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Di-and tri-methylation of histone H3K36 play distinct roles in DNA double-strand break repair

Science China(Life Sciences) 2024年第6期67卷 1089-1105页

作者： Runfa Chen Meng-Jie Zhao Yu-Min Li Ao-Hui Liu Ru-Xin Wang Yu-Chao mei Xuefeng Chen Hai-ning Du Hubei Key Laboratory of Cell Homeostasis College of Life SciencesTaiKang Center for Life and Medical SciencesFrontier Science Center for Immunology and MetabolismHubei Clinical Research Center of Emergency and ResuscitationEmergency Center of Zhongnan HospitalWuhan UniversityWuhan 430072China Hubei Key Laboratory of Cell Homeostasis College of Life SciencesTaiKang Center for Life and Medical SciencesFrontier Science Center for Immunology and MetabolismWuhan UniversityWuhan 430072China

Histone H3 Lys36(H3K36)methylation and its associated modifiers are crucial for DNA double-strand break(DSB)repair,but the mechanism governing whether and how different H3K36 methylation forms impact repair pathways is ***,we unveil the distinct roles of H3K36 dimethylation(H3K36me2)and H3K36 trimethylation(H3K36me3)in DSB repair via non-homologous end joining(NHEJ)or homologous recombination(HR).Yeast cells lacking H3K36me2 or H3K36me3 exhibit reduced NHEJ or HR efficiency.y Ku70 and Rfa1 bind H3K36me2-or H3K36me3-modified peptides and chromatin,*** these interactions impairs y Ku70 and Rfa1 recruitment to damaged H3K36me2-or H3K36me3-rich loci,increasing DNA damage sensitivity and decreasing repair ***,H3K36me2-enriched intergenic regions and H3K36me3-enriched gene bodies independently recruit y Ku70 or Rfa1 under DSB ***,human KU70 and RPA1,the homologs of y Ku70 and Rfa1,exclusively associate with H3K36me2 and H3K36me3 in a conserved *** findings provide valuable insights into how H3K36me2 and H3K36me3 regulate distinct DSB repair pathways,highlighting H3K36 methylation as a critical element in the choice of DSB repair pathway.

关键词： histone H3K36 methylation Ku70 RPA non-homologous end joining homologous recombination

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Subgroups of peripheral immune effector cells in cervical cancer patients are more sensitive to radiation therapy than chemotherapy

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Cancer Advances 2024年第3期7卷 1-7页

作者： ning Zhao Dong-mei Han Cai-Hong Wu Hao Jin National Clinical Research Center for Cancer Tianjin Cancer Hospital Airport HospitalTianjin 300308China Center for Precision Cancer Medicine&Translational Research Tianjin Cancer Hospital Airport HospitalTianjin 300308China Oncology Department Tianjin Cancer Hospital Airport HospitalTianjin 300308China.

Background:CD8 positive T lymphocytes and natural killer(NK)cells in the peripheral blood of cervical cancer patients exhibit varying sensitivities to radiotherapy and ***:A total of 50 healthy peoples and 60 cervical cancer patients were *** patients with cervical cancer were separated into two groups:radiation and chemotherapy,and blood sample were collected before and after *** on the proportion of CD8 positive T lymphocytes and NK cells were gathered for analytical ***:Compared to healthy individuals,patients with cervical cancer exhibit a reduced proportion of CD8 positive T cells within their peripheral *** for patients with cervical cancer,radiation therapy has been found to be more effective than chemotherapy in increasing the proportion of CD8 positive T lymphocytes and NK ***:These results suggest that radiation therapy increases the levels of CD8 positive T lymphocytes and NK cells within the peripheral blood of patients with cervical *** study hypothesis that the changes in the percentage of CD8 positive T lymphocytes may serve as a potential indicator for predicting treatment efficacy.

关键词： CD8 positive T lymphocytes flow cytometry natural killer cells radiotherapy uterine cervical neoplasms

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Prohibitin 1 inhibits cell proliferation and induces apoptosis via the p53-mediated mitochondrial pathway in vitro

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 398-413页

作者： Juan-Juan Shi Yi-Kai Wang Mu-Qi Wang Jiang Deng ning Gao mei Li Ya-Ping Li Xin Zhang Xiao-Li Jia Xiong-Tao Liu Shuang-Suo Dang Wen-Jun Wang Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Department of Operating Room The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina

BACKGROUND Prohibitin 1(PHB1)has been identified as an antiproliferative protein that is highly conserved and ubiquitously expressed,and it participates in a variety of essential cellular functions,including apoptosis,cell cycle regulation,prolifera-tion,and *** evidence indicates that PHB1 may play an important role in the progression of hepatocellular carcinoma(HCC).However,the role of PHB1 in HCC is *** To investigate the effects of PHB1 on the proliferation and apoptosis of human HCC cells and the relevant mechanisms in *** HCC patients and healthy individuals were enrolled in this study according to the inclusion and exclusion criteria;then,PHB1 levels in the sera and liver tissues of these participates were determined using ELISA,RT-PCR,and *** HepG2 and SMMC-7721 cells were transfected with the pEGFP-PHB1 plasmid and PHB1-specific shRNA(shRNA-PHB1)for 24-72 *** prolif-eration was analysed with an MTT *** cycle progression and apoptosis were analysed using flow cytometry(FACS).The mRNA and protein expression levels of the cell cycle-related molecules p21,Cyclin A2,Cyclin E1,and CDK2 and the cell apoptosis-related molecules cytochrome C(Cyt C),p53,Bcl-2,Bax,caspase 3,and caspase 9 were measured by real-time PCR and Western blot,*** Decreased levels of PHB1 were found in the sera and liver tissues of HCC patients compared to those of healthy individuals,and decreased PHB1 was positively correlated with low differentiation,TNM stage III-IV,and alpha-fetoprotein≥400μg/*** of PHB1 significantly inhibited human HCC cell proliferation in a time-dependent *** revealed that the overexpression of PHB1 arrested HCC cells in the G0/G1 phase of the cell cycle and induced *** proportion of cells in the G0/G1 phase was significantly increased and the proportion of cells in the S phase was decreased in HepG2 cells that were transfected with pEGFP-PHB1 compar

关键词： Prohibitin 1 Hepatocellular carcinoma cells Apoptosis Cell cycle Mitochondrial pathway

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Efficacy of hepatic arterial infusion chemotherapy and its combination strategies for advanced hepatocellular carcinoma:A network meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3672-3686页

作者： Shun-An Zhou Qing-mei Zhou Lei Wu Zhi-Hong Chen Fan Wu Zhen-Rong Chen Lian-Qun Xu Bi-LingGan Hao-Sheng Jin ning Shi Department of General Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Geriatrics Ganzhou Hospital-Nanfang HospitalSouthern Medical UniversityGanzhou 341000Jiangxi ProvinceChina Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510000Guangdong ProvinceChina Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China

BACKGROUND With the rapid progress of systematic therapy for hepatocellular carcinoma(HCC),therapeutic strategies combining hepatic arterial infusion chemotherapy(HAIC)with systematic therapy arised increasing ***,there have been no systematic review comparing HAIC and its combination strategies in the first-line treatment for advanced *** To investigate the efficacy and safety of HAIC and its combination therapies for advanced *** A network meta-analysis was performed by including 9 randomized controlled trails and 35 cohort studies to carry out our *** outcomes of interest comprised overall survival(OS),progression-free survival(PFS),tumor response and adverse *** ratios(HR)and odds ratios(OR)with a 95% confidence interval(CI)were calculated and agents were ranked based on their ranking *** HAIC outperformed Sorafenib(HR=0.55,95%CI:0.42-0.72;HR=0.51,95%CI:0.33-0.78;OR=2.86,95%CI:1.37-5.98;OR=5.45,95%CI:3.57-8.30;OR=7.15,95%CI:4.06-12.58;OR=2.89,95%CI:1.99-4.19;OR=0.48,95%CI:0.25-0.92,respectively)and transarterial chemoembolization(TACE)(HR=0.50,95%CI:0.33-0.75;HR=0.62,95%CI:0.39-0.98;OR=3.08,95%CI:1.36-6.98;OR=2.07,95%CI:1.54-2.80;OR=3.16,95%CI:1.71-5.85;OR=2.67,95%CI:1.59-4.50;OR=0.16,95%CI:0.05-0.54,respectively)in terms of efficacy and ***+lenvatinib+ablation,HAIC+ablation,HAIC+anti-programmed cell death 1(PD-1),and HAIC+radiotherapy had the higher likelihood of providing better OS and PFS outcomes compared to HAIC ***+TACE+S-1,HAIC+lenvatinib,HAIC+PD-1,HAIC+TACE,and HAIC+sorafenib had the higher likelihood of providing better partial response and objective response rate outcomes compared to ***+PD-1,HAIC+TACE+S-1 and HAIC+TACE had the higher likelihood of providing better complete response and disease control rate outcomes compared to HAIC *** HAIC proved more effective and safer than sorafenib and ***,combined with other interventions,HAIC showed imp

关键词： Hepatic arterial infusion chemotherapy Hepatocellular carcinoma Network meta-analysis Interventional therapy Systemic treatment

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Extragastrointestinal stromal tumors with diffuse membranous distribution with bleeding:A case report

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World Journal of Clinical Cases 2024年第26期12卷 5990-5997页

作者： Jian-Duo Xu Zheng Wang Qian Zhou ning Meng Shu-mei Zhang Nan Liu Department of Gastrointestinal Surgery Shijiazhuang People’s HospitalShijiazhuang 050000Hebei ProvinceChina Department of Gastroenterology Shijiazhuang People's HospitalShijiazhuang 050000Hebei ProvinceChina Department of General Surgery Shijiazhuang People's HospitalShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Extragastrointestinal stromal tumors(EGIST)and gastrointestinal stromal tumors are of similar pathological type and *** we report a rare case of EGIST diffusely distributed in membranous tissue in abdominal cavity,the feature of which included diffuse tumors at membranous tissue in entire abdominal cavity and spontaneous bleeding of the *** SUMMARY The patient was a 71-year man and hospitalized due to continuous pain at lower abdomen for more than 10 *** physical examination,the patient had flat and tough abdomen with mild pressing pain at lower abdomen,no obvious abdominal mass was touchable,and shifting dullness was *** emission tomography-computed tomography(CT)showed that in his peritoneal cavity,there were multiple nodules of various sizes,seroperitoneum,multiple enlarged lymph nodes in abdominal/pelvic cavity and right external ilium as well as pulmonary *** CT scanning at epigastrium/hypogastrium/pelvic cavity+enhanced three-dimensional reconstruction revealed multiple soft tissue nodules in abdominal/pelvic cavity,peritoneum and right *** marker of carbohydrate antigen 125 was 808 U/mL,diffuse tuberous tumor was seen in abdominal/pelvic cavity during operation with hematocelia,and postoperative pathological examination confirmed *** was administered with better therapeutic *** Gene testing showed breast cancer susceptibility gene 1 interacting protein C-terminal helicase 1 and KIT genovariation,and the patient was treated with imatinib follow-up visit found that his clinical symptoms disappeared and the tumor load alleviated obviously via imageological examination.

关键词： Diffuse tumor in abdominal cavity Extragastrointestinal stromal tumors Gastrointestinal stromal tumors Malignant extragastrointestinal stromal tumors Diffusely membranous metastasis

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结合模式记忆和自监督注意力的人群异常行为检测方法

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计算机工程与设计 2024年第8期45卷 2527-2533页

作者：宁冬梅梁莉南昌理工学院计算机信息工程学院江西南昌330029 成都理工大学数理学院四川成都610059

为实现复杂环境下监控视频中异常事件的快速检测和准确定位,提出一种结合正常模式记忆和自监督注意力机制的异常检测框架。记忆机制综合考虑正常模式的多样性和差异性,解决卷积神经网络(CNN)泛化性过强的问题。自监督模块包含遮罩卷积... 详细信息

为实现复杂环境下监控视频中异常事件的快速检测和准确定位,提出一种结合正常模式记忆和自监督注意力机制的异常检测框架。记忆机制综合考虑正常模式的多样性和差异性,解决卷积神经网络(CNN)泛化性过强的问题。自监督模块包含遮罩卷积层和通道注意力层,通过遮罩信息预测的自监督训练,提高模型对全局特征结构的理解。公开数据集的实验结果表明,所提方法的曲线下面积(AUC)指标分别达到92.6%和82.7%,性能优于当前其它先进的视频异常检测方法,在轨迹检测标准(TBDC)和区域检测标准(RBDC)指标中表现出优秀的异常跟踪和定位能力。

关键词：人群异常行为检测自监督注意力卷积神经网络遮罩卷积全局特征结构轨迹检测标准区域检测标准

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Identification of Key Blood Biomarkers Linking Di(2-ethylhexyl)Phthalate and Autoimmune Diseases in Adolescents Mice

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Biomedical and Environmental Sciences 2024年第5期37卷 521-525页

作者： XU Xiao mei LI Xiao Lu HU Die CAI Xiao Yue LI Qi Meng ZHENG Yuan Zhuo CAI Yang QI Yin Yin XU Tao ZHAO Ling Li ning Xia Department of Infectious Diseases Anhui Provincial Children’s HospitalHefei 231000AnhuiChina Department of Toxicology School of Public HealthKey Laboratory of Environmental Toxicology of Anhui Higher Education InstitutesAnhui Medical UniversityHefei 231000AnhuiChina School of Biology Food and EnvironmentHefei UniversityHefei 230601AnhuiChina

Di(2-ethylhexyl)phthalate(DEHP)is a widely used plasticizer known for its reproductive developmental and immune system toxicity,mainly through esophagal,dermal,and respiratory exposure^([1-3]).Maternal exposure to DEHP during pregnancy can lead to adverse birth outcomes in offspring,including impacts on the thyroid system of adolescent offspring^([2-4]).

关键词： Blood respiratory pregnancy

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癌症患者自我管理行为转变体验质性研究的Meta整合

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中华护理杂志 2024年第7期59卷 865-873页

作者：林雯雯徐梅夏云江宁莫瑜威王莉宁丽浙江中医药大学护理学院杭州市310053 杭州市肿瘤医院护理部杭州市第一人民医院护理部

目的系统评价与整合癌症患者自我管理行为转变的体验,为后续制订针对性的自我管理干预措施提供依据。方法计算机检索Cochrane Library、CINAHL、Embase、PubMed、Web of Science、PsycINFO、中国知网、维普数据库、万方数据库和中国生... 详细信息

目的系统评价与整合癌症患者自我管理行为转变的体验,为后续制订针对性的自我管理干预措施提供依据。方法计算机检索Cochrane Library、CINAHL、Embase、PubMed、Web of Science、PsycINFO、中国知网、维普数据库、万方数据库和中国生物医学文献数据库中有关癌症患者自我管理行为转变体验的质性研究,检索时限为建库至2023年7月。采用澳大利亚乔安娜布里格斯研究所循证卫生保健中心质性研究质量评价标准进行文献质量评价,采用汇集性整合的方法进行结果整合。结果共纳入12篇文献,提炼出50个研究结果,归纳成14个新类别,合成4个整合结果:自我管理行为的转变形式、自我管理行为的转变特征、自我管理行为转变的动力因素、自我管理行为转变的阻碍因素。结论医护人员应关注癌症患者自我管理行为转变的真实体验,根据自我管理行为转变特征及影响因素进行针对性的能力培养和心理干预,促进其自我管理行为的顺利转变。

关键词：肿瘤自我管理行为转变质性研究循证护理学

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突发公共卫生事件视域下北京市公共卫生人力资源建设现状研究

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中国全科医学 2024年第31期27卷 3919-3925页

作者：顾梅赵宁李进杨佳首都医科大学公共卫生学院北京市100069

背景公共卫生人力资源建设是完善公共卫生体系、提高突发公共卫生事件应急处理能力的关键。目的分析突发公共卫生事件发生后北京市公共卫生人力资源建设现状、优势与不足,提出完善北京市公共卫生人力资源建设的对策建议。方法于2022年6... 详细信息

背景公共卫生人力资源建设是完善公共卫生体系、提高突发公共卫生事件应急处理能力的关键。目的分析突发公共卫生事件发生后北京市公共卫生人力资源建设现状、优势与不足,提出完善北京市公共卫生人力资源建设的对策建议。方法于2022年6—9月,从《北京市卫生机构人力基本信息调查表》《北京市社区卫生工作统计资料汇编》中收集2016—2021年的公共卫生人员数量及年龄、学历、职称等信息,分析突发公共卫生事件发生后北京市专业和基层公共卫生人力资源的数量、结构及配置情况。结果2019—2021年,北京市专业公共卫生机构公共卫生人员总数由15157人增至16048人,具有研究生学历的人员占比增长0.93个百分点,拥有高、中级职称的人员占比分别增长2.29、3.87个百分点;基层公共卫生人员总数由3701人增至4017人,具有本科及以上学历的人员占比增长5.36个百分点,拥有高、中级职称的人员占比分别增长0.72、1.70个百分点。2019—2021年,每万常住人口疾控力量配比由1.68人降至1.57人,每千常住人口专业公共卫生机构卫生人员数由0.70人增至0.73人,每万人口基层公共卫生人员数由1.72人增至1.84人。结论突发公共卫生事件发生后,北京市公共卫生人力资源总量增长,人员配备缺口尚存,公共卫生机构梯队建设强化,各机构人力资源质量不均衡,公共卫生人力职称结构趋于合理。建议明确公共卫生人员配置标准,补齐公共卫生人力资源缺口;优化公共卫生人才培养模式,提升公共卫生人力资源质量;完善公共卫生人力发展保障机制,吸引并留住人才。

关键词：公共卫生卫生人力初级卫生保健人才结构北京

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环境监测方法验证中常见的问题探讨

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黑龙江环境通报 2024年第2期37卷 57-59页

作者：宁梅辽宁省丹东生态环境监测中心(中心分析室) 辽宁大连118000

本文主要介绍了环境监测标准方法的验证,并简要阐述了标准方法验证的过程,同时对标准方法验证中的常见问题进行了讨论。

关键词：环境监测实验室方法验证

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