检索结果-南通市图书馆

Dietary intake of advanced glycation endproducts(AGEs)and cancer risk across more than 20 anatomical sites:A multinational cohort study

在线全文

学校读者我要写书评

暂无评论

cancer communications 2022年第10期42卷 1041-1045页

作者： Reynalda córdova Ana-Lucia Mayén Viktoria Knaze Elom Kouassivi Aglago casper Schalkwijk Karl-Heinz wagner Kim Overvad Anne Tjønneland cecilie Kyrø Verena Andrea Katzke charlotte Le cornet Matthias Bernd Schulze Anna Birukov Domenico Palli Sara Grioni Fabrizio Pasanisi Alberto catalano Torkjel Manning Sandanger Inger Torhild Gram Guri Skeie Marta crous-Bou Esther Molina-Montes Pilar Amiano Sandra Milena colorado-Yohar Eva Ardanaz Isabel Drake Jonas Manjer Ingegerd Johansson Anders Esberg Aurora Perez-cornago Elisabete Weiderpass Mazda Jenab Heinz Freisling Nutrition and Metabolism Branch International Agency for Research on Cancer(IARC-WHO)Lyon 69008France Department of Nutritional Sciences University of ViennaVienna 1090Austria Department of Internal Medicine Maastricht University Medical CentreMaastricht 6229the Netherlands Department of Public Health Aarhus UniversityAarhus 8000Denmark Danish cancer Society Research center Copenhagen 2100Denmark Division of cancer Epidemiology German Cancer Research Center(DKFZ)Heidelberg 69120Germany Department of Molecular Epidemiology German Institute of Human Nutrition Potsdam-RehbrueckeNuthetal 14558Germany Institute of Nutritional Science University of PotsdamNuthetal 14558Germany cancer Risk Factors and Lifestyle Epidemiology Unit Institute for Cancer ResearchPrevention and Clinical Network(ISPRO)Florence 2-50139Italy Epidemiology and Prevention Unit Fondazione IRccS Istituto Nazionale dei Tumori di Milano Milan 20133Italy Department of clinical Medicine and Surgery University of Naples Federico IINaples 80138Italy Department of clinical and Biological Sciences University of TurinTurin 1012Italy Department of community Medicine UiT-the Arctic University of NorwayTromsø9037Norway Unit of Nutrition and cancer Cancer Epidemiology Research ProgramCatalan Institute of Oncology(ICO)-Bellvitge Biomedical Research Institute(IDIBELL)L’Hospitalet de LlobregatBarcelona 08908Spain Department of Epidemiology Harvard T.H.Chan School of Public HealthBoston 02115USA Department of Nutrition and Food Science Faculty of PharmacyUniversity of GranadaGranada 18071Spain Ministry of Health of the Basque Government Sub Directorate for Public Health and Addictions of GipuzkoaSan Sebastian 20013Spain Biodonostia Health Research Institute Epidemiology of Chronic and Communicable Diseases GroupSan Sebastián 2014Spain Spanish consortium for Research on Epidemiology and Public Health(cIBERESP) Instituto de Salud Carlos IIIMadrid 28029Spain Department of Epidemiology Murcia Regional Health CouncilIMIB-ArrixacaM

Dear Editor,In the European region,which shares 22.8%of the global cancer burden for 10%of the global population,there were around 4.4 million new cancer cases and 1.9 million deaths from cancer in 2020[1].The reasons for the high cancer incidence rates are complex;however,diet and dietary components are among the main contributors to cancer risk[2].In modern-day living,a growing proportion of people include in their diets ultra-processed *** of food processing and home-prepared foods are so-called dietary advanced glycation endproducts(AGEs),which are reactive metabolites emerging during the breakdown of reducing *** production is preponderant in dry high-heat processes(e.g.,baking,roasting);hence foods such as cakes,crisps,crackers,cereal products,meat and meat-derived products represent a major source of dietary AGEs[3].

关键词： dietary intake hence

儿童癫痫自我管理的干预措施:证据等级是什么

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

癫痫杂志 2019年第2期5卷 130-139页

作者： wagner JL Modi Ac Johnson EK Shegog R Escoffery c Bamps Y Austin JK Schultz RJ MapelLentz S Smith G 江欣悦(译) 熊维希慕洁不详

通过对儿科癫痫领域中自我管理的相关文献进行系统评价,以响应(美国)医学研究所提出的提高青少年中癫痫患者自我管理能力的相关措施。纳入标准:出生到18岁期间出现痫性发作或诊断为癫痫的青少年和(或)其照顾者、1985年–2014年以英文发... 详细信息

通过对儿科癫痫领域中自我管理的相关文献进行系统评价,以响应(美国)医学研究所提出的提高青少年中癫痫患者自我管理能力的相关措施。纳入标准:出生到18岁期间出现痫性发作或诊断为癫痫的青少年和(或)其照顾者、1985年–2014年以英文发表、在人类发展指数较高的国家进行的研究。摘要和关键词中必须明确提到"Self-care"(1996年以前)和/或"Self-management"(1996年以后)。该系统评价分为以下7个步骤:(1)确定相关文献的检索标准以及数据库;(2)评定摘要;(3)全文回顾;(4)将最终引用文献整合到发展、干预以及自我管理类别相关的因素中;(5)依照美国神经病学学会的标准对干预性实验进行证据分级(LOE)评定;(6)对包含对照组的LOEⅢ级的文章进行试验报告统一标准(cONSORT)评价;(7)在四种自我管理领域对干预结局进行分类。共有87篇文章符合纳入标准,其中24篇是LOE等级为Ⅲ或Ⅳ的干预性实验。大多数研究(n=20,80%)为LOEⅢ级;然而只有8项研究包含对照组并符合试验报告统一标准(cONSORT)。其他大部分试验忽视了干预因素(比如实施过程和治疗的精准度)、随机化、参与者、缺失数据以及效应值或置信区间。这24项干预性研究报道有意义的影响体现在4个方面:个体(n=13),家庭(n=6),医疗保健系统(n=3)以及社区(n=2)。所有研究其证据等级均未达到Ⅰ或Ⅱ级,也并未完全符合cONSORT标准。结果描述较好,但自我管理干预的性质(如多病灶,目标技能)和观察到的结果异质性使得各研究之间的比较变得复杂。包括大样本量、干预影响、治疗保真度和功效分析的临床随机对照试验是进一步提高证据基础所必需的。

关键词：家庭管理行为健康干预社会心理干预行为心理干预

荷能重离子辐照常规和高压条件下磷灰石的损伤研究

在线全文

学校读者我要写书评

暂无评论

荷能重离子辐照常规和高压条件下磷灰石的损伤研究

聚乙二醇干扰素α-2b和聚乙二醇干扰素α-2a在慢性丙型肝炎患者中的药代动力学、药效学及其抗病毒作用的比较:一项随机临床试验

第九届全国固体核径迹学术研讨会

作者：刘杰 U.A.Glasmacher M.Lang c.Trautmann K.-0.Voss R.Neumann G.A.wagner R.Miletich 中科院近物所德国海德堡大学地质研究所德国重离子研究中心德国海德堡马普核物理研究所德国海德堡大学矿物研究所

单晶磷灰石(Durango)样品放置于金刚石压腔(DAc)中的两块厚度～1．5-mm 金刚石压砧之间, 加压至10．5 GPa。利用德国重离子研究中心(GSI)的同步加速器(SIS)产生的初始能量106 MeV/u 的 Kr 离子辐照装有样品的压腔。离子穿过真空窗、空气...

单晶磷灰石(Durango)样品放置于金刚石压腔(DAc)中的两块厚度～1．5-mm 金刚石压砧之间, 加压至10．5 GPa。利用德国重离子研究中心(GSI)的同步加速器(SIS)产生的初始能量106 MeV/u 的 Kr 离子辐照装有样品的压腔。离子穿过真空窗、空气,以及一个压砧后到达样品的能量为25

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（胃肠病学分册） 2006年第12期2卷 51-52页

作者： Silva M. Poo J. wagner F. 张红凯 Hospital Universitario Austral PilarArgentina

Background/Aims:To compare the pharmacokinetics,pharmacodynamics,and antiviral activity of peginterferon alfa-2b and peginterferon alfa-2a in patients with chronic hepatitis c virus genotype ***:Thirty-six patients were randomised to peginterferon alfa-2b(1.5 μ g/kg/week) or peginterferon alfa-2a(180 μ g/week) for 4 weeks,then in combination with ribavirin(13 mg/kg/day) for a further 4 *** pharmacokinetic profile of both peginterferons,mRNA expression of a selected group of interferon-induced gene transcripts,and serum HcV-RNA levels were ***:Patients receiving peginterferon alfa-2b had significantly greater up-regul-ation of interferon-alfa response genes compared with those receiving peginterferon ***,patients treated with peginterferon alfa-2b also had a significantly greater log10 maximum and log10 time-weighted average decrease in serum HcV-RNA.A greater proportion of peginterferon alfa-2b patients achieved a ≥ 2.0 log10 reduction in serum HcV-RNA levels by week 8(72% vs 44% of peginterferon alfa-2a patients,P = 0.09) .There was an approximately 16-fold greater exposure to peginterferon in the serum of patients treated with peginterferon ***:These findings suggest that the biological activity,measured by early interferon-induced gene transcripts and early antiviral responsiveness,may have been greater in patients treated with peginterferon alfa-2b despite their lower exposure to the drug compared with patients treated with peginterferon alfa-2a.

关键词：干扰素α 慢性丙型肝炎抗病毒药代动力学药效学随机临床试验干扰素诱导暴露量加权平均数转

海岱地区史前遗址14c测年数据的贝叶斯分析——审视考古年代学

在线全文

学校读者我要写书评

暂无评论

东方考古 2018年第1期 92-112页

作者：龙腾文 Mayke wagner Pavel E.Tarasov 郭珊瑞(译) 饶宗岳(译) 靳桂云(译) 德国考古研究院欧亚考古研究所柏林自由大学地质科学研究所古生物研究室山东大学历史文化学院山东大学文化遗产研究院

以山东省为中心的海岱文化区发现有大量的史前考古遗址,揭示了后李、北辛、大汶口、龙山和岳石这五支风格迥异的新石器或青铜时代文化。通过这五支文化所构建的区域年代序列主要建立在以陶器类型学和地层学为代表的相对年代学基础上;绝... 详细信息

以山东省为中心的海岱文化区发现有大量的史前考古遗址,揭示了后李、北辛、大汶口、龙山和岳石这五支风格迥异的新石器或青铜时代文化。通过这五支文化所构建的区域年代序列主要建立在以陶器类型学和地层学为代表的相对年代学基础上;绝对测年证据仅被视为一种辅助性的资料。这种相对年表被广泛地且经常是不加批判地用于大尺度区域关联(broad-scale correlations)及重建人类—环境相互作用的历史。本文评估了总计317个、分别对应于上述五支文化的已有14c测年数据,并采用了其中275个质量合格的数据进行贝叶斯年代建模。模型结果表明,后李文化(在原有年代序列中为ca. 6500~5500 BcE)开始于ca. 8000~7500 BcE (95%概率范围),结束于ca. 5300~4800 BcE。北辛文化的开始时间(ca. 5300 BcE)比原有年代序列中的(ca. 5000 BcE)要早。这一模拟结果与认为在ca. 5500~5000 BcE存在一个文化断层的假说并不符合。对大汶口文化的分析表明其兴起时间为ca. 4500~3900 BcE,证实了原有序列中的相关年代(ca. 4100 BcE)。大汶口文化衰亡的年代(ca. 2100~1800BcE)比原有年代序列中的(ca. 2600 BcE)至少晚500年。贝叶斯分析将龙山文化置于ca. 2900~2500 BcE和ca. 2100~1700 BcE之间,大体与原有年代序列的分析结果(ca. 2600~1900 BcE)相一致。而岳石文化的模型年代(ca. 3200~2500 BcE)则明显比先前提出的年代(ca. 1900 BcE)要早。大汶口文化、龙山文化和岳石文化之间可能存在的时间重叠,向被广泛接受的该地区单线性文化演变模式提出了疑问,强调了未来进一步进行系统测年和定量分析年代数据的必要性。

关键词：离群分析黄河下游地区 Oxcal软件中国文明早期农业可重叠多阶段模型

Phase separation and coarsening of NiAl(β′)intermetallic in quench-aged Fe-Ni-Al alloys

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2020年第11期27卷 1331-1338页

作者： c.Ferreira-Palma J.A.Rosas-Barrios V.M.Lopez-Hirata D.I.Rivas-Lopez H.J.Dorantes-Rosales Faculty of chemical Sciences Universidad VeracruzanaVeracruz 94294Mexico ESIQIE Instituto Politecnico Nacional.UPALMMexico City 07738Mexico

The coarsening behavior of four quench-aged Fe-Ni-AI alloys with different Ni and Al con tents is *** alloys were solubilized at 1100℃for 24 h,water-quenched and aged at 850℃for periods ranging from 1 to 100 h to promote phase separation and *** two alloys with the highest combined Ni and Al contents(>35 at.%)showed signs of spinodal decomposition,while the alloys with lower Ni and Al contents followed a classical nucleation *** Ni and Al contents promoted an increase in NiAl(β′)phase fraction in concordance with phase equilibrium *** alloy with the highest[3'fraction presented a completely interconnected *** coarsening ofβ′particles in the other three alloys followed the predictions of the Lifshitz-Slyozov-wagner(LSW)*** general trend was an increase in the coarsening kinetics with higher Ni and Al *** highest hardness was found in the alloys with higher fraction albeit these compositions are less resistant to coarsening and have been reported to present a low room-temperature ductility.

关键词： Precipitation Spinodal decomposition coarsening Aging Fe-Ni-Al alloy

年龄、代谢控制和给予胰岛素的类型可影响1型糖尿病儿童和青少年的健康相关性生活质量

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（儿科学分册） 2006年第1期2卷 18-19页

作者： wagner V.M. Mller-Godeffroy E. Von Sengbusch S. 贺莉 Klinik fr Kinder-und Jugendmedizin Universttsklinikum Schleswig-Holstein Campu s Lbeck Ratzeburger Allee 160 23538 Lbeck Germany

The effects of illness and treatment of diabetes mellitus extend beyond medica l outcomes. We therefore evaluated health-related quality of life (HRQOL) in ch ildren (aged 8-12 years) and adolescents (aged 13-16 years) with type 1 diabet es to compare their results with healthy peers and to identify HRQOL determinant s. A total of 68 children and adolescents from a tertiary care clinic which spec ialises in the management of diabetes, completed the generic KINDL-R questionna ire. This instrument for children and adolescents has six dimensions and an addi tional module assessing condition-related HRQOL. Overall, the HRQOL was not dif ferent between patients with type 1 diabetes and healthy controls. In some areas , children and adolescents with diabetes reported a better HRQOL compared to hea lthy peers: adolescents reported better psychological wellbeing ( P children higher levels of well-being in the school domain ( P children reported a better HRQOL ( P cents with type 1 di abetes confirming age-related differences in HRQOL in the general popu lation. Lower HbA1c ( 3 injections/ day) were associated with a better HRQOL in different domains ( P cale “chronic illness”showed a better HRQOL ( P children and ad olescents with diabetes compared to age-matched controls with other chronic con ditions. conclusion:children and adolescents from a paediatric department specia lising in diabetes management report good health-related quality of life. Young er age, good metabolic control and intensified insulin therapy are associated wi th a better health-related quality of life. Dimensions of health-related quali ty of life appear to play different roles at different ages, emphasising the imp ortance of the multidimensional health-related quality of life concept and the value of age-appropriate self-reports.

关键词：代谢控制性生活质量在校儿童慢性疾病患者年龄相关性问卷调查

Intestinal genetic inactivation of caspase-8 diminishes migration of enterocytes

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第15期21卷 4499-4508页

作者： Elke Kaemmerer Paula Kuhn Ursula Schneider Min Kyung Jeon christina Klaus Miriam Schiffer Danika Weisner christian Liedtke J?rg J?kel Lieven Nils Kennes Ralf-Dieter Hilgers Norbert wagner Nikolaus Gassler Institute of Pathology RWTH Aachen University Department of Pediatrics RWTH Aachen University Department of Medicine Ⅲ RWTH Aachen University Department of Medical Statistics RWTH Aachen University

AIM: To verify the hypothesis that caspase-8(casp8), which regulates cellular apoptosis and necroptosis, is critically involved in enterocyte ***: casp8-silenced caco2 cells were used in migration assays. In addition, enterocyte-specific casp8 heterozygous(casp8+/?int) or homozygous knockout mice(casp8?int) were generated by crossing genetically modified mice carrying lox P recombination sites in intron 2 and 4 of the murine casp8 gene with transgenic animals expressing a cre-transgene under control of the villin promoter in a pure c57/BL6 genetic background. The nucleoside analog Brd U was injected i.p. in male casp8+/?int and casp8?int animals 4 h, 20 h, or 40 h before performing morphometric studies. Locations of anti-Brd U-immunostained cells(cellmax) in at least 50 hemi-crypts of 6 histoanatomically distinct intestinal mucosal regions were numbered and extracted for statistical procedures. For the mice cohort(n = 28), the walking distance of enterocytes was evaluated from cellmax within crypt(n = 57), plateau(n = 19), and villus(n = 172) positions, resulting in a total of 6838 observations. Data analysis was performed by fitting a three-level mixed effects modelto the ***: In cell culture experiments with caco2 cells, casp8 knockdown efficiency mediated by RNA interference on casp8 transcripts was 80% controlled as determined by Western blotting. In the scratch assay, migration of casp8-deleted caco2 cells was significantly diminished when compared with controls(casp8?scramble and caco2). In Brd U-labeled casp8?int mice, cellmax locations were found along the hemi-crypts in a lower position than it was for casp8+/?int or control(cre-negative) animals. Statistical data analysis with a three-level mixed effects model revealed that in the six different intestinal locations(distinct segments of the small and large intestine), cell movement between the three mice groups differed widely. Especially in duodenal hemi-crypts, enterocyte movement w

关键词： Barrier function caspase 8 cell migration Inflammatory bowel disease Intestinal morphogenesis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

炭和石墨电极用粘结剂沥青的质量评价

炭素技术 1989年第1期8卷 40-47页

作者： M. H. wagner H. Jager G. wilhelmi I. Letizia 钱湛芬

沥青及其制品的性质可由沥青溶提组份(原生QI和次生QI,β树脂和γ树脂)单独作用的线性组合来估计,也可由沥青其它重要性质(如软化点、等粘温度、沥青的密度、真空馏出液及c/H比)交叉关系来估计。定量地估计了原生QI和β树脂对沥青质量... 详细信息

沥青及其制品的性质可由沥青溶提组份(原生QI和次生QI,β树脂和γ树脂)单独作用的线性组合来估计,也可由沥青其它重要性质(如软化点、等粘温度、沥青的密度、真空馏出液及c/H比)交叉关系来估计。定量地估计了原生QI和β树脂对沥青质量的重要作用。此外,这些线性回归可用于预测沥青组份变化对沥青和制品性质的影响。也图示了杂原子(氮和硫)含量的一些影响。最后,讨论了QI对粘结剂沥青性质的重要影响。原生QI含量高的沥青可导致硬的各向同性的粘结剂沥青焦,该沥青焦热膨胀大,电阻高,导热性差。

关键词：沥青性质软化点沥青质量石墨电极沥青焦体积密度馏出液杂原子沥青用量线性组合