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Effect of Initiation of Basal Insulin Glargine on Glycemic Control in Patients with Diabetes: Real Life Experience from Hong Kong

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Journal of Diabetes Mellitus 2017年第3期7卷 108-120页

作者： Chi-Kin Yeung Fhkcp Fhkam Wilson wai-man Ngai ip-tim Lau Department of Medicine Tseung Kwan O Hospital Hong Kong China Sanofi (Hong Kong) Ltd. Hong Kong China

Introduction: To assess the changes in glycemic control after initiating or switching to a basal insulin analogue in patients with diabetes mellitus. Methods: A retrospective, observational analysis was conducted using electronic data from a Hong Kong regional hospital. Data from adult patients with type 1 and 2 diabetes mellitus (T1DM and T2DM, respectively) who had been prescribed with basal insulin glargine in 2008-2010, with recorded HbA1c levels at the time of initiation, at 6 and 12 months thereafter, were analysed. Results: Data from 106 eligible patients were analysed. Substantial reduction in HbA1c and fasting sugar levels were reported in both T1DM (Δ HbA1c = 1.5%, Δ FBG = 1.3 mmol/L p < 0.05) and T2DM (Δ HbA1c = 1.2%, Δ FBG = 2.9 mmol/L p < 0.05) patients after 12 months of therapy. A total of 42% of T1DM and 26% of T2DM patients achieved HbA1c levels < 7.0%. After adjustment, T2DM patients who were insulin naive achieved a statistically greater HbA1c reduction (Δ = 1.7%) than those who previous treated with premixed or basal bolus insulin (Δ = 0.3%) (p < 0.05). Percentage of patients experiencing hypoglycaemia reduced from 69% to 62% in T1DM but increased from 26% to 36% in T2DM patients. All hypoglycaemic episodes recorded were either asymptomatic or mild and self-limiting. Only 4% of the patients discontinued treatment at the end of 12 months. Conclusions: In real life clinical practice, a single daily basal insulin analogue therapy provided effective glycemic control with an acceptable risk of mild hypoglycaemia.

关键词： Glycemic Control Insulin Initiation Insulin Glargine Type 1 Diabetes Mellitus Type 2 Diabetes Mellitus Hong Kong

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Genome sequencing reveals the role of rare genomic variants in Chinese patients with symptomatic intracranial atherosclerotic disease

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Stroke & Vascular Neurology 2022年第3期7卷 182-189页

作者： Mengmeng Shi Xinyi Leng Ying Li Zihan Chen Ye Cao Tiffany Chung Bonaventure YM ip Vincent HL ip Yannie OY Soo Florence SY Fan Sze Ho Ma Karen Ma Anne Y Y Chan Lisa WC Au Howan Leung Alexander Y Lau Vincent CT Mok Kwong wai Choy Zirui Dong Thomas W Leung Department of Obstetrics and Gynaecology The Chinese University of Hong KongHong KongChina Key Laboratory for Regenerative Medicine Ministry of Education(Shenzhen Base)Shenzhen Research InstituteThe Chinese University of Hong KongShenzhenChina Hong Kong Hub of Paediatric Excellence The Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongPrince of Wales HospitalHong KongChina Department of Paediatrics The Chinese University of Hong KongHong KongChina The Chinese University of Hong Kong-Baylor College of Medicine Joint Center For Medical Genetics The Chinese University of Hong KongHong KongChina

Objectives The predisposition of intracranial atherosclerotic disease(ICAD)to East Asians over Caucasians infers a genetic basis which,however,remains largely *** prevalence of vascular risk factors(VRFs)in Chinese over Caucasian patients who had a stroke,and shared risk factors of ICAD with other stroke subtypes indicate genes related to VRFs and/or other stroke subtypes may also contribute to *** Unrelated symptomatic patients with ICAD were recruited for genome sequencing(GS,60-fold).Rare and potentially deleterious single-nucleotide variants(SNVs)and small insertions/deletions(InDels)were detected in genome-wide and correlated to genes related to VRFs and/or other stroke *** aneuploidies,copy number variants(CNVs)and chromosomal structural rearrangements were also ***,candidate genes were used for pathway and gene ontology enrichment *** Among 92 patients(mean age at stroke onset 61.0±9.3 years),GS identified likely ICAD-associated rare genomic variants in 54.3%(50/92)of ***-eight patients(52.2%,48/92)had 59 rare SNVs/InDels reported or predicted to be deleterious in genes related to VRFs and/or other stroke *** of the 59 rare variants were identified in local subjects without ICAD(n=126).31 SNVs/InDels were related to conventional VRFs,and 28 were discovered in genes related to other stroke *** study also showed that rare CNVs(n=7)and structural rearrangement(a balanced translocation)were potentially related to ICAD in 8.7%(8/92)of ***,candidate genes were significantly enriched in pathways related to lipoprotein metabolism and cellular lipid catabolic *** Our GS study suggests a role of rare genomic variants with various variant types contributing to the development of ICAD in Chinese patients.

关键词： patients metabolism intracranial

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20.231 Gbit/s tricolor red/green/blue laser diode based bidirectional signal remodulation visible-light communication system

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Photonics Research 2018年第5期6卷 422-426页

作者： LIANG-YU WEI CHIN-WEI HSU CHI-wai CHOW CHIEN-hung YEH Department of Photonics and Institute of Electro-Optical Engineering Taiwan Chiao Tung UniversityHsinchu 30010China Department of Electronic Engineering The Chinese University of Hong KongSha TinHong KongChina Department of Photonics Feng Chia UniversityTaichung 40724China

We propose and experimentally demonstrate a recorded 1-m bidirectional 20.231-Gbit/s tricolor R/G/B laser diode(LD) based visible-light communication(VLC) system supporting signal remodulation. In the signal remodulation system, an LD source is not needed at the client side. The client reuses the downstream signal sent from the central office(CO) and remodulates it to produce the upstream signal. As the LD sources are located at the CO, the laser wavelength and temperature managements at the cost-sensitive client side are not *** is the first demonstration, to our knowledge, of a >20 Gbit∕s data rate tricolor R/G/B VLC signal transmission supporting upstream remodulation.

关键词： bidirectional signal remodulation visible-light communication system blue laser

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Novel N-heteroaromatic dyes for textile substrates

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Chinese Chemical Letters 2014年第8期25卷 1165-1168页

作者： Kim-hung Lam Sarah Sze-Wah Ho Pik-Ling Lam Johnny Cheuk-On Tang Zhao-Xiang Bian Albert Sun-Chi Chan Hua Li wai-Yeung Wong Chung-Hin Chui Department of Applied Biology and Chemical Technology Institute of Textile and Clothing The Hong Kong Polytechnic University Clinical Division School of Chinese Medicine Hong Kong Baptist University Institute of Molecular Functional Materials Department of Chemistry and Institute of Advanced Materials Hong Kong Baptist University College of Life and Environmental Sciences Minzu University of China HKBU Institute of Research and Continuing Education Shenzhen Virtual University Park

This study reports the synthesis and characterization of quinoline derivatives. The synthesized quinoline compounds were applied to the dyeing treatment of acrylic fabrics. The color fastness to washing and light of quinoline compound-dyed fabrics was examined. Human skin HaCaT cell line was also used for the skin cytotoxicity evaluation of the quinoline compound-dyed acrylic fabrics.

关键词： Acrylic fabrics Fluorescent Quinoline dyes Skin cytotoxicity

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Unique anti-angiogenic effects,pharmacological targets and therapeutic mechanisms of Chinese herbal medicines for endometriosis

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Genes & Diseases 2024年第5期11卷 63-65页

作者： Bo Liang Rui Dong Sze Wan hung Yiran Li Yuezhen Lin Ling Wu Tao Zhang Gene Chi wai Man Hui Xu Jacqueline Pui Wah Chung Chi Chiu Wang Guangdong Provincial Key Laboratory of Marine Biotechnology Institute of Marine SciencesShantou UniversityShantouGuangdong 515063China Department of Obstetrics and Gynaecology The Chinese University of Hong KongHong Kong SARChina Reproduction and Development Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong SARChina School of Biomedical Sciences The Chinese University of Hong KongHong Kong SARChina Chinese University of Hong Kong-Sichuan University Joint Laboratory in Reproductive Medicine The Chinese University of Hong KongHong Kong SARChina

Endometriosis is a common and benign angiogenesisdependent gynecological disorder,which refers to the proliferation and growth of endometrium-like tissues with neovasculature formation outside of the uterus.1 Available medical treatments for endometriosis containing hormonal and non-hormonal treatments had been limited for longterm usage by their side effects.2 Ideal medical treatment for endometriosis with efficacy to relieve symptoms and suppress endometriotic lesion growth and minimal side effects has been longing for decades.3 Angiogenesis is a promising therapeutic target for endometriosis.

关键词： therapeutic endometriosis herbal

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Outcome of severely injured trauma patients at a designated trauma centre in the Hong Kong Special Administrative Region

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Chinese Medical Journal 2010年第10期123卷 1251-1254页

作者： LEUNG Ka Kit Gilberto HO Wendy TONG King hung Daniel YUEN wai Key Trauma Service Queen Mary Hospital and The University of Hong Kong The Hong Kong Special Administrative Region (HKSAR) China

Background The Hong Kong Special Administrative Region （HKSAR） of the People＇s Republic of China （PRC） has seen significant changes in its trauma service over the last ten years including the implementation of a regional trauma system. The author＇s institution is one of the five trauma centres designated in 2003. This article reports our initial clinical experience. Methods A prospective single-centre trauma registry from January 2004 to December 2008 was reviewed. The primary clinical outcome measure was hospital mortality. The Trauma and Injury Severity Score （TRISS） methodology was used for bench-marking with the North America Major Trauma Outcome Study （MTOS） database. Results There were 1451 patients. The majority （83.9%） suffered from blunt injury. The overall mortality rate was 7.8%. Severe injury, defined as the Injury Severity Score 〉15, occurred in 22.5% of patients, and was associated with a mortality rate of 31.6%. A trend of progressive improvement was noted. The M-statistic was 0.99, indicating comparable case-mix with the MTOS. The Z- and W-statistics of each individual year revealed fewer, but not significantly so, number of survivors than expected. Conclusions Trauma centre designation was feasible in the HKSAR and was associated with a gradual improvement in patient care. Trauma system implementation may be considered in regions equipped with the necessary socio-economic and organizational set-up.

关键词： trauma, nervous system outcome trauma and injury severity score Hong Kong, China

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Overview of methodologies and statistical strategies in observational studies and meta-analyses on the risk of hepatocellular carcinoma in patients with chronic hepatitis B on entecavir or tenofovir therapy

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Hepatoma Research 2022年第1期8卷 143-156页

作者： Terry Cheuk-Fung Yip Vincent wai-Sun Wong Mandy Sze-Man Lai Vicki Wing-Ki Hui Yee-KitTse Grace Lai-hung Wong Medical Data Analytics Centre Department of Medicine and TherapeuticsThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics 9/F Lui Che Woo Clinical Sciences BuildingPrince of Wales Hospital30-32 Ngan Shing StreetShatinHong KongChina Institute of Digestive Disease The Chinese University of Hong KongHong KongChina

Entecavir(ETV)and tenofovir disoproxil fumarate(TDF)are first-line antiviral therapies for patients with chronic hepatitis B(CHB)and reduce the risk of disease progression and liver-related complications,as well as improve survival by effectively suppressing viral ***,since the first publication in 2019 on a lower risk of hepatocellular carcinoma(HCC)in Korean patients receiving TDF than those receiving ETV,the topic has remained a hot and unsettled *** studies and meta-analyses have yielded conflicting *** HCC takes time to develop,studies are mainly observational to benefit from a larger sample size and longer follow-up that provides a higher statistical power to compare the two ***,TDF was available to CHB patients a few years later than ETV in most countries,thus leading to a difference in follow-up ***,despite studying the same topic,the difference in data sources and available parameters,inclusion and exclusion criteria,and use of statistical methods complicated the interpretation and comparison of the findings and contributed to between-study heterogeneity in *** review describes some caveats in interpreting and comparing the results from these observational studies and *** studies should explore better designed observational studies with high-quality data sources,and aggregation of patient data in metaanalysis to tackle between-study heterogeneity.

关键词： Bias confounding hepatitis B virus hepatocellular carcinoma liver cancer nucleos(t)ide analogues propensity score

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香港教科书的编辑:提升质量的建议

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西南大学学报（社会科学版） 2010年第4期36卷 72-76页

作者：霍秉坤叶慧虹黄显华香港中文大学教育学院

教科书是教育系统中重要的环节,它是教学的重要内容、知识的系统性组织、课程与教学间的连结。然而,香港对教科书的探讨仍然不足,而且教科书的质量仍有待提升。在制度层面分析香港教科书编审情况的基础上;从教科书研究、政府审书尺度、... 详细信息

教科书是教育系统中重要的环节,它是教学的重要内容、知识的系统性组织、课程与教学间的连结。然而,香港对教科书的探讨仍然不足,而且教科书的质量仍有待提升。在制度层面分析香港教科书编审情况的基础上;从教科书研究、政府审书尺度、政府审书取向、教科书内容质素等四方面,阐述提升教科书效能的建议。作者认为,香港特区政府仍负有最重要的责任。能否加强教科书研究?能否强化审书机制?能否扮演更积极的审书角色?这些都是特区政府能否提升教科书质量所必须面对和解决的重要问题。

关键词：香港教科书编辑效能品质政府

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Enhanced Intrusion Detection System for an EH IoT Architecture Using a Cooperative UAV Relay and Friendly UAV Jammer

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IEEE/CAA Journal of Automatica Sinica 2021年第11期8卷 1786-1799页

作者： Van Nhan Vo hung Tran Chakchai So-In Institute of Research and Development Duy Tan UniversityDa Nang 550000Vietnam Faculty of Information Technology Duy Tan UniversityDa Nang 550000Vietnam Applied Network Technology Laboratory Department of Computer ScienceFaculty of ScienceKhon Kaen UniversityKhon Kaen 40002Thailand Faculty of Computer Science Phenikaa UniversityHanoi 100000Vietnam

In this paper,the detection capabilities and system performance of an energy harvesting(EH)Internet of Things(Io T)architecture in the presence of an unmanned aerial vehicle(UAV)eavesdropper(UE)are *** communication protocol is divided into two *** the first phase,a UAV relay(UR)cooperates with a friendly UAV jammer(UJ)to detect the UE,and the UR and UJ harvest energy from a power beacon(PB).In the second phase,a ground base station(GBS)sends a confidential signal to the UR using non-orthogonal multiple access(NOMA);the UR then uses its harvested energy to forward this confidential signal to IoT destinations(IDs)using the decode-and-forward(DF)***,the UJ uses its harvested energy to emit an artificial signal to combat the detected UE.A closed-form expression for the probability of detecting the UE(the detection probability,DP)is derived to analyze the detection ***,the intercept probability(ip)and throughput of the considered IoT architecture are ***,we identify the optimal altitudes for the UR and UJ to enhance the system and secrecy *** Carlo simulations are employed to verify our approach.

关键词： Detection probability(DP) energy harvesting(EH) friendly UAV jammer Internet of Things(IoT) system performance UAV detection

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Simple Modifications to Standard TRIzol®Protocol Allow High-Yield RNA Extraction from Cells on Resorbable Materials

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Journal of Biomaterials and Nanobiotechnology 2011年第1期2卷 41-48页

作者： Juliana Tsz Yan Lee wai hung Tsang King Lau Chow 不详

Resorbable bioceramics are attractive for medical applications such as bone substitution. Biochemical analysis on cells cultured on these biomaterials is vital to predict the impact of the materials in vivo and RNA extraction is an essential step in gene expression study using RT-qPCR. In this study, we describe simple modifications to the TRIzol? RNA extraction protocol widely used in biology and these allow high-yield extraction of RNA from cells on resorbable calcium phosphates. Without the modifications, RNA is trapped in the co-precipitated calcium compounds, rendering TRIzol? extraction method infeasible. Among the modifications, the use of extra TRIzol? to dilute the lysate before the RNA precipitation step is critical for extraction of RNA from porous ?-tricalcium phosphate (?-TCP) discs. We also investigate the rationale behind the undesirable precipitation so as to provide clues about the modifications required for other resorbable materials with high application potential in bone tissue engineering.

关键词： Calcium Phosphate Resorbable Materials RNA Extraction TRIzol Acid Guanidium Thiocyanate - Phenol - Chloroform Extraction TRI Reagent TRIsure

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