronic kidney disease(cKD)were defined by an estimated glomerular filtration rate(eGFR)with value ofctively,as estimated by the cKD-Epidemiology collaboration(cKD-EPI)***:Among 529 included NAFLD patients,the prevalence rates of impaired renal function and cKD were 37.4%and 4.9%,*** multivariate analysis,a moderate-high risk of advanced liver fibrosis and cirrhosis according to Agile 3+and Agile 4 scores were independent risk factors for cKD(Pcreased fasting plasma glucose(FPG)and blood pressure were significantly associated with impaired renal function after controlling for the other components of metabolic syndrome(Pcompared with patients with normoglycemia,those with prediabetes[FPG≥5.6 mmol/L or hemoglobin A1c(HbA1c)≥5.7%]were more likely to have impaired renal function(Pconclusions:Agile 3+and Agile 4 are reliable for identifying NAFLD patients with high risk of *** glycemic control in the prediabetic stage might have a potential renoprotective role in these patients.

关键词： Nonalcoholic fatty liver disease Impaired renal function Agile 3+ Agile 4 Metabolic syndrome

Histone demethylase Kdm5c regulates osteogenesis and bone formation via PI3K/Akt/HIF1α and Wnt/β-catenin signaling pathways

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Genes & Diseases 2024年第1期11卷 64-66页

作者： Ying Li Lingli Ding Yage Zhang Bingyu Zhou Gene chi wai Man Min Wang Jinglan Li Yamei Liu Weiping Lin Haibin Wang Sien Lin Liangliang Xu Key Laboratory of Orthopaedics&Traumatology Lingnan Medical Research CenterThe First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou University of Chinese MedicineGuangzhouGuangdong 510000China Department of Orthopaedics&Traumatology Faculty of MedicineThe Chinese University of Hong KongPrince of Wales HospitalShatinHong Kong SAR 999077China Departments of Diagnostics of Traditional chinese Medicine Guangzhou University of Chinese MedicineGuangzhouGuangdong 510000China Orthopaedic Research Lab Affiliated Hospital of Guangdong Medical UniversityGuangdong Medical UniversityZhanjiangGuangdong 524001China

Fractures have an extraordinarily negative impact on individuals'quality of life and functional *** or disability of fracture is a major health issue with important clinical,social,and economic implications.1 Mesenchymal stem cells(MScs)play an indispensable role in the initiation of the fracture repair process including the formation of a callus which is replaced by new *** use of MScs in the treatment of fractures is very attractive as they can reduce the time of healing and occurrence of nonunion.

关键词： PI3K/Akt HIF1α healing

Outcomes of combined mitochondria and mesenchymal stem cellsderived exosome therapy in rat acute respiratory distress syndrome and sepsis

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World Journal of Stem cells 2024年第6期16卷 690-707页

作者： Kun-chen Lin Wen-Feng Fang Jui-Ning Yeh John Y chiang Hsin-Ju chiang Pei-Lin Shao Pei-Hsun Sung hon-Kan Yip Department of Anesthesiology Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Division of Pulmonary and critical care Medicine Department of Internal MedicineKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung 83301TaiwanChina Department of cardiology The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of computer Science and Engineering National Sun Yat-sen UniversityKaohsiung 804201TaiwanChina Department of Healthcare Administration and Medical Informatics Kaohsiung Medical UniversityKaohsiung 80708TaiwanChina School of Medicine Chung Shan Medical UniversityTaichung 40201TaiwanChina Department of Nursing Asia UniversityTaichung 41354TaiwanChina Division of cardiology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301TaiwanChina Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina center for Shockwave Medicine and Tissue Engineering Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402TaiwanChina School of Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

BAcKGROUND The treatment of acute respiratory distress syndrome(ARDS)complicated by sepsis syndrome(SS)remains *** To investigate whether combined adipose-derived mesenchymal-stem-cells(ADMScs)-derived exosome(EXAD)and exogenous mitochondria(mitoEx)protect the lung from ARDS complicated by *** In vitro study,including L2 cells treated with lipopolysaccharide(LPS)and in vivo study including male-adult-SD rats categorized into groups 1(sham-operated-control),2(ARDS-SS),3(ARDS-SS+EXAD),4(ARDS-SS+mitoEx),and 5(ARDS-SS+EXAD+mitoEx),were included in the present *** In vitro study showed an abundance of mitoEx found in recipient-L2 cells,resulting in significantly higher mitochondrial-cytochrome-c,adenosine triphosphate and relative mitochondrial DNA levels(Pcrosis factor(TNF)-α/nuclear factor-κB/toll-like receptor(TLR)-4/matrix-metalloproteinase(MMP)-9/oxidative-stress(NOX-1/NOX-2)/apoptosis(cleaved-caspase3/cleaved-poly(ADP-ribose)polymerase)]were significantly attenuated in lipopolysaccharide(LPS)-treated L2 cells with EXAD treatment than without EXAD treatment,whereas the protein expressions of cellular junctions[occluding/β-catenin/zonula occludens(ZO)-1/E-cadherin]exhibited an opposite pattern of inflam-mation(all Pction,and lung tissues were *** 72 h,flow cytometric analysis of bronchoalveolar lavage fluid demonstrated that the levels of inflam-matory cells(Ly6G+/cD14+/cD68+/cD11b/c+/myeloperoxidase+)and albumin were lowest in group 1,highest in group 2,and significantly higher in groups 3 and 4 than in group 5(all PcD68+/γ-H2AX)displayed an identical pattern of SaO2%among the groups(all P<0.0001).The pro

关键词： Acute respiratory distress syndrome Sepsis syndrome Exosomes Mitochondria Adipose tissue-derived mesenchymal stem cells Inflammation

Immunoregulatory and Anti-cancer Activities of combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast cancer Bearing Mice

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chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu Kan Ben chung-Lap chan Grace Gar-Lee Yue LI Pei-ting Sharon Sze-Man hon HUANG Dan-qi Miranda Sin-Man Tsang clara Bik-San Lau Ping-chung Leung chun-Kwok Wong Institute of chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of chemical Pathology The Chinese University of Hong KongHong Kong SARChina china-Australia International Research centre for chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio chin R&D centre for chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TNBc).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(Pcyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as c-c motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(Pcin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines chinese medicine tumor microenvironment

NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma

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cancer communications 2024年第2期44卷 251-272页

作者： Yue Yao Yi Xu Liang Yu Ting-Mao Xue Zhi-Jie Xiao Pui-chi Tin Hiu-Ling Fung Hoi-Tang Ma Jing-Ping Yun Judy wai Ping Yam Department of Pathology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongP.R.China Department of Endocrinology and Metabolism Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China Department of Hepatopancreatobiliary Surgery Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China State Key Laboratory of Oncology in South china Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Hepatobiliary Surgery II Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Scientific Research center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdongP.R.China State Key Laboratory of Liver Research The University of Hong KongHong KongP.R.China Department of Pathology Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Small extracellular vesicles(sEVs)mediate intercellular commu-nication that contributes to hepatocellular carcinoma(Hcc)progression via multifaceted *** success of cell entry determines the effect of sEV on recipient ***,we aimed to delineate the mechanisms underlying the uptake of sEV in ***:AF,Alexa Fluor;ANOVA,analysis of variance;ATP9A,ATPase Phospholipid Transporting 9A;BcEcF-AM,2’,7’-bis-(2-barboxyethyl)-5-(and-6)-carboxyfluorescein,acetoxymethyl ester;BSA,bovine serum albumin;ccMR,centre for comparative Medicine Research;cRISPR,clustered regularly interspaced short palindromic repeats;cTL,ctrl;cXcR4,c-X-c chemokine Receptor Type 4;DAPI,4′,6-diamidino-2-phenylindole;DFS,disease-free survival;DMEM,Dulbecco’s Modified Eagle Medium;DMSO,dimethyl sulfoxide;Dox,doxycycline;EEA1,early endosome antigen 1;EIPA,5-(N-ethyl-N-isopropyl)-amiloride;FBS,fetal bovine serum;FITc,fluorescein isothiocyanate;GAPDH,glyceraldehyde-3-phosphate dehydrogenase;GM130,Golgi matrix protein 130;Hcc,hepatocellular carcinoma;HEPES,4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid;HPRT1,hypoxanthine phosphoribosyltransferase 1;H-score,histoscore;IAA,indole-3-acetic acid;KD,knockdown;KO,knockout;mAID,mini-auxin-inducible degron;MTT,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide;NHE7,Na(+)/H(+)exchanger 7;ns,non-significant;OD,optical density;OS,overall survival;PBS,phosphate-buffered saline;PcR,polymerase chain reaction;pHe,endosomal pH;pHi,intracellular pH;PKH67,Paul Karl Horan 67;Rab21,Ras-associated binding protein 21;RIPA,radioimmunoprecipitation assay;SAM,synergistic activation mediator;SEMs,standard error of the means;sEVs,small extracellular vesicles;sgRNA,single-guide RNA;shRNA,short-hairpin RNA;SLc9,solute carrier gene 9;SLicE,Seamless Ligation cloning Extract;TcGA,The cancer Genome Atlas;TcL,total cell lysates;TGN,trans-Golgi network;TMA,tissue microarray;TMR,tetramethyl rhodamine;TSG101,tumor susceptibility gene *** Yao an

关键词： hepatocellular carcinoma small extracellular vesicles macropinocytosis pH regulation sodium-hydrogen exchanger

香港地区中学文凭考试诊断反馈系统的开发及改进

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中国考试 2024年第2期 40-46页

作者：禤美瑶萧伟乐周钜宽杨汉基席小明香港考试及评核局中国香港999077

为进一步推动“评核促进学习”,香港地区考试及评核局以历年香港地区中学文凭考试(HKDSE)的评核数据为基础开发了HKDSE诊断反馈系统。目前,该系统结合HKDSE 6个科目选择题的试题库,对学生学习表现数据加以分析并建立统计模型,为教师与... 详细信息

为进一步推动“评核促进学习”,香港地区考试及评核局以历年香港地区中学文凭考试(HKDSE)的评核数据为基础开发了HKDSE诊断反馈系统。目前,该系统结合HKDSE 6个科目选择题的试题库,对学生学习表现数据加以分析并建立统计模型,为教师与学生提供诊断性反馈报告,突出学生在不同能力或范畴的不足与强项。来自14所学校的约2200名学生及教师试用了该系统,通过问卷调查和访谈法,收集意见建议,以改进系统设计。系统改良版在“数据主导评核提升计划”中正式推出,辅之以学科教师培训,以帮助学校提升评核质量。

关键词：香港地区中学文凭考试诊断反馈评核促进学习个性化学习