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Model Checking for a General Linear Model with Nonignorable Missing Covariates

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Acta Mathematicae Applicatae Sinica 2012年第1期28卷 99-110页

作者： Zhi-hua SUN wai-Cheung ip Heung WONG School of Mathematical sciences Graduate University of Chinese Academy of SciencesBeijing 100049China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China Department of Applied Mathematics Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

In this paper, we investigate the model checking problem for a general linear model with nonignorable missing covariates. We show that, without any parametric model assumption for the response probability, the least squares method yields consistent estimators for the linear model even if only the complete data are applied. This makes it feasible to propose two testing procedures for the corresponding model checking problem： a score type lack-of-fit test and a test based on the empirical process. The asymptotic properties of the test statistics are investigated. Both tests are shown to have asymptotic power 1 for local alternatives converging to the null at the rate n-r, 0 ≤ r 〈 1/2. Simulation results show that both tests perform satisfactorily.

关键词： general linear model model checking nonignorable missing covariates sensitivity analysis

Wavelets in probability and statistics——A review in recent advances

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Chinese Science Bulletin 2002年第9期47卷 705-716页

作者： XIE Zhongjie Heung Wong wai-Cheung ip School of Mathematical Sciences Peking UniversityBeijing 100871China Department of Applied Mathematics The Hong Kong Polytechnic UniversityHong KongChina

The main purpose of this paper is to give a review on recent advances of wavelet in probability and statistics. Many interesting new ideas, new results and new methods are introduced in this review. From many aspects of this paper, probability and statistics researchers may find many new interesting research topics for further studying on wavelets in stochastic processes. New results, such as K- sta-tionarity, wavelet representation of Karhunen processes, hidden periodicities analysis by wavelet approach, hetero-scedasticity in wavelet regression, wavelets and neural networks, etc. are introduced in this paper. Comments, discussions and plentiful references are also involved in this review.

关键词： wavelets K-stationarity time varying spectral analysis nonlinear modeling wavelet variance.

Ileocolonic mucormycosis in adult immunocompromised patients:A surgeon's perspective

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World Journal of Gastroenterology 2010年第9期16卷 1165-1170页

作者： Oswens Siu-hung Lo wai-Lun Law Division of Colorectal Surgery Department of SurgeryUniversity of Hong Kong Medical CentreQueen Mary Hospital

We report three cases of ileocolic mucormycosis in adult immunocompromised patients presenting as acute *** patients underwent laparotomy but two of them died from multiorgan failure before the diagnoses were *** diagnosis of gastrointestinal mucormycosis is rarely suspected,and antemortem diagnosis is made in only 25%-50% of *** cases illustrate the difficulty encountered by surgeons in managing acute abdomen in neutropenic patients with hematological *** management of colonic mucormycosis in the published literature is also reviewed.

关键词： Gastrointestinal mucormycosis Colon Immunocompromised Surgery

WJG 20^(th) Anniversary Special Issues(1): Hepatocellular carcinoma Risk prediction of hepatitis B virus-related hepatocellular carcinoma in the era of antiviral therapy

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World Journal of Gastroenterology 2013年第39期19卷 6515-6522页

作者： Grace Lai-hung Wong Vincent wai-Sun Wong Institute of Digestive Disease and Department of Medicine and Therapeutics The Chinese University of Hong Kong

Chronic hepatitis B(CHB)-related hepatocellular carcinoma(HCC)is a major health problem in AsianPacific *** therapy reduces,but does not eliminate the risk of *** would be a heavy financial burden in most low and middle economic countries if all CHB patients received antiviral therapy and HCC ***,there is a need for accurate risk prediction to assist prognostication,decisions on the need for antiviral therapy and HCC surveillance.A few wellestablished risk factors for HCC,namely advanced age,male gender,high viral load,cirrhosis etc.,are the core components of three HCC risk scores:CU-HCC,GAGHCC and REACH-B *** 3 scores were confirmed to be accurate in predicting HCC up to 10 years in treatment-na ve *** validity and applicability have recently been demonstrated in a large cohort of entecavir treatment patients.A decrease in risk scores after antiviral therapy translates to a lower risk of *** findings support the application of HCC risk scores in all CHB *** levels of care and different intensities of HCC surveillance should be offered according to the risk profile of *** at risk of HCC should undergo regular HCC surveillance,even when they are receiving antiviral treatment.

关键词： Antiviral therapy Cirrhosis Hepatitis B virus DNA Hepatocellular carcinoma Risk prediction score Transient elastography

Rare complication of inflammatory bowel disease-like colitis from glycogen storage disease type 1b and its surgical management:A case report

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World Journal of Clinical Cases 2021年第16期9卷 4081-4089页

作者： Frederick Chi-wai Lui Oswens Siu-hung Lo Department of Surgery LKS Faculty of MedicineThe University of Hong KongHong KongChina

BACKGROUND Glycogen storage disease(GSD)is an autosomal recessive inborn metabolic *** with GSD are prone to hypoglycaemia,hyperlactacidemia and *** type 1b(GSD-1b)patients specifically can develop neutropenia,recurrent bacterial infection and inflammatory bowel disease(IBD).Documentation of the long-term outcomes of surgical management of GSD-1b has been scarce,especially for Asian *** herein describe a case of GSD-1b complicated by IBD-like colitis and coloduodenal *** patient was managed successfully with surgical *** SUMMARY A 20-year-old Chinese lady confirmed by genetic testing to have GSD-1b was initially managed with uncooked cornstarch and granulocyte-colony stimulating *** recurrent abdominal symptoms,her condition was treated as clinical“Crohn’s disease”with mesalazine,prednisolone and azathioprine *** showed a tight stricture at the hepatic *** computerized tomographic colonography revealed a phlegmon at the ileocaecal region with a suspected coloduodenal *** an exploratory laparotomy was performed and severe colitis at the ascending colon with coloduodenal fistula was *** hemicolectomy with primary anastomosis and repair of the duodenum were *** management of complications from GSD-1b associated IBD-like colitis has rarely been ***-line treatment would usually be *** intervention like hemicolectomy is mainly reserved for refractory *** Surgical management of coloduodenal fistula in GSD-1b patients is a feasible and safe option when failed conservative management.

关键词： Glycogen storage disease Coloduodenal fistula Inflammatory bowel diseaselike colitis Case report Perioperative management

The Relationship of Corporate Culture and Positive Conflict Management

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厦门大学学报（自然科学版） 2002年第S1期41卷 253-254页

作者： wai-hung Ng S F Lee SAE Magnetics （H.K.） Ltd. HKSAR Hong Kong Productivity Council Hong Kong China Hong Kong

With a unique corporate culture based on ancient Ch in ese wisdom being implemented at workplace for more than 10 years, we have been e ncountering various issue of managing conflicts, in particular at organization r estructure period, although we perceive that conflict does not necessarily have dysfunctional effect on our group performance. However, conflicts between and am ong various levels of the organization hierarchy are inevitably creating certain impact on our organization cohesiveness, performa...

关键词： The Relationship of Corporate Culture and Positive Conflict Management

Viral integration detection strategies and a technical update on Virus-Clip

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BIOCELL 2021年第6期45卷 1495-1500页

作者： DANIEL wai-hung HO XUEYING LYU IRENE OI-LIN NG Department of Pathology The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Oncovirus infection is crucial in human *** oncoviruses can lead to structural variations in the human genome known as viral genomic integration,which can contribute to *** viral integration detection tools differ in their underlying algorithms pinpointing different aspects or features of viral integration *** discuss about major procedures in performing viral integration *** importantly,we provide a technical update on Virus-Clip to facilitate its usage on the latest human genome builds(hg19 and hg38)and the adoption of multi-thread mode for faster initial read *** comparing the execution of Virus-Clip using single-thread and multi-thread modes of read alignment on targeted-panel sequencing data of HBV-associated hepatocellular carcinoma patients,we demonstrate the marked improvement of multi-thread mode in terms of significantly reduced execution time,while there is negligible difference in memory *** together,with the current update of Virus-Clip,it will continue supporting the in silico detection of oncoviral integration for better understanding of various human malignancies.

关键词： Oncovirus Viral genomic integration In silico detection Tumorigenesis Human malignancies

TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma

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Frontiers of Medicine 2015年第3期9卷 322-330页

作者： Daniel wai-hung Ho Alan Ka-Lun Kai Irene Oi-Lin Ng Department of Pathology and State Key Laboratory for Liver Research The University of Hong Kong ttong Kong SAR China

This study systematically evaluates the TCGA whole-transcriptome sequencing data of hepatocellular carcinoma （HCC） by comparing the global gene expression profiles between tumors and their corresponding non- tumorous liver tissue. Based on the differential gene expression analysis, we identified a number of novel dysregulated genes, in addition to those previously reported. Top-listing upregulated （CENPF and FOXM1） and downregulated （CLEC4G, CRHBP, and CLEC1B） genes were successfully validated using qPCR on our cohort of 65 pairs of human HCCs. Further examination for the mechanistic overview by subjecting significantly upregulated and downregulated genes to gene set enrichment analysis showed that different cellular pathways were involved. This study provides useful information on the transcriptomic landscape and molecular mechanism of hepatocarcinogenesis for development of new biomarkers and further in-depth characterization.

关键词： TCGA whole-transcriptome sequencing HCC liver cancer

Single cell analysis informing therapy response in hepatocellular carcinoma and intrahepatic cholangiocarcinoma

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 126-128页

作者： Daniel wai-hung Ho Irene Oi-Lin Ng Department of Pathology The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Liver cancer is known to have significant degree of intra-tumoral heterogeneity(ITH)(1).Hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(ICC)are major forms of primary liver cancer,accounting for>95%of *** is linked,as least in part,to the aggressiveness and refractoriness of liver cancer,rendering its high lethality among human malignancies(2).The complex tumor microenvironment promotes tumor progression and contributes to poor treatment ***,it is vital to address the biological mechanisms underlying liver cancer progression and treatment response analyzing the cells in high resolution rather than the mixture of many cell *** advances in single-cell RNA sequencing(scRNA-seq)provide an avenue to dissect liver cancer in an unprecedented degree of high resolution to characterize the underlying pathogenesis and heterogeneity.

关键词： cancer intrahepatic Liver