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A cross-sectional study on compliance with topical glaucoma medication and its associated socioeconomic burden for a Chinese population

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 293-299页

作者： Man-Hin Lui Jason Chun Ho lam Yi Lee Kwong Tak Siu Wong Pak Long Cheung Sherri Shun Yan Lai Pak Lun Yuen wai yiu lam Ho Yan Chan yiu Fai Wong Jimmy Shiu Ming Lai Kendrick Co Shih Li Ka Shing Faculty of Medicine the University of Hong KongPokfulamHong KongChina Department of Ophthalmology Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHongKongChina Department of Ophthalmology Queen Mary HospitalPokfulamHong KongChina

AIM： To estimate the overall drug compliance for local Chinese glaucoma patients on long-term topical ***： This was a retrospective cross-sectional ***-seven primary glaucoma patients from the subspecialty clinic of a publicly-funded tertiary care hospital in Hong Kong completed a questionnaire on compliance with topical glaucoma medication,attitude towards glaucoma and therapy and vision related quality of *** was defined as reporting missing more than or equal to 10% of the prescribed topical glaucoma medication during the 2wk immediately prior to the *** between noncompliance and demographics,attitude,disease and treatment status was *** was estimated with quality of life and direct medical cost involved with *** logistic regression on noncompliance was performed on selected ***： Compliance was calculated as 75%（95% CI： 64%-87%） among 57 subjects（mean age 69 y,female 51%）.No statistical significant relationship was established between noncompliance and any single factors or ***（P=0.048） and forgetfulness（P=0.064） were found to be marginally significant predictive factors on noncompliance in multivariable logistic *** might be related（P=0.130） to poorer self-rated vision-associated quality of *** societal cost of noncompliance was estimated to be over 2510 life-years and US$ 3.7 million ***： The compliance of Chinese glaucoma patients in Hong Kong is comparable to other parts in the world,and carries detrimental impacts on individual and societal *** and forgetfulness are two possible independent predictors for noncompliance.

关键词： glaucoma eye drop compliance quality of life

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Effect of Rorrico, extracted from group of Chinese medicines, on influenza A and H1N1 infections

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Journal of Traditional Chinese Medicine 2016年第6期36卷 701-705页

作者： Shiu Hon Chui Yee Hou Wong Ming yiu Fong Yee Man Chiu Christopher wai Kei lam State Key Laboratory of Quality Research in Chinese Medicine Macao Institute for Applied Research in Medicine and Health Macao University of Science and Technology Clinical Laboratory Diagnostix Medical Center Central

OBJECTIVE: To investigate the therapeutic and preventive effects of Rorrico on influenza, especially influenza A viral infection, including swine flu(H1N1)in ***: Eighty-nine subjects were recruited in Hong Kong and Macao, and divided into treatment group(TG) and prevention group(PG) based on their influenza A and swine flu symptoms. All subjects were prescribed Rorrico or placebo, and monitored by a Chinese medicine practitioner. Blood samples were collected before and after 7-day Rorrico or placebo treatment for laboratory ***: After treatment, there were some full recoveries and obvious relief of onset symptoms in the TG. Blood test results showed that Rorrico produced(a) no adverse effects on subjects' renal andliver functions, muscle enzyme and hematological status,(b) no up-regulation of pro-inflammatory cytokines tumour necrosis factor-a and interleukin-18 in both TG and PG,(c) mild yet statistically significant elevation of plasma mannose-binding lectin(MBL) in ***: Rorrico has no up-regulating effect on the participants' immune response, or, equally likely, the immuno-modulatory effects of Rorrico do not non-specifically or unnecessarily promote inflammation when not required. It is possible that oral administration of Rorrico can promote hepatic synthesis of MBL in healthy PG subjects, thereby conferring increased protection against infection.

关键词： Rorrico Influenza A Virus H1N1 Subtype Tumor necrosis factor-alpha Interleukin-18

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Arsenic Accumulation in Rice:Sources,Human Health Impact and Probable Mitigation Approaches

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Rice science 2022年第4期29卷 309-327页

作者： Md ROKONUZZAMAN LI wai Chin MAN Yu Bon TSANG yiu Fai YE Zhihong Department of Science and Environmental Studies the Education University of Hong KongHong Kong 999077China School of Life Sciences Sun Yat-Sen UniversityGuangzhou 510006China

The human body loading with arsenic(As)through rice consumption is a global health *** is a crucial need to limit As build-up in rice,either by remediating As accumulation in soils or reducing As levels in irrigation *** conventional approaches have been utilized to alleviate the As accumulation in ***,except for some irrigation practices,those approaches success and the adoption rate are not *** review presents human health risks posed due to consumption of As contaminated rice,evaluates different biomarkers for tracing As loading in the human body,and discusses the latest advancement in As reducing technologies emphasizing the application of seed priming,nanotechnology,and biochar application for limiting As loading in rice *** also evaluate different irrigation techniques to reduce As accumulation in *** water management regimes significantly reduces grain As ***-and nano-priming of rice seeds improve germination and minimize As translocation in rice tissues by protecting cell membrane,building pool around seed coat,methylation and volatilization,or quenching harmful effects of reactive oxygen *** application in the form of nano-adsorbents or nano-fertilizers facilitates nano-remediation of As through the formation of Fe plaque or sorption or oxidation *** biochar in the rice fields significantly reduces As through immobilization,physical adsorption,or surface *** conclusion,As content in cooked rice depends on irrigation source and raw rice As level.

关键词： arsenic rice scalp hair irrigation management seed priming nanotechnology biochar human health

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Economic Growth, Energy Use, and Greenhouse Gases Emission in Macao SAR, China

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Chinese Journal of Urban and Environmental Studies 2022年第1期10卷 23-43页

作者： wai Ming TO King Hang lam School of Business Macao Polytechnic Institute Department of Electrical and Electronic Engineering The University of Hong Kong

A city’s economic structure and energy mix would change when the city is developed to accommodate more residents, visitors, and activities. This paper reviews Macao’s economic growth, energy use, and greenhouse gases(GHG) emission from 1985 to 2020. Specifically, Macao’s gross domestic product(GDP), energy use, and GHG emission have surged after the gaming industry was liberalized in *** official data show that Macao’s GDP was MOP 11 billion in 1985, increased by four-fold to MOP54 billion in 2000, and then surged rapidly to MOP 445 billion in 2019. Additionally, Macao’s total energy use increased from 8,840 TJ in 1985 to 48,330 TJ in 2019 while Macao’s GHG emission increased from 0.70 Mt of CO2-equivalent in 1985 to 6.13 Mt of CO2-equivalent in 2019. Macao’s GHG emission from all local sources per capita and GDP per capita exhibit an inverted U-shaped relationship, showing an environmental Kuznets curve. Due to the negative impact of COVID-19pandemic, Macao’s GDP dropped by 56% to MOP 194 billion while its total energy use and GHG emission dropped by 33% and 17% to 32,198 TJ and 5.06 Mt of CO2-equivalent, respectively, in 2020.

关键词： Economic growth energy use greenhouse gases environmental Kuznets curve COVID-19

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Virtual reality based multiple life skill training for intellectual disability:A multicenter randomized controlled trial

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Engineered Regeneration 2022年第2期3卷 121-130页

作者： James Chung-wai Cheung Ming Ni Andy yiu-Chau Tam Tim Tin-Chun Chan Alyssa Ka-Yan Cheung Ocean Yu-Hong Tsang Chi-Bun Yip Wing-Kai lam Duo wai-Chi Wong Department of Biomedical Engineering Faculty of EngineeringThe Hong Kong Polytechnic UniversityHong Kong 999077China Research Institute for Smart Ageing The Hong Kong Polytechnic UniversityHong Kong 999077China Jockey Club Smart Ageing Hub Department of Biomedical EngineeringFaculty of EngineeringThe Hong Kong Polytechnic UniversityHong Kong 999077China Department of Orthopaedics Pudong New Area People’s Hospital Affiliated to Shanghai Jiaotong UniversityShanghai 201299China Social Service Department Yan Chai HospitalHong Kong 999077China C2 Innovations and Research Limited Hong Kong 999077China Department of Kinesiology Shenyang Sport UniversityShenyang 110102China Sports Information and External Affairs Centre Hong Kong Sports InstituteHong Kong 999077China

Life skill-based training is essential for intellectual disabled individuals to regain autonomy and social *** reality(VR)could deliver a nascent application that is more engaging and *** objective of this study was to evaluate the training effects of the VR-based multiple life skill training program on life skill perfor-mance,self-efficacy,memory,cognitive and behavioral functions via a multicenter randomized controlled trial.A total of 145 intellectual disabled participants were recruited for a randomized controlled trial with three in-tervention arms:VR(n=42);traditional(n=53);and control(n=50).The life skill tasks for the interventions included 1)grocery shopping,2)cooking,and 3)kitchen *** measures were performance scores for the three tasks,self-efficacy scale,digit span score,and Frontal Assessment Battery score,graded by blinded ***-after effects of each group were evaluated using separated Wilcoxon Signed-rank *** sig-nificantly improved cooking,cleaning performance,and memory span,while traditional training significantly improved shopping,cooking,and cleaning *** generalized estimating equation evaluated effects between groups adjusted for age,gender and intelligence quotient(IQ).VR had significantly larger improvement effects in cooking and cleaning than the control group and memory span compared to traditional training and controls *** appeared to be a significant confounder on the training *** work may consider developing artificial intelligence to customize programs depending on IQ level.

关键词： Mental retardation Intellectual development X-reality Immersive rehabilitation Metaverse

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p53-independent pRB degradation contributes to a drug-induced apoptosis in AGS cells

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Cell Research 2005年第9期 20-28页

作者： wai Keung LEUNG,Joseph Jao-yiu SUNG Department of Medicine and Therapeutics The Chinese University of Hong Kong Prince of Wales Hospital Shatin Hong Kong SAR China Department of Medicine and Therapeutics The Chinese University of Hong Kong Prince of Wales Hospital Shatin Hong Kong SAR China

The retinoblastoma (RB) tumor suppressor protein, pRB, plays an important role in the regulation of mammalian cell cycle. Furthermore, several lines of evidence suggest that pRB also involves in the regulation of apoptosis. In the present study, the degradation of pRB was observed in apoptotic gastric tumor cells treated with a new potent anti-tumor component, tripchlorolide (TC). The inhibition of pRB degradation by a general cysteine protease inhibitor IDAM resulted in the reduction of the apoptotic cells. Furthermore, the survival of the gastric tumor cells under the TC treatment was enhanced by an over-expression of exogenous pRB. These results suggest that the pRB degradation of the gastric tumor cells under the TC treatment involves in the apoptotic progression. In addition, the same extent of TC- induced pRB-degradation was detected in the gastric tumor cells containing a p53 dominant-negative construct, indicat- ing that this kind of pRB degradation is p53-independent.

关键词： pRB degradation p53 apoptosis.

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Insight into evolution of invasive patterns on fingering phenomenon during immiscible two-phase flow through pore structure

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Petroleum Science 2024年第5期21卷 3307-3325页

作者： Yu Li Hui-Qing Liu Chao Peng Peng Jiao wai lam Loh Qing Wang State Key Laboratory of Petroleum Resources and Engineering China University of PetroleumBeijing102249China Department of Mechanical Engineering National University of Singapore117575Singapore Oil and gas production Business Department Kunlun Shuzhi Technology Co.LTDBeijing100040China

Understanding fingering, as a challenge to stable displacement during the immiscible flow, has become a crucial phenomenon for geological carbon sequestration, enhanced oil recovery, and groundwater protection. Typically governed by gravity, viscous and capillary forces, these factors lead invasive fluids to occupy pore space irregularly and incompletely. Previous studies have demonstrated capillary numbers,describing the viscous and capillary forces, to quantificationally induce evolution of invasion *** the evolution mechanisms of invasive patterns have not been deeply elucidated under the constant capillary number and three variable parameters including velocity, viscosity, and interfacial *** research employs two horizontal visualization systems and a two-phase laminar flow simulation to investigate the tendency of invasive pattern transition by various parameters at the pore scale. We showed that increasing invasive viscosity or reducing interfacial tension in a homogeneous pore space significantly enhanced sweep efficiency, under constant capillary number. Additionally, in the fingering crossover pattern, the region near the inlet was prone to capillary fingering with multi-directional invasion, while the viscous fingering with unidirectional invasion was more susceptible occurred in the region near the outlet. Furthermore, increasing invasive viscosity or decreasing invasive velocity and interfacial tension promoted the extension of viscous fingering from the outlet to the inlet, presenting that the subsequent invasive fluid flows toward the outlet. In the case of invasive trunk along a unidirectional path, the invasive flow increased exponentially closer to the outlet, resulting in a significant decrease in the width of the invasive interface. Our work holds promising applications for optimizing invasive patterns in heterogeneous porous media.

关键词： Immiscible two-phase flow Fingering phenomenon Invasive pattern Capillary number Parameters optimization

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Smart phone apps every ophthalmologist should know about

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International Journal of Ophthalmology(English edition) 2020年第8期13卷 1329-1333页

作者： Ming Yang Amy Cheuk Yin Lo wai Ching lam Department of Ophthalmology Li Ka Shing Faculty of Medicinethe University of Hong KongHong Kong Special Administrative Region 999077China

We are living in a mobile world,where the number of medical apps is surging in recent *** 320000 healthcare apps are now available as shown in the latest *** major function and potential of these apps vary,from assisting the learning and practice of clinicians as well as achieving better outcomes of patients to preventing eye diseases through the education of healthy ***,based on the various features,ophthalmology apps nowadays contain a wide range of subjects and focus on dif ferent stakeholder s in the ophthalmic practice,including but not limited to doctors,patients,and ***,we review special and advanced apps that ophthalmologists will find useful in their clinical practice.

关键词： applications healthcare clinic ophthalmology ophthalmologist

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Dipyridyl Azo Compound 4,4'-Azopyridine as a Potential Coating Material for Toilet Sanitizer

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Chemical Research in Chinese Universities 2023年第6期39卷 864-869页

作者： WANG Qiwei JIANG Lu lam Pik-Ling CHUI Chung-Hin WONG wai-Yeung Antibiotics Research and Reevaluation Key Laboratory of Sichuan Province Sichuan Industrial Institute of AntibioticsChengdu UniversityChengdu 610052P.R.China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomHong KongP.R.China Research and Development Division One Health International LimitedHong KongP.R.China

Good toilet hygiene can reduce the risk of pathogenic *** flushing,pathogenic bacteria can be spread by the water droplets,especially in the toilet *** coli(***)is one of the frequently occurring Gram-negative bacterial pathogens found in the toilet *** this study,we investigated the potential *** activity of some azobenzene *** them,compound 2,with the heterocyclic nitrogen in both phenyl rings,showed the strongest antibacterial effect on ***,with the minimum inhibitory concentration of 80μg/mL and the minimum bactericidal concentration of 320μg/*** 2 displayed a comparative zone of clearance[(14.50±2.29)mm]to that of ampicillin[(13.17±1.76)mm].The reactive oxygen species(ROS)assay suggested that compound 2 might induce the loss of bacteria via the oxidative stress by eliciting the generation of intracellular *** further examined the potential cytotoxicity of compound 2 to the human skin HaCaT *** 2-treated skin cells showed a good maintenance of cellular morphology and a clear definition of cell nuclei,with a satisfactory cell viability(ca.90%)at 80μg/***,compound 2 would be a possible antibacterial coating agent for the surface sanitizer of the toilet seats to inhibit the growth of ***.

关键词： Antibacterial Azobenzene Escherichia coli Skin cytotoxicity Toilet seat

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Ferroptosis and glaucoma: implications in retinal ganglion cell damage and optic nerve survival

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Neural Regeneration Research 2023年第3期18卷 545-546页

作者： Ming Yang Kwok-Fai So wai-Ching lam Amy Cheuk Yin Lo Department of Ophthalmology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administrative RegionChina GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Glaucoma and visual pathway degeneration:Glaucoma is the leading cause of irreversible blindness worldwide,which leads to a progressive loss of *** can be classified into two types:primary open-angle glaucoma and primary closed-angle *** open-angle glaucoma can be caused by the blockage of the trabecular meshwork,and this results in elevation of the intraocular pressure(IOP),leading to retinal ganglion cell(RGC)***,many glaucoma patients have normal IOP;this is known as normal-tension ***,excitotoxic damage and oxidative stress can also lead to RGC damage in normal-tension glaucoma(Almasieh et al.,2012).Glaucomatous genes such as TIGR,OPTN,and CYP1B1 have been suggested to contribute to the pathogenesis of ***,some glaucomatous patients may remain asymptomatic in the early,moderate,and late *** type of glaucoma is primary closed-angle *** this clinical condition,a relative pupillary block is contributed by the iris obstructing aqueous *** patients may suffer from corneal swelling,headache,nausea,and blurred vision during the acute phase.

关键词： glaucoma damage degeneration

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